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Cancers publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Epidemiology of Cancer and Risk Factors: Pushing Boundaries in Public Health Research and Policy

edited by

The Phuong Nguyen

submission deadline 30 Apr 2026 | 5 articles | Viewed by 8914 | Submission Open

Keywords: cancer epidemiology; risk factors; public health policy; cancer prevention; early detection; genetic determinants; environmental exposures; behavioral health; interdisciplinary approaches; innovative methodologies

(This special issue belongs to the Section Cancer Epidemiology and Prevention)

Prognosis and Treatment of Cutaneous Melanoma (2nd Edition)

edited by

Eduardo Nagore

submission deadline 30 Apr 2026 | 3 articles | Viewed by 8783 | Submission Open

Keywords: prognosis; melanoma; adjuvant; germline; somatic; genetic; epigenetic; neoadjuvant

(This special issue belongs to the Section Cancer Therapy)

Surgical Oncology for Hepato-Pancreato-Biliary Cancer

edited by Zaed Z. R. Hamady

submission deadline 30 Apr 2026 | 6 articles | Viewed by 8055 | Submission Open

Keywords: pancreatic cancer; liver cancer; liver metastases; surgical oncology; multidisciplinary approach

(This special issue belongs to the Section Clinical Research of Cancer)

Neuroblastoma: Molecular Insights and Clinical Implications

edited by Mary Beth Madonna

submission deadline 30 Apr 2026 | 2 articles | Viewed by 7263 | Submission Open

Keywords: neuroblastoma; molecular mechanisms; targeted therapies; immunotherapies; small molecule therapies

(This special issue belongs to the Section Molecular Cancer Biology)

Radiomics in Cancer Imaging: Theory and Applications in Solid Tumours

edited by

Francesco Bianconi

and

Barbara Palumbo

submission deadline 30 Apr 2026 | 3 articles | Viewed by 6840 | Submission Open

Keywords: radiomics for the diagnosis; prognostication and treatment planning of solid tumours; methods; translational research and clinical applications; conventional and deep learning radiomics; interpretability of radiomics features and prediction models; image processing (including acquisition; segmentation and feature extraction); imaging methods (including CT; MRI; PET; SPECT and US)

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

Combination Therapy in Lymphoma

edited by

Afua Adjeiwaa Mensah

and Alberto Arribas

submission deadline 30 Apr 2026 | 2 articles | Viewed by 6223 | Submission Open

Keywords: combination therapy; non-Hodgkin lymphoma; Hodgkin lymphoma; targeted agents; antibody drug conjugates; bispecific agents; cellular therapies; immune checkpoint inhibitors and epigenetic agents

(This special issue belongs to the Section Cancer Therapy)

Mesothelioma Epidemiology, Pathogenesis, Emerging Treatments and Pre-Clinical Models

edited by

Francesca Pentimalli

submission deadline 30 Apr 2026 | 3 articles | Viewed by 3976 | Submission Open

Keywords: mesothelioma; epidemiology; pathogenesis; emerging treatments; risk factors; biomarkers; surgical techniques; targeted therapies; immunotherapies; pre-clinical models

(This special issue belongs to the Section Cancer Epidemiology and Prevention)

Cancer Immunotherapy as Part of Precision Clinical Medicine

edited by

Peter Lang

and

Christo Kole

submission deadline 30 Apr 2026 | 2 articles | Viewed by 3888 | Submission Open

Keywords: cancer; immunotherapy; tumor microenvironment; molecular biology and genetics

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

Acute Myeloid Leukemia: Updates on Diagnosis, Treatment and Management

edited by

Francesco Lanza

and

Giovanni Marconi

submission deadline 30 Apr 2026 | 2 articles | Viewed by 3846 | Submission Open

Keywords: acute myeloid leukemia; treatment; targeted therapy; molecular profiling; resistance

(This special issue belongs to the Section Methods and Technologies Development)

Interrogating Molecular Regulators and Chemical Agents in Brain Tumor Progression

edited by Shilpi Singh

submission deadline 30 Apr 2026 | 2 articles | Viewed by 3729 | Submission Open

Keywords: brain tumor progression; molecular mechanisms; small molecule inhibitors; natural compounds; synthetic drugs; biomarkers; oncogenic pathways; metabolic reprogramming

(This special issue belongs to the Section Tumor Microenvironment)

Integrating Bioinformatics, AI, Imaging, and Clinical Informatics in Cancer Research

edited by Jason Li

submission deadline 30 Apr 2026 | 1 articles | Viewed by 3687 | Submission Open

Keywords: bioinformatics; multiomics; genomics; transcriptomics artificial intelligence; deep learning; clinical informatics; medical imaging; functional genomics; multi-discipline

(This special issue belongs to the Section Cancer Informatics and Big Data)

Molecular PET Imaging in Cancer Metabolic Studies

edited by

Aditi Mulgaonkar

and

Sashi Debnath

submission deadline 30 Apr 2026 | 1 articles | Viewed by 3557 | Submission Open

Keywords: PET imaging; PET/CT; PET/MRI; cancer metabolism; tumor microenvironment; cancer antigens; radiotracers

(This special issue belongs to the Section Methods and Technologies Development)

Advances in Molecular and Genetic Biomarkers in Head and Neck Squamous Cell Carcinoma

edited by

Joanna Katarzyna Strzelczyk

and Michal Masternak

submission deadline 30 Apr 2026 | 1 articles | Viewed by 3516 | Submission Open

Keywords: head and neck squamous cell carcinoma (HNSCC); molecular biomarkers; genetic biomarkers; multi-omics approaches; HNSCC carcinogenesis; prognostic biomarkers; translational medicine; molecular pathology

(This special issue belongs to the Section Molecular Cancer Biology)

Biomarkers for Therapy Response in Gastrointestinal Malignancies: Predicting Outcomes and Personalizing Care

edited by

Devalingam Mahalingam

submission deadline 30 Apr 2026 | 3 articles | Viewed by 2988 | Submission Open

Keywords: immunotherapy; biomarkers; resistance mechanisms; predictive markers; clinical trials; translational research

(This special issue belongs to the Section Cancer Biomarkers)

Health Disparities and Outcomes in Cancer Survivors

edited by

Claire Jungyoun Han

submission deadline 30 Apr 2026 | 3 articles | Viewed by 2918 | Submission Open

Keywords: cancer survivorship; quality of life; social behavioral determinants of health (SBDH); health disparities; symptom management

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

CT/MRI/PET in Cancer

edited by

Dávid Sipos

Ritter Zsombor

and

Elif Hindié

submission deadline 30 Apr 2026 | 3 articles | Viewed by 2828 | Submission Open

Keywords: PET imaging; CT; MRI; cancer; characterization; treatment monitoring; biomarkers; predictive value; AI integration

(This special issue belongs to the Section Methods and Technologies Development)

Myeloma: Pathogenesis and Targeted Therapies

edited by Fenghuang (Frank) Zhan, Gang An and Cody Ashby

submission deadline 30 Apr 2026 | 2 articles | Viewed by 2818 | Submission Open

Keywords: multiple myeloma; drug resistance; car-t cell therapy; immunotherapy targets; biomarkers; genetic alterations; molecular pathogenesis

(This special issue belongs to the Section Tumor Microenvironment)

Real-World Evidence and Emerging Therapeutic Strategies in Refractory Metastatic Colorectal Cancer

edited by

Carlo Signorelli

submission deadline 30 Apr 2026 | 2 articles | Viewed by 2771 | Submission Open

Keywords: real-world evidence; refractory metastatic colorectal cancer; treatment resistance; third-line and beyond therapies; targeted therapies; immunotherapy; patient outcomes; clinical practice; biomarkers; precision oncology

(This special issue belongs to the Section Cancer Metastasis)

G Protein-Coupled Receptors in Cancer Progression

edited by

Songhai Chen

submission deadline 30 Apr 2026 | 1 articles | Viewed by 2739 | Submission Open

Keywords: GPCRs; heterotrimeric G proteins; signal transduction; mutations; cancer development

(This special issue belongs to the Section Tumor Microenvironment)

Chemo-Radio-Immunotherapy for Colorectal Cancer

edited by Shoichi Hazama

submission deadline 30 Apr 2026 | 3 articles | Viewed by 2628 | Submission Open

Keywords: colorectal cancer; immunotherapy; chemotherapy; radiotherapy; combination therapy; neoadjuvant therapy; biomarkers for treatment response; anal cancer; squamous cell carcinoma; minimally invasive surgery; conversion surgery

(This special issue belongs to the Section Cancer Therapy)

Prostate Cancer Epidemiology and Genetics: 2nd Edition

edited by

Steven Narod

submission deadline 30 Apr 2026 | 2 articles | Viewed by 2593 | Submission Open

Keywords: prostate cancer; epidemiology; clinical genetics; aging; population-level databases

(This special issue belongs to the Section Cancer Epidemiology and Prevention)

Stem Cell Origin of Cancers: Biological and Clinical Implications of a Unified Theory of Cancer (2nd Edition)

edited by Shi-Ming Tu, Louis L. Pisters and

John F. Ward

submission deadline 30 Apr 2026 | 2 articles | Viewed by 2313 | Submission Open

Keywords: cancer stem cells; cancer-initiating cell; progenitor cell; epithelial; Mesenchymal transition; pluripotency; plasticity; heterogeneity; embryogenesis; stem-like; stemness

(This special issue belongs to the Section Cancer Pathophysiology)

Advances in the Treatment of Urological Cancer

edited by Anna Patrikidou

submission deadline 30 Apr 2026 | 1 articles | Viewed by 2151 | Submission Open

Keywords: urological oncology; chemotherapy; hormone therapy; immunotherapy; targeted therapy; radioligand therapy; antibody-drug conjugates; novel therapeutics

(This special issue belongs to the Section Cancer Therapy)

From Molecular Insights to Cancer Treatments: Progress in Translational Science

edited by

Sanjay V. Malhotra

, Dhanir Tailor and

Annah Rolig

submission deadline 30 Apr 2026 | 1 articles | Viewed by 1961 | Submission Open

Keywords: cancer biology; therapeutics; molecular targets; translational research

(This special issue belongs to the Section Cancer Therapy)

The Latest Advancements in Cutaneous Melanoma

edited by Zhenyu Ji

submission deadline 30 Apr 2026 | 1 articles | Viewed by 1897 | Submission Open

Keywords: cutaneous melanoma; skin cancer; immunotherapy; targeted therapy; melanoma biomarkers

(This special issue belongs to the Section Cancer Therapy)

Immune Checkpoint Therapy in Liver Cancer: Current Evidence, Underlying Biology, and What's Next

edited by

Luca Marzi

and

Rodolfo Sacco

submission deadline 30 Apr 2026 | 1 articles | Viewed by 1878 | Submission Open

Keywords: hepatocellular carcinoma; immunotherapy; immuno-oncology; immune checkpoint inhibitors; clinical trial; immunological microenvironments

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

New Diagnostic and Therapeutic Perspectives of Gynecological Carcinomas

edited by

Carlo Ronsini

submission deadline 30 Apr 2026 | 1 articles | Viewed by 1869 | Submission Open

Keywords: gynecologic oncology; surgical gynecology; biomarkers; endometrial carcinoma; ovarian carcinoma; cervical carcinoma

(This special issue belongs to the Section Cancer Therapy)

Exosomes in Cancer Metastasis (2nd Edition)

edited by

Theresa L. Whiteside

submission deadline 30 Apr 2026 | 1 articles | Viewed by 1815 | Submission Open

Keywords: exosomes; biomarkers; cancer metastasis

(This special issue belongs to the Section Cancer Metastasis)

Significance of CAR T-Cell Therapy in Aggressive B-Cell Lymphoma Treatment

edited by

Wing Keung Chan

submission deadline 30 Apr 2026 | 1 articles | Viewed by 1716 | Submission Open

Keywords: CAR-T therapy; non-hodgkin lymphoma; hodgkin lymphoma; CAR-T persistence; immune-related adverse events (irAEs); resistance mechanisms; combination therapy; tumor microenvironment; multiomics data analysis

(This special issue belongs to the Section Cancer Therapy)

Genetic Screening and Personalized Prevention in Hereditary Gastrointestinal Cancer Syndromes

edited by

Candida Fasano

and Vittoria Disciglio

submission deadline 30 Apr 2026 | 1 articles | Viewed by 1688 | Submission Open

Keywords: hereditary gastrointestinal cancer syndromes; NGS multigene panel tests; pathogenic variant (PV); variant of uncertain significance (VUS); mismatch repair (MMR) genes; gastrointestinal cancer susceptibility; personalized medicine; genetic risk assessment; germline variants; genetic counseling; functional impact of the genetic variant

(This special issue belongs to the Section Cancer Pathophysiology)

Prostate Cancer: Contemporary Standards and Challenges

edited by

Filip Ionescu

and

Jingsong Zhang

submission deadline 30 Apr 2026 | 1 articles | Viewed by 1602 | Submission Open

Keywords: prostate cancer; molecular pathogenesis; precision oncology; biomarkers; treatment de-escalation

(This special issue belongs to the Section Cancer Therapy)

Immune Biomarkers and Checkpoint Inhibitors: Advancing Immunotherapy in Gynecologic Cancers

edited by Ting-Tai Yen and Eugene Patrick Toy

submission deadline 30 Apr 2026 | 1 articles | Viewed by 1376 | Submission Open

Keywords: immune checkpoints; checkpoint inhibitors; PD-1/PD-L1 pathway; immune biomarkers; tumor microenvironment; immunosuppressive pathways; T-cell activation in solid tumors; gynecologic tumors

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

Glioma: From Intracellular Oncogenic Pathways to Targeting Therapeutic Strategies

edited by

Shilpi Singh

submission deadline 30 Apr 2026 | 1 articles | Viewed by 1376 | Submission Open

Keywords: glioma; targeted therapies; resistance mechanisms; oncogenic pathways; therapeutic resistance; combination therapies; tumor heterogeneity

(This special issue belongs to the Section Cancer Therapy)

Innovations in Endocrine Cancer—Technology, Techniques and Therapy (Second Edition)

edited by

Emad H. Kandil

submission deadline 30 Apr 2026 | 1 articles | Viewed by 1321 | Submission Open

Keywords: endocrine cancer; thyroid cancer; parathyroid; adrenals; melanoma; pancreas; neoplasms; minimally invasive surgeries

(This special issue belongs to the Section Methods and Technologies Development)

Recent Advances and Strategies for the Management of CIN and HPV Eradication Starategies for the Prevention of Uterine Cervical Cancer

edited by

Masaru Sakamoto

submission deadline 30 Apr 2026 | 1 articles | Viewed by 1241 | Submission Open

Keywords: CIN; 9-valent HPV vaccine; HPV L2-VLP vaccine; HPV therapeutic vaccine; endocervical conization; laser vaporization; PDT

Image-Guided Treatment of Liver Tumors

edited by

Maarten L. J. Smits

and Niek Wijnen

submission deadline 30 Apr 2026 | 2 articles | Viewed by 990 | Submission Open

Keywords: liver; thermal ablation; radioembolization; TACE; yttrium-90; portal vein embolization; radiation oncology; interventional oncology

(This special issue belongs to the Section Cancer Therapy)

Radical Pelvic Surgery and Reconstructive Innovations in Pelvic Oncology

edited by Evrim Erdemogľu

submission deadline 30 Apr 2026 | 1 articles | Viewed by 780 | Submission Open

Keywords: pelvic exenteration; LEER; radical pelvic surgery; reconstruction; flap surgery; multivisceral resection; gynecologic oncology; pelvic cancer; surgical outcomes; minimally invasive surgery

(This special issue belongs to the Section Clinical Research of Cancer)

The Role of Human Papillomavirus (HPV) in Cancers: Epidemiology, Molecular Biology, and Advancements in Detection Methods

edited by Peter C. Angeletti

submission deadline 30 Apr 2026 | 1 articles | Viewed by 716 | Submission Open

Keywords: human papillomavirus (HPV); cancer; HPV-related cancer; epidemiology; oncogenesis; molecular mechanisms; diagnostic technologies; epidemiological trends; risk factors; HPV-associated cancers; molecular pathways; cellular pathways; biomarkers; diagnostic tools; immune response; host– pathogen interaction

(This special issue belongs to the Section Cancer Epidemiology and Prevention)

The Biomarkers of Oral Cancer

edited by

Yasumasa Kakei

submission deadline 30 Apr 2026 | 1 articles | Viewed by 468 | Submission Open

Keywords: oral cancer; oral squamous cell carcinoma; oral melanoma; surgery; combination therapy; radiation therapy; immunotherapy; drug resistance; biomarker; liquid biopsy; prognosis

(This special issue belongs to the Section Cancer Biomarkers)

Advances in the Molecular Pathogenesis of T-Cell Lymphoma

edited by

Richard Flavin

submission deadline 30 Apr 2026 | Viewed by 455 | Submission Open

Keywords: pathogenesis; molecular biology; T-cell neoplasia/lymphoma; biomarkers

(This special issue belongs to the Section Cancer Pathophysiology)

Medical Treatment for Urological Cancers

edited by

Jozefina Casuscelli

submission deadline 30 Apr 2026 | Viewed by 442 | Submission Open

Keywords: prostate cancer; urothelial cancer; renal cancer; antibody– drug conjugates; cytotoxic chemotherapy; immune checkpoint inhibitors

(This special issue belongs to the Section Cancer Therapy)

Advantages and Benefits: Proton Therapy vs. X-Ray Treatment in Cancer

edited by

Felipe A. Calvo

submission deadline 30 Apr 2026 | Viewed by 406 | Submission Open

Keywords: proton therapy; X-ray therapy; foton therapy; in silico dosimetry; in vivo dosimetry; quality assurance; NTCP models; pediatric cancer patients; vascular biomarkers; hematological biomarkers; hepatic biomarkers; lymphopenia; cardiac toxicity; hepatotoxicity; neurocognition; pneumonitis; long-term sequelae; radiation induced cancer; survival; supportive care; survivors; quality of life; health value; cost

(This special issue belongs to the Section Cancer Therapy)

Current Concept and Management of Pediatric ATRTs—2nd Edition

edited by

Tadanori Tomita

and Alicia C. Lenzen

submission deadline 30 Apr 2026 | 2 articles | Viewed by 393 | Submission Open

Keywords: atypical teratoid rhabdoid tumors (ATRTs); CNS tumor; embryonal tumors

(This special issue belongs to the Section Pediatric Oncology)

The Influence of Epigenetic Regulation on the Tumor Microenvironment: Mechanisms and Therapeutic Implications

edited by

Mariarosaria Conte

submission deadline 30 Apr 2026 | Viewed by 365 | Submission Open

Keywords: tumor microenvironment; epigenetics; cancer; immune system; remodeling mechanisms; therapy; clinical application

(This special issue belongs to the Section Tumor Microenvironment)

Cancer Inhibitory Receptors and Related Cancer Immunotherapy

edited by Keqiang Chen, Feng Zhu and Xin Li

submission deadline 30 Apr 2026 | Viewed by 354 | Submission Open

Keywords: cancer inhibitory receptors; ligands for inhibitor receptors; immune checkpoint inhibitors; cancer cells; immune cells; non-immune cells; inhibitor receptor pathways; immune checkpoint blockade therapy

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

Targeted Therapies for Pediatric Nervous System Tumors

edited by

Mohamed S. Abdelbaki

and Nicole Brossier

submission deadline 30 Apr 2026 | Viewed by 347 | Submission Open

Keywords: glioma; ependymoma; medulloblastoma; pediatric brain tumors; targeted therapy; MEK inhibitors; NTRK inhibitors; glioma neuroscience; diffuse intrinsic pontine glioma

(This special issue belongs to the Section Pediatric Oncology)

Precision Medicine in Hematological Malignancies: Current Insights and Future Directions

edited by Giuseppe Saglio and Mohamed Yassin

submission deadline 30 Apr 2026 | Viewed by 269 | Submission Open

Keywords: hematological malignancies; precision medicine; targeted therapy; next-generation sequencing; biomarkers; molecular profiling

(This special issue belongs to the Section Cancer Therapy)

Extracellular Matrix—Role in the Tumor Microenvironment and Impact on Cancer Therapy

edited by Heena Kumra and Makoto Noda

submission deadline 30 Apr 2026 | Viewed by 263 | Submission Open

Keywords: extracellular matrix; stroma; tumor microenvironment; therapy resistance

(This special issue belongs to the Section Cancer Pathophysiology)

Next-Generation Boron Neutron Capture Therapy (BNCT) for Cancer Treatment

edited by Dayron Ramos López, Gabriella Pugliese and Raffaella Radogna

submission deadline 30 Apr 2026 | Viewed by 245 | Submission Open

Keywords: BNCT; boron agents; dosimetry; neutron detectors; cancer therapy; imaging; simulation; neutron sources; treatment planning; medical physics

(This special issue belongs to the Section Methods and Technologies Development)

The Role of Artificial Intelligence in Thyroid, Thoracic and Gastrointestinal Tumors: Transforming the Landscape of Diagnosis and Treatment

edited by