The Long Journey into BRCA1/2 Genes Goes On: The Emerging Landscape in BRCA-Mediated Tumors
A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Molecular Cancer Biology".
Deadline for manuscript submissions: closed (31 December 2020) | Viewed by 37228
Special Issue Editors
Interests: predictive and prognostic factors in solid tumors; identification of therapeutic target; pancreatic cancer; hereditary breast and ovarian cancer; meta-analysis; liquid biopsy; precision oncology
Special Issues, Collections and Topics in MDPI journals
Interests: soft tissue sarcomas; gastrointestinal stromal tumors; gynecological and genitourinary tumors; cancer genetics; hereditary breast and ovarian cancers; prognostic and predictive biomarkers; molecular mechanisms of targeted therapy and immunotherapy resistance
Special Issues, Collections and Topics in MDPI journals
Interests: Molecular biology and translational research of rare tumors; heredo-familial tumors; Gene expression; Molecular pathway network in solid tumors; Cancer tumor microenvironment; Tumor immunology; Predictive and prognostic biomarkers in oncology
Special Issues, Collections and Topics in MDPI journals
Interests: cancer genetics and genomics; familial/hereditary solid tumors; breast/ovarian cancer genes; homologous recombination; liquid biopsy; precision oncology
Special Issue Information
Dear Colleague,
The critical role of BRCA1 and BRCA2 genes was discovered for the first time in 1994 and 1995 in families with a high prevalence of breast and ovarian cancers. Pathogenic variants in these genes remain, to date, the primary inherited cause of breast and ovarian tumors, with an 85% lifetime risk for breast and a 20–40% risk for ovarian cancer. However, research in the past two decades has brought great progress and change in the field of breast and ovarian cancer, screening, prevention, and treatment. The diffusion of high-throughput next-generation sequencing technologies has provided a deep insight into the molecular biology of these tumors and many other genes and proteins within the homologous recombination pathway have been evaluated. The development of poly(ADP-ribose) polymerase inhibitors (PARPi) has been a major advance in the treatment of ovarian tumors and several clinical and translational trials are ongoing to validate prognostic and predictive utility of germline and/or somatic pathogenic variants in BRCA1/2 or other genes associated with HRD as biomarkers in breast and ovarian cancer. More recent evidence has shown the presence of BRCA1/2 and pathogenic variants of other genes also in pancreatic and prostate cancer; this event increases the risk and contributes to the prevalence of these cancers not just in high-risk families but in the general population as well.
That is how the long journey into BRCA genes goes on, and the emerging landscape of genetic testing and management of BRCA-mediated tumor phenotypes (and beyond) continues to evolve.
Prof. Antonio Russo
Dr. Lorena Incorvaia
Dr. Daniele Fanale
Prof. Viviana Bazan
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- hereditary breast and ovarian cancer
- genetic predisposition to cancer
- BRCA1 and BRCA2
- homologous recombination deficiency (HRD)
- BRCA-related pancreatic cancer
- BRCA-related prostate cancer
- multigene panel
- NGS
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.
Further information on MDPI's Special Issue polices can be found here.