Special Issues

Cells publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Cellular and Molecular Mechanisms of Idiopathic Pulmonary Fibrosis
edited by and
submission deadline 20 Apr 2026 | Viewed by 50 | Submission Open
Keywords: idiopathic pulmonary fibrosis; fibroblast activation; epithelial– mesenchymal interaction; extracellular matrix remodeling; inflammation; signaling pathways; biomarkers; molecular targets; autophagy; senescence
New Mechanistic Insights and Novel Therapeutic Options for Pulmonary Vascular Disease (PVD)
edited by
submission deadline 20 Apr 2026 | Viewed by 46 | Submission Open
Keywords: pulmonary vascular disease; pulmonary hypertension; pulmonary arterial hypertension; vascular contraction; vascular remodeling
Molecular Mechanisms and Treatment Strategies in Metabolic Syndromes and Neurological Disorders submission deadline 20 Apr 2026 | Viewed by 28 | Submission Open
Keywords: neurological disorders; metabolic syndromes; neurodegenerative disease; systems biology; precision medicine; target therapy
(This special issue belongs to the Section Cells of the Nervous System)
Therapeutic Targets in Glioblastoma
edited by Candice Mazewski and
submission deadline 25 Apr 2026 | 5 articles | Viewed by 16430 | Submission Open
Keywords: glioblastoma; signaling targets; blood-brain-barrier; complementary and alternative medicine; combination therapy; glioma stem cells; progression; resistance; nutrient-sensing
(This special issue belongs to the Section Cells of the Nervous System)
Identifying Functional Genomics and Pathways in Cancer Pathogenesis and Therapy Resistance
edited by and Ramkrishna Mitra
submission deadline 25 Apr 2026 | 2 articles | Viewed by 3580 | Submission Open
Keywords: functional genomics; cancer signaling pathways; targeted therapy; drug resistance; tumor microenvironment; oncogenomics; acquired resistance; tumor mutations
(This special issue belongs to the Section Cellular Pathology)
Regulation of Vascular Endothelial Growth Factor (VEGF) and Its Receptor (VEGFR) in Angiogenesis
edited by Alessandra Loda and
submission deadline 25 Apr 2026 | 1 articles | Viewed by 2786 | Submission Open
Keywords: vascular endothelial growth factor (VEGF); VEGF receptors (VEGFRs); angiogenesis; endothelial cells; anti-angiogenic therapies; VEGFR inhibitors
Retinal Pigmented Epithelium (RPE) and the Choroid: Players and Partners for Vision
edited by and Janet R. Sparrow
submission deadline 25 Apr 2026 | Viewed by 604 | Submission Open
Keywords: retinal pigment epithelium; photoreceptor cell; choroid; Bruch’ s membrane; neural retina; visual cycle; phagocytosis; secretion; organelles; mitochondria; retinoid; melanin; albinism; age-related macular degeneration
(This special issue belongs to the Section Tissues and Organs)
Molecular and Cellular Insights into Platelet Function, 2nd Edition submission deadline 25 Apr 2026 | Viewed by 137 | Submission Open
Keywords: platelet; wound healing; fibrinolysis; regeneration and tissue remodeling; angiogenesis; lymphatic development; inflammation and immunity
Stem Cells in Action: Unlocking the Potential of Next-Generation Therapies
edited by George G. Koliakos
submission deadline 25 Apr 2026 | Viewed by 84 | Submission Open
Keywords: stem cell biology; differentiation and niche interaction; secretome/extracellular vesicles; organoids and disease modeling; regenerative medicine and tissue repair; immunomodulation and antimicrobial function; cell-based therapies and  cGMP translation; scaffold and biomaterial integration
(This special issue belongs to the Section Stem Cells)
Gene Editing Using Synthetic Nucleic Acids
edited by Debmalya Bhunia
submission deadline 25 Apr 2026 | Viewed by 60 | Submission Open
Keywords: gene editing; synthetic nucleic acids; genetic diseases; targeted gene therapy; antisense binding
(This special issue belongs to the Section Cell and Gene Therapy)
Unlocking the Secrets Behind Drug Resistance at the Cellular Level submission deadline 30 Apr 2026 | 5 articles | Viewed by 18674 | Submission Open
Keywords: molecular mechanisms; effective treatments; drug tests; bacterial resistance; chemoresistance
(This special issue belongs to the Section Cellular Immunology)
Eosinophils and Their Role in Allergy and Related Diseases
edited by
submission deadline 30 Apr 2026 | 5 articles | Viewed by 8594 | Submission Open
Keywords: eosinophils; asthma; allergy; inflammation; anti-eosinophil biologics; interleukin-5; interleukin-5 receptor; degranulation; mediator release
(This special issue belongs to the Section Cellular Immunology)
Research on T Cells in Skin Inflammatory Disorders
edited by and Qing-Sheng Mi
submission deadline 30 Apr 2026 | 1 articles | Viewed by 7749 | Submission Open
Keywords: T cell; vitiligo; atopic dermatitis; T cell lymphoma
(This special issue belongs to the Section Cellular Immunology)
Onco-Hematology and Immunotherapy
edited by and Régis T. Costello
submission deadline 30 Apr 2026 | 2 articles | Viewed by 6107 | Submission Open
Keywords: immunotherapy; onco-hematology; CAR T cells; NK cells; immune system; immune cells; leukemias; lymphomas
(This special issue belongs to the Section Cellular Immunology)
Control of Gene Expression by Co-Transcriptional Processes in Cell Homeostasis and Cell Fate Specification: Second Edition
edited by
submission deadline 30 Apr 2026 | 2 articles | Viewed by 3915 | Submission Open
Keywords: gene transcription; transcription elongation; RNA processing; RNA modification; RNA transport; lncRNA; histone modification; biomolecular condensates; diseases associated with dysregulation of gene regulation
(This special issue belongs to the Section Cell Nuclei: Function, Transport and Receptors)
New Discoveries in Calcium Signaling-Related Neurological Disorders
edited by Matheus De Castro Fonseca
submission deadline 30 Apr 2026 | 1 articles | Viewed by 2994 | Submission Open
Keywords: Ca2+ signaling; neurons; neurological disorders; intracellular signaling; synaptic dysfunction
(This special issue belongs to the Section Cells of the Nervous System)
Advances in Cardiomyocyte and Stem Cell Biology in Heart Disease
edited by Ki Ho Park
submission deadline 30 Apr 2026 | 3 articles | Viewed by 2731 | Submission Open
Keywords: cardiomyocytes; stem cells; heart disease; regenerative medicine; ion channels; protein therapeutics; bioengineering; molecular biology
(This special issue belongs to the Section Cells of the Cardiovascular System)
Cellular Mechanisms and Targeted Therapy of Acute Myeloid Leukemia
edited by
submission deadline 30 Apr 2026 | 2 articles | Viewed by 2464 | Submission Open
Keywords: Acute Myeloid Leukemia (AML); molecular targets; gene therapy; drug resistance; targeted therapy; leukemia stem cells; oncogenic mutations; apoptosis; cell cycle regulation
(This special issue belongs to the Section Cellular Pathology)
Modulation of P2X Receptors: Emerging Implications for Cellular Signaling and Disease Management
edited by Luca Antonioli and
submission deadline 30 Apr 2026 | 2 articles | Viewed by 2425 | Submission Open
Keywords: purinergic receptors; purinergic signaling; adenosine; ATP; ADP
Pathogenesis and Novel Therapies in Epithelial Cancers
edited by Jung Wook Park and Sanjeevram Dhandapani
submission deadline 30 Apr 2026 | 1 articles | Viewed by 2204 | Submission Open
Keywords: transformation; malignant; oncogene; tumor suppressor; molecular mechanisms; epigenetic; metabolic; immune; biomarkers; personalized medicine; primary cells; small-molecule inhibitor
(This special issue belongs to the Section Cellular Pathology)
Advancements in Cardiac Metabolism
edited by
submission deadline 30 Apr 2026 | 2 articles | Viewed by 2106 | Submission Open
Keywords: cardiovascular disease; metabolism; fatty acids; heart failure; mitochondrial dysfunction
(This special issue belongs to the Section Cells of the Cardiovascular System)
Immune Cells from Pluripotent Stem Cells
edited by
submission deadline 30 Apr 2026 | 1 articles | Viewed by 2050 | Submission Open
Keywords: pluripotent stem cells; T cells; B cells; macrophages; natural killer (NK) cells; dendritic cells; megakaryocytes; platelets
(This special issue belongs to the Section Stem Cells)
The Artificial Intelligence to the Rescue of Cancer Research submission deadline 30 Apr 2026 | 1 articles | Viewed by 1519 | Submission Open
Keywords: cancer research; artificial intelligence; personalized medicine; multi-omics data integration; AI-driven drug discovery; precision medicine
(This special issue belongs to the Section Cell Methods)
Telomere Maintenance and Metabolic Reprogramming in the Tumor Microenvironment
edited by and Jiyue Zhu
submission deadline 30 Apr 2026 | 1 articles | Viewed by 1121 | Submission Open
Keywords: telomere maintenance mechanisms (TMM); tumor microenvironment (TME); telomerase activation; alternative lengthening of telomeres (ALT); cancer metabolism; mitochondrial dysfunction; redox homeostasis; DNA damage response (DDR); epigenetic regulation; cancer therapeutics; senescence-associated secretory phenotypes (SASPs)
(This special issue belongs to the Section Cell Microenvironment)
Mechanisms Underlying Cell Growth and Development
edited by
submission deadline 30 Apr 2026 | 1 articles | Viewed by 1049 | Submission Open
Keywords: cell growth; cell development; cell differentiation; cell cycle; mitosis; meiosis; molecular rearrangements; chromosomes; gene expression
Molecular Mechanisms Underlying Inflammatory Pain
edited by
submission deadline 30 Apr 2026 | 1 articles | Viewed by 952 | Submission Open
Keywords: molecular mechanisms; inflammatory pain; nociception; neuronal sensitization; neuroimmune interactions
Role of Gamma Delta T Cells in Immunotherapy
edited by and Wenwei Tu
submission deadline 30 Apr 2026 | Viewed by 396 | Submission Open
Keywords: gamma delta T cells; adoptive cell therapy; chimeric antigen receptors; bispecific antibodies; cancer immunotherapy; tumor microenvironment; phosphoantigens; butyrophilin 2A1/3A1; virus infection; multidrug-resistant bacteria; extracellular vesicles
(This special issue belongs to the Section Cellular Immunology)
Advances in Bacterial Cell Biophysics: Metabolic Engineering and Host Interactions
edited by Shahid Khan
submission deadline 30 Apr 2026 | Viewed by 380 | Submission Open
Keywords: bacterial cell biophysics; mechanical properties; biophysical techniques; host interactions; metabolic engineering
Spatial Biology: Decoding Cellular Complexity in Tissues submission deadline 30 Apr 2026 | Viewed by 372 | Submission Open
Keywords: spatial biology; spatial tissue profiling; proteomics; transcriptomics; cell and tissue
(This special issue belongs to the Section Tissues and Organs)
Synaptic Dysregulation in Nervous System Disorders
edited by Pragya Goel
submission deadline 30 Apr 2026 | Viewed by 325 | Submission Open
Keywords: synapses; synaptic transmission; synaptic plasticity; neurodegeneration; neuropsychiatric disorders; neurodevelopmental diseases
(This special issue belongs to the Section Cells of the Nervous System)
Novel Therapies and Biomarkers for Rare Diseases
edited by Reena Kartha
submission deadline 30 Apr 2026 | Viewed by 269 | Submission Open
Keywords: rare diseases; translational research; novel therapies; biomarker discovery; precision medicine
Autophagy in Neurological Disorders submission deadline 30 Apr 2026 | Viewed by 254 | Submission Open
Keywords: autophagy; selective autophagy; neurodegeneration; proteostasis; lysosomes; aging; oxidative stress; aging; biomarkers; pharmacological agents
(This special issue belongs to the Section Cells of the Nervous System)
Interleukin-1 Signaling in Cancer: Novel Mechanisms and Therapeutic Opportunities
edited by Afshan Fathima Nawas and
submission deadline 30 Apr 2026 | Viewed by 202 | Submission Open
Keywords: interleukin-1 signaling; tumor microenvironment; inflammatory pathways; cytokine networks; cancer cell proliferation; epigenetic regulation in cancer; non-coding RNAs; immune modulation; cancer metabolism
Advances in Liquid Biopsy for Early Detection and Monitoring of Cancer
edited by Nicola Normanno, and
submission deadline 30 Apr 2026 | Viewed by 195 | Submission Open
Keywords: ctDNA; circulating tumor cells; microRNAs; exosomes; methylation; fragmentomics; early detection; minimal residual disease; artificial intelligence
The Role of Integrins and Small GTPases in Health and Disease
edited by
submission deadline 30 Apr 2026 | Viewed by 172 | Submission Open
Keywords: cell signaling; integrins; cell adhesion; integrins diseases; infectious diseases
Psilocybe Mushrooms Constituents—Therapeutic Implications
edited by and Janet Schloss
submission deadline 30 Apr 2026 | Viewed by 168 | Submission Open
Keywords: Psilocybe mushrooms; psilocybin; pre-clinical research; neurodegeneration
(This special issue belongs to the Section Plant, Algae and Fungi Cell Biology)
Kidney Development: Cellular and Molecular Insights submission deadline 30 Apr 2026 | Viewed by 114 | Submission Open
Keywords: kidney development; nephrogenesis; single-cell RNA-seq/ATAC-seq; congenital anomalies of the kidney and urinary tract (CAKUT); blood pressure regulation
Glycosylation and Glycoproteins in Human Disease
edited by and
submission deadline 30 Apr 2026 | Viewed by 104 | Submission Open
Keywords: glycobiology; glycosylation; glycoproteins; glycolipids; glycan biomarkers; congenital disorders of glycosylation (cdg); immune modulation; glycan profiling; glycoengineering; host– pathogen interactions; therapeutic glycoproteins; bioorthogonal chemistry
Advances in Neuropathology: Cellular, Molecular and Precision Mechanisms in Neurodegenerative Diseases submission deadline 30 Apr 2026 | Viewed by 102 | Submission Open
Keywords: neurodegeneration; Alzheimer's disease; Parkinson's disease; glial cells; synaptic dysfunction; protein aggregation; lysosomal function; autophagy; precision medicine
Molecular Mechanisms of Autophagy, Apoptosis and Senescence and Therapeutic Advances in Cancer Progression submission deadline 30 Apr 2026 | Viewed by 93 | Submission Open
Keywords: cancer progression; cell death; senescence; cancer therapy
Hematologic Diseases: From Cellular and Molecular Mechanisms to Therapies submission deadline 30 Apr 2026 | Viewed by 91 | Submission Open
Keywords: hematologic diseases; mechanisms; therapies
Molecular Signaling and Mechanism on Vascular Remodeling
edited by Ki Ho Park and Yitao Huang
submission deadline 30 Apr 2026 | Viewed by 90 | Submission Open
Keywords: vascular diseases; atherosclerosis; aneurysm; intimal hyperplasia; vascular remodeling; cellular mechanisms; cellular signaling
New Therapeutic Approaches to Cardiac Repair
edited by Dinakar Iyer
submission deadline 30 Apr 2026 | Viewed by 90 | Submission Open
Keywords: cardiac regeneration; CRISPR/base editing; mRNA therapeutics; circular RNA (circRNA); lipid nanoparticles (LNPs); engineered exosomes/extracellular vesicles; direct cardiac reprogramming; engineered heart muscle/3D cardiac patches; myocardial infarction repair; translational cardiology
Noncoding RNAs: Immunity, Mechanisms, and Biomarker Potential
edited by
submission deadline 30 Apr 2026 | Viewed by 87 | Submission Open
Keywords: noncoding RNAs (ncRNAs); MicroRNAs (miRNAs); long noncoding RNAs (lncRNAs); circular RNAs (circRNAs); immune regulation; tumor microenvironment; immune checkpoints; cancer immunotherapy; liquid biopsy biomarkers; immune evasion
Advancing Breast Cancer Research: Multi-Omics, AI, and Emerging Cellular Mechanisms
edited by Rahul Sanawar, and Satheesh Kumar Sengodan
submission deadline 30 Apr 2026 | Viewed by 78 | Submission Open
Keywords: breast cancer; cancer stem cells; cell plasticity; immune evasion; drug resistance; tumor microenvironment; non-coding RNAs; circulating tumor cells (CTC); circulating tumor DNA (ctDNA); exosomes; signaling pathways (e.g.; PI3K/AKT; MAPK); targeted therapy; immunotherapy
Mechanisms and Therapies of Cell Death Pathways
edited by and Deniz Gulfem Ozturk
submission deadline 30 Apr 2026 | Viewed by 61 | Submission Open
Keywords: cell death; mitochondrial regulation; BCL-2 family; non-apoptotic cell death; cell death pathways interactions; small molecules; therapeutic strategy; therapy resistance
(This special issue belongs to the Section Cellular Pathology)
Post-Transcriptional Control of Stem Cell Fate and Neural Development
edited by
submission deadline 30 Apr 2026 | Viewed by 44 | Submission Open
Keywords: post-transcriptional regulation; stem cell biology; neural development; developmental biology
(This special issue belongs to the Section Stem Cells)
Exploiting Stem Cell Pathways for Immune Protection
edited by
submission deadline 30 Apr 2026 | Viewed by 40 | Submission Open
Keywords: stem cell; immune tolerance; immune modulation; autoimmunity; immunosuppression; immunotherapy; immune escape; immune evasion; immune privilege; stemness
Autoimmune Diseases: Immune Cells and Genetic and Epigenetic Regulations
edited by
submission deadline 30 Apr 2026 | Viewed by 27 | Submission Open
Keywords: autoimmune diseases; immune cells; lymphocytes; antigen-presenting cells; natural killer cells; innate lymphoid cells; epigenetic modifications; autoimmunity
(This special issue belongs to the Section Cellular Immunology)
Lipoprotein and the Cardiovascular Diseases Therapy
edited by Verity Ramirez and Wenliang Song
submission deadline 30 Apr 2026 | Viewed by 27 | Submission Open
Keywords: lipoprotein; cholesterol; cardiovascular disease; lipid-lowering therapy
(This special issue belongs to the Section Cells of the Cardiovascular System)
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