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Open AccessArticle

Contribution of the CK2 Catalytic Isoforms α and α’ to the Glycolytic Phenotype of Tumor Cells

Department of Biomedical Sciences, University of Padova, 35131 Padova, Italy
CNR Neuroscience Institute, 35131 Padova, Italy
Author to whom correspondence should be addressed.
Cells 2021, 10(1), 181;
Received: 28 November 2020 / Revised: 4 January 2021 / Accepted: 15 January 2021 / Published: 18 January 2021
CK2 is a Ser/Thr protein kinase overexpressed in many cancers. It is usually present in cells as a tetrameric enzyme, composed of two catalytic (α or α’) and two regulatory (β) subunits, but it is active also in its monomeric form, and the specific role of the different isoforms is largely unknown. CK2 phosphorylates several substrates related to the uncontrolled proliferation, motility, and survival of cancer cells. As a consequence, tumor cells are addicted to CK2, relying on its activity more than healthy cells for their life, and exploiting it for developing multiple oncological hallmarks. However, little is known about CK2 contribution to the metabolic rewiring of cancer cells. With this study we aimed at shedding some light on it, especially focusing on the CK2 role in the glycolytic onco-phenotype. By analyzing neuroblastoma and osteosarcoma cell lines depleted of either one (α) or the other (α’) CK2 catalytic subunit, we also aimed at disclosing possible pro-tumor functions which are specific of a CK2 isoform. Our results suggest that both CK2 α and α’ contribute to cell proliferation, survival and tumorigenicity. The analyzed metabolic features disclosed a role of CK2 in tumor metabolism, and suggest prominent functions for CK2 α isoform. Results were also confirmed by CK2 pharmacological inhibition. Overall, our study provides new information on the mechanism of cancer cells addiction to CK2 and on its isoform-specific functions, with fundamental implications for improving future therapeutic strategies based on CK2 targeting. View Full-Text
Keywords: CK2; casein kinase 2; isoforms; cancer metabolism CK2; casein kinase 2; isoforms; cancer metabolism
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MDPI and ACS Style

Zonta, F.; Borgo, C.; Quezada Meza, C.P.; Masgras, I.; Rasola, A.; Salvi, M.; Pinna, L.A.; Ruzzene, M. Contribution of the CK2 Catalytic Isoforms α and α’ to the Glycolytic Phenotype of Tumor Cells. Cells 2021, 10, 181.

AMA Style

Zonta F, Borgo C, Quezada Meza CP, Masgras I, Rasola A, Salvi M, Pinna LA, Ruzzene M. Contribution of the CK2 Catalytic Isoforms α and α’ to the Glycolytic Phenotype of Tumor Cells. Cells. 2021; 10(1):181.

Chicago/Turabian Style

Zonta, Francesca; Borgo, Christian; Quezada Meza, Camila P.; Masgras, Ionica; Rasola, Andrea; Salvi, Mauro; Pinna, Lorenzo A.; Ruzzene, Maria. 2021. "Contribution of the CK2 Catalytic Isoforms α and α’ to the Glycolytic Phenotype of Tumor Cells" Cells 10, no. 1: 181.

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