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Cancers publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Stereotactic Body Radiation and Stereotactic Ablative Radiotherapy Therapy for Cancers 2nd edition

edited by

Sam Beddar

and Michael D. Chuong

submission deadline 31 Dec 2025 | 3 articles | Viewed by 2436 | Submission Open

Keywords: radiation therapy (oncology); stereotactic body radiation therapy (SBRT) and stereotactic ablative radiotherapy (SABR); ultra-hypofractionated and hypofractionated studies; ablative/dose-escalated studies; SBRT; SABR; and cyberknife technology; MRI guidance; tumor motion techniques and management; frame and frameless immobilization devices; SBRT/SABR dose constraints and toxicities; artificial intelligence/machine learning

(This special issue belongs to the Section Cancer Therapy)

Feature Papers in Section “Methods and Technologies Development” in 2025

edited by

Damiano Caruso

and

Marta Zerunian

submission deadline 31 Dec 2025 | 1 articles | Viewed by 2425 | Submission Open

Keywords: innovative diagnostic technology; artificial intelligence; cancer diagnosis; personalized treatment; diagnostic and therapeutic strategies

(This special issue belongs to the Section Methods and Technologies Development)

New Insights into Kidney Disease Development and Therapy Strategies

edited by

José I. López

and

Claudia Manini

submission deadline 31 Dec 2025 | 1 articles | Viewed by 2410 | Submission Open

(This special issue belongs to the Section Cancer Therapy)

Latest Advancements in Health-Related Quality of Life Research in Cancer Survivorship (2nd Edition)

edited by

Richard Crevenna

and

Thomas Licht

submission deadline 31 Dec 2025 | 3 articles | Viewed by 2408 | Submission Open

Keywords: cancer survivors; oncology; psycho-oncology; health-related quality of life; patient-reported outcome measures; self-report

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

Advances in Ovarian Cancer Treatment: Past, Present and Future

edited by Dimitrios Tsolakidis and Dimitrios Zouzoulas

submission deadline 31 Dec 2025 | 1 articles | Viewed by 2213 | Submission Open

Keywords: ovarian cancer; cytoreductive surgery; HIPEC; chemotherapy; immunotherapy

(This special issue belongs to the Section Cancer Therapy)

Multidisciplinary Treatment with Surgery and Chemotherapy of Liver Metastases from Colorectal Cancer

edited by

Luca Viganò

and Pietro Majno

submission deadline 31 Dec 2025 | 1 articles | Viewed by 2201 | Submission Open

Keywords: colorectal liver metastases; liver surgery; oncology; multidisciplinary approach; prognosis; recurrence; precision medicine; genetics; tumor biology; liver transplantation; perioperative therapy and conversion therapy

(This special issue belongs to the Section Cancer Therapy)

Fertility Preservation in Gynecological Cancer

edited by

Giuseppe Gullo

and

Luigi Della Corte

submission deadline 31 Dec 2025 | 1 articles | Viewed by 2175 | Submission Open

Keywords: gynecological cancer; fertility preservation; surgery treatments; fertility sparing; psychological implication

(This special issue belongs to the Section Methods and Technologies Development)

Next-Generation Cancer Therapies

edited by

Achilleas Mitrakas

, Ioannis Lamprou and Erasmia Xanthopoulou

submission deadline 31 Dec 2025 | 2 articles | Viewed by 2123 | Submission Open

Keywords: cancer; current therapies; cancer cells metabolism; autophagy; immunotherapy; targeted treatments; oncolytic viruses; vaccines

(This special issue belongs to the Section Cancer Therapy)

Novel Therapeutic Targets for Metastatic Lung Cancer

edited by

Andrea De Giglio

submission deadline 31 Dec 2025 | 1 articles | Viewed by 1950 | Submission Open

Keywords: metastatic lung cancer; targeted therapy; immunotherapy; resistance mechanisms; tumor microenvironment; biomarkers; novel drug targets; translational oncology; precision medicine; epigenetic modulation

(This special issue belongs to the Section Cancer Therapy)

Treatment Options and Risk Factors of Pancreatic Neuroendocrine Neoplasms

edited by Anna Caterina Milanetto and

Claudio Pasquali

submission deadline 31 Dec 2025 | 1 articles | Viewed by 1912 | Submission Open

Keywords: pancreatic neuroendocrine neoplasms; CT scan; MRI; PET/CT; target therapy; radioligand therapy; chemotherapy; microwave ablation; radiofrequency ultrasound ablation; hepatic arterial embolization

(This special issue belongs to the Section Cancer Therapy)

Sarcoma Management in Orthopaedic Oncology

edited by

Vasileios Kontogeorgakos

and Jendrik Hardes

submission deadline 31 Dec 2025 | 3 articles | Viewed by 1883 | Submission Open

Keywords: orthopaedic surgical oncology; sarcoma; orthopaedic surgery; bone and soft tissue sarcoma; diagnose; neoadjuvant therapy; targeted therapy; immunotherapy

(This special issue belongs to the Section Methods and Technologies Development)

Technical and Technological Innovations in Head and Neck Cancer Surgery

edited by Marta Filauro

submission deadline 31 Dec 2025 | 1 articles | Viewed by 1839 | Submission Open

Keywords: head and neck; squamous cell carcinoma; larynx; oral cavity; free flap; exoscope; TORS

(This special issue belongs to the Section Methods and Technologies Development)

New Insights in the Management of Resectable Esophageal Malignancy

edited by

Tania Triantafyllou

and Dimitrios A. Theodorou

submission deadline 31 Dec 2025 | 1 articles | Viewed by 1762 | Submission Open

Keywords: esophageal cancer; perioperative chemotherapy; radiotherapy; immunotherapy; radical surgical resection

(This special issue belongs to the Section Methods and Technologies Development)

Radioimmunotherapy, Neoadjuvant Immunotherapy, and Adjuvant Immunotherapy for Cancer

edited by

Rashidul Alam Mahumud

submission deadline 31 Dec 2025 | 1 articles | Viewed by 1735 | Submission Open

Keywords: immunotherapy; radioimmunotherapy; neoadjuvant immunothearpy; radiopharmaceuticals

(This special issue belongs to the Section Cancer Therapy)

Novel Diagnosis and Treatment Approaches in Pancreatic Cancer

edited by

Atsushi Masamune

submission deadline 31 Dec 2025 | 2 articles | Viewed by 1712 | Submission Open

Keywords: pancreatic cancer; pancreatic fibrosis; biomarker; risk factor; genetic testing; artificial intelligence; endoscopic ultrasound; stroma; cancer-associated fibroblasts; familial pancreatic cancer

(This special issue belongs to the Section Cancer Therapy)

Image-Guided Adaptive Radiation Therapy (IGART): Advancing Precision Oncology

edited by An Liu, Bin Cai and Murat Surucu

submission deadline 31 Dec 2025 | 2 articles | Viewed by 1695 | Submission Open

Keywords: advanced imaging techniques; adaptive radiotherapy; computational models

(This special issue belongs to the Section Methods and Technologies Development)

Advances in the Management of Oropharyngeal Cancer: Navigating the HPV-Associated Landscape

edited by Jon Mallen-St Clair

submission deadline 31 Dec 2025 | 1 articles | Viewed by 1685 | Submission Open

Keywords: oropharyngeal cancer; human papillomavirus; clinical trials; transoral robotic surgery; epidemiology; HPV-related oropharyngeal cancer

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

Oral Cancer: Prevention and Early Detection (2nd Edition)

edited by

Gianluca Tenore

and

Umberto Romeo

submission deadline 31 Dec 2025 | 1 articles | Viewed by 1678 | Submission Open

Keywords: oral cancer; oral squamous cell carcinoma; alcohol and tobacco; human papillomavirus (HPV); biomarkers; biopsy and liquid biopsy; oral potentially malignant disorders (OPMDs); oral pathology and oral medicine; oral and maxillofacial surgery; radiotherapy and chemotherapy

(This special issue belongs to the Section Cancer Epidemiology and Prevention)

Feature Paper in Section ‘Cancer Epidemiology and Prevention’ in 2025

edited by Roger Anderson and

Paweł Koczkodaj

submission deadline 31 Dec 2025 | 1 articles | Viewed by 1676 | Submission Open

Keywords: cancer prevention; cancer epidemiology; health policy; public health; global health; health education; health promotion

(This special issue belongs to the Section Cancer Epidemiology and Prevention)

Innovations in Addressing Disparities in Cancer

edited by

Rajesh Singh

and

Shailesh Singh

submission deadline 31 Dec 2025 | 1 articles | Viewed by 1666 | Submission Open

Keywords: artificial intelligence on health equity; artificial intelligence and machine learning technologies in cancer care; genomic testing and biomarkers; AI in social determinants of health; health justice; precision medicine and health informatics; innovative cancer care delivery model for overcoming health disparity; equity lens; racial differences in the immunological landscape; racial differences in treatment and disease outcome

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

Lymphoma Biology, Pathology and Stem Cells

edited by

Mingyi Chen

submission deadline 31 Dec 2025 | 1 articles | Viewed by 1620 | Submission Open

Keywords: lymphoma biology; pathology; CAR-T; immunotherapy; stem cell transplant

(This special issue belongs to the Section Cancer Pathophysiology)

New Challenges in Allogeneic Hematopoietic Stem Cell Transplantation for Acute Myeloid Leukemia

edited by Federico Mosna and Irene Cavattoni

submission deadline 31 Dec 2025 | 2 articles | Viewed by 1560 | Submission Open

Keywords: acute myeloid leukemia (AML); allogeneic hematopoietic stem cells transplantation (allo-HSCT); immunotherapy; leukemic stem cells; graft versus host disease (GVHD); infections in immunodepressed patients; immune reconstitution; post-transplant management; long-term results; clinical

(This special issue belongs to the Section Cancer Therapy)

Challenges and New Developments in the Diagnosis and Treatment of Sarcoma

edited by

Xiaolan Feng

submission deadline 31 Dec 2025 | 1 articles | Viewed by 1515 | Submission Open

Keywords: bone and soft tissue sarcoma; prognostic and predictive biomarker; transcriptomic/genomic profiling; immunotherapy; targeted treatment

(This special issue belongs to the Section Cancer Therapy)

Advances in Cell and Gene Therapy in Tumors: From Bench to Bedside

edited by Shuhang Wang

submission deadline 31 Dec 2025 | 1 articles | Viewed by 1469 | Submission Open

Keywords: cell therapy; gene therapy; genetically engineered cells; cancer treatment; clinical trials; pre-clinical study

(This special issue belongs to the Section Cancer Therapy)

New Insights into Microbial-Based Cancer Therapy

edited by Amitabha Ray

submission deadline 31 Dec 2025 | 1 articles | Viewed by 1430 | Submission Open

Keywords: microbial therapy; cancer immunotherapy; bioengineering; immune modulation; tumor microenvironment

(This special issue belongs to the Section Cancer Therapy)

New Diagnostic and Therapeutic Perspectives of Gynecological Carcinomas

edited by

Carlo Ronsini

submission deadline 31 Dec 2025 | 1 articles | Viewed by 1374 | Submission Open

Keywords: gynecologic oncology; surgical gynecology; biomarkers; endometrial carcinoma; ovarian carcinoma; cervical carcinoma

(This special issue belongs to the Section Cancer Therapy)

Burkitt Lymphoma: From Pathogenesis to Current Treatments

edited by Lorenzo Leoncini and

German K. Ott

submission deadline 31 Dec 2025 | 1 articles | Viewed by 1257 | Submission Open

Keywords: Burkitt lymphoma; high-grade B-cell lymphoma; EBV; NGS; whole-exome sequencing; RNAseq; methylation analysis; tumor microenvironment; immunotherapy; chemotherapy

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

Nanomedicine’s Role in Oncology

edited by

Efstathios Efstathopoulos

and

Ellas Spyratou

submission deadline 31 Dec 2025 | 1 articles | Viewed by 1253 | Submission Open

Keywords: nanomedicine; oncology; interventional oncology; nanotechnology development; cancer diagnosis; cancer treatment; cancer imaging

(This special issue belongs to the Section Methods and Technologies Development)

Cost-Effectiveness Studies in Cancers

edited by

Ippazio Cosimo Antonazzo

Paolo Cortesi

and

Pietro Ferrara

submission deadline 31 Dec 2025 | 2 articles | Viewed by 1225 | Submission Open

Keywords: cancer therapies; cost-effectiveness; cost-utility; cost-consequence; treatment economic impact; health economic; economic sustainability; public health; decision analytical models.

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

Molecular Pathology and Human Cancers

edited by Stefano Marletta, Alessandro Russo and Giuliana Pavone

submission deadline 31 Dec 2025 | 1 articles | Viewed by 1177 | Submission Open

Keywords: molecular pathology; cancer pathogenesis; targeted therapy; personalized medicine; cancer signaling

(This special issue belongs to the Section Cancer Pathophysiology)

Feature Papers in the Section “Cancer Therapy” in 2025

edited by

Abdullah Esmail

, Qiang Wang and

Hiroyuki Takei

submission deadline 31 Dec 2025 | 1 articles | Viewed by 1173 | Submission Open

Keywords: chemotherapy; immunotherapy for cancer; oncology; systemic treatment and targeted therapy.

(This special issue belongs to the Section Cancer Therapy)

Surgical Innovations in Advanced Gastric Cancer

edited by Ugo Elmore, Francesco Puccetti and Andrea Cossu

submission deadline 31 Dec 2025 | 1 articles | Viewed by 1092 | Submission Open

Keywords: gastric cancer; gastrectomy; oligometastatic cancer; recurrence; peritoneal carcinomatosis; multimodal management

(This special issue belongs to the Section Cancer Therapy)

At the Interface of Genetics, Epigenetics, and Metabolism in Cancer: 2nd Edition

edited by

Kenta Masui

and

Linlin Guo

submission deadline 31 Dec 2025 | 1 articles | Viewed by 1080 | Submission Open

Keywords: cancer metabolism; epigenetic reprogramming; histone modification; DNA methylation; chromatin structure; intermediary metabolites; microenvironment; mTOR complexes; glioblastoma

(This special issue belongs to the Section Cancer Pathophysiology)

Chromatin-Remodeling Factors in Cancer Cells

edited by

Sudhakar Jha

submission deadline 31 Dec 2025 | 1 articles | Viewed by 1080 | Submission Open

Keywords: chromatin remodeling; transcription factors; epigenetic therapy; cancer epigenomics; SWI/SNF complex; CRISPR functional screens; single-cell epigenomics; gene regulation in cancer; therapy resistance; targeted cancer therapies

(This special issue belongs to the Section Cancer Pathophysiology)

Accelerated Partial Breast Irradiation

edited by Roxolyana Abdah-Bortnyak

submission deadline 31 Dec 2025 | 1 articles | Viewed by 1063 | Submission Open

Keywords: radiotherapy; accelerated partial breast irradiation; breast cancer; intraoperative radiotherapy; external beam radiotherapy; brachytherapy

(This special issue belongs to the Section Cancer Therapy)

Pituitary Tumors: Clinical and Surgical Challenges

edited by

Michal Hlavac

and

Andrej Pala

submission deadline 31 Dec 2025 | 1 articles | Viewed by 978 | Submission Open

Keywords: pituitary; neuroendocrine tumors; transsphenoidal endoscopic surgery; MRI imaging; quality of life

(This special issue belongs to the Section Clinical Research of Cancer)

Advances in the Molecular Biology of Sarcoma and Drug Development

edited by Francis Hornicek and

Zhenfeng Duan

submission deadline 31 Dec 2025 | 1 articles | Viewed by 949 | Submission Open

Keywords: sarcoma; sarcoma models; kinases; drug development; multidrug resistance; targeted therapy; immunotherapy

(This special issue belongs to the Section Molecular Cancer Biology)

Plasma and Cancer Treatment

edited by

Michael Keidar

and

Vikas Soni

submission deadline 31 Dec 2025 | 1 articles | Viewed by 929 | Submission Open

Keywords: cold atmospheric plasma (CAP); cancer treatment; plasma medicine; reactive oxygen species (ROS); apoptosis; tumor; non-thermal plasma; plasma oncology; cancer and molecular biology; clinical translation; in vivo/preclinical

(This special issue belongs to the Section Cancer Therapy)

Emerging Concepts in Mesothelioma

edited by Georgios T. Stathopoulos and Tonia Adamides

submission deadline 31 Dec 2025 | 1 articles | Viewed by 880 | Submission Open

Keywords: mesothelioma; asbestos; pleura; tumor suppressor; cell lines; patient-derived xenograft; surgery; chemotherapy; folate antagonist; immunotherapy

(This special issue belongs to the Section Clinical Research of Cancer)

Molecular and Genetic Biomarkers in Oral Squamous Cell Carcinoma

edited by

Kalu U.E. Ogbureke

submission deadline 31 Dec 2025 | 1 articles | Viewed by 807 | Submission Open

Keywords: oral cancer; oropharyngeal cancer; biomarkers; liquid biopsy; genetic determinants

(This special issue belongs to the Section Cancer Biomarkers)

Innovations in Microsurgical Techniques for Breast Cancer Reconstruction

edited by

Babak J. Mehrara

and Robert J. Allen

submission deadline 31 Dec 2025 | 1 articles | Viewed by 674 | Submission Open

Keywords: breast reconstruction; autologous breast reconstruction; DIEP flap; robotic DIEP flap; sensibility; alternative flaps; post-mastectomy pain; PAP flap; LAP flap; GAP flap; LTP flap; perforator flap; latissimus flap; fat grafting; nerve repair

(This special issue belongs to the Section Methods and Technologies Development)

Advanced Ovarian Cancer (2nd Edition)

edited by

Sheng-Mou Hsiao

submission deadline 31 Dec 2025 | 1 articles | Viewed by 597 | Submission Open

Keywords: advanced ovarian cancer; medical treatment; surgical treatment; hyperthermic intraperitoneal chemotherapy; intraperitoneal chemotherapy

(This special issue belongs to the Section Cancer Therapy)

Facial Paralysis in Cancer Patients—from Diagnosis to Treatment and Facial Reanimation

edited by

Barbara Kofler

, Niels van Heerbeek, Giulia Molinari and Benedikt Hofauer

submission deadline 31 Dec 2025 | Viewed by 512 | Submission Open

Keywords: facial nerve; facial nerve reanimation; head and neck cancer; facial reconstructive surgery

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

Breast Cancer Research and Treatment

edited by

Huaitian Liu

submission deadline 31 Dec 2025 | Viewed by 450 | Submission Open

Keywords: breast cancer; tumor microenvironment; immune microenvironment; intratumoral heterogeneity; immunotherapy

(This special issue belongs to the Section Tumor Microenvironment)

Innovations in Soft Tissue Sarcoma Diagnosis and Treatment (2nd Edition)

edited by Erlinda M. Gordon,

Sant P. Chawla

and Frederick L. Hall

submission deadline 31 Dec 2025 | Viewed by 379 | Submission Open

Keywords: soft tissue sarcoma; gene therapy; natural killer cell therapy; immune and cell cycle checkpoint inhibitors; targeted therapy

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

Recent Advances in Peritoneal Carcinomatosis

edited by Neda Dadgar and Patrick L. Wagner

submission deadline 31 Dec 2025 | Viewed by 354 | Submission Open

Keywords: peritoneal carcinomatosis; tumor microenvironment; immunotherapy biomarkers; microbiome– host interactions; epithelial– mesenchymal transition (emt); intra-cavitary therapies; cytokine signaling; translational oncology; multiomics profiling; organoid

(This special issue belongs to the Section Clinical Research of Cancer)

Stereotactic Body Radiotherapy in Gynecologic Malignancies—a Practical Framework of SBRT, Chemoradiotherapy and Immunotherapy

edited by Antonio Pontoriero

submission deadline 31 Dec 2025 | Viewed by 346 | Submission Open

Keywords: SBRT; gynecologic cancer; chemoradiotherapy; immunotherapy; oligometastatic; oligoecurrent; oligopersistent; reirradiation

(This special issue belongs to the Section Cancer Therapy)

Surgical Aspects of Ovarian/Tubal/Peritoneal Cancer Management

edited by