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Advancements in Head and Neck Cancer Surgery (2nd Edition)

A special issue of Cancers (ISSN 2072-6694).

Deadline for manuscript submissions: 31 December 2026 | Viewed by 410

Special Issue Editor


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Guest Editor
Department of Otorhinolaryngology-Head and Neck Surgery, Hospital Universitario Donostia, San Sebastian, Spain
Interests: reconstruvtive surgery; molecular pathology; salivary gland; artificial intelligence; laryngeal cancer
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Special Issue Information

Dear Colleagues,

In recent years, the field of head and neck cancer surgery has witnessed remarkable advancements, driven by innovative techniques, technological developments, and a deeper understanding of tumor biology. This Special Issue aims to showcase the latest research regarding surgical and non-surgical techniques, rehabilitation, as well as multidisciplinary approaches that are shaping the future of head and neck cancer surgery.

In this Special Issue, we will cover a wide range of topics related to head and neck cancer surgery, including, but not limited to, minimally invasive surgical techniques, robotic-assisted surgery, reconstructive surgery and microvascular techniques, surgical management of advanced and recurrent tumors, surgical innovations and technological advancements, multidisciplinary approaches to treatment planning and execution, surgical outcomes and quality-of-life assessments, patient-centered care and shared decision-making, and training and education in head and neck surgical oncology. The main objective of this Special Issue is to provide a comprehensive platform for researchers, clinicians, and healthcare professionals to share their research findings in the field of head and neck cancer surgery.

This Special Issue is the second edition of a previous Issue, titled “Advancements in Head and Neck Cancer Surgery” (https://www.mdpi.com/journal/cancers/special_issues/E3Z52H8YT6).

Prof. Dr. Carlos M. Chiesa-Estomba
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • minimal invasive
  • transoral
  • robotic
  • reconstructive
  • 3D printing
  • targeting therapies
  • imaging

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Published Papers (1 paper)

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Research

12 pages, 914 KB  
Article
Long-Term Oncologic Outcomes of Induction Chemotherapy Followed by Surgery Versus Upfront Surgery in Oral Cavity Squamous Cell Carcinoma
by Yu-Fu Su, Po-Chien Shen, Yi-Jan Hsia, Wen-Yen Huang and Jing-Min Hwang
Cancers 2026, 18(10), 1590; https://doi.org/10.3390/cancers18101590 - 14 May 2026
Viewed by 195
Abstract
Background: The optimal role of induction chemotherapy (IC) in the management of oral cavity squamous cell carcinoma (OCSCC) remains controversial. This study compared oncologic outcomes between IC followed by surgery and concurrent chemoradiotherapy (CCRT) and upfront surgery followed by adjuvant CCRT. Methods: We [...] Read more.
Background: The optimal role of induction chemotherapy (IC) in the management of oral cavity squamous cell carcinoma (OCSCC) remains controversial. This study compared oncologic outcomes between IC followed by surgery and concurrent chemoradiotherapy (CCRT) and upfront surgery followed by adjuvant CCRT. Methods: We retrospectively analyzed 98 patients with OCSCC treated between 2011 and 2017. Overall survival (OS), cancer-specific survival (CSS), and local control (LC) were evaluated using Kaplan–Meier survival analysis and Cox proportional hazards models to identify prognostic factors. Results: Fifty patients received IC and 48 underwent upfront surgery. With a median follow-up of 77.8 months, no significant differences in OS, CSS, or LC were observed between treatment groups (OS: HR 1.31, p = 0.415; CSS: HR 1.36, p = 0.421; LC: HR 1.29, p = 0.475). Positive surgical margins independently predicted inferior OS, CSS, and LC, while extracapsular spread was independently associated with inferior CSS. Although tumor downstaging was frequently observed after IC, it did not translate into survival benefit. Conclusions: IC followed by surgery was associated with no statistically significant differences in oncologic outcomes compared with upfront surgery followed by adjuvant CCRT. Prognosis was primarily determined by pathological risk factors rather than treatment sequence. Full article
(This article belongs to the Special Issue Advancements in Head and Neck Cancer Surgery (2nd Edition))
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