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Cancers publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Current Status of Neuroendocrine Tumors with a Special Focus on Diagnosis and Novel Treatments—3rd Edition
edited by
submission deadline 30 Sep 2026 | Viewed by 78 | Submission Open
Keywords: neuroendocrine tumors; somatostatin analogues; PRRT; chemotherapy; 68Gallium-DOTATOC; PET; CT; targeted therapies; mTOR; inhibitors; angiogenesis
(This special issue belongs to the Section Cancer Therapy)
Advances in Clinical Trials and Precision Medicine for Neuro-Oncology
edited by Malaka Ameratunga
submission deadline 30 Sep 2026 | Viewed by 74 | Submission Open
Keywords: clinical trials; neuro-oncology; precision oncology; molecular targets; precision medicine
(This special issue belongs to the Section Clinical Research of Cancer)
Extracellular Matrix Proteins in Cancer (2nd Edition)
edited by and Aikaterini Berdiaki
submission deadline 30 Sep 2026 | Viewed by 72 | Submission Open
Keywords: extracellular matrix (ECM); tumor microenvironment (TME); stromal remodeling; cancer-associated fibroblasts (CAFs); fibrous proteins; mechanotransduction; interstitial fluid pressure; proteoglycans and glycoproteins; matrix crosslinking; epithelial-to-mesenchymal transition (EMT); angiogenesis; matrikines; therapy resistance
(This special issue belongs to the Section Tumor Microenvironment)
Ablation Treatment for Malignant Tumors submission deadline 30 Sep 2026 | Viewed by 71 | Submission Open
Keywords: ablative therapies; thermal ablation; image-guided therapy; minimally invasive; radiofrequency ablation (RFA); microwave ablation (MWA); cryoablation; irreversible electroporation (IRE); malignant tumors; oligometastatic disease; immunotherapy combinations; interventional oncology
(This special issue belongs to the Section Cancer Therapy)
Advances in Pathogenesis and Pathology Diagnosis of Gynecologic Cancers
edited by
submission deadline 30 Sep 2026 | Viewed by 68 | Submission Open
Keywords: gynecologic cancers; molecular pathology; tumor pathogenesis; diagnostic biomarkers; precision medicine; endometrial carcinoma; ovarian cancer; cervical cancer; histopathology; translational research
New Era of Systemic Therapy for Different Types of Skin Cancer
edited by Magdalena Ciazynska
submission deadline 30 Sep 2026 | Viewed by 67 | Submission Open
Keywords: skin cancer systemic therapy; immunotherapy in skin cancer; targeted therapy in skin malignancies; melanoma and nonmelanoma skin cancer; biomarkers and treatment response; resistance mechanisms; combination therapy; real worldreal-world outcomes; novel therapeutic agents; precision oncology
(This special issue belongs to the Section Cancer Therapy)
Hematologic Malignancies: Clinical Features and Prognostic Indicators
edited by Danijela Leković
submission deadline 30 Sep 2026 | Viewed by 64 | Submission Open
Keywords: leukemia; myelodysplastic syndrome; myeloproliferative neoplasms; lymphoma; multiple myeloma; diagnosis; prognosis; molecular markers; infections; survival; machine learning
(This special issue belongs to the Section Clinical Research of Cancer)
The Tumor Microenvironment and Molecular Aberrations Convey Immune Evasion (Third Edition)
edited by
submission deadline 30 Sep 2026 | Viewed by 61 | Submission Open
Keywords: CD8+ tumor-infiltrating lymphocytes; cytotoxic T lymphocytes -associated protein 4; dendritic cells; immune evasion; hypoxia-inducible factors; myeloid-derived suppressor cells; natural killer; programmed death receptor and ligand; regulatory T cells; tumor-associated macrophages; tumor microenvironment
(This special issue belongs to the Section Cancer Immunology and Immunotherapy)
PSMA Targeted Strategies and Radioligand Therapies in Prostate Cancer: From Preclinical Models to Clinical Translation
edited by Neha Vapiwala and John Nikitas
submission deadline 30 Sep 2026 | Viewed by 60 | Submission Open
Keywords: prostate cancer; prostate-specific membrane antigen; radioligand therapy; radiopharmaceutical therapy; radiotherapy; theranostics
(This special issue belongs to the Section Cancer Therapy)
Advances in Clinical Pharmacology in Lung Cancer—2nd Edition
edited by
submission deadline 30 Sep 2026 | Viewed by 56 | Submission Open
Keywords: lung cancer; target therapy; immunotherapy; antiangiogenic agent; chemotherapy; NGS
(This special issue belongs to the Section Cancer Drug Development)
New Clinical Insights into Gynecological Malignancies
edited by
submission deadline 30 Sep 2026 | Viewed by 54 | Submission Open
Keywords: innovative care; data science; precision medicine; uterine cancer; ovarian cancer; vulvar cancer; vaginal cancer
(This special issue belongs to the Section Cancer Therapy)
Translational Advances in Reproductive Cancers: From Targets to Therapies
edited by
submission deadline 30 Sep 2026 | Viewed by 54 | Submission Open
Keywords: reproductive cancers; signal transduction pathways; hormonal regulation; targeted therapy; therapeutic limitations
(This special issue belongs to the Section Molecular Cancer Biology)
The Cellular Ecosystem of Cancer: New Insights into Cell Biology
edited by Xiaochao Tan and
submission deadline 30 Sep 2026 | Viewed by 52 | Submission Open
Keywords: cell organelle; ER; mitochondria; lysosome; Golgi; secretion; tumor microenvironment
(This special issue belongs to the Section Molecular Cancer Biology)
Leukemia Stem Cells: Persistence, Resistance, and Novel Eradication Strategies
edited by Elisa Donato and Darja Karpova
submission deadline 30 Sep 2026 | Viewed by 46 | Submission Open
Keywords: leukemia stem cells (LSCs); acute myeloid leukemia (AML); therapeutic resistance; minimal residual disease (MRD); LSC quiescence; cellular therapy; hematopoietic stem cell transplantation (HSCT); LSC microenvironment
Health-Related Quality of Life in Cancer Survivorship
edited by Deniz Gencer and Elisabeth Coyne
submission deadline 30 Sep 2026 | Viewed by 45 | Submission Open
Keywords: cancer survivorship; health-related quality of life (HRQoL); interventions; psychological support; personalized care; educational resources
(This special issue belongs to the Section Cancer Survivorship and Quality of Life)
Recent Advances in Myeloma: From Molecular Pathways to Drug Development
edited by Natalia Neparidze
submission deadline 30 Sep 2026 | Viewed by 43 | Submission Open
Keywords: myeloma; plasma cell disorders; monoclonal gammopathy; bispecifics; T cell engagers; CART therapy; monoclonal antibodies; MRD
(This special issue belongs to the Section Cancer Drug Development)
Cytoreductive Surgery, Hyperthermic Intraperitoneal Chemotherapy, and Beyond in Peritoneal Disease: Advances in Clinical Care and Therapeutics
edited by
submission deadline 30 Sep 2026 | Viewed by 42 | Submission Open
Keywords: peritoneal surface malignancies; peritoneal carcinomatosis; colorectal cancer; appendiceal cancer; pseudomyxoma peritonei; ovarian cancer; mesothelioma; gastric cancer; small bowel cancer; cytoreductive surgery; HIPEC; PIPAC; photodynamic therapy; chemotherapy; chemoresistance; novel therapies; rare diseases
(This special issue belongs to the Section Cancer Therapy)
Pancreatic Cancer Ultrasound: A Problem-Based Approach
edited by and Andrea Boccatonda
submission deadline 30 Sep 2026 | Viewed by 36 | Submission Open
Keywords: cancer; ultrasound; pancreas; CEUS; malignancy
(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)
Clinical Trials and Translational Research in Multiple Myeloma
edited by Laszlo Varoczy
submission deadline 30 Sep 2026 | Viewed by 32 | Submission Open
Keywords: multiple myeloma; disease evolution; translational research; personalizing therapy; clinical trial
(This special issue belongs to the Section Clinical Research of Cancer)
Cancer and Melatonin: Updates on Current Findings
edited by
submission deadline 30 Sep 2026 | Viewed by 4 | Submission Open
Keywords: cancer; melatonin; oxidative stress; inflammation; antioxidant defense
Head and Neck Cancer Recurrence: Diagnosis, Treatment and Prognosis (2nd Edition)
edited by
submission deadline 10 Oct 2026 | 1 articles | Viewed by 1274 | Submission Open
Keywords: head and neck cancer; recurrence; squamous cell carcinoma; HPV; larynx; oral cavity; oropharynx
(This special issue belongs to the Section Cancer Therapy)
Multidisciplinary Advances and Surgical Impact in Brain and Central Nervous System Tumors: From Molecular Insights to Clinical Outcomes
edited by Paolo Tini, Salvatore Chibbaro and
submission deadline 10 Oct 2026 | Viewed by 28 | Submission Open
Keywords: glioblastoma; low-grade gliomas; ependymomas; PNET; meningiomas; medulloblastomas; other brain tumors
Outcomes in Glioblastoma Patients: From Diagnosis to Palliation: 2nd Edition
edited by and Giorgio Mantovani
submission deadline 15 Oct 2026 | 1 articles | Viewed by 575 | Submission Open
Keywords: high-grade glioma; outcome assessment; prognostic factors; neuro-oncology; glioblastoma
(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)
Cancer Rehabilitation and Physical Activity: Advancing Function, Recovery, and Quality of Life Across the Cancer Continuum
edited by Jennifer Michelle Jones
submission deadline 15 Oct 2026 | Viewed by 74 | Submission Open
Keywords: cancer rehabilitation; exercise science; physical activity; prehabilitation; adverse side effects
(This special issue belongs to the Section Cancer Survivorship and Quality of Life)
The Robotic Revolution in Endometrial Cancer: Advancing Surgical Staging and Patient Care
edited by Roberto Berretta
submission deadline 20 Oct 2026 | Viewed by 96 | Submission Open
Keywords: endometrial cancer; robotic surgery; minimally invasive surgery; gynecologic oncology; surgical innovation; obesity; surgical staging; uterine cancer; lymphadenectomy; sentinel node mapping
(This special issue belongs to the Section Cancer Therapy)
The Future of Precision Radiotherapy for Cancer: Technology, Optimization, and Clinical Integration
edited by Thomas J. Fitzgerald
submission deadline 20 Oct 2026 | Viewed by 54 | Submission Open
Keywords: radiation; proton; photon; brachytherapy
(This special issue belongs to the Section Methods and Technologies Development)
Radiation Therapy for Brain Tumors
edited by
submission deadline 25 Oct 2026 | 4 articles | Viewed by 12290 | Submission Open
Keywords: radiosurgery; hypofractionated radiosurgery; spectroscopic MRI; proton radiation; image-guided radiotherapy; radiotherapy for benign tumors; radiotherapy for gliomas; gamma knife
(This special issue belongs to the Section Cancer Therapy)
The Future of Machine Learning in Predicting Cancer Treatment Response
edited by
submission deadline 25 Oct 2026 | Viewed by 45 | Submission Open
Keywords: machine learning; genomic language models; multiomics integration; enhancer prediction; interpretable AI; tumour stratification; deep learning; translational oncology; cancer treatment response
(This special issue belongs to the Section Methods and Technologies Development)
Gynecological Cancers: From Bench to Bedside submission deadline 30 Oct 2026 | 1 articles | Viewed by 332 | Submission Open
Keywords: gynecologic oncology; translational research; molecular mechanisms; targeted therapy; immunotherapy; personalized medicine
(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)
Clinical Research of Brachytherapy in Cancer
edited by Ludmiła Grzybowska-Szatkowska, and Aleksandra Kozłowska
submission deadline 30 Oct 2026 | 1 articles | Viewed by 141 | Submission Open
Keywords: brachytherapy; LDR; HDR; genitourinary cancers; breast cancer; skin cancer; gastrointestinal cancers; oligometastatic disease; personalized treatment and neoplasm
(This special issue belongs to the Section Clinical Research of Cancer)
The Role of Sphingolipids in Cancer Progression
edited by
submission deadline 30 Oct 2026 | Viewed by 118 | Submission Open
Keywords: sphingolipids; tumorigenesis; tumor progression; metastasis; spatial transcriptomics; spatial metabolomics; spatial proteomics; transcriptomics; metabolomics; proteomics; drug development
(This special issue belongs to the Section Molecular Cancer Biology)
Gynecologic Cancer: From Diagnosis to Treatment: 2nd Edition submission deadline 30 Oct 2026 | Viewed by 114 | Submission Open
Keywords: endometrial cancer; cervical cancer; ovarian cancer; borderline ovarian tumor; diagnosis and treatment
(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)
Cancer Prevention and Screening: Innovations, Implementation, and Access
edited by and Rahma S. Mkuu
submission deadline 30 Oct 2026 | Viewed by 107 | Submission Open
Keywords: cancer; prevention; screening; intervention; implementation
(This special issue belongs to the Section Cancer Epidemiology and Prevention)
The Current Status of Brain Tumor Imaging: 2nd Edition
edited by
submission deadline 30 Oct 2026 | Viewed by 105 | Submission Open
Keywords: neuro-oncology; glioma; brain metastasis; CT scan; MRI; radiogenomics; radiomics; artificial intelligence; MR spectroscopy; MR perfusion; fMRI
(This special issue belongs to the Section Cancer Therapy)
Unraveling Immune Dynamics and Novel Therapeutic Strategies in the Tumor Microenvironment
edited by Shahidul M. Islam
submission deadline 30 Oct 2026 | Viewed by 73 | Submission Open
Keywords: tumor microenvironment; immune dynamics; tumor heterogeneity; immune checkpoints; CAR T; cancer immunology; adoptive cell transfer; resistance; biomarkers; combination therapy; machine learning; molecular modeling
(This special issue belongs to the Section Tumor Microenvironment)
Epigenetic Modifiers in Cancer Treatment: Molecular Mechanisms and Clinical Applications
edited by and Umamaheswari Natarajan
submission deadline 30 Oct 2026 | Viewed by 66 | Submission Open
Keywords: epigenetics; histones; DNA methylation; histone acetylations; chromatin remodeling; DNMTs (DNMT1; DNMT3A; DNMT3B); PRMTs; HDACs; miRNA; ncRNAs; lncRNA
(This special issue belongs to the Section Molecular Cancer Biology)
Gastrointestinal Tumors: Screening and Prevention
edited by
submission deadline 30 Oct 2026 | Viewed by 65 | Submission Open
Keywords: cancer; early detection; esophageal; gastric; pancreatic; hepatocellular; colorectal; risk stratification; endoscopy; liquid biopsy
Solid Tumors, with a Focus on Urological Cancers: From Molecular Mechanisms to Predictive Biomarkers
edited by and
submission deadline 30 Oct 2026 | Viewed by 56 | Submission Open
Keywords: solid tumors; urological cancers; tumor microenvironment; molecular mechanisms; predictive biomarkers
(This special issue belongs to the Section Cancer Biomarkers)
Pathological Diagnosis and Surgical Treatment of Cholangiocarcinoma: Current Status and Novel Perspectives
edited by
submission deadline 30 Oct 2026 | Viewed by 46 | Submission Open
Keywords: cholangiocarcinoma; intrahepatic cholangiocarcinoma; small-duct type; large-duct type; immune checkpoint inhibitor; conversion surgery
Advances in Immunotherapy, Biomarkers, and Clinical Practice in Pleural Mesothelioma and Thoracic Cancers
edited by
submission deadline 30 Oct 2026 | Submission Open
Keywords: pleural mesothelioma; thoracic cancers; immunotherapy; biomarkers; immunotherapy resistance; molecular and genetic testing; precision oncology; real-world clinical practice
(This special issue belongs to the Section Cancer Immunology and Immunotherapy)
Combination Therapies for Brain Tumors
edited by Jason H. Huang and Ekokobe Fonkem
submission deadline 31 Oct 2026 | 8 articles | Viewed by 17979 | Submission Open
Keywords: novel diagnostics; therapies; glioblastoma; meningioma; astrocytoma
(This special issue belongs to the Section Cancer Therapy)
Oncologic Pathology: Diagnostic Challenges, Molecular Advances, and Clinical Correlations submission deadline 31 Oct 2026 | 3 articles | Viewed by 2119 | Submission Open
Keywords: solid neoplasia; predictive and prognostic biomarkers; target therapy; tumor microenvironment; molecular biology
(This special issue belongs to the Section Cancer Pathophysiology)
The Role of Nutrients in Cancer Progression
edited by
submission deadline 31 Oct 2026 | Viewed by 331 | Submission Open
Keywords: vitamins; phytochemicals; trace minerals; ketogenic diet; cancer recurrence; cancer metastasis; treatment response; radiotherapy; chemotherapy; immunotherapy
(This special issue belongs to the Section Cancer Pathophysiology)
Current Research in Pediatric Hematological Oncology submission deadline 31 Oct 2026 | 1 articles | Viewed by 239 | Submission Open
Keywords: pediatric hematology; childhood leukemia; acute myeloid leukemia (AML); juvenile myelomonocytic leukemia (JMML); acute lymphoblastic leukemia (ALL); immunotherapy; CAR-T cell therapy; targeted therapies; translational research; survivorship; pediatric oncology models
(This special issue belongs to the Section Pediatric Oncology)
Artificial Intelligence-Driven Multi-Omics Integration for Precision Oncology and Complex Disease Research
edited by and
submission deadline 31 Oct 2026 | Viewed by 213 | Submission Open
Keywords: artificial intelligence; multi-omics; precision medicine; biomarker; deep learning
(This special issue belongs to the Section Cancer Informatics and Big Data)
Overcoming Drug Resistance: Precision Medicine Drug Therapy
edited by , Yuting Huang and Raveena Manem
submission deadline 31 Oct 2026 | Viewed by 182 | Submission Open
Keywords: drug resistance; precision medicine; molecular and cellular mechanisms; biomarker-guided therapy; genomic profiling; combination treatment; novel drug delivery system
(This special issue belongs to the Section Cancer Drug Development)
Molecular Targets and Therapeutic Pathways in Cancer
edited by Ashish H. Shah and Deepa Seetharam
submission deadline 31 Oct 2026 | Viewed by 168 | Submission Open
Keywords: cancer therapeutics; molecular targets; signal transduction pathways; targeted therapy; drug resistance; precision oncology; tumor microenvironment; immunotherapy; kinase inhibitors; translational cancer research
(This special issue belongs to the Section Cancer Drug Development)
Omics Data for Cancer Therapies: From Molecular Profiling to Clinical Applications
edited by
submission deadline 31 Oct 2026 | Viewed by 156 | Submission Open
Keywords: multi-omics integration; precision oncology; biomarker discovery; computational oncology; translational cancer research
(This special issue belongs to the Section Cancer Informatics and Big Data)
Role of Pathology in Detection, Prognosis and Treatment of Gastrointestinal Cancers
edited by and Luís Ortega-Medina
submission deadline 31 Oct 2026 | Viewed by 145 | Submission Open
Keywords: gastrointestinal cancer; pathology; histopathology; molecular pathology; biomarkers; prognosis; precision medicine; digital pathology; cancer detection; targeted therapy
(This special issue belongs to the Section Cancer Pathophysiology)
Artificial Intelligence in Urological Oncology: Applications in Imaging, Prognostics, and Precision Disease Management
edited by
submission deadline 31 Oct 2026 | Viewed by 117 | Submission Open
Keywords: artificial intelligence; machine learning; urological oncology; imaging; precision medicine; digital pathology; therapeutic decision-making
(This special issue belongs to the Section Cancer Therapy)
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