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Cancers publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Neoantigen Vaccines for Cancer Therapy
edited by Takashi Morisaki
submission deadline 28 Feb 2027 | 3 articles | Viewed by 5482 | Submission Open
Keywords: neoantigens; vaccine; dendritic cells; cancer; immunotherapy; priming; CTL; helper T cells
(This special issue belongs to the Section Cancer Immunology and Immunotherapy)
Long-Term Health Outcomes and Quality of Life in Survivors of Childhood Cancer submission deadline 28 Feb 2027 | 2 articles | Viewed by 4150 | Submission Open
Keywords: acute lymphoblastic leukemia; brain tumors; childhood cancer survivors; pollutants; environment; quality of life; nutrition; chemotherapy; air and water purification
(This special issue belongs to the Section Pediatric Oncology)
Tumor Microenvironment in Cancer Therapies: Supportive or Hostile? submission deadline 28 Feb 2027 | 1 articles | Viewed by 3533 | Submission Open
Keywords: tumor microenvironment; protumor effects; antitumor effects; immune cells; stromal cells; extracellular matrix; cancer therapies
(This special issue belongs to the Section Tumor Microenvironment)
Integrating Chemotherapy and Immunotherapy for Head and Neck Cancer
edited by Ken Saijo
submission deadline 28 Feb 2027 | 1 articles | Viewed by 3282 | Submission Open
Keywords: head and neck squamous cell carcinomas; HNSCC; immune checkpoint inhibitor; biomarker; chemotherapy
(This special issue belongs to the Section Cancer Metastasis)
Surgery for Lung Cancer: Robot-Assisted Versus Video-Assisted Thoracoscopic Surgery and Open Thoracotomy
edited by
submission deadline 28 Feb 2027 | 3 articles | Viewed by 3178 | Submission Open
Keywords: laparoscopic thoracic surgery; open thoracotomy; robotic thoracic surgery (RTS); lung cancer; surgical treatment; minimally invasive intervention
(This special issue belongs to the Section Cancer Therapy)
Advanced Segmentation in Multimodal Nuclear Imaging of Solid Tumors and Lymphomas: Tools, Challenges, and Clinical Integration
edited by and Robert Förster
submission deadline 28 Feb 2027 | 2 articles | Viewed by 2645 | Submission Open
Keywords: multimodal nuclear imaging; artificial intelligence in nuclear medicine; radiomics in nuclear medicine; tumor segmentation; segmentation techniques; segmentation tools; outcome prediction; radioligand therapy
(This special issue belongs to the Section Methods and Technologies Development)
Transformative Genomic Technologies Shaping the Future of Precision Approaches for Haematological Malignancies submission deadline 28 Feb 2027 | 1 articles | Viewed by 2638 | Submission Open
Keywords: multi-omics; risk stratification; bioinformatics; AI/machine learning; hematological malignancies; biomarkers; targeted therapeutics; genomics; cancer cell biology
Minimally Invasive and Innovative Approaches in Breast Cancer Surgery: Techniques and Outcomes submission deadline 28 Feb 2027 | 3 articles | Viewed by 2626 | Submission Open
Keywords: minimally invasive breast surgery; endoscopic mastectomy; robotic mastectomy; targeted axillary dissection; breast-conserving surgery; breast reconstruction; cryoablation; surgical outcomes; patient-reported outcomes; quality of life
(This special issue belongs to the Section Clinical Research in Cancer)
Next-Generation Biomarkers and AI-Enhanced Digital Pathology Alliance: Revolutionizing Therapeutic Strategies and Prognostic Assessment in Colorectal Cancer submission deadline 28 Feb 2027 | 2 articles | Viewed by 2569 | Submission Open
Keywords: liquid biopsy; precision oncology; predictive prognostication
Oncological Healthcare: Emergency and Supportive/Palliative Approaches
edited by Ahmed Elsayem and Pavitra Parimala Krishnamani
submission deadline 28 Feb 2027 | 2 articles | Viewed by 2546 | Submission Open
Keywords: supportive oncology; palliative care; symptom distress; emergency medicine; critical care; goals of care
(This special issue belongs to the Section Cancer Survivorship and Quality of Life)
Role of Inflammation in Cancer
edited by
submission deadline 28 Feb 2027 | 2 articles | Viewed by 2284 | Submission Open
Keywords: cancer; inflammation; immune cells; cytokines; anti-inflammatory; tumor microenvironment; immunotherapy; immune-related adverse events; targeted therapy; chemotherapy and chemoprevention
Decoding the Tumor Microenvironment: Immune Cell–Tumor Interplay in Breast Cancer
edited by Abirami Sivapiragasam and Roberto A. Leon Ferre
submission deadline 28 Feb 2027 | 1 articles | Viewed by 2237 | Submission Open
Keywords: tumor microenvironment; breast cancer; immune cell–tumor interaction; immunotherapy; T cells; macrophages; dendritic cells; single-cell transcriptomics; spatial transcriptomics; artificial intelligence; prognostic biomarkers; predictive biomarkers; personalized therapy
(This special issue belongs to the Section Tumor Microenvironment)
Molecular Mechanisms and Therapeutic Resistance in Hematological Malignancies
edited by
submission deadline 28 Feb 2027 | 1 articles | Viewed by 2050 | Submission Open
Keywords: genomic and epigenomic alterations; signaling pathway dysregulation; non-coding RNAs; metabolic reprogramming; antigen escape mechanisms; antigen presentation defects; interferon signaling impairment; T-cell exhaustion; memory T-cell dysfunction; myeloid-mediated immunosuppression; bone marrow immune microenvironment; spatial immune architecture; CAR-T cell therapy; next-generation CAR engineering; bispecific antibodies and T-cell engagers; antibody-drug conjugates; NK-cell and macrophage immunotherapy; immune checkpoint modulation; combination immunotherapy strategies; liquid biopsy–guided precision therapy
Multimodal Management of Hepatobiliary Cancers: Development of Surgical and Locoregional Strategies
edited by
submission deadline 28 Feb 2027 | 2 articles | Viewed by 2004 | Submission Open
Keywords: hepatocarcinoma; liver metastasis; ultrasound guided liver resection; tumoral ablative tehniques; biliary cancers
Molecular Insights into Drug Resistance in Cancer: 2nd Edition
edited by Yuqi Yang
submission deadline 28 Feb 2027 | 3 articles | Viewed by 1928 | Submission Open
Keywords: drug resistance; cancer treatment; molecular mechanism; chemotherapeutic therapy; small molecules; biologics/large molecules; leukemia; solid tumor
Host-Related Prognostic Factors in Gastrointestinal Malignancies: From Genetics to Phenomics
edited by and Yoshihiro Nabeya
submission deadline 28 Feb 2027 | 3 articles | Viewed by 1847 | Submission Open
Keywords: pharmacogenetics; body composition assessment; nutritional oncology; systemic inflammation; therapeutic management
(This special issue belongs to the Section Molecular Cancer Biology)
Surgery for Head and Neck Cancer
edited by , and Stefan Grasl
submission deadline 28 Feb 2027 | 2 articles | Viewed by 1753 | Submission Open
Keywords: head and neck cancer; oncologic surgery; minimally invasive surgery; transoral robotic surgery; neck dissection; reconstructive surgery; multidisciplinary treatment; functional outcomes
(This special issue belongs to the Section Cancer Therapy)
Advances in Treatment of Bladder Cancer submission deadline 28 Feb 2027 | 2 articles | Viewed by 1734 | Submission Open
Keywords: bladder cancer; diagnostic biomarkers; genomics; therapeutic approaches
(This special issue belongs to the Section Cancer Therapy)
The Molecular Biology of Cholangiocarcinoma
edited by and Padma-Sheela Jayaraman
submission deadline 28 Feb 2027 | 1 articles | Viewed by 1432 | Submission Open
Keywords: cholangiocarcinoma; biliary tract cancer; early detection; targeted therapy; tumour microenvironment; spatial biology; genomics; transcriptomics; proteomics
(This special issue belongs to the Section Molecular Cancer Biology)
Gastrointestinal Tumors: Prevention, Screening and Predictive Analytics
edited by Mohamed I. Elsaid, and Vinod Rustgi
submission deadline 28 Feb 2027 | 1 articles | Viewed by 1408 | Submission Open
Keywords: gastrointestinal and hepatobiliary cancers; prevention and screening; chemoprevention; risk stratification; biomarkers and liquid biopsy (ctDNA); imaging and radiomics; predictive analytics and machine learning; causal inference; population-based studies; implementation science and health equity
(This special issue belongs to the Section Cancer Epidemiology and Prevention)
Advancements in Brain Cancer Research: From Molecular Mechanisms to Translational Therapeutic Strategies submission deadline 28 Feb 2027 | 1 articles | Viewed by 1403 | Submission Open
Keywords: brain cancer; glioblastoma; tumor microenvironment; cancer stem cells; molecular therapeutics; epigenetic regulation; nanomedicine; translational oncology; therapeutic resistance
Obesity and Cancers (2nd Edition)
edited by Edward Sauter and Tanya Agurs-Collins
submission deadline 28 Feb 2027 | 1 articles | Viewed by 1285 | Submission Open
Keywords: obesity; cancer; mitigating factors; weight loss; weight gain; obesity interventions
(This special issue belongs to the Section Cancer Epidemiology and Prevention)
Precision Prediction of Cardiotoxicity: Imaging, Biomarkers, Genetics, Risk Models, and Digital Innovation in Cardio-Oncology
edited by Kalliopi Keramida
submission deadline 28 Feb 2027 | 2 articles | Viewed by 1237 | Submission Open
Keywords: cardio-oncology; imaging; biomarkers; genetics; risk models; digital innovation
Robotic and Thoracoscopic Surgery for Lung Cancer
edited by Benjamin Wei
submission deadline 28 Feb 2027 | 2 articles | Viewed by 1217 | Submission Open
Keywords: robotic; thoracoscopic; lobectomy; segmentectomy; wedge resection; lymph node dissection; neoadjuvant therapy; immunotherapy; spread through air spaces; radiomics
(This special issue belongs to the Section Methods and Technologies Development)
Cellular Senescence, Aging and the Tumor Microenvironment in Cancer
edited by Jabed Iqbal and Jeremy Wee Kiat Ng
submission deadline 28 Feb 2027 | 1 articles | Viewed by 1205 | Submission Open
Keywords: aging; senescence; immunosenescence; SASP; tumor microenvironment; immunotherapy
(This special issue belongs to the Section Tumor Microenvironment)
mTOR Signaling in Cancer
edited by
submission deadline 28 Feb 2027 | 1 articles | Viewed by 1186 | Submission Open
Keywords: mTOR; cancer; cell signaling; pathway addiction; tumor metabolism; glycolysis; autophagy; apoptosis; rapamycin
(This special issue belongs to the Section Molecular Cancer Biology)
Heat Shock Proteins in Metastatic Cancer: From Molecular Mechanisms to Clinical Targeting
edited by Daniel Jay and
submission deadline 28 Feb 2027 | 1 articles | Viewed by 1179 | Submission Open
Keywords: HSPs and eHSPs (Hsp90, Hsp70, Hsp60, Hsp40 and Hsp27); HSF1; chaperone; cancer metastasis; EMT; tumor microenvironment; ECM remodelling; anoikis resistance; circulating tumor cell survival; premetastatic niche; metastatic colonisation; extracellular vesicles; exosomes; cancer stem cells; therapy resistance; metastatic biomarkers; immunotherapy; HSP-targeted therapy
Redox Balance, Antioxidant Defenses, and Inflammation in Cancer: From Initial Changes to Tumor Progression
edited by Andrej Veljković, and
submission deadline 28 Feb 2027 | 1 articles | Viewed by 1058 | Submission Open
Keywords: oxidative stress; inflammation; cancer progression; pre-malignant changes; biomarkers; tumor microenvironment; cell signaling; therapeutic targets
(This special issue belongs to the Section Tumor Microenvironment)
Role of TP53 Mutation in Cancer
edited by
submission deadline 28 Feb 2027 | 1 articles | Viewed by 994 | Submission Open
Keywords: TP53 mutation; p53 aggregate; gain-of-function; cancer progression; transcriptional reprogramming; therapeutic targeting; biomarker; translational research; precision oncology
(This special issue belongs to the Section Molecular Cancer Biology)
Surgical Treatment and Prognosis of Hepato-Biliary and Pancreatic Tumors—the Role of Minimally Invasive Surgery
edited by Giorgio Ercolani
submission deadline 28 Feb 2027 | 2 articles | Viewed by 989 | Submission Open
Keywords: liver tumor; cholangiocarcinoma; pancreatic tumor; robotic surgery; mini-invasive treatment; treatment multimodality
CAR T Cell Therapy in Cancer: Progress and Challenges Across Solid and Hematologic Malignancies
edited by John F. Marshall and Lauren C. Cutmore
submission deadline 28 Feb 2027 | 1 articles | Viewed by 879 | Submission Open
Keywords: CAR-T cell therapy; adoptive cell therapy; immunotherapy; antigen escape; solid tumor; hematologic malignancies
(This special issue belongs to the Section Cancer Immunology and Immunotherapy)
Liquid Biopsy Innovation: From ctDNA to RNA Modifications in Genitourinary Cancers
edited by , and Jacopo Venturini
submission deadline 28 Feb 2027 | 1 articles | Viewed by 639 | Submission Open
Keywords: liquid biopsy; cell-free DNA (cfDNA); circulating tumor DNA (ctDNA); RNA modification
(This special issue belongs to the Section Cancer Biomarkers)
Recent Developments on PET-CT in Multiple Myeloma
edited by
submission deadline 28 Feb 2027 | Viewed by 438 | Submission Open
Keywords: PET/CT; multiple myeloma; novel radiopharmaceuticals; radiomics; theranostics
(This special issue belongs to the Section Methods and Technologies Development)
Advances in the Multimodal Management of Pancreatic Ductal Adenocarcinoma submission deadline 28 Feb 2027 | Viewed by 420 | Submission Open
Keywords: pancreatic ductal adenocarcinoma (PDAC); multimodal approach; systemic therapy; radiotherapy; targeted strategies; neoadjuvant therapy; adjuvant therapy
(This special issue belongs to the Section Cancer Therapy)
Tumor Microenvironment in Bone Sarcoma submission deadline 28 Feb 2027 | Viewed by 392 | Submission Open
Keywords: osteosarcoma; microenvironment; oncogene; tumor suppressor; CAR cell therapy; epithelial–mesenchymal transition; metabolism; epigenetics
(This special issue belongs to the Section Tumor Microenvironment)
Next-Generation Biomarkers in Oncology: From Multi-Omics to AI-Powered Diagnostics
edited by
submission deadline 28 Feb 2027 | Viewed by 379 | Submission Open
Keywords: multi-omics; cancer biomarkers; precision oncology; liquid biopsy; circulating tumor DNA (ctDNA); single-cell sequencing; spatial transcriptomics; epigenomics; proteogenomics; metabolomics; tumor microenvironment; radiomics; digital pathology; machine learning; explainable AI
(This special issue belongs to the Section Cancer Biomarkers)
Research on Clinical Treatment of Mesothelioma: 2nd Edition
edited by
submission deadline 28 Feb 2027 | Viewed by 371 | Submission Open
Keywords: pleural mesothelioma; targeted therapy; local treatments; radiomics; genetic traits; occupational health; asbestos exposure
(This special issue belongs to the Section Clinical Research in Cancer)
Innovative Approaches of Multimodal Imaging of Cancer Characteristics in Nuclear Medicine submission deadline 28 Feb 2027 | Viewed by 368 | Submission Open
Keywords: multimodal imaging; molecular imaging; PET; SPECT; MRI; CT; ultrasound; optical imaging; cancer
(This special issue belongs to the Section Methods and Technologies Development)
Digital Pathology and AI for Tumor Microenvironment Mapping
edited by Mohammadreza Azimi
submission deadline 28 Feb 2027 | Viewed by 350 | Submission Open
Keywords: tumor microenvironment; digital pathology; artificial intelligence; spatial analysis; computational histopathology; deep learning; cancer prognostics; machine learning; image-based biomarkers; federated learning
The Invasion and Metastasis in Skin Cancer
edited by Emanuela Passoni, and
submission deadline 28 Feb 2027 | Viewed by 302 | Submission Open
Keywords: melanoma; skin cancer; basal cell carcinoma; squamous cell carcinoma; Kaposi’s sarcoma; dermoscopy; photoprotection; skin cancer prevention
Epigenetic Markers of Cancer Diseases
edited by and Jessica Puzzuoli
submission deadline 28 Feb 2027 | Viewed by 291 | Submission Open
Keywords: epigenetics; DNA methylation; histone modifications; tumor suppressor genes; oncogenes; cancer biomarkers; early detection; disease progression; epigenetic therapy; DNA methyltransferase inhibitors; histone deacetylase inhibitors; liquid biopsy; cancer risk assessment; clinical translation
(This special issue belongs to the Section Molecular Cancer Biology)
Genomic Instability in Breast Cancer: Biomarkers, Resistance and Therapeutic Opportunities
edited by Melyssa R. Bratton
submission deadline 28 Feb 2027 | Viewed by 219 | Submission Open
Keywords: genomic instability; somatic mutation; DNA damage response; homologous recombination deficiency (HRD); tumor mutational burden (TMB); chromosomal instability (CIN); tumor evolution; therapeutic resistance
Emerging Roles of HDACs in Cancer Metabolism, Plasticity and Therapeutic Response
edited by Changmin Peng
submission deadline 28 Feb 2027 | Viewed by 195 | Submission Open
Keywords: HDAC biology; cancer metabolism; therapeutic resistance; post-translational modifications; cancer plasticity
(This special issue belongs to the Section Molecular Cancer Biology)
Non-Coding RNAs in Bone Tumors: Pathogenesis, Diagnostic Biomarkers, and Therapeutic Perspectives
edited by Albert Roessner
submission deadline 28 Feb 2027 | Viewed by 192 | Submission Open
Keywords: bone tumors; non-coding RNAs; pathogenesis; biomarkers; non-coding RNA therapeutics
Artificial Intelligence in Cancers: Enhancing Diagnosis and Treatment
edited by , Adam Shephard and Shan E Ahmed Raza
submission deadline 28 Feb 2027 | Viewed by 181 | Submission Open
Keywords: artificial intelligence; machine learning; deep learning; precision oncology; cancer diagnosis; cancer screening; treatment planning; prognostic prediction; digital pathology; medical imaging; radiomics; genomics; multiomics
(This special issue belongs to the Section Cancer Informatics and Big Data)
Novel Pharmacotherapeutic Strategies for Neuroendocrine Tumors: Drug Repurposing, Combinations, and Beyond
edited by Qiyun Tang and Mujie Ye
submission deadline 28 Feb 2027 | Viewed by 178 | Submission Open
Keywords: neuroendocrine tumors; tumor metabolism; immune microenvironment; immunotherapy; targeted therapy (including PRRT); metabolic reprogramming; basic research/translational research; therapeutic resistance; biomarkers
(This special issue belongs to the Section Cancer Drug Development)
Advances in Pathology of Lymphoma and Leukemia—Second Edition
edited by
submission deadline 28 Feb 2027 | Viewed by 160 | Submission Open
Keywords: leukemia; lymphoma; immunohistochemical stains; next-generation sequencing; cytogenetics; flow cytometry analysis
(This special issue belongs to the Section Cancer Pathophysiology)
Signaling Molecules for Brain Tumors
edited by and Akshaya Murugesan
submission deadline 28 Feb 2027 | Viewed by 153 | Submission Open
Keywords: brain tumor; signaling molecules; tumor microenvironment; sensor; diagnosis and treatment; tumor microenvironment; synthesis and characterization; small drug molecules; gene expression; computational studies
(This special issue belongs to the Section Molecular Cancer Biology)
Photodiagnosis and Photodynamic Therapy for CNS Tumors
edited by
submission deadline 28 Feb 2027 | Viewed by 132 | Submission Open
Keywords: photo-diagnosis; photodynamic therapy; central nervous system tumors; photosensitizer
Quality of Life and Management of Pediatric Cancer (2nd Edition) submission deadline 28 Feb 2027 | Viewed by 131 | Submission Open
Keywords: pediatric palliative care; oncology; quality of life; early management
(This special issue belongs to the Section Pediatric Oncology)
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