Bone Metabolism and Skeletal Health in Diabetes

Dear Colleagues,

Diabetes mellitus is increasingly recognized as a systemic disease with profound effects on skeletal health, leading to compromised bone quality, increased fracture risk, and impaired bone repair despite normal or elevated bone mineral density. The underlying mechanisms linking metabolic dysregulation to skeletal fragility, involving complex interactions among insulin signaling, glucose toxicity, inflammation, oxidative stress, adipokines, and mineral metabolism, remain incompletely understood. This Special Issue aims to provide a comprehensive overview of current advances in understanding bone metabolism in the context of diabetes, spanning basic, translational, and clinical research. We invite the contribution of original research articles, reviews, and perspectives addressing molecular and cellular mechanisms regulating osteoblast, osteocyte, and osteoclast function in diabetic conditions, the role of bone–pancreas and bone–adipose crosstalk, genetic and epigenetic contributors to diabetic bone disease, and the impact of antidiabetic therapies on skeletal outcomes. Clinical studies focusing on fracture risk assessment, biomarkers of bone quality, and therapeutic strategies to preserve skeletal integrity in diabetic populations are also encouraged. Collectively, this Special Issue seeks to bridge metabolic and skeletal research to advance precision approaches for preventing and treating diabetic bone disease.

Dr. Shivani Srivastava
Guest Editor

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