Mitochondrial Proteomics for the Understanding of Human Diseases

Dear Colleagues,

 Mitochondria are the organelles deputed to energy production, they are the most complex and the most important organelles of eukaryotic cells and are involved in many cellular processes, including energy metabolism, apoptosis, and aging. Mitochondria dysfunctions have been identified to play a crucial role in several human diseases. Studies aimed at improving the profiling of mitochondrial proteome on different human diseases might enhance the understanding of mitochondria-associated pathologies, providing a substrate for the development of promising therapeutic targets. In the human genome, about 2500 protein have been estimated to be part of the mitochondrial compartment; of these, only 600 have been identified at the protein level. Accordingly, mitochondria contain a significant number of proteins that have yet to be identified and characterized. Thus far, diseases involving mitochondria defects have been studied using classic biochemical approaches. Generally, these approaches are able to focus on a specific protein or, at most, on a small set of proteins. Proteomics, allowing the global analysis of protein expression, localization, and interaction, might provide a more comprehensive, in-depth analysis of whole mitochondrial proteome. This approach offers the likelihood for identify new candidate biomarkers as well as for developing novel therapeutic targets. This Special Issue “Mitochondrial Proteomics for the Understanding of Human Disease” will represent a summary of progression of the mitochondrial proteome profiling in human diseases, as well as the starting point for future prospects in mitochondrial proteomics.  

Dr. Domenica Scumaci
Guest Editor

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Proteomes is an international peer-reviewed open access quarterly journal published by MDPI.

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• Mitochondria
• proteomics
• human disease