Tumor Microenvironment: Cellular Dynamics, Molecular Players, and Mechanisms of Therapy Resistance

Dear Colleagues,

The tumor microenvironment (TME) is a highly dynamic ecosystem where cancer cells interact with stromal, vascular, and immune populations through a complex network of molecular mediators, including cytokines, chemokines, growth factors, extracellular vesicles, and matrix remodeling enzymes. These interactions activate signaling pathways that drive tumor progression, immune evasion, and metabolic adaptation, ultimately fostering therapy resistance across multiple treatment modalities. Deciphering these mechanisms is essential in understanding how tumors adapt under therapeutic pressure and in identifying vulnerabilities that can be exploited. For this Special Issue, we invite the submission of original research and comprehensive reviews exploring the cellular dynamics and molecular players of the TME, with particular emphasis on pathways underlying therapeutic resistance. Contributions highlighting systems biology, omics-driven insights, and translational approaches to reprogramming the TME or enhancing treatment efficacy are encouraged. By integrating mechanistic understanding into innovative therapeutic strategies, this Special Issue will contribute significantly to the development of next-generation cancer therapies.

Dr. Teresa Gagliano
Dr. Angeliki Ditsiou
Dr. Viviana Vella
Guest Editors

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