Special Issues

Cells publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Renewing Reasons to Believe in Gene Therapies for Epilepsy
edited by Casper Gøtzsche
submission deadline 31 Aug 2025 | 2 articles | Viewed by 3081 | Submission Open
Keywords: epilepsy; seizure; gene therapy; gene editing; disease modification; transformative; unmet need
(This special issue belongs to the Section Cells of the Nervous System)
The Role of IgE and IgG Antibodies in Allergic Reactions: Cellular Mechanisms and Biological Implications submission deadline 31 Aug 2025 | 2 articles | Viewed by 2387 | Submission Open
Keywords: IgE; IgG; allergy; inflammation; glycosylation; immunotherapy; autoantibodies; Fc receptors; soluble receptors
(This special issue belongs to the Section Cellular Immunology)
Signaling Pathways Involved in Tumor Microenvironment and Tumor Adaptation to Stresses
edited by Nianli Sang
submission deadline 31 Aug 2025 | 2 articles | Viewed by 2226 | Submission Open
Keywords: microenvironment; metabolic stress; hypoxia; chemoresistance; radiation resistance; apoptosis; metabolic reprogramming; metastasis
(This special issue belongs to the Section Cell Signaling)
The Potential of Induced Pluripotent Stem Cells
edited by Yun Chang
submission deadline 31 Aug 2025 | 1 articles | Viewed by 1116 | Submission Open
Keywords: pluripotent stem cells; reprogramming; engineering; regenerative medicine; differentiation; therapeutic applications; biomaterials
(This special issue belongs to the Section Stem Cells)
Drosophila as a Model for Understanding Human Disease
edited by Zhe Han
submission deadline 31 Aug 2025 | 1 articles | Viewed by 1013 | Submission Open
Keywords: Drosophila melanogaster; human disease models; genetic and molecular mechanisms; neurodegenerative diseases; cardiovascular diseases; cancer biology; metabolic disorders; high-throughput screening; precision medicine; translational research
(This special issue belongs to the Section Cellular Pathology)
Pathophysiology of Signal Transduction in Cardiovascular and Pulmonary Disease II
edited by and
submission deadline 31 Aug 2025 | 1 articles | Viewed by 812 | Submission Open
Keywords: cardiac arrhythmia; atrium; ventricle; pulmonary; vascular; signal transduction
(This special issue belongs to the Section Cellular Pathology)
The Role Glial Cells in Neurodegenerative Disorders
edited by
submission deadline 31 Aug 2025 | Viewed by 376 | Submission Open
Keywords: neurodegeneration; neuroinflammation; microglia; astrocytes; neuron; extracellular vesicles; therapeutics
(This special issue belongs to the Section Cells of the Nervous System)
The Epigenetic Landscape of Aging: Mechanisms and Impacts During Cellular and Organismal Longevity
edited by Siyu Shen and
submission deadline 31 Aug 2025 | Viewed by 372 | Submission Open
Keywords: epigenetic regulation; cellular senescence; aging; DNA methylation; histone modification; non-coding RNA; cancer epigenetics; neurodegenerative diseases; musculoskeletal degenerative disorders; cardiovascular diseases
(This special issue belongs to the Section Cellular Aging)
Hedgehog Signaling: Advances in Development and Cancer—Second Edition
edited by
submission deadline 31 Aug 2025 | Viewed by 347 | Submission Open
Keywords: hedgehog signaling; hh gene; smoothened (SMO)
(This special issue belongs to the Section Cell Signaling)
The Silent Regulators: Non-Coding RNAs in Cell Function and Disease submission deadline 31 Aug 2025 | Viewed by 346 | Submission Open
Keywords: non-coding RNAs; microRNAs; long non-coding RNAs (lncRNAs); regulatory RNAs; RNA interference; epigenetic regulation; RNA editing; cellular signaling; disease biomarkers; RNA therapeutics
(This special issue belongs to the Section Cell and Gene Therapy)
The Role of T Cells in Type 1 Diabetes submission deadline 31 Aug 2025 | Viewed by 324 | Submission Open
Keywords: T cells; inflammation; T cell receptor; type 1 diabetes
(This special issue belongs to the Section Cellular Immunology)
The Role of Microglia in Neurodegenerative Diseases and Neuroinflammation
edited by
submission deadline 31 Aug 2025 | Viewed by 302 | Submission Open
Keywords: microglia; central nervous system; neurodegenerative diseases; neurodegeneration; Alzheimer’ s disease (AD); Parkinson’ s disease (PD)
(This special issue belongs to the Section Cells of the Nervous System)
Immune Cells from Pluripotent Stem Cells
edited by
submission deadline 31 Aug 2025 | Viewed by 293 | Submission Open
Keywords: pluripotent stem cells; T cells; B cells; macrophages; natural killer (NK) cells; dendritic cells; megakaryocytes; platelets
(This special issue belongs to the Section Stem Cells)
Organoids and Models from Stem Cells
edited by Tiziana A. L. Brevini and
submission deadline 31 Aug 2025 | Viewed by 277 | Submission Open
Keywords: cellular microenvironment; 3D culture; organoid
(This special issue belongs to the Section Stem Cells)
Heparanase and Heparanase-2: Function, Regulation, Signaling, and Disease submission deadline 31 Aug 2025 | Viewed by 225 | Submission Open
Keywords: heparanase (Hpa1); heparanase-2 (Hpa2); tumor microenvironment; extracellular matrix; tumor progression; tumor suppression; metastatic niche; glycocalyx; immune cells; inflammation
(This special issue belongs to the Section Cellular Aging)
Impact of Hyponatremia on Cancer Progression and Organ Function: Insights from Murine Models
edited by Giada Marroncini and Mushfiquddin Khan
submission deadline 31 Aug 2025 | Viewed by 146 | Submission Open
Keywords: hyponatremia; cancer progression; neurological disease; heart failure; osteoporosis; liver cirrhosis; kidney injury; vaptans
(This special issue belongs to the Section Tissues and Organs)
Nuclear Pore Complex in Nanomedicine: Third Edition
edited by
submission deadline 31 Aug 2025 | Viewed by 117 | Submission Open
Keywords: intracellular transport; NPC; mitosis; nano; cancer; brain
Autophagy and Neurodegeneration: Unveiling Cellular Pathways in ALS and Beyond
edited by Valeria Gerbino
submission deadline 31 Aug 2025 | Viewed by 109 | Submission Open
Keywords: autophagy; neurodegeneration; amyotrophic lateral sclerosis (ALS); protein aggregation; cellular homeostasis; lysosomal dysfunction; neuronal health; therapeutic targets; molecular pathways; neuroprotective strategies
New Insights into Inflammasome: Mechanisms of Activation, Cell Death, and Diseases
edited by Ana Tapia-Abellán
submission deadline 31 Aug 2025 | Viewed by 97 | Submission Open
Keywords: inflammasomes; inflammation; pyroptosis; chronic diseases; autoinflammatory syndromes
(This special issue belongs to the Section Cellular Pathology)
Ubiquitin Ligases: Key Regulators in Cellular Homeostasis and Disease
edited by Praveen Koganti and
submission deadline 31 Aug 2025 | Viewed by 89 | Submission Open
Keywords: ubiquitin ligases; protein ubiquitination; cellular homeostasis; proteasome pathway
The Role of Cellular Senescence in Health, Disease, and Aging
edited by
submission deadline 5 Sep 2025 | 7 articles | Viewed by 17120 | Submission Open
Keywords: apoptosis; cancer; cell cycle; DNA damage; metabolic diseases; oxidative stress; senolysis; senescence; therapeutic approach
(This special issue belongs to the Section Cellular Aging)
Epigenetic Mechanisms of Tumorigenesis
edited by
submission deadline 10 Sep 2025 | Viewed by 334 | Submission Open
Keywords: epigenetics; tumorigenesis; gene expression; cell identity; precise medicine
New Insights into Vascular Biology in Health and Disease
edited by Bashir M. Rezk
submission deadline 15 Sep 2025 | 5 articles | Viewed by 10733 | Submission Open
Keywords: vascular diseases; cardiovascular; cancer; hyperhomocyteinemia; endothelial dysfunction; vascular smooth muscle cell; autophagy; alcohol; galectins; angiogenesis; neovascularization
(This special issue belongs to the Section Cells of the Cardiovascular System)
Pathogenic Mechanisms of Chronic Inflammation-Associated Cancer
edited by Emiko Mizoguchi
submission deadline 15 Sep 2025 | 4 articles | Viewed by 5884 | Submission Open
Keywords: chronic inflammation; dysplasia; neoplasia; oncogene; cytokine; colitis-associated cancer
(This special issue belongs to the Section Cellular Pathology)
Molecular and Cellular Mechanisms of Marfan Syndrome submission deadline 15 Sep 2025 | 4 articles | Viewed by 2505 | Submission Open
Keywords: Marfan syndrome; aortic aneurysm; aortic dissection; TGFβ ; BMP; matrix metalloproteinase; NO synthase; mitochondrial dysfunction; oxidative stress; endothelium; aortic vascular smooth muscle cells; phenotypic switching; adventitia; hemodynamics; gene therapy; connective tissue disease
(This special issue belongs to the Section Cellular Pathology)
Advancements in Immunotherapy and CAR T Cell Therapy: Unleashing the Power of the Immune System Against Cancer
edited by
submission deadline 15 Sep 2025 | Viewed by 195 | Submission Open
Keywords: CAR T; immunotherapy; cancer; chimeric antigen receptors
(This special issue belongs to the Section Cellular Immunology)
In Vitro Model for Micro- and Nano-Technologies—Second Edition
edited by Tania Limongi
submission deadline 15 Sep 2025 | Viewed by 126 | Submission Open
Keywords: in vitro cell culture; micro- and nano-technology; extracellular vesicles; nanoparticles; quantum dots; biocompatibility; hemocompatibility; diagnosis; drug delivery; tissue engineering
(This special issue belongs to the Section Cellular Biophysics)
Cancer Cell Signaling, Autophagy and Tumorigenesis
edited by Debanjan Bhattacharya
submission deadline 15 Sep 2025 | Viewed by 61 | Submission Open
Keywords: cancer cell signaling; autophagy; tumorigenesis; PI3K/AKT/mTOR pathway; Ras/Raf/MEK/ERK (MAPK) pathway
Molecular and Cellular Advances in Gut-Brain Axis
edited by and Radhakrishna Rao
submission deadline 20 Sep 2025 | 2 articles | Viewed by 21395 | Submission Open
Keywords: gut– brain axis; microbiome; omics; diet; biological sex; gender; early-life stress; immunity; mental health; neurodegenerative diseases; metabolic health
(This special issue belongs to the Section Cells of the Nervous System)
Advances in the Discovery of Retinal Degeneration submission deadline 20 Sep 2025 | 2 articles | Viewed by 1920 | Submission Open
Keywords: retinal cell biology; photoreceptors; oxidative stress; inflammation; blood– retinal barriers; diabetic retinopathy; clinical eye research; inherited retinal diseases; ocular immunology
(This special issue belongs to the Section Cellular Pathology)
Advances in Immunotherapy for Non-Small-Cell Lung Cancer
edited by
submission deadline 20 Sep 2025 | 1 articles | Viewed by 1734 | Submission Open
Keywords: non-small cell lung cancer; immunotherapy; immune checkpoint inhibitors; PD-1; PD-L1; pembrolizumab; nivolumab; atezolizumab; CTLA4
(This special issue belongs to the Section Cellular Immunology)
Gene and Cellular Signaling Related to Muscle
edited by
submission deadline 20 Sep 2025 | 1 articles | Viewed by 1501 | Submission Open
Keywords: skeletal muscle; molecular mechanism; muscle atrophy; therapeutics; metabolic signals; satellite cells
(This special issue belongs to the Section Cell Signaling)
Molecular Insights into Vascular Physiology and Pathology
edited by Suravi Majumder
submission deadline 20 Sep 2025 | Viewed by 249 | Submission Open
Keywords: vascular physiology; vascular pathology; endothelial cells; vascular smooth muscle cells; vascular inflammation; vascular signaling; vascular aging; vascular remodeling; atherosclerosis; cardiovascular diseases; biomarkers; novel therapeutic approaches
(This special issue belongs to the Section Cellular Pathology)
Macrophage-Epithelial Interplay in Pulmonary Fibrosis
edited by and Farhad Khosravi
submission deadline 20 Sep 2025 | Viewed by 216 | Submission Open
Keywords: macrophages; epithelial cells; idiopathic pulmonary fibrosis (IPF); immune response
The Placental Matrix: Trophoblasts, Decidualization, and Embryo Implantation
edited by
submission deadline 20 Sep 2025 | Viewed by 81 | Submission Open
Keywords: trophoblast; decidualization; embryo implantation; uterus; infection; cancer; reproductive immunology; reproductive toxicology; cellular differentiation
(This special issue belongs to the Section Tissues and Organs)
Stem Cells and Endometrium
edited by Shiying Jin
submission deadline 20 Sep 2025 | Viewed by 75 | Submission Open
Keywords: stem cell; homeostasis; regeneration; endometrium
(This special issue belongs to the Section Stem Cells)
Regulation of Vascular Endothelial Growth Factor (VEGF) and Its Receptor (VEGFR) in Angiogenesis
edited by Alessandra Loda and
submission deadline 25 Sep 2025 | 1 articles | Viewed by 1768 | Submission Open
Keywords: vascular endothelial growth factor (VEGF); VEGF receptors (VEGFRs); angiogenesis; endothelial cells; anti-angiogenic therapies; VEGFR inhibitors
Effective Embryo Maternal Interaction Support Favorable Pregnancy Outcome
edited by Eytan R. Barnea, and Guarano Alice
submission deadline 25 Sep 2025 | Viewed by 355 | Submission Open
Keywords: pregnancy; fertilization; tubal transport; embryogenesis; maternal quality control
(This special issue belongs to the Section Tissues and Organs)
Lipid Homeostasis: Mechanisms, Regulation, and Implications for Health and Disease
edited by and Museer Ahmad Lone
submission deadline 25 Sep 2025 | Viewed by 350 | Submission Open
Keywords: lipid metabolism; lipid synthesis and degradation; triglyceride storage; fatty acid oxidation; cholesterol homeostasis; adipogenesis; lipid droplets; lipid signaling pathways; lipid transport proteins; phospholipid balance; sphingolipid metabolism; sterol regulatory element-binding proteins (SREBPs); AMP-activated protein kinase (AMPK); peroxisome proliferator-activated receptors (PPARs); insulin signaling and lipid storage; endoplasmic reticulum stress and lipids; lipoprotein metabolism; non-alcoholic fatty liver disease (NAFLD); lipidomics; autophagy and lipid recycling; lysosomal lipid degradation; lipid-binding proteins; oxidized lipids; lipid imbalance and disease; energy homeostasis and lipid storage; lipid transport vesicles; membrane lipid composition; lipid peroxidation; lipid-related genetic disorders; nutrient sensing and lipid regulation
(This special issue belongs to the Section Cellular Biophysics)
Retinal Pigmented Epithelium (RPE) and the Choroid: Players and Partners for Vision
edited by and Janet R. Sparrow
submission deadline 25 Sep 2025 | Viewed by 339 | Submission Open
Keywords: retinal pigment epithelium; photoreceptor cell; choroid; Bruch’ s membrane; neural retina; visual cycle; phagocytosis; secretion; organelles; mitochondria; retinoid; melanin; albinism; age-related macular degeneration
(This special issue belongs to the Section Tissues and Organs)
Insights into the Pathophysiology of NeuroCOVID: Current Topics submission deadline 25 Sep 2025 | Viewed by 217 | Submission Open
Keywords: neuroCOVID; longCOVID; neurocognitive; cellular and molecular neurobiology; brain fog; anxiety; depression; biomarkers; translational biomedicine; neurodegenerative diseases
(This special issue belongs to the Section Cellular Pathology)
Ovarian Microenvironment and Oocyte Quality: Mechanisms, Aging, and Therapeutic Strategies
edited by Haiyang Wang
submission deadline 25 Sep 2025 | Viewed by 79 | Submission Open
Keywords: ovarian microenvironment; oocyte; mechanisms; aging; therapeutic strategies
(This special issue belongs to the Section Cell Microenvironment)
Amyloid–Metal Interactions in Alzheimer’s Disease: Mechanisms, Biomarkers, and Therapeutic Advances
edited by
submission deadline 25 Sep 2025 | Viewed by 64 | Submission Open
Keywords: Alzheimer’ s; amyloids; Aß ; Tau; neurodegeneration; metal homeostasis; oxidative stress; neuropathology; PET
(This special issue belongs to the Section Cellular Aging)
Identifying Functional Genomics and Pathways in Cancer Pathogenesis and Therapy Resistance
edited by and Ramkrishna Mitra
submission deadline 25 Sep 2025 | Viewed by 63 | Submission Open
Keywords: functional genomics; cancer signaling pathways; targeted therapy; drug resistance; tumor microenvironment; oncogenomics; acquired resistance; tumor mutations
(This special issue belongs to the Section Cellular Pathology)
Cell Migration and Invasion
edited by Veronika Miskolci
submission deadline 28 Sep 2025 | Viewed by 134 | Submission Open
Keywords: cell migration; cell invasion; cancer metastasis; molecular mechanisms; therapeutic strategies; signaling pathways
Potential of CAR-Based Cellular Immunotherapy for Non-oncologic Disorders submission deadline 30 Sep 2025 | 5 articles | Viewed by 18552 | Submission Open
Keywords: adoptive cell transfer; CAR-T cells; cell engineering; CAR products; CAR-T cell therapy; non-oncologic disorders; autoimmune diseases; cardiometabolic diseases; inflammatory organ fibrosis; senescent cell pathologies; infections
(This special issue belongs to the Section Cellular Immunology)
Unlocking the Secrets Behind Drug Resistance at the Cellular Level submission deadline 30 Sep 2025 | 4 articles | Viewed by 7560 | Submission Open
Keywords: molecular mechanisms; effective treatments; drug tests; bacterial resistance; chemoresistance
(This special issue belongs to the Section Cellular Immunology)
Research on T Cells in Skin Inflammatory Disorders
edited by and Qing-Sheng Mi
submission deadline 30 Sep 2025 | 1 articles | Viewed by 4593 | Submission Open
Keywords: T cell; vitiligo; atopic dermatitis; T cell lymphoma
(This special issue belongs to the Section Cellular Immunology)
Onco-Hematology and Immunotherapy
edited by and Régis T. Costello
submission deadline 30 Sep 2025 | 2 articles | Viewed by 4582 | Submission Open
Keywords: immunotherapy; onco-hematology; CAR T cells; NK cells; immune system; immune cells; leukemias; lymphomas
(This special issue belongs to the Section Cellular Immunology)
Eosinophils and Their Role in Allergy and Related Diseases
edited by
submission deadline 30 Sep 2025 | 3 articles | Viewed by 3571 | Submission Open
Keywords: eosinophils; asthma; allergy; inflammation; anti-eosinophil biologics; interleukin-5; interleukin-5 receptor; degranulation; mediator release
(This special issue belongs to the Section Cellular Immunology)
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