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Cancers publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Optimizing Surgical Procedures and Enhancing Outcomes in the Management of Gastrointestinal Cancer

edited by Tim Strate and

Jonas Herzberg

submission deadline 31 Dec 2025 | Viewed by 227 | Submission Open

Keywords: gastrointestinal malignancies; surgical oncology; postoperative outcome; quality of life; anastomotic leakage; anastomotic technique; HIPEC; PIPAC

(This special issue belongs to the Section Cancer Therapy)

Advances in Breast Cancer Imaging: From Detection to Personalized Diagnosis

edited by

Nuno Matela

and

Ana Margarida Mota

submission deadline 31 Dec 2025 | Viewed by 218 | Submission Open

Keywords: breast cancer imaging; artificial intelligence; radiomics; deep learning; personalized diagnosis; multimodal imaging; predictive modeling; early detection; treatment response; clinical applications

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

Artificial Intelligence (AI), Robotics, and Cancer Surgery

edited by Zaid M. Abdelsattar

submission deadline 31 Dec 2025 | Viewed by 208 | Submission Open

Keywords: cancer surgery; artificial intelligence; robotics surgery; surgical outcome; decision-making

(This special issue belongs to the Section Methods and Technologies Development)

The Role of Anatomical Resections in Secondary Lung Cancer: Indications, Techniques, and Outcomes

edited by

Andrea Dell'Amore

and

Alessio Campisi

submission deadline 31 Dec 2025 | Viewed by 204 | Submission Open

Keywords: anatomical resections; segmentectomy; lobectomy; secondary lung cancer; pulmonary metastases; thoracic surgery; minimally invasive surgery; surgical outcomes; lung neoplasms; personalized treatment

(This special issue belongs to the Section Clinical Research of Cancer)

Oxidative Stress-Mediated Regulation of Specific Signaling Pathways in Skin Cancers

edited by

Sanjay Premi

and

Jyoti Srivastava

submission deadline 31 Dec 2025 | Viewed by 197 | Submission Open

Keywords: reactive oxygen species; reactive nitrogen species; oxidative stress; epigenetic regulation; UV-exposure; skin pigmentation; skin cancer; melanoma

(This special issue belongs to the Section Cancer Epidemiology and Prevention)

Clinical and Biological Studies of Pediatric Adrenocortical Tumors, Pheochromocytomas and Paragangliomas

edited by

Ronald R. de Krijger

, Verena Wiegering and

Maria Candida Barisson Villares Fragoso

submission deadline 31 Dec 2025 | Viewed by 196 | Submission Open

Keywords: adrenal gland; pheochromocytoma; paraganglioma; adrenocortical adenoma; adrenocortical carcinoma; pediatric; adrenal tumor

(This special issue belongs to the Section Pediatric Oncology)

Head and Neck Cancer Surgery and Rehabilitation: A Bridge Between Medicine and Dentistry for Reconstruction with Regeneration

edited by

Shahram M. Ghanaati

and Samuel Ebele Udeabor

submission deadline 31 Dec 2025 | Viewed by 184 | Submission Open

Keywords: oral squamous cell carcinoma; oral cancer; head and neck cancer; odontogenic tumors; OSCC management; tumor recurrence; tumor metastasis; adjuvant therapy; biomaterials for maxillofacial reconstruction; tissue regeneration; cancer rehabilitation

(This special issue belongs to the Section Cancer Therapy)

Cancers in Chronic HIV Infection

edited by Diego Ripamonti

submission deadline 31 Dec 2025 | Viewed by 179 | Submission Open

Keywords: cancer; HIV; AIDS; cancer screening; hematologic malignancy; Kaposi sarcoma; HPV; anal cancer; lymphoma

(This special issue belongs to the Section Infectious Agents and Cancer)

Neoadjuvant Chemotherapy in Pancreatic Cancer

edited by

Casper H. J. Van Eijck

submission deadline 31 Dec 2025 | Viewed by 172 | Submission Open

Keywords: neoadjuvant chemotherapy; pancreatic cancer; treatment decision

(This special issue belongs to the Section Cancer Therapy)

New Insights in Parotid Tumors

edited by Chiara Gaudino and Stefan Rohde

submission deadline 31 Dec 2025 | Viewed by 166 | Submission Open

Keywords: advanced imaging in parotid tumors; artificial intelligence tools; parotid gland surgery; facial nerve preservation and reconstruction; chemotherapy in parotid gland malignant tumors; radiotherapy and proton therapy in malignant parotid gland tumors

(This special issue belongs to the Section Cancer Therapy)

New Insights into Pheochromocytoma and Paraganglioma

edited by

Wolfgang Raber

submission deadline 31 Dec 2025 | Viewed by 162 | Submission Open

Keywords: pheochromocytoma; paraganglioma; diagnosis; genetics; imaging; long-term follow-up; standards

(This special issue belongs to the Section Clinical Research of Cancer)

Advanced Research in Surgical Treatment for Spinal Tumors

edited by Alessandro Gasbarrini, Stefano Bandiera and

Giuseppe Tedesco

submission deadline 31 Dec 2025 | Viewed by 160 | Submission Open

Keywords: spine oncology; primary tumors; metastatic tumors; spondylectomy; en bloc resection; minimally invasive surgery; anterior reconstruction; biomaterials; radiosurgery; electrochemotherapy

(This special issue belongs to the Section Cancer Therapy)

Contemporary Trends and Advances in Minimally Invasive and Endoscopic Management of Genitourinary Malignancies

edited by

Francesco Del Giudice

submission deadline 31 Dec 2025 | Viewed by 150 | Submission Open

Keywords: robotic surgery; laparoscopic surgery; endourology; urologic oncology; prostate cancer; urothelial cancer; kidney cancer; testicular cancer; single-port surgery; image-guided surgery; surgical outcomes; oncologic outcomes; advanced surgical techniques; precision medicine

(This special issue belongs to the Section Cancer Therapy)

Advances in Genitourinary Cancer: Biomarkers, Immunotherapy and Novel Therapeutics

edited by Lingbin Meng

submission deadline 31 Dec 2025 | Viewed by 148 | Submission Open

Keywords: genitourinary cancer; biomarkers; immunotherapy; targeted therapy; chemotherapy; drug resistance; tumor microenvironment; liquid biopsy; ctDNA; precision oncology

(This special issue belongs to the Section Cancer Therapy)

Faulty Ribosome Biogenesis and Cancer: Mechanisms and Therapeutic Perspectives

edited by

Paola Bellosta

submission deadline 31 Dec 2025 | Viewed by 144 | Submission Open

Keywords: ribosome biogenesis; ribosomal proteins; nucleolar stress; genomic instability; oncoribosome; ribosomapathies; ribosome-targeting drugs; cancer biomarkers; animal models

(This special issue belongs to the Section Cancer Biomarkers)

Hippo Signaling in Cancer (2nd Edition)

edited by

Michel Ouellette

and

Ying Yan

submission deadline 31 Dec 2025 | Viewed by 130 | Submission Open

Keywords: Hippo signaling; Salvador– Warts– Hippo (SWH) pathway; YAP/TAZ; cancer development; progression; metastasis; therapeutic resistance

(This special issue belongs to the Section Tumor Microenvironment)

Advances in Minimally Invasive Surgery for Colorectal Cancer

edited by Jonathan S. Abelson and Christine A. Schad

submission deadline 31 Dec 2025 | Viewed by 117 | Submission Open

Keywords: colorectal cancer; minimally invasive surgery; endoscopic surgery; endoluminal surgery; laparoscopic surgery; ro-botic surgery; single incision laparoscopic surgery; postoperative outcomes; survival

(This special issue belongs to the Section Cancer Therapy)

Modern Neurosurgical Management of Gliomas

edited by

Arthur Wagner

and

Chiara Negwer

submission deadline 31 Dec 2025 | Viewed by 100 | Submission Open

Keywords: precision medicine; personalized oncological surgery; intraoperative imaging; fluorescence-guided surgery; intraoperative histopathology; liquid biopsy; minimally invasive oncological surgery; radiosurgery

(This special issue belongs to the Section Cancer Therapy)

ALK in Cancer: Lessons from the Future (2nd Edition)

edited by

Petros Christopoulos

and

Richard Bayliss

submission deadline 31 Dec 2025 | Viewed by 99 | Submission Open

Keywords: ALK inhibitors; ALK fusion variants; TP53 mutations; immunotherapy; liquid biopsies; disease monitoring; therapeutic sequencing

(This special issue belongs to the Section Cancer Pathophysiology)

Oncogenetics of Colorectal Cancer (2nd Edition)

edited by

Muhammad Kibriya

and Marc Bissonnette

submission deadline 31 Dec 2025 | Viewed by 96 | Submission Open

Keywords: colorectal carcinoma; somatic mutation; microsatellite instability; methylation; copy number change; tumor-infiltrating leukocyte; immune checkpoint inhibitor; drug resistance; cell-free DNA

(This special issue belongs to the Section Cancer Pathophysiology)

Patients’ Perspective in Gynecological Cancer

edited by

Jalid Sehouli

submission deadline 31 Dec 2025 | Viewed by 91 | Submission Open

Keywords: patient perspective; expectations; PROMs; quality of life; best supportive care

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

Leukemia Cell Signaling Pathways: Recent Advances, Future Perspectives, and Potential Clinical Applications

edited by

Bac Viet Le

and

Srinivas Chatla

submission deadline 31 Dec 2025 | Viewed by 86 | Submission Open

Keywords: leukemia; cell signaling; bone marrow microenvironment; leukemic transformation; drug resistance; therapeutic discovery; cell signaling inhibitors; precision medicine

(This special issue belongs to the Section Tumor Microenvironment)

Tumor Microenvironment of Gynecological Tumors

edited by

Zahid Pranjol

and

Dmitry Aleksandrovich Zinovkin

submission deadline 10 Jan 2026 | 1 articles | Viewed by 395 | Submission Open

Keywords: tumor microenvironment; gynecological cancers; immunomodulation; cancer-associated fibroblasts; angiogenesis; cancer-like stem cells; extracellular matrix; immune evasion; cell signaling; therapeutics

(This special issue belongs to the Section Tumor Microenvironment)

The Role of Flow Cytometry in Hematologic Malignancies

edited by

Kristy Wolniak

and Lucy Fu

submission deadline 12 Jan 2026 | Viewed by 118 | Submission Open

Keywords: flow cytometry; hematology; oncology; malignancy; lymphoma; leukemia; pathology; innovation; methodology; diagnosis

(This special issue belongs to the Section Methods and Technologies Development)

Neoadjuvant Therapy of Breast Cancer

edited by

Hiroyuki Takei

and Takaaki Fujii

submission deadline 15 Jan 2026 | 9 articles | Viewed by 19870 | Submission Open

Keywords: neoadjuvant systemic therapy; chemotherapy; endocrine therapy; molecular targeted therapy; molecular subtypes; response-guided therapy; clinical trials

(This special issue belongs to the Section Cancer Therapy)

Cervical Cancer: Study on Molecular Landscape and Protein Biomarkers. Current Diagnostic and Therapeutic Capabilities

edited by

Christopher Kobierzycki

and

Piotr Dzięgiel

submission deadline 15 Jan 2026 | 6 articles | Viewed by 12122 | Submission Open

Keywords: cervical cancer; cervical dysplasia; human papilloma virus (HPV); tumor markers; cancerogenesis; genotyping

(This special issue belongs to the Section Molecular Cancer Biology)

Clinical and Research Progress in the Resection of Gastro-Esophageal Cancer

edited by Biniam Kidane

submission deadline 15 Jan 2026 | 5 articles | Viewed by 8297 | Submission Open

(This special issue belongs to the Section Clinical Research of Cancer)

Novel Advances in the Molecular Understanding of Myeloproliferative Neoplasms (MPNs)

edited by Wei Chen, Fei Li and

Qiang Jeremy Wen

submission deadline 15 Jan 2026 | 3 articles | Viewed by 5285 | Submission Open

Keywords: MPNs; ET; PV; PMF; post-PV-MF; post-ET-MF; MDS/MPN; JAK2

(This special issue belongs to the Section Molecular Cancer Biology)

Recent Advances in Liquid Biopsy Biomarkers of Cancer

edited by

Hua-Jun He

submission deadline 15 Jan 2026 | 2 articles | Viewed by 1810 | Submission Open

Keywords: liquid biopsy; circulating tumor cells; circulating tumor DNA; extracellular vesicles; circulating RNA; cfDNA methylation; fragmentome; reference material; miRNA; multi-cancer detection

(This special issue belongs to the Section Cancer Biomarkers)

Circulating Tumour DNA and Liquid Biopsy in Oncology

edited by

Yafeng Ma

and Kevin Spring

submission deadline 15 Jan 2026 | 2 articles | Viewed by 1624 | Submission Open

Keywords: cell-free DNA; circulating tumour DNA; liquid biopsy; mutation status; tumour mutational burden; methylation detection; fragmentomics; minimal residual disease; early detection

(This special issue belongs to the Section Cancer Biomarkers)

Cell Biology of Cancer Invasion: 2nd Edition

edited by

Hideki Yamaguchi

submission deadline 15 Jan 2026 | 1 articles | Viewed by 1344 | Submission Open

Keywords: invasion; metastasis; intravasation; extravasation; invadopodia; tumor microenvironment; epithelial– mesenchymal transition; cell migration; cytoskeleton; cell adhesion; extracellular matrix; matrix metalloprotease; cancer-associated fibroblast; tumor-associated macrophage

(This special issue belongs to the Section Cancer Metastasis)

The Survival of Colon and Rectal Cancer (2nd Edition)

edited by

Susanne Merkel

submission deadline 15 Jan 2026 | 1 articles | Viewed by 604 | Submission Open

Keywords: colorectal cancer; colorectal cancer surgery; multidisciplinary treatment; survival; prognostic factors; distant metastasis; locoregional recurrences; standardisation; individualisation

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

Updates on Urothelial Carcinoma

edited by

Toyonori Tsuzuki

and Yasmin Abu-Ghanem

submission deadline 15 Jan 2026 | Viewed by 160 | Submission Open

Keywords: urothelial carcinoma; systemic therapy; molecular biomarkers; personalized medicine

(This special issue belongs to the Section Cancer Therapy)

Pediatric Cancer Research from Basic Biology to Experimental Therapy

edited by

Atif Ahmed

submission deadline 16 Jan 2026 | 3 articles | Viewed by 8396 | Submission Open

Keywords: pediatric tumors; solid cancers; leukemias; cancer predisposition syndromes; genetics; omics; immunotherapy; therapy resistance

(This special issue belongs to the Section Pediatric Oncology)

Survivorship Following Childhood, Adolescent and Young Adult Cancer

edited by Magdalena Balcerek and Judith Gebauer

submission deadline 20 Jan 2026 | 1 articles | Viewed by 1720 | Submission Open

Keywords: cancer survivorship; late effects; long-term follow-up care; supportive care; health prevention and promotion

(This special issue belongs to the Section Pediatric Oncology)

Cancer Cell Vulnerabilities on Pathways Regulating the Cell Cycle

edited by

Hiroaki Kiyokawa

submission deadline 20 Jan 2026 | Viewed by 272 | Submission Open

Keywords: cell cycle; signaling pathway; precision medicine

(This special issue belongs to the Section Molecular Cancer Biology)

Recent Trends in the Development of Theranostics and Multifunctional Tracers in Oncology

edited by

Olaf Prante

submission deadline 20 Jan 2026 | Viewed by 142 | Submission Open

Keywords: multifunctional radiopharmaceuticls; PET/CT; multimodal imaging; cancer treatment

(This special issue belongs to the Section Methods and Technologies Development)

The Prospect of Nanobiotechnology in Cancers

edited by

Wenpan Li

submission deadline 20 Jan 2026 | Viewed by 137 | Submission Open

Keywords: nanobiotechnology; cancer therapy; targeted drug delivery; tumor microenvironment

(This special issue belongs to the Section Methods and Technologies Development)

Recent Updates on Imaging and Staging of Gynecologic Cancers

edited by

David Mutch

and Alexander B. Olawaiye

submission deadline 21 Jan 2026 | 2 articles | Viewed by 1701 | Submission Open

Keywords: imaging; surgical staging; molecular prognostic features; mortality; prognosis

(This special issue belongs to the Section Methods and Technologies Development)

Roles of the Tumor Microenvironment on Liquid Biopsy (2nd Edition)

edited by

Dario Marchetti

submission deadline 22 Jan 2026 | Viewed by 267 | Submission Open

Keywords: liquid biopsy; CTCs; CTC characterization and CTC clustering; ctDNA and ctDNA profiling; exosomes/extracellular vesicles and biology; tumor microenvironment; bone marrow cellular/molecular heterogeneity; CTCs/blood/BM cells crosstalk; analytical validity; clinical validity; and clinical utility of liquid biopsy; liquid biopsy interplaying dormancy and metastasis

(This special issue belongs to the Section Tumor Microenvironment)

Advancements in Salivary Gland Tumors Management: From Diagnostic Imaging to Treatment Strategies

edited by Wioletta Pietruszewska, Małgorzata Wierzbicka and

Boguslaw Mikaszewski

submission deadline 22 Jan 2026 | Viewed by 175 | Submission Open

Keywords: salivary gland tumors; MRI; CT; and PET; minimally invasive approaches

(This special issue belongs to the Section Cancer Therapy)

Innovative Immunotherapies: CAR-T Cell Therapy for Cancers: 2nd Edition

edited by

Shebli Atrash

submission deadline 23 Jan 2026 | 3 articles | Viewed by 1685 | Submission Open

Keywords: CAR-T; NK-CAR; immunotherapy; cancer; resistance mechanisms

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

Targeting Hallmarks of Cancer

edited by

Carlos Pérez Plasencia

submission deadline 25 Jan 2026 | Viewed by 675 | Submission Open

Keywords: epigenetic regulators; organotypic culture models; anticancer drugs; hallmarks of cancer

(This special issue belongs to the Section Cancer Biomarkers)

Towards a Personalized Medicine for the Diagnosis and Management of Gynecological Cancers

edited by

Diego Raimondo

and Gabriele Centini

submission deadline 30 Jan 2026 | 3 articles | Viewed by 14273 | Submission Open

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

The Advance of Pencil Beam Scanning Proton Beam Therapy in Cancers

edited by

Haibo Lin

, Richard A. Amos and Heng Li

submission deadline 30 Jan 2026 | 7 articles | Viewed by 13821 | Submission Open

Keywords: proton therapy; pencil beam scanning; robustness; adaptive radiotherapy; imaging guidance; radiobiological model; FLASH radiotherapy; spatially fractionated radiotherapy (SFRT); proton arc

(This special issue belongs to the Section Cancer Therapy)

Cancer Disparities: Biological, Social, and Environmental Determinants

edited by

Riffat Mehboob

and

Miguel Muñoz

submission deadline 30 Jan 2026 | 3 articles | Viewed by 3654 | Submission Open

Keywords: cancer epidemiology; cancer etiology; environmental factors; screening and diagnostics; SDGs

(This special issue belongs to the Section Cancer Epidemiology and Prevention)

Advances in the Treatment of Upper Gastrointestinal Cancer

edited by Sang-ho Jeong and

Jae-seok Min

submission deadline 30 Jan 2026 | 2 articles | Viewed by 2999 | Submission Open

Keywords: upper gastrointestinal cancer; surgery therapy; chemotherapy therapy; radiation therapy

(This special issue belongs to the Section Cancer Therapy)

Metastasis in Tumor Immunity: Current Perspectives

edited by

Ulrike Stein

, Sebastian Torke and

Wolfgang Walther

submission deadline 30 Jan 2026 | Viewed by 156 | Submission Open

Keywords: immune escape; immune evasion; immune microenvironment; intervention strategies; senescence on metastasis; anti-tumor immunity; cellular interactions; molecular interactions; immune suppression; immune checkpoints

(This special issue belongs to the Section Cancer Metastasis)

Protein Structure and Cancer—2nd Edition

edited by

Michalis Aivaliotis

submission deadline 30 Jan 2026 | Viewed by 150 | Submission Open

Keywords: protein structure dynamics; structural cancer biology; protein pathways in cancer; structure– function alterations; in silico protein structure prediction; protein interactions; cancer mutations and protein structure alterations

(This special issue belongs to the Section Molecular Cancer Biology)

How COVID-19 Affects Cancer Patients

edited by

Maria Fiore

submission deadline 31 Jan 2026 | 15 articles | Viewed by 28462 | Submission Open

Keywords: COVID-19; pandemic; cancer; impact; incidence; mortality; lethality; disparities; gender

(This special issue belongs to the Section Cancer Epidemiology and Prevention)

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