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Cancers publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Global Perspectives on the Epidemiology and Management of Early-Onset Cancers
edited by
submission deadline 31 Dec 2026 | 2 articles | Viewed by 2515 | Submission Open
Keywords: early-onset cancer; adolescent and young adult cancer (AYA); early-onset breast cancer; early-onset colorectal cancer; early-onset pancreatic cancer; early-onset thyroid cancer; early-onset melanoma; early-onset gastrointestinal cancers; early-onset hematological cancers; early-onset cancers of reproductive organs
(This special issue belongs to the Section Cancer Epidemiology and Prevention)
Overcoming the Barriers: Cellular and Molecular Pathology of Pancreatic Cancer
edited by
submission deadline 31 Dec 2026 | 1 articles | Viewed by 2462 | Submission Open
Keywords: pancreatic cancer; metastasis; tumor microenvironment; tumor metabolism; tumor immunity
(This special issue belongs to the Section Molecular Cancer Biology)
Advancing Therapeutic Strategies for Neuroendocrine Tumors: Towards Personalized and Multidisciplinary Care
edited by
submission deadline 31 Dec 2026 | 3 articles | Viewed by 2428 | Submission Open
Keywords: neuroendocrine tumor; neuroendocrine carcinoma; multidisciplinary care; PRRT; hepatic embolization; tumor debulking; targeted therapy; lung carcinoid
(This special issue belongs to the Section Cancer Therapy)
Computational Methods for Integrative Cancer Data Analysis
edited by
submission deadline 31 Dec 2026 | 2 articles | Viewed by 2266 | Submission Open
Keywords: cancer bioinformatics; multi-omics integration; machine learning; translational oncology
(This special issue belongs to the Section Cancer Informatics and Big Data)
CDK4/6 Inhibitors in Cancer: Efficacy, Resistance, and Combination Approaches
edited by
submission deadline 31 Dec 2026 | 2 articles | Viewed by 2259 | Submission Open
Keywords: CDK4/6 inhibitors; palbociclib; abemaciclib; ribociclib; cancer; senescence; combinatorial therapy; prognosis; molecular mechanisms
(This special issue belongs to the Section Cancer Therapy)
Disparities in Cancer Care: Advancing Equity Across the Cancer Continuum
edited by and Ernie Kaninjing
submission deadline 31 Dec 2026 | 2 articles | Viewed by 2256 | Submission Open
(This special issue belongs to the Section Cancer Survivorship and Quality of Life)
A New Road for Cancer Drug Discovery submission deadline 31 Dec 2026 | 3 articles | Viewed by 2253 | Submission Open
Keywords: cancer drug discovery; artificial intelligence in drug discovery and development; targeted therapy; precision oncology; targeted protein degrades; small-molecule therapeutics; immuno-oncology; undruggable targets; drug resistance mechanisms; combination therapy
(This special issue belongs to the Section Cancer Drug Development)
CancersScape: Spatial Biology of the Tumor Ecosystem
edited by and Sammy Ferri-Borgogno
submission deadline 31 Dec 2026 | 1 articles | Viewed by 2242 | Submission Open
Keywords: cancer; health; tumor microenvironment; spatial biology; cancer diagnosis; cancer drug discovery; Omics
The Impact of Minimally Invasive Surgery on Gynecologic Cancers
edited by
submission deadline 31 Dec 2026 | 1 articles | Viewed by 2170 | Submission Open
Keywords: minimally invasive surgery; robotic-assisted surgery; gynecologic malignancy; laparoscopy
(This special issue belongs to the Section Cancer Therapy)
Pathogenesis and Treatment Strategies in Multiple Myeloma: From Basic Research to Real Life: 2nd Edition
edited by Shingen Nakamura
submission deadline 31 Dec 2026 | 1 articles | Viewed by 2127 | Submission Open
Keywords: myeloma bone disease; denosumab; bisphosphonate; infectious complication; proteasome inhibitor; IMiDs; anti-CD38 antibody; venetoclax; immunotherapy
(This special issue belongs to the Section Cancer Therapy)
Next-Generation Boron Neutron Capture Therapy (BNCT) for Cancer Treatment
edited by Dayron Ramos López, Gabriella Pugliese and Raffaella Radogna
submission deadline 31 Dec 2026 | 1 articles | Viewed by 1958 | Submission Open
Keywords: BNCT; boron agents; dosimetry; neutron detectors; cancer therapy; imaging; simulation; neutron sources; treatment planning; medical physics
(This special issue belongs to the Section Methods and Technologies Development)
Molecular Mechanisms of Cancer Progression and Metastasis
edited by
submission deadline 31 Dec 2026 | 1 articles | Viewed by 1933 | Submission Open
Keywords: metastasis; molecular mechanisms; tumor microenvironment (TME); epithelial-to-mesenchymal transition (EMT); cancer stem cell; therapeutic strategies; immune evasion
(This special issue belongs to the Section Cancer Metastasis)
Emerging Therapies for Germ Cell Tumors
edited by and Krinio Giannikou
submission deadline 31 Dec 2026 | 1 articles | Viewed by 1872 | Submission Open
Keywords: testicular cancer; embryonal carcinoma; germ cell tumors; cisplatin; immunotherapy; epigenetics; microRNA; chemoresistance; animal models; targeted therapy
(This special issue belongs to the Section Cancer Therapy)
Advancements in Head and Neck Cancer Surgery (2nd Edition) submission deadline 31 Dec 2026 | 2 articles | Viewed by 1864 | Submission Open
Keywords: minimal invasive; transoral; robotic; reconstructive; 3D printing; targeting therapies; imaging
Evolving Management of Gastroesophageal Cancers: From Local Therapies to Precision Oncology
edited by Matthew Strickland
submission deadline 31 Dec 2026 | 1 articles | Viewed by 1829 | Submission Open
Keywords: gastric cancer; esophageal cancer; immunotherapy targeted therapy; radiation therapy; surgical oncology; precision oncology; molecular biomarkers; multimodal treatment
(This special issue belongs to the Section Cancer Therapy)
Exploring the Processes of Biochemical, Cellular and Molecular Drivers of Cancer Cell and Emerging Therapies
edited by
submission deadline 31 Dec 2026 | 1 articles | Viewed by 1707 | Submission Open
Keywords: redox biology; metabolism; signal transduction; genetics; drug discovery; drug delivery; drug resistance; nanotherapeutics; diagnostic sensors; clinical trial
The Evolving Role of CDK4/6 Inhibitors in Early and Recurrent Breast Cancer: Clinical and Translational Findings and Work in Progress
edited by Hans-Christian Kolberg
submission deadline 31 Dec 2026 | 1 articles | Viewed by 1528 | Submission Open
Keywords: CDK4/6 inhibitors; breast cancer; treatment resistance; combination therapy; biomarkers
Artificial Intelligence and Machine Learning in Cancer Diagnosis, Treatment, and Prognosis
edited by Iakovos Amygdalos
submission deadline 31 Dec 2026 | 1 articles | Viewed by 1507 | Submission Open
Keywords: artificial intelligence in oncology and oncological surgery; machine learning for cancer diagnosis; multimodal data integration; precision oncology and prognostic modeling; federated and explainable AI
(This special issue belongs to the Section Methods and Technologies Development)
Innovations in Cutaneous Oncology and Dermatologic Surgery: Translating Mechanisms into Practice
edited by Paulo Filipe and Maria Catorze
submission deadline 31 Dec 2026 | 1 articles | Viewed by 1433 | Submission Open
Keywords: cutaneous oncology; dermatologic surgery; mohs micrographic surgery; immunotherapy; hedgehog pathway; translational research; skin cancer; digital innovation
(This special issue belongs to the Section Cancer Therapy)
Molecular Mechanisms of Breast Cancer Treatment-Related Side Effects and Precision Interventions
edited by
submission deadline 31 Dec 2026 | 1 articles | Viewed by 1382 | Submission Open
Keywords: breast cancer; treatment-related side effects; biomarker; precision interventions
(This special issue belongs to the Section Cancer Therapy)
Advances in Dermoscopy for Melanoma and Non-Melanoma Skin Cancer
edited by , Warren Chan, Jade Conway and
submission deadline 31 Dec 2026 | 2 articles | Viewed by 1315 | Submission Open
Keywords: dermoscopy; skin cancer; diagnosis; artificial intelligence; multimodal imaging; teledermoscopy
(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)
The Role of Minimally Invasive and Minimally Radical Surgery in Cervical and Endometrial Cancer
edited by , , Christophe Pomel, and Gwénaël Ferron
submission deadline 31 Dec 2026 | 1 articles | Viewed by 1269 | Submission Open
Keywords: cervical cancer; endometrial cancer; laparoscopic surgery; minimally invasive surgery; surgical oncology; fertility-sparing surgery; non-radical surgery; conservative surgery
(This special issue belongs to the Section Cancer Therapy)
Lung Cancer Risk, Disparities, and Outcomes: From Epidemiology to Multimodality Care
edited by Jeffrey B. Velotta
submission deadline 31 Dec 2026 | 1 articles | Viewed by 1253 | Submission Open
Keywords: lung cancer epidemiology; non-smoking risk factors; health disparities; gender differences; biomarkers; AI risk models; multimodality care; family history; real-world outcomes
Living with Cancer as a Chronic Disease: Quality of Life and Supportive Care
edited by
submission deadline 31 Dec 2026 | 1 articles | Viewed by 1198 | Submission Open
Keywords: long-term symptom management; palliative care; awareness; coping strategies; survivorship; caregiver; multidisciplinary care coordination
(This special issue belongs to the Section Cancer Survivorship and Quality of Life)
Cancer Cell Communications, Metastasis and Survival in the Host Microenvironment—2nd Edition
edited by , and Thi-Ngoc Nguyen
submission deadline 31 Dec 2026 | 1 articles | Viewed by 1190 | Submission Open
Keywords: cancer cells; cancer cell-derived cytokines; host microenvironment; metastasis; gene alteration; signaling pathways; host cells
(This special issue belongs to the Section Tumor Microenvironment)
Next-Generation Automation in Radiation Oncology: Innovations in Planning, Informatics, and Clinical Workflow
edited by and Jared Becksfort
submission deadline 31 Dec 2026 | 1 articles | Viewed by 1130 | Submission Open
Keywords: radiation oncology; radiotherapy automation; autosegmentation; rapid automated treatment planning; zero-click quality assurance; fast clinical workflow; artificial intelligence; machine learning; clinical decision support; radiomics; image-guided radiotherapy; adaptive radiation therapy; human-in-the-loop automation; healthcare informatics
(This special issue belongs to the Section Methods and Technologies Development)
Treatment of Relapsed and Refractory Myeloma
edited by Donato Mannina
submission deadline 31 Dec 2026 | 1 articles | Viewed by 1055 | Submission Open
Keywords: myeloma; RRMM; PI; ImiDs; immunotherapy; cellular therapies; CAR-T; bispecific antibodies; resistance
(This special issue belongs to the Section Cancer Therapy)
Diagnosis and Treatment for Hepatocellular Tumors (3rd Edition)
edited by Eleni Theocharidou and Maria Kalafateli
submission deadline 31 Dec 2026 | 1 articles | Viewed by 952 | Submission Open
Keywords: hepatocellular carcinoma; locoregional therapies; immunotherapy; targeted therapies; transarterial chemoemboli-zation; liver transplantation
Contemporary Thoracic Cancer Surgery: Technology and Innovation
edited by
submission deadline 31 Dec 2026 | 1 articles | Viewed by 937 | Submission Open
Keywords: thoracic cancer surgery; robotic-assisted thoracic oncology procedures; video-assisted thoracoscopic surgery for thoracic malignancies; thoracic neoplasms; minimally invasive surgery in cancer treatment; surgical outcomes; lung cancer surgery; surgical innovation in thoracic oncology
(This special issue belongs to the Section Methods and Technologies Development)
Modern Radiation Oncology: Predictions, Prognosis and Survivorship submission deadline 31 Dec 2026 | 1 articles | Viewed by 923 | Submission Open
Keywords: radiation oncology; predictive modeling; radiomics; survivorship; prognosis
Precision Medicine and Emerging Multidisciplinary Treatment Strategies for Bone and Soft Tissue Sarcomas submission deadline 31 Dec 2026 | 1 articles | Viewed by 920 | Submission Open
Keywords: sarcoma therapy; bone sarcoma; soft tissue sarcoma; precision oncology; multidisciplinary treatment
(This special issue belongs to the Section Cancer Therapy)
Cutaneous Lymphomas: Present and Future
edited by
submission deadline 31 Dec 2026 | 1 articles | Viewed by 888 | Submission Open
Keywords: cutaneous lymphoma; T-cell lymphoma; B-cell lymphoma; mycosis fungoides; Sézary syndrome; tumor microenvironment
Emerging Opportunities in Radiation Oncology: AI, Radiomics, and Particle Therapy Breakthroughs submission deadline 31 Dec 2026 | 1 articles | Viewed by 886 | Submission Open
Keywords: radiotherapy; artificial intelligence; radiomics; machine learning; adaptive planning; proton therapy; hadron therapy; precision oncology; particle radiotherapy; clinical outcomes
Basic and Translational Science in Ocular Oncology
edited by Anthony B. Daniels, and
submission deadline 31 Dec 2026 | 1 articles | Viewed by 856 | Submission Open
Keywords: ocular oncology; eye cancer; tumors; melanoma; retinoblastoma; hemangioma; hemangioblastoma; lymphoma
(This special issue belongs to the Section Cancer Pathophysiology)
Tailoring Neoadjuvant Strategies for Breast Cancer Subtypes
edited by Dajiang Guo and Julia Y. Tsang
submission deadline 31 Dec 2026 | 2 articles | Viewed by 831 | Submission Open
Keywords: neoadjuvant therapy; breast cancer subtypes; precision medicine; immunotherapy; targeted therapy; endocrine therapy; liquid biopsies; predictive biomarkers; survival outcome; pathological complete response
Psychosocial Health and Quality of Life Across the Cancer Care Continuum
edited by and Serene Si Ning Goh
submission deadline 31 Dec 2026 | 1 articles | Viewed by 830 | Submission Open
Keywords: cancer survivorship; psychological outcomes; quality of life; health-related quality of life; patient-reported outcomes; fear of recurrence; cancer-related fatigue; mental health; body image; supportive care
(This special issue belongs to the Section Cancer Survivorship and Quality of Life)
Surgical Treatment and Postoperative Outcomes of Gynecological Cancers
edited by Lauren S. Prescott
submission deadline 31 Dec 2026 | 1 articles | Viewed by 809 | Submission Open
Keywords: gynecologic cancers; quality improvement; surgical outcomes; perioperative optimization; surgery; hysterectomy; ovarian cancer; endometrial cancer; cervical cancer
(This special issue belongs to the Section Cancer Therapy)
Prostate Cancer Pathology and Grade submission deadline 31 Dec 2026 | 1 articles | Viewed by 800 | Submission Open
Keywords: prostate cancer; Gleason grading; molecular pathology; artificial intelligence; digital pathology; multimodal algorithms
(This special issue belongs to the Section Cancer Pathophysiology)
Pharmacokinetics in Cancer Treatment
edited by Jing Li
submission deadline 31 Dec 2026 | 1 articles | Viewed by 781 | Submission Open
Keywords: pharmacokinetics (PK); pharmacodynamics (PD); population PK/PD modeling; PBPK modeling; clinical pharmacology; personalized oncology; cancer treatment; pharmacogenetics; molecular pharmacology
(This special issue belongs to the Section Cancer Drug Development)
Recent Advances in Diagnosis and Therapy of Skin Cancers
edited by
submission deadline 31 Dec 2026 | 1 articles | Viewed by 745 | Submission Open
Keywords: skin cancer; basal cell carcinoma; squamous cell carcinoma; melanoma; merkel cell carcinoma; dermatofibrosarcoma protuberans; atypical fibroxanthoma; extramammary Paget’s disease; adnexal carcinoma; rare skin cancer
Surgical Perspectives in Lung Cancer: From Technique to Outcome
edited by Takahiro Homma and Hyun Koo Kim
submission deadline 31 Dec 2026 | Viewed by 743 | Submission Open
Keywords: minimally invasive surgery; enhanced recovery after surgery (ERAS); uniportal VATS; robotic-assisted thoracic surgery (RATS); surgical education; perioperative management; energy devices; lung cancer surgery
(This special issue belongs to the Section Cancer Therapy)
Cancer and Aging: Challenges in Geriatric Cancer Survivorship
edited by and Dana E. Giza
submission deadline 31 Dec 2026 | 1 articles | Viewed by 727 | Submission Open
Keywords: geriatric oncology; survivorship; advance care planning; quality of life; de-escalation of treatment
(This special issue belongs to the Section Cancer Survivorship and Quality of Life)
Cancer Patient Cognitive Disorders: Causes, Prevention and Management submission deadline 31 Dec 2026 | Viewed by 726 | Submission Open
Keywords: delirium; brain health; cognitive impairment; cancer; etiology; risk stratification; screening tool; biomarkers; postoperative delirium; pain management; delirium prevention; management; outcomes
(This special issue belongs to the Section Cancer Survivorship and Quality of Life)
Pharmacogenetics and Pharmacogenomics in Oncology
edited by
submission deadline 31 Dec 2026 | 1 articles | Viewed by 721 | Submission Open
Keywords: pharmacogenetics; pharmacogenomics; precision oncology; cancer care
(This special issue belongs to the Section Cancer Therapy)
Empowered by Next-Generation AI: Paradigm Transformation in Cancer Radiotherapy
edited by and Kuo Men
submission deadline 31 Dec 2026 | 1 articles | Viewed by 713 | Submission Open
Keywords: radiotherapy; next-generation AI; LLM; RL; auto-segmentation; auto-planning; treatment adaptation; treatment outcome
(This special issue belongs to the Section Cancer Therapy)
Molecular Markers and Targets in Modern Gynecologic Oncology
edited by and Chrysoula Margioula-Siarkou
submission deadline 31 Dec 2026 | 1 articles | Viewed by 703 | Submission Open
Keywords: endometrial cancer; ovarian cancer; cervical cancer; vulvar cancer; biomarker; molecular classification; targeted therapy
Risk Stratification and Predictive Biomarkers in Blood Cancers: Enabling Precision Oncology with Data-Driven Insights
edited by
submission deadline 31 Dec 2026 | 1 articles | Viewed by 685 | Submission Open
Keywords: leukemia; biomarkers; ML; AI; agentic; deep learning; risk stratification; risk prediction; survival; progression; relapse; treatment resistance
Advances in Targeted Radiopharmaceuticals: Imaging, Therapy, and Clinical Perspectives submission deadline 31 Dec 2026 | 1 articles | Viewed by 677 | Submission Open
Keywords: PET/SPECT radiotracers for cancer diagnosis and staging; targeted beta- and alpha-emitting radionuclide therapy and theranostics; radiochemistry innovation, chelator, and isotope development; dosimetry modeling, radiobiology, and treatment optimization; preclinical and translational studies; clinical case studies and emerging therapeutic indications; combinational therapies integrating radiopharmaceuticals with systemic therapy, immunotherapy, or external-beam radiation; artificial intelligence (AI) integration for imaging analysis, dosimetry, and therapy planning
Tumor Microenvironment: Cellular Dynamics, Molecular Players, and Mechanisms of Therapy Resistance
edited by , Angeliki Ditsiou and
submission deadline 31 Dec 2026 | Viewed by 597 | Submission Open
Keywords: tumor microenvironment (TME); cellular interactions; molecular mechanisms; resistance mechanisms; signaling pathways; translational cancer therapy
(This special issue belongs to the Section Tumor Microenvironment)
BRCA1 and BRCA2 Pathogenic Variants: Cancer Risk and Genetic Testing
edited by
submission deadline 31 Dec 2026 | Viewed by 595 | Submission Open
Keywords: BRCA1; BRCA2; pathogenic variants; hereditary cancer; genetic testing; PARP inhibitors
(This special issue belongs to the Section Molecular Cancer Biology)
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