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Cancers publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Advanced Segmentation in Multimodal Nuclear Imaging of Solid Tumors and Lymphomas: Tools, Challenges, and Clinical Integration

edited by

Ken Kudura

and Robert Förster

submission deadline 28 Feb 2027 | 2 articles | Viewed by 2725 | Submission Open

Keywords: multimodal nuclear imaging; artificial intelligence in nuclear medicine; radiomics in nuclear medicine; tumor segmentation; segmentation techniques; segmentation tools; outcome prediction; radioligand therapy

(This special issue belongs to the Section Methods and Technologies Development)

Transformative Genomic Technologies Shaping the Future of Precision Approaches for Haematological Malignancies

edited by

Chung Hoow Kok

and

Barbara McClure

submission deadline 28 Feb 2027 | 1 articles | Viewed by 2709 | Submission Open

Keywords: multi-omics; risk stratification; bioinformatics; AI/machine learning; hematological malignancies; biomarkers; targeted therapeutics; genomics; cancer cell biology

Role of Inflammation in Cancer

edited by

Li Yang

submission deadline 28 Feb 2027 | 2 articles | Viewed by 2367 | Submission Open

Keywords: cancer; inflammation; immune cells; cytokines; anti-inflammatory; tumor microenvironment; immunotherapy; immune-related adverse events; targeted therapy; chemotherapy and chemoprevention

Decoding the Tumor Microenvironment: Immune Cell–Tumor Interplay in Breast Cancer

edited by Abirami Sivapiragasam and Roberto A. Leon Ferre

submission deadline 28 Feb 2027 | 1 articles | Viewed by 2289 | Submission Open

Keywords: tumor microenvironment; breast cancer; immune cell–tumor interaction; immunotherapy; T cells; macrophages; dendritic cells; single-cell transcriptomics; spatial transcriptomics; artificial intelligence; prognostic biomarkers; predictive biomarkers; personalized therapy

(This special issue belongs to the Section Tumor Microenvironment)

Surgery for Head and Neck Cancer

edited by

Boban M. Erovic

Blazen Marijic

and Stefan Grasl

submission deadline 28 Feb 2027 | 3 articles | Viewed by 2169 | Submission Open

Keywords: head and neck cancer; oncologic surgery; minimally invasive surgery; transoral robotic surgery; neck dissection; reconstructive surgery; multidisciplinary treatment; functional outcomes

(This special issue belongs to the Section Cancer Therapy)

Molecular Insights into Drug Resistance in Cancer: 2nd Edition

edited by Yuqi Yang

submission deadline 28 Feb 2027 | 3 articles | Viewed by 2156 | Submission Open

Keywords: drug resistance; cancer treatment; molecular mechanism; chemotherapeutic therapy; small molecules; biologics/large molecules; leukemia; solid tumor

Molecular Mechanisms and Therapeutic Resistance in Hematological Malignancies

edited by

Rui Bergantim

submission deadline 28 Feb 2027 | 1 articles | Viewed by 2090 | Submission Open

Keywords: genomic and epigenomic alterations; signaling pathway dysregulation; non-coding RNAs; metabolic reprogramming; antigen escape mechanisms; antigen presentation defects; interferon signaling impairment; T-cell exhaustion; memory T-cell dysfunction; myeloid-mediated immunosuppression; bone marrow immune microenvironment; spatial immune architecture; CAR-T cell therapy; next-generation CAR engineering; bispecific antibodies and T-cell engagers; antibody-drug conjugates; NK-cell and macrophage immunotherapy; immune checkpoint modulation; combination immunotherapy strategies; liquid biopsy–guided precision therapy

Multimodal Management of Hepatobiliary Cancers: Development of Surgical and Locoregional Strategies

edited by

Adrian Bartoș

submission deadline 28 Feb 2027 | 2 articles | Viewed by 2088 | Submission Open

Keywords: hepatocarcinoma; liver metastasis; ultrasound guided liver resection; tumoral ablative tehniques; biliary cancers

Host-Related Prognostic Factors in Gastrointestinal Malignancies: From Genetics to Phenomics

edited by

Kiyohiko Shuto

and Yoshihiro Nabeya

submission deadline 28 Feb 2027 | 3 articles | Viewed by 1938 | Submission Open

Keywords: pharmacogenetics; body composition assessment; nutritional oncology; systemic inflammation; therapeutic management

(This special issue belongs to the Section Molecular Cancer Biology)

Advances in Treatment of Bladder Cancer

edited by

Murat Akand

and

Guglielmo Mantica

submission deadline 28 Feb 2027 | 2 articles | Viewed by 1880 | Submission Open

Keywords: bladder cancer; diagnostic biomarkers; genomics; therapeutic approaches

(This special issue belongs to the Section Cancer Therapy)

Advancements in Brain Cancer Research: From Molecular Mechanisms to Translational Therapeutic Strategies

edited by

Hernando Lopez-Bertoni

submission deadline 28 Feb 2027 | 1 articles | Viewed by 1497 | Submission Open

Keywords: brain cancer; glioblastoma; tumor microenvironment; cancer stem cells; molecular therapeutics; epigenetic regulation; nanomedicine; translational oncology; therapeutic resistance

The Molecular Biology of Cholangiocarcinoma

edited by

Kevin Gaston

and Padma-Sheela Jayaraman

submission deadline 28 Feb 2027 | 1 articles | Viewed by 1489 | Submission Open

Keywords: cholangiocarcinoma; biliary tract cancer; early detection; targeted therapy; tumour microenvironment; spatial biology; genomics; transcriptomics; proteomics

(This special issue belongs to the Section Molecular Cancer Biology)

Gastrointestinal Tumors: Prevention, Screening and Predictive Analytics

edited by Mohamed I. Elsaid,

Electra D. Paskett

and Vinod Rustgi

submission deadline 28 Feb 2027 | 1 articles | Viewed by 1442 | Submission Open

Keywords: gastrointestinal and hepatobiliary cancers; prevention and screening; chemoprevention; risk stratification; biomarkers and liquid biopsy (ctDNA); imaging and radiomics; predictive analytics and machine learning; causal inference; population-based studies; implementation science and health equity

(This special issue belongs to the Section Cancer Epidemiology and Prevention)

Obesity and Cancers (2nd Edition)

edited by Edward Sauter and Tanya Agurs-Collins

submission deadline 28 Feb 2027 | 2 articles | Viewed by 1438 | Submission Open

Keywords: obesity; cancer; mitigating factors; weight loss; weight gain; obesity interventions

(This special issue belongs to the Section Cancer Epidemiology and Prevention)

Precision Prediction of Cardiotoxicity: Imaging, Biomarkers, Genetics, Risk Models, and Digital Innovation in Cardio-Oncology

edited by Kalliopi Keramida

submission deadline 28 Feb 2027 | 2 articles | Viewed by 1360 | Submission Open

Keywords: cardio-oncology; imaging; biomarkers; genetics; risk models; digital innovation

Heat Shock Proteins in Metastatic Cancer: From Molecular Mechanisms to Clinical Targeting

edited by Daniel Jay and

Pragya Singh

submission deadline 28 Feb 2027 | 2 articles | Viewed by 1333 | Submission Open

Keywords: HSPs and eHSPs (Hsp90, Hsp70, Hsp60, Hsp40 and Hsp27); HSF1; chaperone; cancer metastasis; EMT; tumor microenvironment; ECM remodelling; anoikis resistance; circulating tumor cell survival; premetastatic niche; metastatic colonisation; extracellular vesicles; exosomes; cancer stem cells; therapy resistance; metastatic biomarkers; immunotherapy; HSP-targeted therapy

Robotic and Thoracoscopic Surgery for Lung Cancer

edited by Benjamin Wei

submission deadline 28 Feb 2027 | 2 articles | Viewed by 1314 | Submission Open

Keywords: robotic; thoracoscopic; lobectomy; segmentectomy; wedge resection; lymph node dissection; neoadjuvant therapy; immunotherapy; spread through air spaces; radiomics

(This special issue belongs to the Section Methods and Technologies Development)

Cellular Senescence, Aging and the Tumor Microenvironment in Cancer

edited by Jabed Iqbal and Jeremy Wee Kiat Ng

submission deadline 28 Feb 2027 | 1 articles | Viewed by 1260 | Submission Open

Keywords: aging; senescence; immunosenescence; SASP; tumor microenvironment; immunotherapy

(This special issue belongs to the Section Tumor Microenvironment)

mTOR Signaling in Cancer

edited by

Don Benjamin

submission deadline 28 Feb 2027 | 1 articles | Viewed by 1237 | Submission Open

Keywords: mTOR; cancer; cell signaling; pathway addiction; tumor metabolism; glycolysis; autophagy; apoptosis; rapamycin

(This special issue belongs to the Section Molecular Cancer Biology)

Redox Balance, Antioxidant Defenses, and Inflammation in Cancer: From Initial Changes to Tumor Progression

edited by Andrej Veljković,

Gordana Kocic

and

Aleksandra Klisic

submission deadline 28 Feb 2027 | 1 articles | Viewed by 1112 | Submission Open

Keywords: oxidative stress; inflammation; cancer progression; pre-malignant changes; biomarkers; tumor microenvironment; cell signaling; therapeutic targets

(This special issue belongs to the Section Tumor Microenvironment)

Surgical Treatment and Prognosis of Hepato-Biliary and Pancreatic Tumors—the Role of Minimally Invasive Surgery

edited by Giorgio Ercolani

submission deadline 28 Feb 2027 | 2 articles | Viewed by 1048 | Submission Open

Keywords: liver tumor; cholangiocarcinoma; pancreatic tumor; robotic surgery; mini-invasive treatment; treatment multimodality

Role of TP53 Mutation in Cancer

edited by

Naoyuki Iwahashi

submission deadline 28 Feb 2027 | 1 articles | Viewed by 1028 | Submission Open

Keywords: TP53 mutation; p53 aggregate; gain-of-function; cancer progression; transcriptional reprogramming; therapeutic targeting; biomarker; translational research; precision oncology

(This special issue belongs to the Section Molecular Cancer Biology)

CAR T Cell Therapy in Cancer: Progress and Challenges Across Solid and Hematologic Malignancies

edited by John F. Marshall and Lauren C. Cutmore

submission deadline 28 Feb 2027 | 1 articles | Viewed by 988 | Submission Open

Keywords: CAR-T cell therapy; adoptive cell therapy; immunotherapy; antigen escape; solid tumor; hematologic malignancies

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

Artificial Intelligence in Cancers: Enhancing Diagnosis and Treatment

edited by

Rong Wang

, Adam Shephard and Shan E Ahmed Raza

submission deadline 28 Feb 2027 | 2 articles | Viewed by 835 | Submission Open

Keywords: artificial intelligence; machine learning; deep learning; precision oncology; cancer diagnosis; cancer screening; treatment planning; prognostic prediction; digital pathology; medical imaging; radiomics; genomics; multiomics

(This special issue belongs to the Section Cancer Informatics and Big Data)

Liquid Biopsy Innovation: From ctDNA to RNA Modifications in Genitourinary Cancers

edited by

Edoardo Francini

Giuseppe Fanelli

and Jacopo Venturini

submission deadline 28 Feb 2027 | 1 articles | Viewed by 712 | Submission Open

Keywords: liquid biopsy; cell-free DNA (cfDNA); circulating tumor DNA (ctDNA); RNA modification

(This special issue belongs to the Section Cancer Biomarkers)

The Invasion and Metastasis in Skin Cancer

edited by Emanuela Passoni,

Nerina Denaro

and

Gianluca Nazzaro

submission deadline 28 Feb 2027 | 1 articles | Viewed by 617 | Submission Open

Keywords: melanoma; skin cancer; basal cell carcinoma; squamous cell carcinoma; Kaposi’s sarcoma; dermoscopy; photoprotection; skin cancer prevention

Recent Developments on PET-CT in Multiple Myeloma

edited by

Carmelo Caldarella

submission deadline 28 Feb 2027 | Viewed by 447 | Submission Open

Keywords: PET/CT; multiple myeloma; novel radiopharmaceuticals; radiomics; theranostics

(This special issue belongs to the Section Methods and Technologies Development)

Advances in the Multimodal Management of Pancreatic Ductal Adenocarcinoma

edited by

Olav F. Dajani

Knut Jørgen Labori

and

Arne Westgaard

submission deadline 28 Feb 2027 | Viewed by 425 | Submission Open

Keywords: pancreatic ductal adenocarcinoma (PDAC); multimodal approach; systemic therapy; radiotherapy; targeted strategies; neoadjuvant therapy; adjuvant therapy

(This special issue belongs to the Section Cancer Therapy)

Epigenetic Markers of Cancer Diseases

edited by

Himanshu Narayan Singh

and Jessica Puzzuoli

submission deadline 28 Feb 2027 | 1 articles | Viewed by 420 | Submission Open

Keywords: epigenetics; DNA methylation; histone modifications; tumor suppressor genes; oncogenes; cancer biomarkers; early detection; disease progression; epigenetic therapy; DNA methyltransferase inhibitors; histone deacetylase inhibitors; liquid biopsy; cancer risk assessment; clinical translation

(This special issue belongs to the Section Molecular Cancer Biology)

Tumor Microenvironment in Bone Sarcoma

edited by

Fan Shen

and

Consolato M. Sergi

submission deadline 28 Feb 2027 | Viewed by 407 | Submission Open

Keywords: osteosarcoma; microenvironment; oncogene; tumor suppressor; CAR cell therapy; epithelial–mesenchymal transition; metabolism; epigenetics

(This special issue belongs to the Section Tumor Microenvironment)

Next-Generation Biomarkers in Oncology: From Multi-Omics to AI-Powered Diagnostics

edited by

Caroline G. Lee

submission deadline 28 Feb 2027 | Viewed by 385 | Submission Open

Keywords: multi-omics; cancer biomarkers; precision oncology; liquid biopsy; circulating tumor DNA (ctDNA); single-cell sequencing; spatial transcriptomics; epigenomics; proteogenomics; metabolomics; tumor microenvironment; radiomics; digital pathology; machine learning; explainable AI

(This special issue belongs to the Section Cancer Biomarkers)

Research on Clinical Treatment of Mesothelioma: 2nd Edition

edited by

Giulia M. Stella

submission deadline 28 Feb 2027 | Viewed by 376 | Submission Open

Keywords: pleural mesothelioma; targeted therapy; local treatments; radiomics; genetic traits; occupational health; asbestos exposure

(This special issue belongs to the Section Clinical Research in Cancer)

Innovative Approaches of Multimodal Imaging of Cancer Characteristics in Nuclear Medicine

edited by

Daniel Gündel

and

Sophie Stotz

submission deadline 28 Feb 2027 | Viewed by 373 | Submission Open

Keywords: multimodal imaging; molecular imaging; PET; SPECT; MRI; CT; ultrasound; optical imaging; cancer

(This special issue belongs to the Section Methods and Technologies Development)

Digital Pathology and AI for Tumor Microenvironment Mapping

edited by Mohammadreza Azimi

submission deadline 28 Feb 2027 | Viewed by 360 | Submission Open

Keywords: tumor microenvironment; digital pathology; artificial intelligence; spatial analysis; computational histopathology; deep learning; cancer prognostics; machine learning; image-based biomarkers; federated learning

Genomic Instability in Breast Cancer: Biomarkers, Resistance and Therapeutic Opportunities

edited by Melyssa R. Bratton

submission deadline 28 Feb 2027 | Viewed by 222 | Submission Open

Keywords: genomic instability; somatic mutation; DNA damage response; homologous recombination deficiency (HRD); tumor mutational burden (TMB); chromosomal instability (CIN); tumor evolution; therapeutic resistance

Emerging Roles of HDACs in Cancer Metabolism, Plasticity and Therapeutic Response

edited by Changmin Peng

submission deadline 28 Feb 2027 | Viewed by 197 | Submission Open

Keywords: HDAC biology; cancer metabolism; therapeutic resistance; post-translational modifications; cancer plasticity

(This special issue belongs to the Section Molecular Cancer Biology)

Non-Coding RNAs in Bone Tumors: Pathogenesis, Diagnostic Biomarkers, and Therapeutic Perspectives

edited by Albert Roessner

submission deadline 28 Feb 2027 | Viewed by 196 | Submission Open

Keywords: bone tumors; non-coding RNAs; pathogenesis; biomarkers; non-coding RNA therapeutics

Novel Pharmacotherapeutic Strategies for Neuroendocrine Tumors: Drug Repurposing, Combinations, and Beyond

edited by Qiyun Tang and Mujie Ye

submission deadline 28 Feb 2027 | Viewed by 186 | Submission Open

Keywords: neuroendocrine tumors; tumor metabolism; immune microenvironment; immunotherapy; targeted therapy (including PRRT); metabolic reprogramming; basic research/translational research; therapeutic resistance; biomarkers

(This special issue belongs to the Section Cancer Drug Development)

Advances in Pathology of Lymphoma and Leukemia—Second Edition

edited by

Siba El Hussein

submission deadline 28 Feb 2027 | Viewed by 167 | Submission Open

Keywords: leukemia; lymphoma; immunohistochemical stains; next-generation sequencing; cytogenetics; flow cytometry analysis

(This special issue belongs to the Section Cancer Pathophysiology)

Signaling Molecules for Brain Tumors

edited by

Meenakshisundaram Kandhavelu

and Akshaya Murugesan

submission deadline 28 Feb 2027 | Viewed by 157 | Submission Open

Keywords: brain tumor; signaling molecules; tumor microenvironment; sensor; diagnosis and treatment; tumor microenvironment; synthesis and characterization; small drug molecules; gene expression; computational studies

(This special issue belongs to the Section Molecular Cancer Biology)

Quality of Life and Management of Pediatric Cancer (2nd Edition)

edited by

Luca Giacomelli

and

Momcilo Jankovic

submission deadline 28 Feb 2027 | Viewed by 139 | Submission Open

Keywords: pediatric palliative care; oncology; quality of life; early management

(This special issue belongs to the Section Pediatric Oncology)

Photodiagnosis and Photodynamic Therapy for CNS Tumors

edited by

Jiro Akimoto

submission deadline 28 Feb 2027 | Viewed by 136 | Submission Open

Keywords: photo-diagnosis; photodynamic therapy; central nervous system tumors; photosensitizer

Minimally Invasive Treatments for Prostate Cancer

edited by Javier Romero-Otero

submission deadline 28 Feb 2027 | Viewed by 135 | Submission Open

Keywords: prostate cancer; robotic surgery; focal therapy; single-port surgery; artificial intelligence

(This special issue belongs to the Section Cancer Therapy)

The Role of PSMA PET/CT in Prostate Cancer Therapy and Prognosis

edited by

Marco Cuzzocrea

and Gennaro Cusato

submission deadline 28 Feb 2027 | Viewed by 125 | Submission Open

Keywords: PSMA PET/CT; prostate cancer; radioligand therapy; [177Lu]Lu-PSMA; theranostic; treatment response assessment; prognostic biomarkers; metastatic castration-resistant prostate cancer; patient selection; quantitative imaging

Tumor Microenvironment and Precision Therapeutics: From Biological Insights to Clinical Applications in Solid and Hematological Malignancies

edited by

Matin Sheriff

and Eleni D. Kapsali

submission deadline 28 Feb 2027 | Viewed by 112 | Submission Open

Keywords: tumor microenvironment; precision oncology; precision therapeutics; solid tumors; hematological malignancies; tumor heterogeneity; immunotherapy; targeted therapy; cellular therapy; therapeutic resistance; biomarkers; molecular profiling; single-cell sequencing; stromal cells; cancer-associated fibroblasts; extracellular matrix; extracellular vesicles; liquid biopsy; translational oncology; personalized medicine

(This special issue belongs to the Section Tumor Microenvironment)

Emerging Therapies and Non-Pharmacologic Interventions for Lymphoma Treatment

edited by Max J. Gordon

submission deadline 28 Feb 2027 | Viewed by 105 | Submission Open

Keywords: non-hodgkin lymphoma; hodgkin lymphoma; targeted therapy; immunotherapy; epigenetic drugs; T-cell lymphoma; B-cell lymphoma; energy balance; body composition; cellular therapy

(This special issue belongs to the Section Cancer Therapy)

Precision Diagnostics and Therapeutic Innovation in Brain Tumors

edited by

Anudeep Yekula

submission deadline 28 Feb 2027 | Viewed by 98 | Submission Open

Keywords: brain tumors; neuro-oncology; precision oncology; molecular diagnostics; methylation profiling; liquid biopsy; radiomics; targeted therapy; immunotherapy; clinical trials

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

Chemo-Radio-Immunotherapy for Colorectal Cancer: 2nd Edition

edited by Shoichi Hazama

submission deadline 28 Feb 2027 | Viewed by 97 | Submission Open

Keywords: colorectal cancer; immunotherapy; chemotherapy; radiotherapy; combination therapy; neoadjuvant therapy; biomarkers for treatment response; anal cancer; squamous cell carcinoma; minimally invasive surgery; conversion surgery

(This special issue belongs to the Section Cancer Therapy)

Boron Neutron Capture Therapy (BNCT) for Solid Cancers: (1) Preclinical Innovations and Biological Mechanisms

edited by

Yasuaki Ichikawa

and

Tadashi Hanafusa

submission deadline 28 Feb 2027 | Viewed by 85 | Submission Open

Keywords: boron neutron capture therapy (BNCT); refractory cancer; targeted therapy; good patient QOL; preclinical research

(This special issue belongs to the Section Methods and Technologies Development)

Progress and Perspectives of Organoid Technology in Precision Oncology

edited by Leli Zeng

submission deadline 28 Feb 2027 | Viewed by 85 | Submission Open

Keywords: organoids; precision oncology; patient-derived tumor models; drug screening; tumor microenvironment; treatment resistance; multi-omics; translational cancer research

(This special issue belongs to the Section Clinical Research in Cancer)

Displaying special issue 701-750 on page 15 of 22.

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