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Cancers publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Innovative and Personalized Approaches to Improve Patient Outcomes in Gynecological Oncology

edited by Anke Smits and James Dilley

submission deadline 31 Dec 2026 | 1 articles | Viewed by 3166 | Submission Open

Keywords: gynecological cancer; lifestyle; prehabilitation; rehabilitation; survival; quality of life

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

Clinical Application of Proton Therapy and Advanced Radiotherapy in Gynecological Cancer

edited by Amy Tien Yee Chang and

Bin Yang

submission deadline 31 Dec 2026 | 3 articles | Viewed by 3165 | Submission Open

Keywords: proton therapy; cervical cancer; endometrial cancer; vaginal cancer; MR-guided radiotherapy; MR-guided brachytherapy; stereotactic body radiotherapy

(This special issue belongs to the Section Cancer Therapy)

Advancements in Surgical and Multidisciplinary Management of Hepatopancreaticobiliary Cancers

edited by Aleksey A. Novikov

submission deadline 31 Dec 2026 | 2 articles | Viewed by 3066 | Submission Open

Keywords: fatty pancreas; pancreatic steatosis; intra-pancreatic fat deposition; pancreatic ductal adenocarcinoma; metabolic dysfunction; pancreatic imaging; oncogenesis; endoscopic ultrasound

(This special issue belongs to the Section Clinical Research in Cancer)

Unveiling the Complexity of Hepato-Biliary-Pancreatic Cancers: From Pathogenesis to Management

edited by

Stefano Cacciatore

and Luiz Zerbini

submission deadline 31 Dec 2026 | 1 articles | Viewed by 2997 | Submission Open

Keywords: hepatocellular carcinoma (HCC); cholangiocarcinoma; pancreatic ductal adenocarcinoma (PDAC); tumour microenvironment; molecular biomarkers; therapeutic resistance; cancer immunotherapy; early cancer detection; precision oncology; targeted therapy

(This special issue belongs to the Section Clinical Research in Cancer)

Advanced Research in Oncology in 2026

edited by

Dimitrios Moris

submission deadline 31 Dec 2026 | 1 articles | Viewed by 2947 | Submission Open

Keywords: cancer; tumour; oncology

Autophagy and Apoptosis in Cancer Progression

edited by Antonio Ieni

submission deadline 31 Dec 2026 | 1 articles | Viewed by 2827 | Submission Open

Keywords: autophagy; apoptosis; cancer progression; cell death pathways; therapeutic resistance

(This special issue belongs to the Section Molecular Cancer Biology)

Hepatocellular Carcinoma: Clinical Evidence and Emerging Therapeutic Benefits

edited by

Alessandro Loglio

submission deadline 31 Dec 2026 | 2 articles | Viewed by 2822 | Submission Open

Keywords: artificial intelligence; downstaging; immunotherapy; multidisciplinary approaches; risk factors; nutrition

(This special issue belongs to the Section Cancer Therapy)

Laparoscopic and Robotic Surgery for Gastrointestinal and Hepato-Pancreato-Biliary Cancers

edited by

Kosei Takagi

submission deadline 31 Dec 2026 | 2 articles | Viewed by 2722 | Submission Open

Keywords: minimally invasive surgery; laparoscopic surgery; robotic surgery; gastrointestinal cancers; hepato-pancreato-biliary cancers; neoadjuvant therapy; adjuvant therapy; outcomes

(This special issue belongs to the Section Clinical Research in Cancer)

Single-Cell Biology of Cancer

edited by

Chang Zou

submission deadline 31 Dec 2026 | 2 articles | Viewed by 2577 | Submission Open

Keywords: tumor heterogeneity; single-cell sequencing; drug resistance; tumor microenvironment; cell–cell communication; precision oncology

(This special issue belongs to the Section Molecular Cancer Biology)

Global Perspectives on the Epidemiology and Management of Early-Onset Cancers

edited by

Duke Appiah

submission deadline 31 Dec 2026 | 2 articles | Viewed by 2510 | Submission Open

Keywords: early-onset cancer; adolescent and young adult cancer (AYA); early-onset breast cancer; early-onset colorectal cancer; early-onset pancreatic cancer; early-onset thyroid cancer; early-onset melanoma; early-onset gastrointestinal cancers; early-onset hematological cancers; early-onset cancers of reproductive organs

(This special issue belongs to the Section Cancer Epidemiology and Prevention)

Overcoming the Barriers: Cellular and Molecular Pathology of Pancreatic Cancer

edited by

Jelena Grahovac

submission deadline 31 Dec 2026 | 1 articles | Viewed by 2459 | Submission Open

Keywords: pancreatic cancer; metastasis; tumor microenvironment; tumor metabolism; tumor immunity

(This special issue belongs to the Section Molecular Cancer Biology)

Advancing Therapeutic Strategies for Neuroendocrine Tumors: Towards Personalized and Multidisciplinary Care

edited by

Robert A. Ramirez

submission deadline 31 Dec 2026 | 3 articles | Viewed by 2413 | Submission Open

Keywords: neuroendocrine tumor; neuroendocrine carcinoma; multidisciplinary care; PRRT; hepatic embolization; tumor debulking; targeted therapy; lung carcinoid

(This special issue belongs to the Section Cancer Therapy)

Computational Methods for Integrative Cancer Data Analysis

edited by

Kai Li

submission deadline 31 Dec 2026 | 2 articles | Viewed by 2256 | Submission Open

Keywords: cancer bioinformatics; multi-omics integration; machine learning; translational oncology

(This special issue belongs to the Section Cancer Informatics and Big Data)

CDK4/6 Inhibitors in Cancer: Efficacy, Resistance, and Combination Approaches

edited by

Boshi Wang

submission deadline 31 Dec 2026 | 2 articles | Viewed by 2242 | Submission Open

Keywords: CDK4/6 inhibitors; palbociclib; abemaciclib; ribociclib; cancer; senescence; combinatorial therapy; prognosis; molecular mechanisms

(This special issue belongs to the Section Cancer Therapy)

Disparities in Cancer Care: Advancing Equity Across the Cancer Continuum

edited by

Gladys Asiedu

and Ernie Kaninjing

submission deadline 31 Dec 2026 | 2 articles | Viewed by 2241 | Submission Open

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

CancersScape: Spatial Biology of the Tumor Ecosystem

edited by

Samuel C. Mok

and Sammy Ferri-Borgogno

submission deadline 31 Dec 2026 | 1 articles | Viewed by 2225 | Submission Open

Keywords: cancer; health; tumor microenvironment; spatial biology; cancer diagnosis; cancer drug discovery; Omics

A New Road for Cancer Drug Discovery

edited by

Navnath S. Gavande

and

Yubin Ge

submission deadline 31 Dec 2026 | 3 articles | Viewed by 2211 | Submission Open

Keywords: cancer drug discovery; artificial intelligence in drug discovery and development; targeted therapy; precision oncology; targeted protein degrades; small-molecule therapeutics; immuno-oncology; undruggable targets; drug resistance mechanisms; combination therapy

(This special issue belongs to the Section Cancer Drug Development)

The Impact of Minimally Invasive Surgery on Gynecologic Cancers

edited by

Gabriel Levin

submission deadline 31 Dec 2026 | 1 articles | Viewed by 2169 | Submission Open

Keywords: minimally invasive surgery; robotic-assisted surgery; gynecologic malignancy; laparoscopy

(This special issue belongs to the Section Cancer Therapy)

Pathogenesis and Treatment Strategies in Multiple Myeloma: From Basic Research to Real Life: 2nd Edition

edited by Shingen Nakamura

submission deadline 31 Dec 2026 | 1 articles | Viewed by 2115 | Submission Open

Keywords: myeloma bone disease; denosumab; bisphosphonate; infectious complication; proteasome inhibitor; IMiDs; anti-CD38 antibody; venetoclax; immunotherapy

(This special issue belongs to the Section Cancer Therapy)

Next-Generation Boron Neutron Capture Therapy (BNCT) for Cancer Treatment

edited by Dayron Ramos López, Gabriella Pugliese and Raffaella Radogna

submission deadline 31 Dec 2026 | 1 articles | Viewed by 1944 | Submission Open

Keywords: BNCT; boron agents; dosimetry; neutron detectors; cancer therapy; imaging; simulation; neutron sources; treatment planning; medical physics

(This special issue belongs to the Section Methods and Technologies Development)

Molecular Mechanisms of Cancer Progression and Metastasis

edited by

Babak Behnam

submission deadline 31 Dec 2026 | 1 articles | Viewed by 1925 | Submission Open

Keywords: metastasis; molecular mechanisms; tumor microenvironment (TME); epithelial-to-mesenchymal transition (EMT); cancer stem cell; therapeutic strategies; immune evasion

(This special issue belongs to the Section Cancer Metastasis)

Emerging Therapies for Germ Cell Tumors

edited by

Ratnakar Singh

and Krinio Giannikou

submission deadline 31 Dec 2026 | 1 articles | Viewed by 1869 | Submission Open

Keywords: testicular cancer; embryonal carcinoma; germ cell tumors; cisplatin; immunotherapy; epigenetics; microRNA; chemoresistance; animal models; targeted therapy

(This special issue belongs to the Section Cancer Therapy)

Advancements in Head and Neck Cancer Surgery (2nd Edition)

edited by

Carlos M. Chiesa-Estomba

submission deadline 31 Dec 2026 | 2 articles | Viewed by 1852 | Submission Open

Keywords: minimal invasive; transoral; robotic; reconstructive; 3D printing; targeting therapies; imaging

Evolving Management of Gastroesophageal Cancers: From Local Therapies to Precision Oncology

edited by Matthew Strickland

submission deadline 31 Dec 2026 | 1 articles | Viewed by 1807 | Submission Open

Keywords: gastric cancer; esophageal cancer; immunotherapy targeted therapy; radiation therapy; surgical oncology; precision oncology; molecular biomarkers; multimodal treatment

(This special issue belongs to the Section Cancer Therapy)

Exploring the Processes of Biochemical, Cellular and Molecular Drivers of Cancer Cell and Emerging Therapies

edited by

Amit Kunwar

submission deadline 31 Dec 2026 | 1 articles | Viewed by 1689 | Submission Open

Keywords: redox biology; metabolism; signal transduction; genetics; drug discovery; drug delivery; drug resistance; nanotherapeutics; diagnostic sensors; clinical trial

Artificial Intelligence and Machine Learning in Cancer Diagnosis, Treatment, and Prognosis

edited by Iakovos Amygdalos

submission deadline 31 Dec 2026 | 1 articles | Viewed by 1504 | Submission Open

Keywords: artificial intelligence in oncology and oncological surgery; machine learning for cancer diagnosis; multimodal data integration; precision oncology and prognostic modeling; federated and explainable AI

(This special issue belongs to the Section Methods and Technologies Development)

The Evolving Role of CDK4/6 Inhibitors in Early and Recurrent Breast Cancer: Clinical and Translational Findings and Work in Progress

edited by Hans-Christian Kolberg

submission deadline 31 Dec 2026 | 1 articles | Viewed by 1503 | Submission Open

Keywords: CDK4/6 inhibitors; breast cancer; treatment resistance; combination therapy; biomarkers

Innovations in Cutaneous Oncology and Dermatologic Surgery: Translating Mechanisms into Practice

edited by Paulo Filipe and Maria Catorze

submission deadline 31 Dec 2026 | 1 articles | Viewed by 1429 | Submission Open

Keywords: cutaneous oncology; dermatologic surgery; mohs micrographic surgery; immunotherapy; hedgehog pathway; translational research; skin cancer; digital innovation

(This special issue belongs to the Section Cancer Therapy)

Molecular Mechanisms of Breast Cancer Treatment-Related Side Effects and Precision Interventions

edited by

Jennifer Hu

submission deadline 31 Dec 2026 | 1 articles | Viewed by 1371 | Submission Open

Keywords: breast cancer; treatment-related side effects; biomarker; precision interventions

(This special issue belongs to the Section Cancer Therapy)

Advances in Dermoscopy for Melanoma and Non-Melanoma Skin Cancer

edited by

Clay J. Cockerell

, Warren Chan, Jade Conway and

Iman Ali

submission deadline 31 Dec 2026 | 2 articles | Viewed by 1304 | Submission Open

Keywords: dermoscopy; skin cancer; diagnosis; artificial intelligence; multimodal imaging; teledermoscopy

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

The Role of Minimally Invasive and Minimally Radical Surgery in Cervical and Endometrial Cancer

edited by

Raj Naik

Marie Plante

, Christophe Pomel,

Roberto Tozzi

and Gwénaël Ferron

submission deadline 31 Dec 2026 | 1 articles | Viewed by 1266 | Submission Open

Keywords: cervical cancer; endometrial cancer; laparoscopic surgery; minimally invasive surgery; surgical oncology; fertility-sparing surgery; non-radical surgery; conservative surgery

(This special issue belongs to the Section Cancer Therapy)

Lung Cancer Risk, Disparities, and Outcomes: From Epidemiology to Multimodality Care

edited by Jeffrey B. Velotta

submission deadline 31 Dec 2026 | 1 articles | Viewed by 1231 | Submission Open

Keywords: lung cancer epidemiology; non-smoking risk factors; health disparities; gender differences; biomarkers; AI risk models; multimodality care; family history; real-world outcomes

Living with Cancer as a Chronic Disease: Quality of Life and Supportive Care

edited by

Paolo Cotogni

submission deadline 31 Dec 2026 | 1 articles | Viewed by 1191 | Submission Open

Keywords: long-term symptom management; palliative care; awareness; coping strategies; survivorship; caregiver; multidisciplinary care coordination

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

Cancer Cell Communications, Metastasis and Survival in the Host Microenvironment—2nd Edition

edited by

Nan-Shan Chang

Yanping Liu

and Thi-Ngoc Nguyen

submission deadline 31 Dec 2026 | 1 articles | Viewed by 1183 | Submission Open

Keywords: cancer cells; cancer cell-derived cytokines; host microenvironment; metastasis; gene alteration; signaling pathways; host cells

(This special issue belongs to the Section Tumor Microenvironment)

Next-Generation Automation in Radiation Oncology: Innovations in Planning, Informatics, and Clinical Workflow

edited by

Ozgur Ates

and Jared Becksfort

submission deadline 31 Dec 2026 | 1 articles | Viewed by 1127 | Submission Open

Keywords: radiation oncology; radiotherapy automation; autosegmentation; rapid automated treatment planning; zero-click quality assurance; fast clinical workflow; artificial intelligence; machine learning; clinical decision support; radiomics; image-guided radiotherapy; adaptive radiation therapy; human-in-the-loop automation; healthcare informatics

(This special issue belongs to the Section Methods and Technologies Development)

Treatment of Relapsed and Refractory Myeloma

edited by Donato Mannina

submission deadline 31 Dec 2026 | 1 articles | Viewed by 1051 | Submission Open

Keywords: myeloma; RRMM; PI; ImiDs; immunotherapy; cellular therapies; CAR-T; bispecific antibodies; resistance

(This special issue belongs to the Section Cancer Therapy)

Diagnosis and Treatment for Hepatocellular Tumors (3rd Edition)

edited by Eleni Theocharidou and Maria Kalafateli

submission deadline 31 Dec 2026 | 1 articles | Viewed by 948 | Submission Open

Keywords: hepatocellular carcinoma; locoregional therapies; immunotherapy; targeted therapies; transarterial chemoemboli-zation; liver transplantation

Contemporary Thoracic Cancer Surgery: Technology and Innovation

edited by

Yoshikane Yamauchi

submission deadline 31 Dec 2026 | 1 articles | Viewed by 934 | Submission Open

Keywords: thoracic cancer surgery; robotic-assisted thoracic oncology procedures; video-assisted thoracoscopic surgery for thoracic malignancies; thoracic neoplasms; minimally invasive surgery in cancer treatment; surgical outcomes; lung cancer surgery; surgical innovation in thoracic oncology

(This special issue belongs to the Section Methods and Technologies Development)

Precision Medicine and Emerging Multidisciplinary Treatment Strategies for Bone and Soft Tissue Sarcomas

edited by

Alexander L. Lazarides

submission deadline 31 Dec 2026 | 1 articles | Viewed by 916 | Submission Open

Keywords: sarcoma therapy; bone sarcoma; soft tissue sarcoma; precision oncology; multidisciplinary treatment

(This special issue belongs to the Section Cancer Therapy)

Modern Radiation Oncology: Predictions, Prognosis and Survivorship

edited by

Victor H. F. Lee

and

Shing Yau Tam

submission deadline 31 Dec 2026 | 1 articles | Viewed by 914 | Submission Open

Keywords: radiation oncology; predictive modeling; radiomics; survivorship; prognosis

Emerging Opportunities in Radiation Oncology: AI, Radiomics, and Particle Therapy Breakthroughs

edited by

Antonio Pontoriero

and

Sara Lillo

submission deadline 31 Dec 2026 | 1 articles | Viewed by 882 | Submission Open

Keywords: radiotherapy; artificial intelligence; radiomics; machine learning; adaptive planning; proton therapy; hadron therapy; precision oncology; particle radiotherapy; clinical outcomes

Basic and Translational Science in Ocular Oncology

edited by Anthony B. Daniels,

Arun D. Singh

and

Jens Folke Kiilgaard

submission deadline 31 Dec 2026 | 1 articles | Viewed by 850 | Submission Open

Keywords: ocular oncology; eye cancer; tumors; melanoma; retinoblastoma; hemangioma; hemangioblastoma; lymphoma

(This special issue belongs to the Section Cancer Pathophysiology)

Psychosocial Health and Quality of Life Across the Cancer Care Continuum

edited by

Qin Xiang Ng

and Serene Si Ning Goh

submission deadline 31 Dec 2026 | 1 articles | Viewed by 817 | Submission Open

Keywords: cancer survivorship; psychological outcomes; quality of life; health-related quality of life; patient-reported outcomes; fear of recurrence; cancer-related fatigue; mental health; body image; supportive care

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

Surgical Treatment and Postoperative Outcomes of Gynecological Cancers

edited by Lauren S. Prescott

submission deadline 31 Dec 2026 | 1 articles | Viewed by 809 | Submission Open

Keywords: gynecologic cancers; quality improvement; surgical outcomes; perioperative optimization; surgery; hysterectomy; ovarian cancer; endometrial cancer; cervical cancer

(This special issue belongs to the Section Cancer Therapy)

Prostate Cancer Pathology and Grade

edited by

Stefano Marletta

and

Giuseppe Fanelli

submission deadline 31 Dec 2026 | 1 articles | Viewed by 797 | Submission Open

Keywords: prostate cancer; Gleason grading; molecular pathology; artificial intelligence; digital pathology; multimodal algorithms

(This special issue belongs to the Section Cancer Pathophysiology)

Tailoring Neoadjuvant Strategies for Breast Cancer Subtypes

edited by Dajiang Guo and Julia Y. Tsang

submission deadline 31 Dec 2026 | 2 articles | Viewed by 794 | Submission Open

Keywords: neoadjuvant therapy; breast cancer subtypes; precision medicine; immunotherapy; targeted therapy; endocrine therapy; liquid biopsies; predictive biomarkers; survival outcome; pathological complete response

Cutaneous Lymphomas: Present and Future

edited by

Alessandro Pileri

submission deadline 31 Dec 2026 | 1 articles | Viewed by 790 | Submission Open

Keywords: cutaneous lymphoma; T-cell lymphoma; B-cell lymphoma; mycosis fungoides; Sézary syndrome; tumor microenvironment

Pharmacokinetics in Cancer Treatment

edited by Jing Li

submission deadline 31 Dec 2026 | 1 articles | Viewed by 778 | Submission Open

Keywords: pharmacokinetics (PK); pharmacodynamics (PD); population PK/PD modeling; PBPK modeling; clinical pharmacology; personalized oncology; cancer treatment; pharmacogenetics; molecular pharmacology

(This special issue belongs to the Section Cancer Drug Development)

Surgical Perspectives in Lung Cancer: From Technique to Outcome

edited by Takahiro Homma and Hyun Koo Kim

submission deadline 31 Dec 2026 | Viewed by 741 | Submission Open

Keywords: minimally invasive surgery; enhanced recovery after surgery (ERAS); uniportal VATS; robotic-assisted thoracic surgery (RATS); surgical education; perioperative management; energy devices; lung cancer surgery

(This special issue belongs to the Section Cancer Therapy)

Recent Advances in Diagnosis and Therapy of Skin Cancers

edited by

Kelly Harms

submission deadline 31 Dec 2026 | 1 articles | Viewed by 736 | Submission Open

Keywords: skin cancer; basal cell carcinoma; squamous cell carcinoma; melanoma; merkel cell carcinoma; dermatofibrosarcoma protuberans; atypical fibroxanthoma; extramammary Paget’s disease; adnexal carcinoma; rare skin cancer

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