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Cancers publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Skin and Hair Side Effects of Cancer Treatment
edited by Ian W. Tattersall
submission deadline 31 Oct 2026 | Viewed by 316 | Submission Open
Keywords: oncodermatology; toxicity management; supportive oncology
(This special issue belongs to the Section Cancer Therapy)
Radiotherapy and the Tumor Microenvironment: From Basic Mechanisms to Clinical Translation
edited by Eleanor J. Cheadle and
submission deadline 31 Oct 2026 | Viewed by 315 | Submission Open
Keywords: radiotherapy; tumor microenvironment; immune response; biomarkers; stroma; immunogenic cell death
Local, Systemic and Combined Therapy for Hepatocellular Carcinoma
edited by Xiaoqun Dong
submission deadline 31 Oct 2026 | Viewed by 308 | Submission Open
Keywords: hepatocellular carcinoma; immunotherapy; cell therapy; targeted therapy; local therapy; combination therapy; oncolytic virus; precision oncology; drug resistance; translational research
(This special issue belongs to the Section Cancer Therapy)
Molecular Therapy Targets of Uterine and Ovarian Cancer
edited by Salvatore Lopez and
submission deadline 31 Oct 2026 | Viewed by 300 | Submission Open
Keywords: endometrial cancer; ovarian cancer; molecular targets; immunotherapy; PARP inhibitor resistance; HER2-targeted therapy; biomarkers; CDK4/6 inhibition; tumor microenvironment; precision medicine
(This special issue belongs to the Section Cancer Therapy)
Advances in Skull Base Tumor Surgery: From Diagnosis to Minimally Invasive Treatment
edited by James P Chandler and
submission deadline 31 Oct 2026 | Viewed by 297 | Submission Open
Keywords: skull base tumors; minimally invasive neurosurgery; advanced imaging; molecular diagnostics; cranial base reconstruction; targeted therapies; radiosurgery; precision medicine
(This special issue belongs to the Section Clinical Research in Cancer)
The Tumor Microenvironment and Its Role in Tumor Growth and Angiogenesis—2nd Edition
edited by
submission deadline 31 Oct 2026 | Viewed by 295 | Submission Open
Keywords: tumor microenvironment; tumor angiogenesis; tumor targeted therapies; inflammation; immunotherapies
(This special issue belongs to the Section Tumor Microenvironment)
Novel Agents and Treatments in Leiomyosarcoma
edited by and Roberta Sanfilippo
submission deadline 31 Oct 2026 | Viewed by 288 | Submission Open
Keywords: leiomyosarcoma; uterine leiomyosarcoma; STUMP; retroperitoneal leiomyosarcoma; targeted therapies; precision medicine; immunotherapy; drug development; clinical trials; translational oncology
Epigenetic Modifications as Biomarkers of Tumor Development
edited by
submission deadline 31 Oct 2026 | Viewed by 279 | Submission Open
Keywords: DNA Methylation; histone acetylation; liquid biopsies; oncogenesis; chromatin remodeling; early detection biomarkers; precision oncology; pharmaco-epigenetics
(This special issue belongs to the Section Cancer Biomarkers)
Exploring the Genetic and Epigenetic Factors in Leukemia and Lymphoma (2nd Edition) submission deadline 31 Oct 2026 | Viewed by 276 | Submission Open
Keywords: hematology; leukemia; lymphoma; epigenetics; bioinformatics; gene expression; chromatin conformation
(This special issue belongs to the Section Cancer Therapy)
Advances in Radiation Therapy for Head and Neck Cancer: 2nd Edition submission deadline 31 Oct 2026 | Viewed by 273 | Submission Open
Keywords: adaptive radiotherapy; hyper- and hypo-fractionated radiotherapy; artificial intelligence in radiotherapy for head and neck cancer; quality assurance and set-up errors associated with IMRT, VMAT, IGRT, and SGRT techniques; protons and heavy ions for radiotherapy; re-irradiation; nanoparticles plus radiotherapy; hyperthermia plus radiotherapy; radiotherapy plus immunotherapy; the de-escalation of radiation therapy
(This special issue belongs to the Section Cancer Therapy)
Innovations in Imaging and Endoscopic Diagnosis of Esophageal Cancer: From Early Detection to Clinical Decision Support
edited by , and Mahendra Bhatu Gawali
submission deadline 31 Oct 2026 | Viewed by 269 | Submission Open
Keywords: esophageal cancer; endoscopic imaging; early detection; image-enhanced endoscopy; optical imaging; artificial intelligence; computer-aided diagnosis; multimodal imaging; risk stratification; clinical decision support systems
(This special issue belongs to the Section Methods and Technologies Development)
Advancing Novel Cancer Therapeutics: Discovery, Validation and Translation of Molecular Targets
edited by Chandan Narayan and
submission deadline 31 Oct 2026 | Viewed by 269 | Submission Open
Keywords: cancer therapeutics; precision medicine; aptamers; chimeric antigen receptor T cell therapy (CAR-T); CRISPR-Cas systems; AI
(This special issue belongs to the Section Cancer Therapy)
Nutritional Strategies Across the Cancer Continuum: Prevention, Therapeutic Intervention, Support, and Survivorship
edited by
submission deadline 31 Oct 2026 | Viewed by 259 | Submission Open
Keywords: cancer prevention; clinical nutrition; malnutrition and cachexia; sarcopenia and nutrition; dietary patterns as cancer therapy; treatment-related sensory changes; cancer survivorship
(This special issue belongs to the Section Cancer Survivorship and Quality of Life)
Advances in Immune Therapies for Hematological Malignancies
edited by Mohammad S. Hossain
submission deadline 31 Oct 2026 | Viewed by 258 | Submission Open
Keywords: hematological malignancies; immunotherapy; bone marrow transplantation; graft-versus-host disease (GVHD); CAR T-cell therapy; immune checkpoint inhibitors; bispecific monoclonal antibodies; cytomegalovirus (CMV) infection; antigen–antibody interactions
(This special issue belongs to the Section Cancer Therapy)
Artificial Intelligence in Cancer Prevention and Control
edited by Syed Nabeel Zafar
submission deadline 31 Oct 2026 | Viewed by 241 | Submission Open
Keywords: artificial intelligence; machine learning; cancer continuum; low-resource settings; health equity; low- and middle-income countries; global health; cancer
(This special issue belongs to the Section Methods and Technologies Development)
Computational Multi-Omics in Liquid Biopsy: Integrating Tumor and Immune Signals for Precision Oncology submission deadline 31 Oct 2026 | Viewed by 229 | Submission Open
Keywords: liquid biopsy; minimal residual disease (MRD); circulating tumor DNA (ctDNA); immunogenomics; tumor evolution; ultra-low frequency variant detection; computational oncology; error modeling and noise suppression; clonal hematopoiesis; longitudinal molecular monitoring; tumor/immune system coevolution
(This special issue belongs to the Section Methods and Technologies Development)
Advances in Prevention, Diagnosis, and Therapy for Cervical and Vulvar Cancer submission deadline 31 Oct 2026 | Viewed by 215 | Submission Open
Keywords: vulvar carcinoma; cervical intraepithelial neoplasia; surgical management; colposcopy; lymph node management; molecular classification; sentinel lymph node procedure; HPV infection and prevention
Applications of High-Throughput Technologies in Cancer
edited by Timothy P. Spicer and
submission deadline 31 Oct 2026 | Viewed by 211 | Submission Open
Keywords: solid tumors; high throughput screening (HTS); artificial intelligence; drug discovery; antibody–drug conjugates (ADCs); CAR T cells; bispecific T cell engagers (BiTEs)
(This special issue belongs to the Section Methods and Technologies Development)
Molecular Biology for Germ Cell Tumors
edited by
submission deadline 31 Oct 2026 | Viewed by 198 | Submission Open
Keywords: germ cell tumors; intratumoral heterogeneity; cancer stem cells; somatic transformation; extragonadal germ cells; subsequent malignant neoplasms
(This special issue belongs to the Section Molecular Cancer Biology)
Advances in MRI Applications for Neuro-Oncology submission deadline 31 Oct 2026 | Viewed by 198 | Submission Open
Keywords: brain tumors; magnetic resonance imaging; MRI field strength; quantitative MRI; radiomics; imaging biomarkers
Beyond Breast Cancer—Rehabilitation for Survivorship submission deadline 31 Oct 2026 | Viewed by 197 | Submission Open
Keywords: breast cancer; rehabilitation; person-centered: clinical follow-up; physiotherapy; psycho-social support; existential support; patient education and self-management
Progress in Skin Cancer: Diagnostics, Therapy, and Outcomes
edited by Marco Ardigo and Francesco Piscazzi
submission deadline 31 Oct 2026 | Viewed by 184 | Submission Open
Keywords: skin cancer; dermoscopy; reflectance confocal microscopy (RCM); line-field confocal optical coherence tomography (LC-OCT); non-invasive diagnostics; systemic therapy; locally advanced skin cancer; minimally invasive treatments; tumor prediction; clinical outcomes
Innovations in Pathological and Clinical Research in Colorectal Cancer submission deadline 31 Oct 2026 | Viewed by 179 | Submission Open
Keywords: colorectal cancer; clinicopathological prognostic biomarkers; pathology-guided therapeutic strategies
Biliary Tract Cancer: Challenges and Strategies in Centralizing Care for Rare Tumors
edited by Angela Lamarca
submission deadline 31 Oct 2026 | Viewed by 174 | Submission Open
Keywords: biliary tract cancer; centralization of care; recommendations
Hepatocellular Carcinoma—from Molecular Insight to Surgical Strategy
edited by
submission deadline 31 Oct 2026 | Viewed by 168 | Submission Open
Keywords: hepatocellular carcinoma (HCC); clinical diagnosis; molecular biology; biomarkers; surgical strategy; liver transplantation; prognosis
Optimizing Breast Cancer Treatment: Integration of Systemic Therapy, Surgical Innovation, and De-Escalation Strategies
edited by
submission deadline 31 Oct 2026 | Viewed by 164 | Submission Open
Keywords: breast cancer; chemotherapy; neoadjuvant therapy; adjuvant therapy; axillary management; surgical innovation; energy devices; de-escalation; personalized medicine; multidisciplinary care
Advances in Virus-Associated Head and Neck Cancer submission deadline 1 Nov 2026 | 3 articles | Viewed by 13827 | Submission Open
Keywords: onco-virus; virus-associated cancer; head and neck cancers; diagnosis; pathogenesis; epidemiology; prevalence; treatment; HPV; EBV
(This special issue belongs to the Section Infectious Agents and Cancer)
Urologic Cancer: Endoscopic, Laparoscopic, and Robot-Assisted Surgery Management (2nd Edition)
edited by Kouji Izumi
submission deadline 1 Nov 2026 | 1 articles | Viewed by 6113 | Submission Open
Keywords: prostate cancer; urothelial cancer; kidney cancer; adrenal cancer; transurethral technique; ureteroscopy; ureteral stent
(This special issue belongs to the Section Cancer Therapy)
Epigenetic Mechanisms Linking Aging and Cancer: Molecular Drivers, Hallmarks and Therapeutic Perspectives, with a Focus on Hepatocellular Carcinoma
edited by
submission deadline 1 Nov 2026 | 1 articles | Viewed by 1213 | Submission Open
Keywords: aging; cancer; epigenetics; life span; health span
Cellular Immunotherapy for Hematological Malignancies
edited by
submission deadline 1 Nov 2026 | Viewed by 252 | Submission Open
Keywords: cellular immunotherapy; CAR-T cell therapy; translational biomarkers; immune monitoring; cell manufacturing; hematological malignancies; clinical outcomes
(This special issue belongs to the Section Cancer Immunology and Immunotherapy)
New Perspectives on Claudins and Tight Junction Complexes: From Membrane Architecture to Targeted Cancer Therapy submission deadline 1 Nov 2026 | Viewed by 236 | Submission Open
Keywords: cancer; claudins; tight junction; metastasis; drug resistance; biomarkers; prognostic; tumour microenvironment; epithelial barrier function; epithelial–mesenchymal transition (EMT); targeted cancer therapy
(This special issue belongs to the Section Molecular Cancer Biology)
Pediatric Cancer Surgery—New Techniques and Innovations
edited by Elisabeth T. Tracy
submission deadline 2 Nov 2026 | Viewed by 184 | Submission Open
Keywords: pediatric cancer; solid tumor; surgical oncology; operative techniques; complex tumor; 3D modeling; intraoperative localization
(This special issue belongs to the Section Pediatric Oncology)
Immune Cells Within the Tumor Microenvironment
edited by Diego Carlos dos Reis
submission deadline 3 Nov 2026 | Viewed by 265 | Submission Open
Keywords: tumor microenvironment; tumor-infiltrating lymphocytes; macrophage polarization; T cell exhaustion; immune evasion; cancer immunotherapy; single-cell transcriptomics; spatial pathology; immune checkpoint; innate and adaptive immunity
(This special issue belongs to the Section Cancer Immunology and Immunotherapy)
Advances in Radiation Therapy for Brain Metastases
edited by Luis A. Pérez-Romasanta
submission deadline 5 Nov 2026 | 3 articles | Viewed by 4580 | Submission Open
Keywords: brain metastasis; metastatic brain tumor; imaging; radiotherapy; stereotactic radiosurgery; radiomics; machine learning; magnetic resonance imaging; positron emission tomography
(This special issue belongs to the Section Cancer Therapy)
Clinical and Molecular Biomarkers in Breast Cancer Management
edited by Zahi I. Mitri
submission deadline 5 Nov 2026 | 4 articles | Viewed by 4434 | Submission Open
Keywords: prognostic biomarkers; predictive biomarkers; molecular assays; therapeutics; special situations in breast cancer
(This special issue belongs to the Section Cancer Biomarkers)
Novel Insights into Glioma Immunotherapy
edited by
submission deadline 5 Nov 2026 | Viewed by 254 | Submission Open
Keywords: glioma immunotherapy; tumor microenvironment; immune evasion; microglia; checkpoint inhibitors; CAR‑T; neoantigen vaccines
(This special issue belongs to the Section Cancer Immunology and Immunotherapy)
Exosomes in Cancer Metastasis (2nd Edition) submission deadline 10 Nov 2026 | 3 articles | Viewed by 4983 | Submission Open
Keywords: exosomes; biomarkers; cancer metastasis
(This special issue belongs to the Section Cancer Metastasis)
Systematic Reviews and Meta-Analyses in Cancer Research: The Therapeutic Potential of Phytochemicals and Bioactive Compounds with Defined Mechanisms and Safety Profiles submission deadline 10 Nov 2026 | 1 articles | Viewed by 2182 | Submission Open
Keywords: phytochemicals in cancer therapy; bioactive natural compounds; systematic reviews and meta-analyses; molecular mechanisms of anticancer agents; translational oncology; pharmacokinetics and toxicity of natural products; evidence-based integrative oncology; natural product drug discovery; chemoprevention and cancer therapeutics; mechanistic and safety profiling of phytochemicals
(This special issue belongs to the Section Systematic Review or Meta-Analysis in Cancer Research)
Anticancer Drug Discovery and Development: Integrating Natural Compounds, Synthetic Chemistry, Nanotechnology and Computational Approaches
edited by Cheng-Hao Jin
submission deadline 12 Nov 2026 | Viewed by 204 | Submission Open
Keywords: anticancer drug development; natural compounds; synthetic chemistry; nanotechnology; cancer therapy
(This special issue belongs to the Section Cancer Drug Development)
Artificial Intelligence for Cancer Precision Medicine
edited by Chenyang Shen and
submission deadline 13 Nov 2026 | 1 articles | Viewed by 1314 | Submission Open
Keywords: artificial intelligence; cancer; radiomics
(This special issue belongs to the Section Methods and Technologies Development)
New Advances in Flow Cytometry: From Diagnosis to Disease Monitoring in Acute Leukemia
edited by , and Raffaele Palmieri
submission deadline 13 Nov 2026 | Viewed by 282 | Submission Open
Keywords: flow cytometry; multiparametric flow cytometry (MFC); acute leukemia; measurable residual disease (MRD); prognostic biomarker; MRD monitoring
Recent Advances in Endoscopic, Metabolomic, and Ultrasound Approaches to Gastrointestinal, Hepatic, and Pancreatic Tumors
edited by Ciprian Brisc and Nadim Al Hajjar
submission deadline 15 Nov 2026 | 2 articles | Viewed by 8129 | Submission Open
Keywords: gastrointestinal, hepatic and pancreatic tumors; metabolomics; endoscopy; ultrasound; elastography; molecular investigations and treatment; robotic surgery; laparoscopic surgery; early lesions; radiofrequency and microwave ablation; irreversible electroporation; cryoablation; targeted chemo- or radio-embolization
(This special issue belongs to the Section Cancer Therapy)
Molecular and Genetic Diagnosis and Targeted Therapy of Myeloproliferative Neoplasms (2nd Edition)
edited by and
submission deadline 15 Nov 2026 | 3 articles | Viewed by 6703 | Submission Open
Keywords: myeloproliferative neoplasm; chronic myeloid leukemia; polycythemia vera; essential thrombocythemia; primary myelofibrosis; MPN; CML; PMF; PV; ET
(This special issue belongs to the Section Molecular Cancer Biology)
Advances in Locoregional Therapies for Gastrointestinal Cancer Metastases submission deadline 15 Nov 2026 | 3 articles | Viewed by 3149 | Submission Open
Keywords: gastrointestinal cancer metastases; locoregional therapies; interventional radiology; endoscopy; radiation therapy; invasive operations; cytoreductive surgery (CRS); intraperitoneal chemotherapy (IP); heated intraperitoneal chemotherapy (HIPEC); tumor debulking; stereotactic body radiation therapy (SBRT); selective internal radiation therapy (SIRT)
(This special issue belongs to the Section Methods and Technologies Development)
Oncogenesis of Lymphoma (2nd Edition)
edited by and Giancarlo Pruneri
submission deadline 15 Nov 2026 | 1 articles | Viewed by 989 | Submission Open
Keywords: lymphomagenesis; molecular genetics; immunology; molecular virology; KSHV/HHV8; EBV; HIV; pathogenetic pathways; genotypic subgroups; tumor microenvironment; follicular lymphoma; mantle cell lymphoma; diffuse large B-cell lymphoma; targeted therapy; drug target
(This special issue belongs to the Section Molecular Cancer Biology)
Translational Research and Clinical Trials in Gastric Cancer: Advances and Future Directions
edited by Yanghee Woo
submission deadline 15 Nov 2026 | 1 articles | Viewed by 885 | Submission Open
Keywords: gastric cancer; multidisciplinary management; conversion gastrectomy; molecular biomarker testing; diagnostic laparoscopy; neoadjuvant therapy; upfront surgery; intraperitoneal treatment
(This special issue belongs to the Section Clinical Research in Cancer)
Gene Editing and Delivery for Cancer Therapy (2nd Edition)
edited by and
submission deadline 15 Nov 2026 | Viewed by 478 | Submission Open
Keywords: gene therapy; gene editing; gene delivery; oncolytic viruses; nanomaterial; peptides; nanostructures; exosomes; translational science
(This special issue belongs to the Section Cancer Therapy)
Targeting Head and Neck Cancer: From Tumor Microenvironment to Therapy Resistance
edited by and
submission deadline 15 Nov 2026 | Viewed by 477 | Submission Open
Keywords: head and neck squamous cell carcinoma (HNSCC); tumor microenvironment (TME); therapy resistance; HPV-associated cancers; immunotherapy; cancer-associated fibroblasts (CAFs); tumor heterogeneity; precision oncology; biomarkers; metastasis
Evaluating the Clinical Impact of Robotic Surgery in the Management of Colorectal Cancer
edited by and Miguel Leon-Arellano
submission deadline 15 Nov 2026 | Viewed by 450 | Submission Open
Keywords: robotic surgery; colorectal cancer; oncological outcomes; surgical technique; laparoscopic comparison; margin status; postoperative recovery; quality of life; intraoperative imaging; surgical navigation; learning curve; complications; cost-effectiveness; surgical training; technological innovation
(This special issue belongs to the Section Clinical Research in Cancer)
Impact of Anesthetic/Analgetic Drugs on Cancer Recurrence submission deadline 15 Nov 2026 | Viewed by 203 | Submission Open
Keywords: effect of amide-type local anesthetics; role of IV and analgesic drugs; opioids: pro or anti-cancer
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