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Pharmacogenetics and Pharmacogenomics in Oncology

A Special Issue of Cancers (ISSN 2072-6694) belonging to the section "Cancer Therapy".

Deadline for manuscript submissions: 31 December 2026 | Viewed by 721

Editor


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Guest Editor
Department of Pharmacology and Toxicology, Morehouse School of Medicine, Atlanta, GA, USA
Interests: pharmacogenomics; prostate; cancer; gene; target
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Pharmacogenetics and pharmacogenomics are reshaping cancer therapeutics by enabling more precise, individualized treatment. These advances promise better efficacy, reduced toxicity, and meaningful progress in precision oncology. This Special Issue seeks high‑quality manuscripts exploring these scientific advances, as well as the real‑world challenges that accompany these advances.

We welcome submissions that address clinical applications of pharmacogenomic testing, innovative research methodologies, and emerging biomarkers that guide drug selection and dosing in oncology. Also encouraged are studies examining barriers to implementation across diverse settings, including ethical concerns, patient protections, cost considerations, and the infrastructural needs required for the sustainable integration of these tools into cancer care.

We look forward to receiving your contributions to advancing the future of equitable precision in cancer care.

Dr. Cheryl D. Cropp
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-anonymized peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • pharmacogenetics
  • pharmacogenomics
  • precision oncology
  • cancer care

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Published Papers (1 paper)

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Research

18 pages, 5026 KB  
Article
Flype: Integrating Molecular and Pharmacogenomic Results to Enhance Oncology Patient Care in a Community-Based Academic Cancer Center
by Donald L. Helseth, Jr., Nicholas Miller, Mathew Yang, Henry Wittich, Qin Zhao, Tom Werth, Linda M. Sabatini, Mir Alikhan, Megan Parilla, Amandeep Kaur, Xiaoyan Yang, Kathy A. Mangold, Michael Bouma, Henry M. Dunnenberger, Dyson T. Wake, Annette Sereika, Gayathri Moorthy, Peter J. Hulick, Karen L. Kaul and Janaradan D. Khandekar
Cancers 2026, 18(16), 2560; https://doi.org/10.3390/cancers18162560 - 10 Aug 2026
Viewed by 373
Abstract
Background/Objectives: We describe how our in-house bioinformatics platform, Flype, has evolved from being a variant repository to an enterprise role as an electronic medical record (EMR) content provider, powering molecular pathology reporting, pharmacogenomics reporting, sending discrete data to our EMR, aggregating internal and [...] Read more.
Background/Objectives: We describe how our in-house bioinformatics platform, Flype, has evolved from being a variant repository to an enterprise role as an electronic medical record (EMR) content provider, powering molecular pathology reporting, pharmacogenomics reporting, sending discrete data to our EMR, aggregating internal and external molecular test results and powering our molecular tumor board (MTB). Methods: In response to critical pain points, we developed Docket, a sample tracking system in Flype, which manages multiple individual in-house molecular tests for NGS assays, pharmacogenomic (PGX) assays and additional molecular testing. To help with interpretation and integration of all internal and external assays, we developed a clinical outcomes view in Flype. To improve the efficiency of our molecular pathologists reporting results, we developed Convo 2.0, which integrates OncoKB interpretations and other information. Flype can also be used by our pathologists to submit patient molecular results to NCI’s ComboMATCH and retrieve clinical trial recommendations. Results: Flype was used during our Kellogg Cancer Genomic Initiative for reporting PGX integration, MTB review and integration of EMR prescription information with internal and external molecular test results. Integrating PGX results led to several recommendations against the use of drugs metabolized by, for example, CYP2D6 or TPMT, along with warnings about altered pain relief. Enhancements in report sign-out and the use of file transfer scripts have led to reduced turnaround time. Conclusions: Flype supports hundreds of users performing different roles in molecular diagnostics. We discuss lessons learned adapting our software to support continuously changing test requirements. Full article
(This article belongs to the Special Issue Pharmacogenetics and Pharmacogenomics in Oncology)
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