Amyloid–Metal Interactions in Alzheimer’s Disease: Mechanisms, Biomarkers, and Therapeutic Advances
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cellular Aging".
Deadline for manuscript submissions: 25 September 2025 | Viewed by 56
Special Issue Editor
Interests: Alzheimer’s' disease (AD); white matter dementia; vascular dysfunction; multiple sclerosis; neuropathology; omics technologies; stem cell culture; amyloid biology
Special Issue Information
Dear Colleagues,
Alzheimer’s disease (AD) is not merely a story of amyloid–beta (Aβ) plaques—it is a story of metals.
Iron, copper, and zinc are now well recognised as key players in amyloid aggregation, oxidative stress, and neurotoxicity, creating a vicious cycle that accelerates neurodegeneration. As evidence proving that metal dyshomeostasis is a pivotal driver in neurological conditions in general, and AD in particular, continues to grow, the need to unravel these interactions has never been more urgent. Understanding how metals influence amyloid pathology could open avenues for new diagnostic tools and groundbreaking therapeutic strategies. In addition, disruptions in metal homeostasis may serve as early biomarkers of AD, while novel imaging techniques are making it possible to track metal abnormalities in the brain with greater precision. At the same time, innovative treatments targeting metal–Aβ interactions are opening new avenues for disease intervention.
This Special Issue invites original research, reviews, and perspectives that explore the intricate relationship between amyloids and metals, their role in AD pathology, and potential targets for diagnosis and therapeutic intervention. We welcome cutting-edge contributions that push the boundaries of AD research and offer fresh perspectives on how metal-targeted strategies could transform the field.
Dr. Jonathan Pansieri
Guest Editor
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Keywords
- Alzheimer’s
- amyloids
- Aß
- Tau
- neurodegeneration
- metal homeostasis
- oxidative stress
- neuropathology
- PET
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