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Diagnostic Advances in Obstetrics and Gynecology, Breast Disease and Women’s...
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Diagnostic Advances in Obstetrics and Gynecology, Breast Disease and Women’s Health

A special issue of Diagnostics (ISSN 2075-4418). This special issue belongs to the section "Clinical Diagnosis and Prognosis".

Deadline for manuscript submissions: 30 November 2026 | Viewed by 6808

Special Issue Editor

Prof. Dr. Menelaos Zafrakas

E-Mail Website
Guest Editor
School of Health Science, International Hellenic University, 57400 Thessaloniki, Greece
Interests: obstetrics; gynecology; breast

Special Issue Information

Dear Colleagues,  

Currently, many specialists from various research areas engage in women’s health. The constant progress in the field of obstetrics and gynecology has led to the development of four distinct subspecialties, i.e., gynecologic oncology, maternal–fetal medicine, reproductive medicine (also referred to as reproductive endocrinology and infertility) and urogynecology (also referred to as female pelvic medicine and reconstructive surgery), along with the partially overlapping fields, which are of special interest and require continuous research. Those research areas are gynecological endoscopy (also referred to as minimally invasive gynecologic surgery), advanced gynecological and obstetrical ultrasound, mastology and breast surgery (i.e., diagnosis and treatment of breast disease, especially breast cancer),  pediatric and adolescent gynecology, menopausal and geriatric gynecology, and family planning. Modern translational research and good clinical practice dictate multidisciplinary co-operation. Therefore, obstetricians and gynecologists co-operate in research and clinical practice with specialists from various other disciplines, including radiology, general and plastic surgery, anesthesiology, radiotherapy, medical oncology, pathology, molecular biology, psychiatry and psycho-oncology, and public health. Finally, women’s health also includes health issues that are common to both genders, especially cardiovascular and neurologic disease in the elderly, considered from the female perspective. This Special Issue welcomes original research and review articles on each and all of these areas.  

Prof. Dr. Menelaos Zafrakas
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Diagnostics is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • obstetrics
  • gynecology
  • maternal–fetal medicine
  • breast
  • women’s health
  • diagnostics

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Published Papers (2 papers)

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Review

19 pages, 829 KB  
Review
Preoperative Breast MRI and Histopathology in Breast Cancer: Concordance, Challenges and Emerging Role of CEM and mpMRI
by Aikaterini-Gavriela Giannakaki, Maria-Nektaria Giannakaki, Dimitris Baroutis, Sophia Koura, Eftychia Papachatzopoulou, Spyridon Marinopoulos, Georgios Daskalakis and Constantine Dimitrakakis
Diagnostics 2025, 15(23), 3032; https://doi.org/10.3390/diagnostics15233032 - 28 Nov 2025
Viewed by 456
Abstract
Background: Preoperative breast MRI is widely used in surgical planning because of its high sensitivity. However, discrepancies with histopathology remain common and can affect tumor size assessment and treatment decisions. In addition, recent comparative studies have highlighted the growing role of contrast-enhanced mammography [...] Read more.
Background: Preoperative breast MRI is widely used in surgical planning because of its high sensitivity. However, discrepancies with histopathology remain common and can affect tumor size assessment and treatment decisions. In addition, recent comparative studies have highlighted the growing role of contrast-enhanced mammography (CEM) and multiparametric MRI (mpMRI), both of which may improve specificity and accessibility compared to conventional MRI. Methods: A structured literature review was conducted in PubMed (2000–2025) according to PRISMA guidelines. Studies included if they evaluated preoperative breast MRI with histopathological correlation and reported sensitivity, specificity, or concordance outcomes. Data extraction focused on study design, patient and tumor characteristics, imaging methods, and clinical impact. Results: MRI demonstrates high sensitivity, particularly in detecting IDC and ILC. However, overestimation of tumor size remains a concern, particularly in ILC and high-grade DCIS, while underestimation is frequently observed after neoadjuvant therapy, especially in Luminal A tumors. Tumor size and stage significantly affect concordance, with advanced-stage tumors (T2–T3) showing better MRI-histopathology concordance than early-stage lesions (T0–T1). Specificity remains limited, particularly in DCIS and multifocal disease. Emerging evidence suggests that contrast-enhanced mammography (CEM) achieves comparable sensitivity with higher specificity, while multiparametric MRI (mpMRI) incorporating diffusion-weighted imaging (DWI) improves lesion characterization and prediction of treatment response. Conclusions: While MRI remains a valuable diagnostic tool for breast cancer, histopathological validation is essential to guide treatment decisions. Future research should focus on AI-enhanced imaging techniques, CEM and multiparametric MRI to improve concordance rates, reduce overdiagnosis and translate imaging advances into meaningful clinical outcomes. Full article
(This article belongs to the Special Issue Diagnostic Advances in Obstetrics and Gynecology, Breast Disease and Women’s Health)
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21 pages, 2906 KB  
Review
Diagnosis and Surgical Treatment of Hydatidiform Mole
by Antônio Braga, Marcela Chagas, Manisha Asrani, Juliana Pereira Soares, Sue Yazaki Sun, Edward Araujo Júnior, Rosiane Mattar, Joffre Amim Junior, Jorge Rezende-Filho, Neil S. Horowitz and Ross S. Berkowitz
Diagnostics 2025, 15(16), 2068; https://doi.org/10.3390/diagnostics15162068 - 18 Aug 2025
Cited by 3 | Viewed by 6009
Abstract
Hydatidiform mole is a trophoblastic disorder resulting from abnormal fertilization. Diagnosis is established through a combination of clinical findings, elevated serum human chorionic gonadotropin (hCG) levels, and characteristic features on transvaginal ultrasound. Timely and accurate diagnosis is essential for initiating prompt treatment and [...] Read more.
Hydatidiform mole is a trophoblastic disorder resulting from abnormal fertilization. Diagnosis is established through a combination of clinical findings, elevated serum human chorionic gonadotropin (hCG) levels, and characteristic features on transvaginal ultrasound. Timely and accurate diagnosis is essential for initiating prompt treatment and preventing medical complications. Uterine evacuation, preferably via vacuum aspiration, is the treatment of choice due to its high efficacy and safety profile. Adjunctive techniques, such as hysteroscopy and intraoperative ultrasonography, enhance the safety and effectiveness of uterine evacuation and should be available to patients, especially at specialized referral centers equipped to manage this diagnosis. In selected cases, particularly in women with fulfilled reproductive goals or those at a high risk of developing post-molar gestational trophoblastic neoplasia (GTN), total abdominal hysterectomy is appropriate. Postoperative follow-up with serial measurements of hCG is essential for monitoring remission and for the early detection of post-molar GTN, which develops in approximately 20% of cases of complete molar pregnancies and 1–4% of partial molar pregnancies. This article provides a comprehensive review of the diagnosis of hydatidiform mole and the surgical techniques employed in the treatment of this condition, emphasizing individualized care and the use of appropriate surgical strategies to treat complications associated with this trophoblastic disease. Full article
(This article belongs to the Special Issue Diagnostic Advances in Obstetrics and Gynecology, Breast Disease and Women’s Health)
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