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The Role of Mitochondria in the Chemoresistance of Pancreatic Cancer Cells

1
General Surgery Department, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China
2
Department of Biotechnology and Bioscience, University of Milano Bicocca, 20126 Milano, Italy
3
Department of Nuclear Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China
4
Clinical Immunology Center, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this study.
Academic Editor: Paola Cappello
Cells 2021, 10(3), 497; https://doi.org/10.3390/cells10030497
Received: 14 December 2020 / Revised: 16 January 2021 / Accepted: 14 February 2021 / Published: 25 February 2021
The first-line chemotherapies for patients with unresectable pancreatic cancer (PC) are 5-fluorouracil (5-FU) and gemcitabine therapy. However, due to chemoresistance the prognosis of patients with PC has not been significantly improved. Mitochondria are essential organelles in eukaryotes that evolved from aerobic bacteria. In recent years, many studies have shown that mitochondria play important roles in tumorigenesis and may act as chemotherapeutic targets in PC. In addition, according to recent studies, mitochondria may play important roles in the chemoresistance of PC by affecting apoptosis, metabolism, mtDNA metabolism, and mitochondrial dynamics. Interfering with some of these factors in mitochondria may improve the sensitivity of PC cells to chemotherapeutic agents, such as gemcitabine, making mitochondria promising targets for overcoming chemoresistance in PC. View Full-Text
Keywords: pancreatic cancer; mitochondria; chemoresistance; metabolism; apoptosis pancreatic cancer; mitochondria; chemoresistance; metabolism; apoptosis
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MDPI and ACS Style

Fu, Y.; Ricciardiello, F.; Yang, G.; Qiu, J.; Huang, H.; Xiao, J.; Cao, Z.; Zhao, F.; Liu, Y.; Luo, W.; Chen, G.; You, L.; Chiaradonna, F.; Zheng, L.; Zhang, T. The Role of Mitochondria in the Chemoresistance of Pancreatic Cancer Cells. Cells 2021, 10, 497. https://doi.org/10.3390/cells10030497

AMA Style

Fu Y, Ricciardiello F, Yang G, Qiu J, Huang H, Xiao J, Cao Z, Zhao F, Liu Y, Luo W, Chen G, You L, Chiaradonna F, Zheng L, Zhang T. The Role of Mitochondria in the Chemoresistance of Pancreatic Cancer Cells. Cells. 2021; 10(3):497. https://doi.org/10.3390/cells10030497

Chicago/Turabian Style

Fu, Yibo; Ricciardiello, Francesca; Yang, Gang; Qiu, Jiangdong; Huang, Hua; Xiao, Jianchun; Cao, Zhe; Zhao, Fangyu; Liu, Yueze; Luo, Wenhao; Chen, Guangyu; You, Lei; Chiaradonna, Ferdinando; Zheng, Lianfang; Zhang, Taiping. 2021. "The Role of Mitochondria in the Chemoresistance of Pancreatic Cancer Cells" Cells 10, no. 3: 497. https://doi.org/10.3390/cells10030497

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