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Cells publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Gastrointestinal Disease: From Cellular Mechanisms to Targeted Therapy

edited by

Grazia Serino

and

Amilcare Barca

submission deadline 31 Oct 2025 | 3 articles | Viewed by 8397 | Submission Open

Keywords: gastrointestinal cancer; gastric cancer; colorectal cancer; esophageal cancer; liver cancer; pancreatic cancer; inflammatory bowel disease; miRNAs; in vitro and in vivo models; molecular networks; molecular pathways; translational medicine; epithelial barrier functions/processes

(This special issue belongs to the Section Cellular Pathology)

Immune Cell Effect on the Endothelium

edited by

Constantinos Mikelis

and Margarita Lamprou

submission deadline 31 Oct 2025 | 1 articles | Viewed by 3999 | Submission Open

Keywords: immune cells; endothelial cells; cytokines; extracellular vesicles; angiogenesis; vascular permeability

(This special issue belongs to the Section Cellular Immunology)

Non-Coding and Coding RNAs in Targeted Cancer Therapy

edited by

César López-Camarillo

and

Macrina B. Silva-Cázares

submission deadline 31 Oct 2025 | 4 articles | Viewed by 3994 | Submission Open

Keywords: gene expression; non-coding RNAs; lncRNAs; microRNAs; piwi-associated RNA; circular RNAs; therapeutic targets

(This special issue belongs to the Section Cell and Gene Therapy)

Small Molecular Therapeutics Promoting Neuronal Plasticity, Hippocampal Learning, and Memory

edited by

Avik Roy

submission deadline 31 Oct 2025 | 2 articles | Viewed by 3918 | Submission Open

Keywords: synaptic transmission; dendritic spines; metabotropic calcium influx; dendritic morphogenesis; small molecular therapeutics promoting neuronal plasticity

(This special issue belongs to the Section Cells of the Nervous System)

Advances in Cell-Based Studies and Therapeutic Approaches for Tissue Regeneration

edited by

Anişoara Cîmpean

and

Andreea-Mariana Negrescu

submission deadline 31 Oct 2025 | 5 articles | Viewed by 3714 | Submission Open

Keywords: soft/hard tissue regeneration; therapeutical approaches; cell culture studies; inflammation-based diseases; degenerative diseases

(This special issue belongs to the Section Tissues and Organs)

Cilia-Based New Discoveries: Ciliogenesis, Function, and Human Diseases

edited by

Lisbeth Birk Møller

submission deadline 31 Oct 2025 | 2 articles | Viewed by 3592 | Submission Open

Keywords: primary cilium; human disease; cell signaling; mTOR; Hedgehog; WNT; PDGFRalpha

The Role of Oxidative Stress in Cardiovascular Diseases—2nd Edition

edited by

Liya Yin

and

Chuanxi Cai

submission deadline 31 Oct 2025 | 1 articles | Viewed by 2564 | Submission Open

Keywords: oxidative stress; antioxidants; apoptosis; atherosclerosis; blood vessel; heart failure; hypertension; inflammation; mitochondria; microcirculation; reactive oxygen species

(This special issue belongs to the Section Cells of the Cardiovascular System)

How Can We Optimise Cancer Therapy? Tumour Microenvironment and Immune Evasion Strategies

edited by

Agnieszka Bojarska-Junak

and

Michal Zarobkiewicz

submission deadline 31 Oct 2025 | 3 articles | Viewed by 2319 | Submission Open

Keywords: immunosurveillance; immune evasion in cancer; tumour microenvironment; immune suppression; immunotherapy; immune checkpoints; cancer immunity; drug intervention

(This special issue belongs to the Section Cell Microenvironment)

New Discoveries in Calcium Signaling-Related Neurological Disorders

edited by Matheus De Castro Fonseca

submission deadline 31 Oct 2025 | 1 articles | Viewed by 2099 | Submission Open

Keywords: Ca2+ signaling; neurons; neurological disorders; intracellular signaling; synaptic dysfunction

(This special issue belongs to the Section Cells of the Nervous System)

Natural Killer (NK) Cells in Immunity: Limitations and Potential

edited by Rehan Mujeeb Faridi

submission deadline 31 Oct 2025 | 1 articles | Viewed by 1505 | Submission Open

Keywords: natural killer cells; adaptive NK cells; infection

(This special issue belongs to the Section Cellular Immunology)

Galectins in Cancer, Fibrosis and Immune Modulation: Mechanisms, Therapeutic Strategies and Translational Advances

edited by Tsung-Chieh Shih

submission deadline 31 Oct 2025 | 2 articles | Viewed by 1316 | Submission Open

Keywords: Galectin; tumor microenvironment; immunosuppression; fibrosis; epithelial– mesenchymal transition (EMT); cancer metastasis; immune evasion; therapy resistance; myeloid-derived suppressor cells (MDSCs); tumor-associated macrophages (TAMs); extracellular matrix remodeling; Galectin-targeted therapy; combination immunotherapy; fibroblast activation; chronic inflammation; tumor– stroma interactions; novel inhibitors of Galectins

(This special issue belongs to the Section Cellular Immunology)

Glial Cells: Physiological and Pathological Perspective

edited by

Qing Richard Lu

submission deadline 31 Oct 2025 | 1 articles | Viewed by 1281 | Submission Open

Keywords: neurodegeneration; oligodendrocytes; astrocytes; microglia; neuroinflammation; demyelination neuron– glial interactions; homeostasis; glia-targeted therapies

(This special issue belongs to the Section Cells of the Nervous System)

Recent Advances in Astrocyte Neuron Communication

edited by

Stefano Ferroni

and

Francesco Formaggio

submission deadline 31 Oct 2025 | Viewed by 841 | Submission Open

Keywords: astrocytes; calcium signaling; ion channels; gliotransmitters; brain circuits; reactive astrogliosis; astrocyte heterogeneity; astrocyte– neuron networks; synaptic plasticity

(This special issue belongs to the Section Cells of the Nervous System)

Cellular Pathways on Brain Control of Energy Metabolism

edited by Liangyou Rui

submission deadline 31 Oct 2025 | 1 articles | Viewed by 712 | Submission Open

Keywords: energy balance neurocircuit; molecular pathways governing energy balance neurocircuits; gut– brain axis in obesity; neuroinflammation in obesity and metabolic disease; neural sensing of metabolites and hormones

Molecular Research of Cardiomyopathy

edited by

Luigi Sansone

and

Manuel Belli

submission deadline 31 Oct 2025 | Viewed by 400 | Submission Open

Keywords: cardiomyopathy; heart failure; hypertrophic cardiomyopathy; cellular and molecular rehabilitation

(This special issue belongs to the Section Cells of the Cardiovascular System)

Mechanisms Underlying Cell Growth and Development

edited by

Rustem E. Uzbekov

submission deadline 31 Oct 2025 | 1 articles | Viewed by 394 | Submission Open

Keywords: cell growth; cell development; cell differentiation; cell cycle; mitosis; meiosis; molecular rearrangements; chromosomes; gene expression

Updates and Perspectives on Prion-Like Tau Pathology Propagation

edited by Kunie Ando, Jean-Pierre Brion and Siranjeevi Nagaraj

submission deadline 31 Oct 2025 | Viewed by 346 | Submission Open

Keywords: tau; amyloid beta; prion-like; propagation; Alzheimer’ s disease; neurodegenerative diseases; protein-protein interactions; synaptic dysfunction; aggregation; protein misfolding; risk factors; post-translational modifications

Advances in Bacterial Cell Biophysics: Metabolic Engineering and Host Interactions

edited by Shahid Khan

submission deadline 31 Oct 2025 | Viewed by 238 | Submission Open

Keywords: bacterial cell biophysics; mechanical properties; biophysical techniques; host interactions; metabolic engineering

Autophagy in Cancer Regulation

edited by Tejinder Pal Khaket

submission deadline 31 Oct 2025 | Viewed by 223 | Submission Open

Keywords: autophagy; drug resistance; immune response: cancer stemness

(This special issue belongs to the Section Autophagy)

Cell and Tissue Engineering for Functional Analysis (2nd Edition)

edited by

Masamichi Kamihira

submission deadline 31 Oct 2025 | Viewed by 207 | Submission Open

Keywords: animal cell engineering; tissue engineering; genome engineering; stem cell technology; synthetic biology

(This special issue belongs to the Section Tissues and Organs)

Potential Therapeutic Biomarkers for Prostate Cancer

edited by Benyi Li

submission deadline 31 Oct 2025 | Viewed by 149 | Submission Open

Keywords: prostate cancer; novel biomarkers; treatment

(This special issue belongs to the Section Cellular Pathology)

Kidney and Lung Disorders: The Role of Tubular and Alveolar Epithelia in Health, Disease, Infection, and Organ Crosstalk

edited by Aparna Renigunta and

Poornima Mahavadi

submission deadline 31 Oct 2025 | Viewed by 138 | Submission Open

Keywords: renal tubular disorders; alveolar lung diseases; transport mechanism; intracellular signaling; viral infection; crosstalk; dialysis; ventilation

Role of Lysosomes in Mediating Cancer Drug Resistance

edited by

Petr Mlejnek

submission deadline 31 Oct 2025 | Viewed by 123 | Submission Open

Keywords: drug resistance; autophagic cell death; lysosomal-mediated cell death; autophagy; apoptosis; lysosomal exocytosis; lysosomal sequestration; tumor microenvironment

(This special issue belongs to the Section Cell Microenvironment)

From Bench to Bedside: Animal Models and Molecular Mechanisms in Cancer Therapeutics

edited by Sijana H. Dzinic

submission deadline 31 Oct 2025 | Viewed by 96 | Submission Open

Keywords: animal models in cancer research; cancer therapeutics; preclinical research; drug development; efficacy testing of novel anticancer agents; translational research

(This special issue belongs to the Section Cellular Pathology)

Cellular and Molecular Mechanisms in Peritoneal Malignancies: Insights into Pathogenesis and Therapeutic Advances

edited by

Tarkan Jäger

, Ibrahim Büdeyri and Jan Philipp Ramspott

submission deadline 31 Oct 2025 | Viewed by 86 | Submission Open

Keywords: peritoneal metastasis; cytoreductive surgery; HIPEC; PIPAC; biomarker; tumor microenvironment; epigenetics; precision oncology; tumor metabolism; immunotherapy

(This special issue belongs to the Section Cellular Pathology)

Plasticity of Skeletal, Cardiac and Smooth Muscles in COPD: Repair and Remodeling

edited by Joaquim Gea Guiral

submission deadline 31 Oct 2025 | Viewed by 78 | Submission Open

Keywords: injury; repair; adaptation; aerobic metabolism; muscle mass; limb muscles; respiratory muscles; proteolysis

Functional Differences in Periostin Splicing Isoforms in Cancer and Inflammatory Disorders

edited by

Yoshiaki Taniyama

and Nobutaka Koibuchi

submission deadline 31 Oct 2025 | Viewed by 67 | Submission Open

Keywords: periostin; splicing variant; treatment-resistant cancer; diagnostics; periostin suppression therapy

Exploring Mitochondrial Dysfunction and Neuroinflammation in Neurodegeneration for New Therapeutic Advances

edited by Hanhan Liu

submission deadline 31 Oct 2025 | Viewed by 64 | Submission Open

Keywords: mitochondria; neuroinflammation; neurodegeneration; neuroprotective therapy; innate immunity

(This special issue belongs to the Section Cellular Pathology)

Macrophages in Cancer: Immunosuppression, Immunoregulation, and Immunotherapy

edited by Abdullah Saeed

submission deadline 5 Nov 2025 | 1 articles | Viewed by 3058 | Submission Open

Keywords: macrophage; immunosuppression; immunoregulation; immunotherapy; tumor immune microenvironment

(This special issue belongs to the Section Cellular Immunology)

Stem Cells in Cancer

edited by

Ajit Kumar Sharma

submission deadline 10 Nov 2025 | 2 articles | Viewed by 3949 | Submission Open

Keywords: cancer stem cells; heterogeneity; metastasis; plasticity; self-renewal

(This special issue belongs to the Section Stem Cells)

Molecular Mechanism and Therapeutic Opportunities of Breast Cancer

edited by

Athanasios A. Panagiotopoulos

submission deadline 10 Nov 2025 | 2 articles | Viewed by 1899 | Submission Open

Keywords: breast cancer; molecular mechanisms; targeted therapy; genomic profiling; hormone receptors; tumor microenvironment; immunotherapy; drug resistance; metastasis; precision medicine

(This special issue belongs to the Section Cellular Pathology)

Synaptic Plasticity and the Neurobiology of Learning and Memory

edited by Erica Berretta, Laura Petrosini and Anna Panuccio

submission deadline 10 Nov 2025 | 1 articles | Viewed by 1254 | Submission Open

Keywords: learning and memory; neuronal and glial cells; long-term potentiation and long-term depression; molecular mechanisms

(This special issue belongs to the Section Cells of the Nervous System)

Biomarkers in Breast Cancer

edited by Julie Decock and Sana A. Bentebbal

submission deadline 10 Nov 2025 | 1 articles | Viewed by 722 | Submission Open

Keywords: breast cancer biomarkers; AI in oncology; multi-omics; exosomes; tumor immune microenvironment; liquid biopsy; precision oncology; personalized medicine

(This special issue belongs to the Section Cellular Pathology)

Recent Advances in the Molecular Mechanisms of Neurodegenerative Diseases: Current Progress and Future Directions for Disease-Modifying Therapies

edited by

Rengasamy Balakrishnan

and

Balamuralikrishnan Balasubramanian

submission deadline 10 Nov 2025 | Viewed by 215 | Submission Open

Keywords: neuroprotection; new drug development; natural products; blood– brain barrier; molecular mechanisms; neuronal signaling; neuroinflammation; microglial cells; neurotoxicity; neurodegenerative diseases

(This special issue belongs to the Section Cellular Aging)

Immunoregulation in Cardiovascular Disease

edited by

Hong Wang

submission deadline 10 Nov 2025 | Viewed by 80 | Submission Open

Keywords: cardiovascular disease (CVD); immunoregulation; inflammation; immune cells; immune mediators; immunomodulatory therapies; biomarkers; epigenetics; microbiome; cellular methods/technologies

Modeling Developmental Processes and Disorders in Zebrafish

edited by

Natascia Tiso

and

Francesco Argenton

submission deadline 15 Nov 2025 | 12 articles | Viewed by 42984 | Submission Open

(This special issue belongs to the Section Cellular Biophysics)

Effects and Mechanisms of Environmental Toxicants and Nanoparticles on Germ Cells, Gonads, Embryos and Stem Cells

edited by

Silvia Garagna

Maurizio Zuccotti

Danilo Cimadomo

and Giulia Fiorentino

submission deadline 15 Nov 2025 | 1 articles | Viewed by 2702 | Submission Open

Keywords: environmental toxicants; gonadal steroid hormones; ovary; folliculogenesis; oogenesis and oocyte; testis; spermatogenesis and sperm; embryo development; epigenetics; omics; cells lines and stem cells; embryoid bodies; gastruloids and organoids; 3D cell culture and imaging; nanoparticles; nanomaterials

(This special issue belongs to the Section Stem Cells)

Advances in Intestinal Epithelial Plasticity and Regeneration

edited by

Aiguo Tian

submission deadline 15 Nov 2025 | 1 articles | Viewed by 2512 | Submission Open

Keywords: intestinal epithelium; epithelial plasticity; stem cells; tissue repair; self-renewal; regeneration

Innate-Like T Cells: The Variegated Roles of Semi-Invariant TCRs in Health and Disease

edited by

Ethan Shevach

and Akshat Sharma

submission deadline 15 Nov 2025 | Viewed by 1499 | Submission Open

Keywords: innate-like T cells; cancer; autoimmunity; cytokines; immune mechanisms

(This special issue belongs to the Section Cellular Pathology)

Novel Therapies and Biomarkers for Rare Diseases

edited by Reena Kartha

submission deadline 15 Nov 2025 | Viewed by 138 | Submission Open

Keywords: rare diseases; translational research; novel therapies; biomarker discovery; precision medicine

The Role of Integrins and Small GTPases in Health and Disease

edited by

Tione Buranda

submission deadline 15 Nov 2025 | Viewed by 40 | Submission Open

Keywords: cell signaling; integrins; cell adhesion; integrins diseases; infectious diseases

Lipids and Lipidomics in Neurodegenerative Diseases

edited by

Nathalie Bernoud-Hubac

and Catherine Malaplate

submission deadline 20 Nov 2025 | 1 articles | Viewed by 8226 | Submission Open

Keywords: lipids; lipidomics; neurodegenerative disease diagnosis; prevention; or treatment; cellular and molecular mechanisms

(This special issue belongs to the Section Cells of the Nervous System)

Molecular Advances in Prenatal Exposure to Environmental Toxicants

edited by

Douglas M. Ruden

and

Sudipta Dutta

submission deadline 20 Nov 2025 | 4 articles | Viewed by 7618 | Submission Open

Keywords: prenatal exposures; toxicogenomics; epigenomics; placenta; perinatal outcomes; neurodevelopmental outcomes; respiratory outcomes

Molecular Mechanism of Liver Transplantation

edited by Carmen Peralta and Juan Carlos Cutrin

submission deadline 20 Nov 2025 | 1 articles | Viewed by 3260 | Submission Open

Keywords: liver transplantation; ischemia-reperfusion injury; signaling pathways; graft dysfunction; sterile inflammation; liver regeneration; fatty grafts; normothermic machine perfusion; defatting strategies

(This special issue belongs to the Section Tissues and Organs)

Second Edition of Advances in Adipose Tissue Biology

edited by

Melvin K. S. Leow

submission deadline 20 Nov 2025 | 2 articles | Viewed by 3095 | Submission Open

Keywords: adipocyte differentiation; progenitors; and stem cells; adipokines; myokines; hepatokines; cytokines; cellular signaling; and molecular crosstalk; white adipose tissue (WAT) and brown adipose tissue (BAT); beige fat and browning of WAT; research techniques and methodologies; diagnostics and therapeutics; genomics; metabolomics; other ‘ omics’ technologies; metabolic syndrome; obesity; insulin resistance; cancer

(This special issue belongs to the Section Tissues and Organs)

Decoding the Complexity of Angiogenesis: Insights into Vascular Formation and Disease

edited by

Kay-Dietrich Wagner

submission deadline 20 Nov 2025 | 1 articles | Viewed by 504 | Submission Open

Keywords: angiogenesis; vasculogenesis; development; physiological angiogenesis; pathophysiology; cell– cell communication; cell signaling

(This special issue belongs to the Section Cells of the Cardiovascular System)

Ripening and Degradation Mechanisms of Neutrophil Extracellular Traps

edited by

Martin Herrmann

and Maximilian Dölling

submission deadline 20 Nov 2025 | Viewed by 408 | Submission Open

Keywords: neutrophil extracellular traps; degradation of NETs; ripening of NETs

(This special issue belongs to the Section Cellular Immunology)

Aging and Metabolic Diseases

edited by

Carlos Guillen

submission deadline 20 Nov 2025 | Viewed by 403 | Submission Open

Keywords: aging; insulin resistance; diabetes; obesity; mitochondrial dysfunction; beta-galactosidase; senescent-associated secretory phenotype; pancreatic beta cells

(This special issue belongs to the Section Cellular Aging)

Tumor Stroma Interaction

edited by