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Cancers publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Lymph Node Dissection for Gynecologic Cancers
edited by
submission deadline 31 Dec 2025 | 5 articles | Viewed by 10768 | Submission Open
(This special issue belongs to the Section Methods and Technologies Development)
Advances in Spine Oncology: Research and Clinical Studies
edited by Oluwaseun O. Akinduro
submission deadline 31 Dec 2025 | 8 articles | Viewed by 10633 | Submission Open
Keywords: metastatic spine cancer; targeted therapy; stereotactic body radiotherapy; proton radiotherapy; chordoma; chondrosarcoma; spondylectomy
(This special issue belongs to the Section Clinical Research of Cancer)
Physiotherapy in Advanced Cancer and Palliative Care
edited by Nele Adriaenssens
submission deadline 31 Dec 2025 | 3 articles | Viewed by 10626 | Submission Open
Keywords: advanced cancer; palliative care; palliative needs; physiotherapy; physical therapy modalities; quality of life; physical autonomy
(This special issue belongs to the Section Cancer Survivorship and Quality of Life)
Medical Complications and Supportive Care in Patients with Cancer (2nd Edition) submission deadline 31 Dec 2025 | 9 articles | Viewed by 9757 | Submission Open
Keywords: cancer; oncological emergencies; immune-related adverse events; immunotherapy; supportive care; palliative care; infectious diseases; thromboembolic disease; treatment; toxicities; CAR-T cell therapy
(This special issue belongs to the Section Cancer Survivorship and Quality of Life)
Overcoming Chemoresistance in Cancer: Identifying Biomarkers and Novel Targets submission deadline 31 Dec 2025 | 4 articles | Viewed by 9064 | Submission Open
Keywords: cancer treatment; chemoresistance; tumor microenvironment; cancer signaling pathways; targeted therapy; personalized anti-cancer therapies; biomarker; anti-cancer drug response prediction
(This special issue belongs to the Section Cancer Biomarkers)
Unravelling Cancer Mechanism and Developing Novel Therapeutics: An Urgent Need to Treat Cancer (2nd Edition) submission deadline 31 Dec 2025 | 6 articles | Viewed by 9006 | Submission Open
Keywords: cancer; anticancer therapy; combination therapy; natural compound; nanotherapy; exosome therapy; targeted therapy; immunotherapy; chemokines; cytokines; antibodies; drug resistance
(This special issue belongs to the Section Cancer Therapy)
Ovarian Cancer Biomarkers, Diagnostic, and Therapeutic Technologies 2nd Edition
edited by
submission deadline 31 Dec 2025 | 5 articles | Viewed by 8986 | Submission Open
Keywords: diagnostic; prognostic; theranostic; therapy; metastasis; biomarker; regression; chemoresistance; invasion
(This special issue belongs to the Section Cancer Biomarkers)
Technological Development for Advances in Cancer Research and Precision Oncology
edited by , and Fenglong Ma
submission deadline 31 Dec 2025 | 4 articles | Viewed by 8907 | Submission Open
Keywords: bioengineering; bioinformatics; biosensor; extracellular vesicles; genome editing; machine learning; molecular profiling; nanoparticles; organoids; robotics
(This special issue belongs to the Section Molecular Cancer Biology)
Radiomics in Cancer
edited by Isabelle M. Germano
submission deadline 31 Dec 2025 | 4 articles | Viewed by 7939 | Submission Open
Keywords: radiomic; medical imaging; personalized treatment; diagnosis; staging; management; targeted treatment; patient outcome; clinical practice; cancer therapies; patient care
(This special issue belongs to the Section Cancer Therapy)
Immunotherapy in Non-Small Cell Lung Cancers
edited by Marco Russano
submission deadline 31 Dec 2025 | 3 articles | Viewed by 7841 | Submission Open
Keywords: non-small cell lung cancer; immune checkpoint inhibitors; PD-1/PD-L1 blockade; immunotherapy; biomarkers
(This special issue belongs to the Section Cancer Immunology and Immunotherapy)
Application of Artificial Intelligence-Based Approaches in Cancer Diagnosis, Treatment and Prognosis
edited by
submission deadline 31 Dec 2025 | 4 articles | Viewed by 7836 | Submission Open
Keywords: cancer genomics; artificial intelligence; machine learning; deep learning; tumor microenvironment; graph-based convolutional neural network; computational cancer biology
(This special issue belongs to the Section Methods and Technologies Development)
Ovarian Cancer Stem Cells and Tumor Microenvironment
edited by
submission deadline 31 Dec 2025 | 2 articles | Viewed by 7640 | Submission Open
Keywords: cancer stem cells; stem-like cells; tumor initiation; chemotherapy resistance; tumor relapse; tumor microenvironment; tumor immunology; stromal cells; cancer-associated fibroblasts
(This special issue belongs to the Section Tumor Microenvironment)
Advancements in Head and Neck Cancer Surgery submission deadline 31 Dec 2025 | 4 articles | Viewed by 7619 | Submission Open
Keywords: minimal invasive; transoral; robotic; reconstructive; 3D printing; targeting therapies; imaging
(This special issue belongs to the Section Clinical Research of Cancer)
The Development and Application of Imaging Biomarkers in Cancer
edited by
submission deadline 31 Dec 2025 | 4 articles | Viewed by 7371 | Submission Open
Keywords: imaging biomarkers; oncology; cancer imaging; artificial intelligence
(This special issue belongs to the Section Cancer Therapy)
Celebrating the 2024 Nobel Prize in Chemistry: Advancements in Artificial Intelligence and Machine Learning for Cancer Therapeutics submission deadline 31 Dec 2025 | 3 articles | Viewed by 7217 | Submission Open
Keywords: AI in cancer therapeutics; machine learning for drug discovery; protein structure prediction; personalized cancer treatment; clinical AI applications
(This special issue belongs to the Section Cancer Therapy)
Advances in Radiation Therapy for Head and Neck Cancer submission deadline 31 Dec 2025 | 4 articles | Viewed by 6753 | Submission Open
Keywords: adaptive radiotherapy  ; hyper- and hypo-fractionated radiotherapy  ; artificial intelligence in radiotherapy for head and neck cancer  ; quality assurance and set-up errors associated with IMRT; VMAT; IGRT; and SGRT techniques  ; protons and heavy ions for radiotherapy  ; re-irradiation  ; nanoparticles plus radiotherapy  ; hyperthermia plus radiotherapy  ; radiotherapy plus immunotherapy  ; the de-escalation of radiation therapy
(This special issue belongs to the Section Cancer Therapy)
Advances in Surgical Treatment of Urinary Tumors
edited by Pierre I. Karakiewicz and
submission deadline 31 Dec 2025 | 2 articles | Viewed by 6684 | Submission Open
Keywords: bladder cancer; prostate cancer; kidney cancer; quality of life; urologic oncology
(This special issue belongs to the Section Cancer Therapy)
Recent Advances in Non-muscle Invasive Bladder Cancer
edited by Paul L. Crispen
submission deadline 31 Dec 2025 | 3 articles | Viewed by 6660 | Submission Open
Keywords: non-muscle invasive bladder cancer; adjuvant therapy; surveillance; BCG refractory; intravesical therapy
(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)
Perspectives on the Efficacy and Biomarkers of Immunotherapy and Targeted Therapy for Patients with Colorectal Cancer submission deadline 31 Dec 2025 | 2 articles | Viewed by 6357 | Submission Open
Keywords: colorectal cancer; precision medicine; targeted therapeutics; immunotherapy; KRAS; BRAF; HER2; biomarkers
(This special issue belongs to the Section Cancer Therapy)
Precision Oncology for Rare Skin Cancers
edited by Gino K. In and Aparna Nallagangula
submission deadline 31 Dec 2025 | 4 articles | Viewed by 6279 | Submission Open
Keywords: rare skin cancers; melanoma; cutaneous squamous cell carcinoma; basal cell carcinoma; Merkel cell carcinoma; sebaceous carcinoma; adnexal/sweat gland carcinoma; dermatofibrosarcoma protuberans; extramammary Paget’ s disease; cutaneous sarcomas
(This special issue belongs to the Section Molecular Cancer Biology)
Advances in Pancreatic Ductal Adenocarcinoma Diagnosis and Treatment 2nd Edition
edited by
submission deadline 31 Dec 2025 | 2 articles | Viewed by 6165 | Submission Open
Keywords: pancreatic cancer; pancreatic ductal adenocarcinoma; genetic changes; genomics; surgical resection; radiotherapy; radiochemotherapy; chemotherapy; targeted therapy; immunotherapy; resectable tumor; borderline resectable tumor; metastatic disease; nutritional treatment; quality of life
(This special issue belongs to the Section Cancer Therapy)
Artificial Intelligence-Assisted Radiomics in Cancer
edited by
submission deadline 31 Dec 2025 | 2 articles | Viewed by 6101 | Submission Open
Keywords: radiomics; learning tools; data normalization; segmentation; artificial intelligence; quantitative imaging; multi-dimensional feature analysis; statistical models; precision medicine
(This special issue belongs to the Section Methods and Technologies Development)
Enhancing Cancer Treatments through Fluorescence-Guided Surgery
edited by Ibrahim Khot and Yazan Sulaiman Khaled
submission deadline 31 Dec 2025 | 3 articles | Viewed by 5991 | Submission Open
Keywords: fluorescence-guided resection; fluorescent imaging; cancer surgery; tumour targeting; intraoperative staging; oncological fluorescence; precision medicine
(This special issue belongs to the Section Methods and Technologies Development)
Surgical Treatment of Hepatocellular Carcinoma
edited by
submission deadline 31 Dec 2025 | 4 articles | Viewed by 5871 | Submission Open
Keywords: surgical techniques; surgical indications; surgical outcomes; clinical trials; liver transplantation; adjuvant therapy; basic research
(This special issue belongs to the Section Clinical Research of Cancer)
Hereditary and Familial Colorectal Cancer
edited by Bryson W. Katona and Peter P. Stanich
submission deadline 31 Dec 2025 | 4 articles | Viewed by 5795 | Submission Open
Keywords: hereditary colorectal cancer; familial colorectal cancer; genetic predisposition; polyposis; Lynch syndrome; familial adenomatous polyposis (FAP); MUTYH-associated polyposis (MAP); genetic testing
(This special issue belongs to the Section Cancer Pathophysiology)
Innovative Biomarkers and Imaging Techniques for the Early Detection and Risk Stratification of Urological Tumours
edited by
submission deadline 31 Dec 2025 | 2 articles | Viewed by 5696 | Submission Open
Keywords: urological tumours; novel biomarkers; advanced imaging techniques; early detection; risk stratification; molecular diagnostics; multimodal data integration; personalized treatment
(This special issue belongs to the Section Cancer Epidemiology and Prevention)
Natural Compounds in Cancers: 2nd Edition submission deadline 31 Dec 2025 | 1 articles | Viewed by 5551 | Submission Open
Keywords: nutrition; bioactive molecules; inflammation; natural extracts; nutraceuticals; immunotherapy; chemotherapy
(This special issue belongs to the Section Molecular Cancer Biology)
Radiosurgery for Brain Tumors
edited by Anna Petoukhova
submission deadline 31 Dec 2025 | 4 articles | Viewed by 5339 | Submission Open
Keywords: radiosurgery with photons and protons; stereotactic radiosurgery (SRS); brain tumors; gliomas; meningioma; pituitary adenoma; magnetic resonance imaging (MRI); magnetic resonance linac (MRL)
(This special issue belongs to the Section Cancer Therapy)
Clear Cell Renal Cell Carcinoma 2024–2025 submission deadline 31 Dec 2025 | 2 articles | Viewed by 5307 | Submission Open
Keywords: clear cell renal cell carcinoma; pathology; diagnosis; hypoxia; intratumor heterogeneity; immune checkpoint blockage antiangiogenic therapy
(This special issue belongs to the Section Cancer Pathophysiology)
AI-Based Applications in Cancers
edited by
submission deadline 31 Dec 2025 | 6 articles | Viewed by 5178 | Submission Open
Keywords: AI; machine learning; deep learning; Bayesian networks; causal learning; LLM; cancer
(This special issue belongs to the Section Cancer Informatics and Big Data)
Advances in the Use of PET/CT and MRI in Prostate Cancer
edited by Carmelo Caldarella
submission deadline 31 Dec 2025 | 3 articles | Viewed by 4968 | Submission Open
Keywords: PET/CT; MRI; prostate cancer; radiomic; receptor-targeted radiopharmaceuticals
(This special issue belongs to the Section Methods and Technologies Development)
Advances in Breast and Gynecologic Cancer Pathology: Molecular Insights and Therapeutic Implications
edited by
submission deadline 31 Dec 2025 | 1 articles | Viewed by 4933 | Submission Open
Keywords: breast cancer; gynecologic malignancies; diagnostic pathology; molecular biomarkers; histopathology; cytopathology; prognostic markers; targeted therapy
(This special issue belongs to the Section Cancer Pathophysiology)
Novel Diagnosis and Treatment Approaches in Pancreatic Cancer
edited by
submission deadline 31 Dec 2025 | 3 articles | Viewed by 4840 | Submission Open
Keywords: pancreatic cancer; pancreatic fibrosis; biomarker; risk factor; genetic testing; artificial intelligence; endoscopic ultrasound; stroma; cancer-associated fibroblasts; familial pancreatic cancer
(This special issue belongs to the Section Cancer Therapy)
Feature Papers in Section “Methods and Technologies Development” in 2025 submission deadline 31 Dec 2025 | 1 articles | Viewed by 4792 | Submission Open
Keywords: innovative diagnostic technology; artificial intelligence; cancer diagnosis; personalized treatment; diagnostic and therapeutic strategies
(This special issue belongs to the Section Methods and Technologies Development)
Multidisciplinary Treatment with Surgery and Chemotherapy of Liver Metastases from Colorectal Cancer
edited by and Pietro Majno
submission deadline 31 Dec 2025 | 1 articles | Viewed by 4753 | Submission Open
Keywords: colorectal liver metastases; liver surgery; oncology; multidisciplinary approach; prognosis; recurrence; precision medicine; genetics; tumor biology; liver transplantation; perioperative therapy and conversion therapy
(This special issue belongs to the Section Cancer Therapy)
Feature Papers in Section “Cancer Informatics and Big Data”
edited by
submission deadline 31 Dec 2025 | 3 articles | Viewed by 4698 | Submission Open
Keywords: artificial intelligence; deep learning; next-generation sequencing; precision medicine and clinical decision-making; single-cell data analytics
(This special issue belongs to the Section Cancer Informatics and Big Data)
Feature Review for Cancer Therapy: 2nd Edition submission deadline 31 Dec 2025 | 3 articles | Viewed by 4625 | Submission Open
Keywords: cancer therapy; chemotherapy; targeted therapy; cancer co-treatment; biomarkers; natural compounds; drug-repurposing; nanomaterials
(This special issue belongs to the Section Cancer Therapy)
New Perspectives in the Management of Central Nervous System (CNS) Tumors
edited by , Francesco Bruno and
submission deadline 31 Dec 2025 | 2 articles | Viewed by 4507 | Submission Open
Keywords: gliomas; brain metastases; leptomeningeal metastases; liquid biopsy; neuroradiological tools; brain surgery; targeted therapy; immunotherapy; clinical trials; molecular factors
(This special issue belongs to the Section Cancer Therapy)
Molecular Mechanisms in Bone and Soft Tissue Sarcomas
edited by and Zachary D.C. Burke
submission deadline 31 Dec 2025 | 2 articles | Viewed by 4482 | Submission Open
Keywords: sarcoma; bone sarcoma; soft tissue sarcoma; osteosarcoma; molecular level; translation
(This special issue belongs to the Section Molecular Cancer Biology)
Latest Advancements in Health-Related Quality of Life Research in Cancer Survivorship (2nd Edition) submission deadline 31 Dec 2025 | 4 articles | Viewed by 4436 | Submission Open
Keywords: cancer survivors; oncology; psycho-oncology; health-related quality of life; patient-reported outcome measures; self-report
(This special issue belongs to the Section Cancer Survivorship and Quality of Life)
Pancreatic Cancer: Clinical Standards, Unmet Needs and Future Directions submission deadline 31 Dec 2025 | 2 articles | Viewed by 4406 | Submission Open
Keywords: standard clinical management; surgery; neoadjuvant and/or adjuvant treatment; cancer immunotherapy; targeted therapy; detection and elimination of MRD
(This special issue belongs to the Section Clinical Research of Cancer)
Cost-Effectiveness Studies in Cancers submission deadline 31 Dec 2025 | 4 articles | Viewed by 4319 | Submission Open
Keywords: cancer therapies; cost-effectiveness; cost-utility; cost-consequence; treatment economic impact; health economic; economic sustainability; public health; decision analytical models.
(This special issue belongs to the Section Cancer Survivorship and Quality of Life)
Novel Treatments for Ocular and Periocular Cancers
edited by
submission deadline 31 Dec 2025 | 3 articles | Viewed by 4315 | Submission Open
Keywords: ocular cancer; intraocular tumor; retinoblastoma; uveal melanoma
(This special issue belongs to the Section Cancer Therapy)
New Insights on Management of Acute Lymphoblastic Leukemia in the Contemporary Era
edited by Talha Badar
submission deadline 31 Dec 2025 | 1 articles | Viewed by 4098 | Submission Open
Keywords: B-cell ALL; T-cell ALL; MRD in ALL; Ph+ve ALL; CAR T-cells; NGS-MRD; menin inhibitors; blinatumomab; inotuzumab; ponatinib; BCR-ABL1; TKI
(This special issue belongs to the Section Cancer Therapy)
Feature Paper in Section ‘Cancer Epidemiology and Prevention’ in 2025
edited by Roger Anderson and
submission deadline 31 Dec 2025 | 3 articles | Viewed by 3955 | Submission Open
Keywords: cancer prevention; cancer epidemiology; health policy; public health; global health; health education; health promotion
(This special issue belongs to the Section Cancer Epidemiology and Prevention)
Sequence Variants in Breast/Ovarian Cancer Susceptibility Genes: From Risk Assessment to Clinical Management in Carrier Individuals and Their Blood Relatives
edited by Arcangela De Nicolo and
submission deadline 31 Dec 2025 | 2 articles | Viewed by 3925 | Submission Open
Keywords: breast/ovarian cancer susceptibility genes; risk assessment and clinical management of carrier individuals and their blood relatives; risk models; variant classification; multifactorial approaches
(This special issue belongs to the Section Cancer Epidemiology and Prevention)
Advances in Diagnostics and Prognostics in the Management of Intrathoracic Malignancies
edited by Akshay Jatin Patel and Marcus Taylor
submission deadline 31 Dec 2025 | 2 articles | Viewed by 3717 | Submission Open
Keywords: intrathoracic malignancies; diagnostics; prognostics; molecular biomarkers; radiomics; artificial intelligence; immunobiological parameters; personalized therapy
(This special issue belongs to the Section Methods and Technologies Development)
Cancer Mechanosensing
edited by Meenal Datta and Xin Tang
submission deadline 31 Dec 2025 | 1 articles | Viewed by 3708 | Submission Open
Keywords: cancer mechanosensing; mechanotransduction; mechanical cues; mechanosensitive ion channels; focal adhesions; cytoskeletal elements; tumor microenvironments; fluid shear stress; stiffness; cell compression; tumor progression; metastasis; drug resistance; immune response; biophysical tools
(This special issue belongs to the Section Cancer Pathophysiology)
Next-Generation Cancer Therapies
edited by , Ioannis Lamprou and Erasmia Xanthopoulou
submission deadline 31 Dec 2025 | 2 articles | Viewed by 3650 | Submission Open
Keywords: cancer; current therapies; cancer cells metabolism; autophagy; immunotherapy; targeted treatments; oncolytic viruses; vaccines
(This special issue belongs to the Section Cancer Therapy)
New Challenges in Allogeneic Hematopoietic Stem Cell Transplantation for Acute Myeloid Leukemia
edited by Federico Mosna and Irene Cavattoni
submission deadline 31 Dec 2025 | 4 articles | Viewed by 3446 | Submission Open
Keywords: acute myeloid leukemia (AML); allogeneic hematopoietic stem cells transplantation (allo-HSCT); immunotherapy; leukemic stem cells; graft versus host disease (GVHD); infections in immunodepressed patients; immune reconstitution; post-transplant management; long-term results; clinical
(This special issue belongs to the Section Cancer Therapy)
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