Global Perspectives on the Epidemiology and Management of Early-Onset Cancers

Dear Colleagues,

Since 1990, the incidence of early-onset cancers, commonly defined as cancer in adults under 50, has been on the rise worldwide, while mortality in some cases has remained stable. Alarmingly, the incidence has been projected to continue in the coming decades unless preventive factors are implemented to slow down this increasing trend. While the rise could be attributed to improved detection of these cancers, other important factors pertaining to dietary intake, specific behavior and lifestyle patterns, as well as environmental and occupational factors, which also have the potential to change the human microbiome, may also play salient roles in the development of these cancers. With some adults less than 50 years old considered too young to be eligible for routine screenings, and many also diagnosed with early-onset cancers for which there are no reliable screening tools, it is important to explore and understand the epidemiology of early-onset cancer and the impact of treatment and management modalities on the prognosis of these cancers. Equally important is understanding how the potential causes and factors associated with early-onset cancers that vary across countries interact with social determinants of health to influence the varying development of these cancers in different parts of the world. Research with a life-course approach providing evidence from prospective and longitudinal studies exploring the epidemiology and management of early-onset cancers will go a long way to improving our understanding of these important cancers. This Special Issue welcomes all research articles, reviews, and meta-analyses addressing all the aforementioned areas and factors, as well as new and interesting insights that lead to a better understanding of early-onset cancers.

Dr. Duke Appiah
Guest Editor

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