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Cancers publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Immunoediting in Cancer Therapies

edited by

Vijay Kumar

submission deadline 28 Feb 2026 | 1 articles | Viewed by 2978 | Submission Open

Keywords: cancer; cancer immunology; immunosurveillance; immunoediting; immunotherapy; immunomodulation; immunometabolism

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

Cell Therapy in Hematological Malignancies

edited by

Francesco Gaudio

and

Stefano Martinotti

submission deadline 28 Feb 2026 | 1 articles | Viewed by 2362 | Submission Open

Keywords: cell therapy; immunotherapy; target therapy; hematological malignancies; tumor immunology

(This special issue belongs to the Section Cancer Therapy)

Heterogeneity in Intra-Cranial Tumors: Diagnostic, Prognostic, and Therapeutic Implications

edited by

Francois Ducray

, Shawn L. Hervey-Jumper and Thiebaud Picart

submission deadline 28 Feb 2026 | 1 articles | Viewed by 2358 | Submission Open

Keywords: glioma; histo-molecular classification; intra-tumoral heterogeneity; inter-tumoral heterogeneity; meningioma; neuro-oncology; neurosurgery

(This special issue belongs to the Section Cancer Metastasis)

Innovative and Personalized Approaches to Improve Patient Outcomes in Gynecological Oncology

edited by Anke Smits and James Dilley

submission deadline 28 Feb 2026 | 1 articles | Viewed by 2253 | Submission Open

Keywords: gynecological cancer; lifestyle; prehabilitation; rehabilitation; survival; quality of life

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

Advancements in Technologies for Radiation Biology, Oncology, and Protection

edited by

Zhixiang Wang

and

Yi Wang

submission deadline 28 Feb 2026 | 1 articles | Viewed by 2068 | Submission Open

Keywords: radiation biology; oncology; radiation protection; carcinogenesis; multi-omics; radiomics; radiotherapy; biodosimetry; adverse outcome pathway (AOP); personalized medicine

(This special issue belongs to the Section Cancer Informatics and Big Data)

Chronic Lymphocytic Leukemia: From Genetics to Therapy

edited by

Javier Loscertales-Pueyo

submission deadline 28 Feb 2026 | 3 articles | Viewed by 1911 | Submission Open

Keywords: chronic lymphocytic; leukemia treatment; biology

(This special issue belongs to the Section Cancer Therapy)

Predictive and Prognostic Biomarkers for Response to Neoadjuvant Chemotherapy for Breast Cancer

edited by Tarek M. A. Abdel-Fatah

submission deadline 28 Feb 2026 | 1 articles | Viewed by 1490 | Submission Open

Keywords: breast cancer; predictive and prognostic biomarkers; neoadjuvant chemotherapy; HER2-targeting agents; complete pathological response

(This special issue belongs to the Section Cancer Therapy)

MRI and Artificial Intelligence in Oncology: Current Research and Future Directions

edited by

Amita Shukla-Dave

and

Ramesh Paudyal

submission deadline 28 Feb 2026 | 1 articles | Viewed by 1446 | Submission Open

Keywords: MRI; AI; radiology; oncology; clinical trials

(This special issue belongs to the Section Methods and Technologies Development)

Advances in the Diagnosis and Treatment of Genitourinary Cancers (2nd Edition)

edited by Piotr Radziszewski and

Łukasz Zapała

submission deadline 28 Feb 2026 | 1 articles | Viewed by 1377 | Submission Open

Keywords: genitourinary cancer; point-of-care diagnostics; personalized treatment; immunotherapy

(This special issue belongs to the Section Cancer Therapy)

Clinical Research and Prognosis of HER2-Positive Breast Cancer

edited by

Pierfranco Conte

submission deadline 28 Feb 2026 | 1 articles | Viewed by 1296 | Submission Open

Keywords: HER2-positive breast cancer; targeted therapy; anti-HER2 therapy; long-term impacts; prognostic

(This special issue belongs to the Section Clinical Research of Cancer)

Evolution of Cancer Therapies: Access of Developing Countries to Modern Oncology

edited by

Salem Chouaib

submission deadline 28 Feb 2026 | 1 articles | Viewed by 1153 | Submission Open

Keywords: conventional cancer therapies; modern oncology; recission medicine; cancer immunotherapy; artificial intelligence; targeted agents; equity and globally equal access

(This special issue belongs to the Section Cancer Therapy)

Novel Approaches to Machine Learning and Artificial Intelligence in Cancer Research and Care (2nd Edition)

edited by

Caroline Chung

and Chris J. Gibbons

submission deadline 28 Feb 2026 | 2 articles | Viewed by 1088 | Submission Open

Keywords: machine learning; deep learning; artificial intelligence; interpretable AI; data quality; metadata; data quality; cancer; MLOps; data science; real-world data

(This special issue belongs to the Section Cancer Informatics and Big Data)

State-of-the-Art Research on Multiple Myeloma Progression: 2nd Edition

edited by

Shebli Atrash

submission deadline 28 Feb 2026 | 1 articles | Viewed by 920 | Submission Open

Keywords: multiple myeloma; novel targets; novel therapies; molecular therapy; immunotherapy

(This special issue belongs to the Section Cancer Therapy)

Advances in Choroidal Melanoma: From Treatment to Prognosis

edited by

Giovanni Paolino

submission deadline 28 Feb 2026 | 1 articles | Viewed by 905 | Submission Open

Keywords: melanoma; uveal; choroid; treatments; target; immunotherapy; genetics

(This special issue belongs to the Section Molecular Cancer Biology)

Risk of Skin Cancer: Non-Melanoma/Melanoma

edited by

Eggert Stockfleth

submission deadline 28 Feb 2026 | 1 articles | Viewed by 787 | Submission Open

Keywords: melanoma; non-melanoma skin cancer; keratinocyte cancer; Merkel cell carcinoma; UV exposure; immunosuppression; skin cancer prevention

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

Lung Cancer—Advances in Therapy and Prognostic Prediction

edited by Chinmay T. Jani and Estelamari Rodríguez

submission deadline 28 Feb 2026 | 1 articles | Viewed by 599 | Submission Open

Keywords: lung cancer; biomarkers; targeted therapies; immunotherapy; precision medicine

(This special issue belongs to the Section Cancer Biomarkers)

Precision Health Care and Interventions in Hereditary Breast and Ovarian Cancer and Lynch Syndrome (2nd Edition)

edited by

Maria C. Katapodi

submission deadline 28 Feb 2026 | Viewed by 596 | Submission Open

Keywords: breast cancer; ovarian Cancer; lynch Syndrome; precision healthcare

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

AI-Enhanced Radiotherapy in Oncology: Optimization from Planning to Clinical Impact

edited by Christian Fiandra and Linda Rossi

submission deadline 28 Feb 2026 | 1 articles | Viewed by 537 | Submission Open

Keywords: radiotherapy; oncology; artificial intelligence (AI); image segmentation; dose prediction and monitoring; deep learning; treatment planning optimization; adaptive radiotherapy; clinical decision support; personalized cancer treatment

(This special issue belongs to the Section Methods and Technologies Development)

Advances in PET/CT Application in Urological Cancer

edited by

Marco Roscigno

submission deadline 28 Feb 2026 | Viewed by 347 | Submission Open

Keywords: prostate cancer; urothelial cancer; kidney cancer; diagnosis; staging; treatment; PSMA PET CT; FDG PET CT; CAIX imaging

(This special issue belongs to the Section Cancer Therapy)

MYC Oncogene in Cancer: Cancer Cell Intrinsic and Immune Inhibitory Functions

edited by Wadie Mahauad Fernandez and Konstantinos V. Floros

submission deadline 28 Feb 2026 | Viewed by 292 | Submission Open

Keywords: MYC oncogene; molecular oncology; immuno-oncology; tumor microenvironment

(This special issue belongs to the Section Molecular Cancer Biology)

Image-Assisted High-Precision Radiation Oncology

edited by He C. Wang

submission deadline 28 Feb 2026 | Viewed by 212 | Submission Open

Keywords: medical imaging; radiation oncology; artificial intelligence; radiomics; adaptation; tumor response

(This special issue belongs to the Section Cancer Therapy)

Mitochondria and Cancer: From Hidden Culprits to Healing Targets

edited by

Nicola Amodio

and

Marianna Scrima

submission deadline 28 Feb 2026 | Viewed by 204 | Submission Open

Keywords: mitochondria; mitochondrial dynamics; cancer-associated mitochondrial defects; mitochondrial metabolism

(This special issue belongs to the Section Cancer Pathophysiology)

Advances in Radiotherapy for Gynecological Cancers

edited by Roxolyana Abdah-Bortnyak

submission deadline 28 Feb 2026 | Viewed by 198 | Submission Open

Keywords: gynecological cancer; radiotherapy; brachytherapy; IMRT; SBRT; adaptive radiotherapy; treatment planning; radiomics; toxicity management; quality of life; personalized medicine

(This special issue belongs to the Section Cancer Therapy)

Childhood Acute Lymphoblastic Leukemia

edited by Noriko Satake

submission deadline 28 Feb 2026 | Viewed by 185 | Submission Open

Keywords: childhood acute lymphoblastic leukemia; diagnosis; novel agents; targeted therapy; personalized medicine

(This special issue belongs to the Section Pediatric Oncology)

Drug Resistance Mechanisms and Tumor Microenvironment in Upper Gastrointestinal Cancers

edited by

Zheng Chen

and Heng Lu

submission deadline 28 Feb 2026 | Viewed by 147 | Submission Open

Keywords: drug resistance; tumor microenvironment; gastric cancer; esophageal cancer; immunotherapy; targeted therapy; biomarkers; precision medicine

(This special issue belongs to the Section Tumor Microenvironment)

The Genetics of Head and Neck Squamous Cell Carcinoma

edited by

Sabrina Daniela da Silva

submission deadline 28 Feb 2026 | Viewed by 139 | Submission Open

Keywords: head and neck squamous cell carcinoma; tumor genetics; genomic profiling; precision oncology; biomarkers; tumor microenvironment; epigenetics; somatic mutations; molecular pathways; targeted therapies

(This special issue belongs to the Section Molecular Cancer Biology)

Clinical Application of Proton Pencil Beam Scanning Radiotherapy in Cancer

edited by Pavel Vítek

submission deadline 28 Feb 2026 | Viewed by 133 | Submission Open

Keywords: proton radiotherapy; pencil beam scanning; randomized trial; dosimetry; plan robustness; LET— linear energy transfer; RBE— radiobiologic equivalence; lymphocyte; immunologic reaction

(This special issue belongs to the Section Clinical Research of Cancer)

Epigenetic and Chromatin Alterations in Hematologic Malignancies

edited by Mineko Terao and

Enrico Garattini

submission deadline 28 Feb 2026 | Viewed by 120 | Submission Open

Keywords: myelodysplastic syndrome; acute myeloid leukemia; epigenetics; chromatin alterations; leukemogenesis

(This special issue belongs to the Section Cancer Pathophysiology)

Novel Drugs for Treating Gynecologic Cancers: 2nd Edition

edited by

Tadahiro Shoji

and

Hiroaki Itamochi

submission deadline 28 Feb 2026 | Viewed by 112 | Submission Open

Keywords: gynecological cancers; novel treatment strategies; cytotoxic chemotherapeutic agents; molecularly targeted agents; immune-checkpoint inhibitors

(This special issue belongs to the Section Cancer Drug Development)

Neoadjuvant Immunotherapy in Genitourinary Tumors (2nd Edition)

edited by

Antonio Tufano

, Nadia Cordua and

Antonio Giordano

submission deadline 28 Feb 2026 | Viewed by 112 | Submission Open

Keywords: immunotherapy; immune checkpoint inhibitor; bladder cancer; urothelial cancer; kidney cancer; renal cell carcinoma; prostate cancer; testicular cancer; penile cancer; adrenocortical carcinoma

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

Mechanistic Insights and Therapeutic Advances in the Prostate Tumor Microenvironment

edited by Omar E. Franco

submission deadline 28 Feb 2026 | Viewed by 71 | Submission Open

Keywords: prostate stromal cells; tumor microenvironment; stromal– epithelial interactions; extracellular matrix; tumor immune evasion; metabolic reprogramming; hypoxia; single-cell data analysis; in vitro/in vivo model systems; carcinoma-associated fibroblasts (CAFs)

(This special issue belongs to the Section Tumor Microenvironment)

The Role of Regucalcin in Cancer

edited by

Masayoshi Yamaguchi

submission deadline 1 Mar 2026 | 2 articles | Viewed by 3373 | Submission Open

Keywords: cancer suppressor protein; cell signaling; metabolic regulation; transcription factor; cell proliferation; cell death; drug development; cancer therapy

(This special issue belongs to the Section Tumor Microenvironment)

Lynch Syndrome (HNPCC): Symptoms, Causes, and Outlooks

edited by

Francesca Duraturo

submission deadline 1 Mar 2026 | Viewed by 608 | Submission Open

Keywords: Lynch syndrome; genotype– phenotype correlation; highly immunogenic frame-shift neo-peptides; immunotherapy; mismatch repair genes; unclassified genetic variants; new role of MMR proteins; miRNAs; functional assay MMR deficiency

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

Brain and Spinal Cord Tumors: Symptoms, Diagnosis and Treatment—2nd Edition

edited by

Alberto Feletti

and

Takashi Sugawara

submission deadline 1 Mar 2026 | Viewed by 165 | Submission Open

Keywords: brain; spinal cord; primary tumors; metastases; imaging; neuro-oncology

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

Castration-Resistant Prostate Cancer: Progress and Promise: 2nd Edition

edited by

Shiv Verma

Vaibhav Singh

and

Man Mohan

submission deadline 1 Mar 2026 | Viewed by 129 | Submission Open

Keywords: castrate-resistant prostate cancer (CRPC); prostate cancer; treatment; a new therapy; drug-resistant; marker genes; bone metastasis; androgen receptor (AR); enzalutamid; e abiraterone acetate; Docetaxel

(This special issue belongs to the Section Cancer Therapy)

Prognostic and Predictive Markers in Gynecological Cancers

edited by Anna Plotkin

submission deadline 1 Mar 2026 | Viewed by 78 | Submission Open

Keywords: biomarker; gynecological cancer; management; prognostic marker; predictive marker; personalized medicine

(This special issue belongs to the Section Cancer Biomarkers)

Quality of Care for Patients with Head and Neck Cancer

edited by Khara Marissa Sauro

submission deadline 1 Mar 2026 | Viewed by 78 | Submission Open

Keywords: patient safety; treatment delays; healthcare resource use; effectiveness; health economics; continuity of care; outcomes research

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

Fertility Preservation and Hormonal Health in Oncology

edited by

Amelia Barcellini

and

Chiara Cassani

submission deadline 6 Mar 2026 | 2 articles | Viewed by 869 | Submission Open

Keywords: oncofertility; fertility preservation; hormonal health; cancer survivorship; reproductive oncology

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

Immunotherapy for Skin Cancers

edited by

Reinhard Dummer

and Lara Valeska Maul-Duwendag

submission deadline 10 Mar 2026 | 3 articles | Viewed by 6175 | Submission Open

Keywords: melanoma; non-melanoma skin cancer; merkel cell carcinoma; kaposi sarcoma; cutaneous angi-osarcoma; immune checkpoint; immunotherapy

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

RAS Proteins and Their Regulators in Human Cancer

edited by Zhiwei Zhou

submission deadline 10 Mar 2026 | Viewed by 185 | Submission Open

Keywords: RAS; RAS regulators; RAS-driven diseases; RAS-targeting therapy

(This special issue belongs to the Section Cancer Therapy)

Study on Clinical Treatment of Brain Tumors

edited by Shinya Watanabe

submission deadline 13 Mar 2026 | 3 articles | Viewed by 6421 | Submission Open

Keywords: brain tumors; clinical treatment; anti-tumor drugs; clinical trials

(This special issue belongs to the Section Cancer Therapy)

Molecular Pathology of Brain Tumors

edited by Ho-Keung NG

submission deadline 15 Mar 2026 | 10 articles | Viewed by 30340 | Submission Open

Keywords: molecular pathology; brain tumors; AI; biomarkers; histopathology

(This special issue belongs to the Section Molecular Cancer Biology)

State of the Art: Cardiothoracic Tumors

edited by

Calvin Sze Hang Ng

and Panagiotis Tasoudis

submission deadline 15 Mar 2026 | 5 articles | Viewed by 12149 | Submission Open

Keywords: lung cancer; non-small cell lung cancer; esophageal cancer; diagnostic imaging; robotic-assisted thoracoscopic surgery; video-assisted thoracoscopic surgery; immunotherapy; radiotherapy; molecular oncology; lung cancer screening

(This special issue belongs to the Section Cancer Therapy)

Breast Cancer Survivorship: Challenges and Innovations from Treatment to Long-Term Care

edited by Médéa Locquet

submission deadline 15 Mar 2026 | 6 articles | Viewed by 7621 | Submission Open

Keywords: breast cancer survivorship; cancer treatments; late effects: societal impact; supportive care; psychosocial well-being; cancer treatment optimization; interventions

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

Novel Approaches to the Management of Patients with Gastrointestinal Tumors

edited by Javier Rodriguez and Ignacio Matos García

submission deadline 15 Mar 2026 | 3 articles | Viewed by 3688 | Submission Open

Keywords: clinical management; gastric cancer; colorectal cancer; predictive factors; novel therapies; artificial intelligence

(This special issue belongs to the Section Methods and Technologies Development)

Robot-Assisted Surgery for Urologic Cancer

edited by Gabriele Sorce, Francesco Pellegrino and Ettore Di Trapani

submission deadline 15 Mar 2026 | 3 articles | Viewed by 3417 | Submission Open

Keywords: robot-assisted surgery; urologic oncology; minimally invasive surgery; prostate cancer surgery; kidney cancer surgery; bladder cancer surgery; robotic platforms; robotic surgery training

(This special issue belongs to the Section Cancer Therapy)

Advances in Artificial Intelligence Methodologies and Applications in Cancer

edited by Jennifer G. Le-Rademacher and

Nicholas Larson

submission deadline 15 Mar 2026 | 3 articles | Viewed by 3375 | Submission Open

Keywords: artificial intelligence (AI); AI tools; cancer research; diagnostic tools; medical imaging; biomarkers; ethical considerations; patient care

(This special issue belongs to the Section Methods and Technologies Development)

Advances in the Treatment of Relapsed and Refractory Multiple Myeloma: Novel Agents, Immunotherapies and Beyond: 2nd Edition

edited by

Klaus Podar

and

Xavier Leleu

submission deadline 15 Mar 2026 | 2 articles | Viewed by 2938 | Submission Open

Keywords: myeloma relapse setting; drug development; treatment sequences; immunotherapy

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

Radiotherapy for Sarcoma

edited by Safia K. Ahmed and Miranda Lam

submission deadline 15 Mar 2026 | 3 articles | Viewed by 2403 | Submission Open

Keywords: soft tissue sarcoma; bone sarcoma; advanced sarcoma; radiation therapy; particle therapy; multidisciplinary sarcoma care

(This special issue belongs to the Section Cancer Therapy)

Advances in Lung Cancer Treatment Strategies

edited by

Alessandro Gonfiotti

and

Alice Ravasin

submission deadline 15 Mar 2026 | 1 articles | Viewed by 971 | Submission Open

Keywords: lung cancer; immunotherapy; immune checkpoint inhibitors; chemoimmunotherapy; target therapy; biomarkers; non-small cell lung cancer; precision medicine

(This special issue belongs to the Section Cancer Therapy)

Displaying special issue 401-450 on page 9 of 24.

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