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Cancers publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Infectious Agents and Cancer in Children and Adolescents

edited by

Emmanouel Hatzipantelis

and Eleni Tsotridou

submission deadline 15 May 2026 | 3 articles | Viewed by 3400 | Submission Open

Keywords: infectious agents; immune system; tumor development; immunological memory; oncolytic viruses

(This special issue belongs to the Section Infectious Agents and Cancer)

Endoscopic Advances in Gastrointestinal Oncology

edited by Eduardo Rodrigues-Pinto

submission deadline 15 May 2026 | 1 articles | Viewed by 2288 | Submission Open

Keywords: endoscopic oncology; endoscopic screening; endoscopic resection; endoscopic palliation; staging

(This special issue belongs to the Section Cancer Therapy)

Gene Editing and Delivery for Cancer Therapy (2nd Edition)

edited by

Yong Teng

and

Yamin Li

submission deadline 15 May 2026 | Viewed by 79 | Submission Open

Keywords: gene therapy; gene editing; gene delivery; oncolytic viruses; nanomaterial; peptides; nanostructures; exosomes; translational science

(This special issue belongs to the Section Cancer Therapy)

Molecular and Genetic Diagnosis and Targeted Therapy of Myeloproliferative Neoplasms (2nd Edition)

edited by

Jinming Song

and

Ling Zhang

submission deadline 15 May 2026 | Viewed by 75 | Submission Open

Keywords: myeloproliferative neoplasm; chronic myeloid leukemia; polycythemia vera; essential thrombocythemia; primary myelofibrosis; MPN; CML; PMF; PV; ET

(This special issue belongs to the Section Molecular Cancer Biology)

Mass Spectrometry and Cancers

edited by

Rita Casadonte

and

Kristina Schwamborn

submission deadline 15 May 2026 | Viewed by 38 | Submission Open

Keywords: cancer; biomolecular; mass spectrometry

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

Breast Cancer Screening: Global Practices and Future Directions

edited by Rudolf Morant

submission deadline 15 May 2026 | Viewed by 27 | Submission Open

Keywords: mammography screening; organized screening programs; tomosynthesis; 2D mammography; artificial intelligence; personalized screening

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

The Surgical Management of Colorectal Cancer

edited by Gyung-mo Son

submission deadline 20 May 2026 | 8 articles | Viewed by 16459 | Submission Open

Keywords: colorectal cancer; surgical management; minimally invasive surgery; laparoscopic surgery; robotic surgery; single port surgery; emergency surgery; image-guided surgery; enhanced recovery after surgery (ERAS); systemic metastasis in colorectal cancer (involving the liver; lung; peritoneum; etc.)

(This special issue belongs to the Section Cancer Therapy)

How to Properly Diagnose and Treat Immune-Related Adverse Events During Immunotherapy in Patients with Cancer: Discussion Between Specialists (2nd Edition)

edited by

Angioletta Lasagna

and

Paolo Sacchi

submission deadline 20 May 2026 | Viewed by 26 | Submission Open

Keywords: ICIs; immune-related adverse effects (irAEs); infectious complications; immune reconstitution; inflammatory syndrome (IRIS); microbiota; vaccines; molecular mimicry

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

Viral Oncogenes and Their Role in Cancer Pathogenesis

edited by

Ronen Borenstein

and Yosef Sabo

submission deadline 21 May 2026 | 2 articles | Viewed by 4246 | Submission Open

Keywords: viral oncogenes; cancer pathogenesis; cellular regulation; tumorigenesis mechanisms; antiviral and anticancer strategies

(This special issue belongs to the Section Infectious Agents and Cancer)

Inhibitors in Thyroid Carcinoma (2nd Edition)

edited by

Alessandro Antonelli

submission deadline 24 May 2026 | Viewed by 69 | Submission Open

Keywords: thyroid carcinoma; immune checkpoint inhibitors; tyrosine kinase inhibitors; sorafenib; lenvatinib

(This special issue belongs to the Section Tumor Microenvironment)

Colorectal Cancer: Risk Factors and Underlying Mechanisms

edited by David Achaintre

submission deadline 25 May 2026 | Viewed by 38 | Submission Open

Keywords: colorectal cancer; diet; environmental factors; microbiome; inflammation

(This special issue belongs to the Section Cancer Epidemiology and Prevention)

Molecular Mechanisms of Breast Cancer Treatments-Related Side Effects and Precision Interventions

edited by

Jennifer Hu

submission deadline 26 May 2026 | Submission Open

Keywords: breast cancer; treatment-related side effects; biomarker; precision interventions

(This special issue belongs to the Section Cancer Therapy)

Primary and Recurrent Gynecological Cancer: Epidemiology, Management and New Therapies

edited by Nithya Ratnavelu and Ioannis Biliatis

submission deadline 28 May 2026 | Viewed by 309 | Submission Open

Keywords: ovarian cancer; endometrial cancer; cervical cancer; vulva cancer; vaginal cancer; gynecological cancer

(This special issue belongs to the Section Cancer Epidemiology and Prevention)

New Approaches in Radiotherapy for Cancer

edited by Dandan Zheng, Alexander Podgorsak and Olga Maria Dona Lemus

submission deadline 30 May 2026 | 18 articles | Viewed by 41238 | Submission Open

Keywords: adaptive radiotherapy; FLASH; artificial intelligence; SFRT; particle therapy; proton therapy; SRS; SBRT; HDR; 3D printing; immuno-radiotherapy; radiogenmics

(This special issue belongs to the Section Cancer Therapy)

Current Advances in Management of Neuroendocrine Neoplasms

edited by Ashley Kieran Clift and

Andrea Frilling

submission deadline 30 May 2026 | 1 articles | Viewed by 744 | Submission Open

Keywords: neuroendocrine tumours; epidemiology; clinical prediction models; machine learning; personalised medicine; novel biomarkers; diagnostics; treatment; artificial intelligence

(This special issue belongs to the Section Cancer Therapy)

Genetics of Ovarian Cancer (2nd Edition)

edited by

Stergios Boussios

and

Sola Adeleke

submission deadline 30 May 2026 | Viewed by 83 | Submission Open

Keywords: epithelial ovarian cancer; genomics; epigenetics; translational research; biomarkers; DNA damage response; PARP inhibitors

(This special issue belongs to the Section Cancer Pathophysiology)

Updates on Depression Among Cancer Patients (2nd Edition)

edited by Wen-Yu Hu,

Yun-Chen Chang

and

Elsa Vitale

submission deadline 30 May 2026 | Viewed by 52 | Submission Open

Keywords: depression; psychotherapy; oncology nursing

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

Advances in the Diagnosis and Treatment of Prostate Cancer: From Biomarkers to Precision Surgery

edited by Stamatios N. Katsimperis and

Lazaros Tzelves

submission deadline 30 May 2026 | Viewed by 24 | Submission Open

Keywords: prostate cancer; precision medicine; molecular biomarkers; risk stratification; robotic surgery; artificial intelligence; genomics; personalized treatment; imaging modalities; multidisciplinary approach

(This special issue belongs to the Section Cancer Therapy)

Local Management of Breast Cancer: The Evolving Relationship Between Radiotherapy and Surgery

edited by Shengyang Peter Wu

submission deadline 31 May 2026 | 2 articles | Viewed by 3386 | Submission Open

Keywords: biomarker-guided personalized breast treatment; targeted axillary dissection; neoadjuvant therapy; local therapy; radiotherapy reduction; ultrahypofractionated partial breast irradiation

(This special issue belongs to the Section Cancer Therapy)

Prostate Cancer and Inflammation

edited by Takuji Hayashi

submission deadline 31 May 2026 | 1 articles | Viewed by 1611 | Submission Open

Keywords: prostate cancer; inflammation; immune cells; cytokine; chemokine; anti-inflammatory agents; diet; microbiome

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

Advance in Treatment of Uveal Melanoma

edited by

Bożena Romanowska-Dixon

and

Michał S. Nowak

submission deadline 31 May 2026 | 1 articles | Viewed by 1471 | Submission Open

Keywords: uveal melanoma; distant metastases; treatment modalities

(This special issue belongs to the Section Cancer Therapy)

Focus on Focal Therapy for Prostate Cancer

edited by Abhinav Sidana and Samuel Tremblay

submission deadline 31 May 2026 | 1 articles | Viewed by 1148 | Submission Open

Keywords: focal therapy; prostate cancer treatment; image-guided therapy; oncological outcomes; functional outcome; patient selection; surveillance

(This special issue belongs to the Section Cancer Therapy)

Developments in the Management of Gastrointestinal Malignancies (2nd Edition)

edited by Zachary J. Brown

submission deadline 31 May 2026 | 2 articles | Viewed by 1022 | Submission Open

Keywords: gastrointestinal malignancies; multimodal therapy; chemotherapy; radiotherapy; immunotherapy; localized and metastatic

(This special issue belongs to the Section Cancer Therapy)

Survivorship and Quality of Life in Endometrial Cancer

edited by George Koukourakis,

Antonios Anagnostopoulos

, Georgios Angelopoulos and Anthi Miliadou

submission deadline 31 May 2026 | Viewed by 319 | Submission Open

Keywords: endometrial cancer; quality of life; survivorship

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

Primary Central Nervous System Lymphoma: A Challenging Disease

edited by

Roser Velasco

submission deadline 31 May 2026 | Viewed by 317 | Submission Open

Keywords: primary central nervous system lymphoma (PCNSL); diffuse large B cell lymphoma (DLBCL); advanced imaging; novel therapies; prognostic markers

(This special issue belongs to the Section Clinical Research of Cancer)

The Role of Circulating Tumor Cells in Colorectal Cancer

edited by

Chiara Nicolazzo

submission deadline 31 May 2026 | Viewed by 245 | Submission Open

Keywords: circulating tumor cells (CTC); colorectal cancer (CRC); liquid biopsy; biomarkers; tumor progression; personalized medicine; molecular profiling; metastasis; diagnostic techniques; prognostic evaluation

(This special issue belongs to the Section Cancer Biomarkers)

Therapeutic Optimization of Anti-Tumor Drugs Based on Pharmacokinetics

edited by Paula Fresco and Joaquim António Faria Monteiro

submission deadline 31 May 2026 | Viewed by 233 | Submission Open

Keywords: anti-cancer drugs; pharmacokinetics; therapeutic drug monitoring; cancer; populational pharmacokinetics models

(This special issue belongs to the Section Cancer Drug Development)

Gut Microbiome, Diet and Cancer Risk

edited by

Byeongsang Oh

submission deadline 31 May 2026 | Viewed by 111 | Submission Open

Keywords: gut microbiome; cancer; diet; dysbiosis; immunity; dietary fiber; probiotic; short-chain fatty acids (SCFAs)

(This special issue belongs to the Section Cancer Epidemiology and Prevention)

Emerging Nanotechnology and Advanced Materials for Cancer Therapy

edited by

Iraj Alipourfard

submission deadline 31 May 2026 | Viewed by 87 | Submission Open

Keywords: biomaterials; theranostics; cancer therapy; targeted drug delivery; precision oncology

(This special issue belongs to the Section Methods and Technologies Development)

Clinical and Translational Research of Urological Cancer

edited by

Mauro Ragonese

and

Luca Di Gianfrancesco

submission deadline 31 May 2026 | Viewed by 84 | Submission Open

Keywords: urological cancer; bladder cancer; surgery; conservative treatment; immunotherapy; radical cystectomy; artifical intelligence

(This special issue belongs to the Section Clinical Research of Cancer)

The Future of Cancer Immunotherapy: Biomarkers, Tumor Microenvironment, and Precision Medicine

edited by Aftab Alam

submission deadline 31 May 2026 | Viewed by 69 | Submission Open

Keywords: immunotherapy; genomics; proteomics checkpoint; CAR T cells; predictive biomarkers; resistance mechanisms; combination approaches; tumor microenvironment

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

Mutagenesis and DNA Methylation in Aging

edited by Steven S. Smith

submission deadline 31 May 2026 | Viewed by 61 | Submission Open

Keywords: genome structure evolution; epigenetics; aging; tumorigenesis; endogenous mutagenisis; endogenous decay of methylation patterns

(This special issue belongs to the Section Molecular Cancer Biology)

Advances in High-Grade Serous Ovarian Cancer: New Perspectives Promising Hope for Eradicating a Devastating Disease

edited by

Carlos M. Telleria

submission deadline 31 May 2026 | Viewed by 55 | Submission Open

Keywords: high-grade serous ovarian cancer; risk factors; prevention; early detection; symptoms; screening; standard of care; platinum resistant ovarian cancer; novel therapeutic approaches; drug repositioning; artificial intelligence; life expectancy; quality of life; and prognosis

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

Clinical Imaging and Immunotherapy in Cancer Research

edited by

Fabio Sandomenico

submission deadline 31 May 2026 | Viewed by 52 | Submission Open

Keywords: immunotherapy; immune checkpoint inhibitors; molecular imaging; tumor microenvironment; artificial intelligence (AI); radiomics

(This special issue belongs to the Section Clinical Research of Cancer)

Role of Cytokines in Cancer (2nd Edition)

edited by

Venkataswarup Tiriveedhi

submission deadline 31 May 2026 | Viewed by 51 | Submission Open

Keywords: inflammation; tumor microenvironment; cytokines

(This special issue belongs to the Section Tumor Microenvironment)

Advances in Surgical and Multimodal Treatments of Hepatopancreatobiliary Cancers

edited by

Andrea Belli

, Matteo Serenari and

Benedetto Ielpo

submission deadline 31 May 2026 | Viewed by 50 | Submission Open

Keywords: pancreatic cancer; liver metastases; hepatocellular carcinoma; cholangiocarcinoma; neuroendocrine tumours; intraductal papillary mucinous neoplasms (IPMN); pancreatic cystic tumours; robotic surgery; laparoscopic surgery; 3D reconstruction; liver hypertrophy

(This special issue belongs to the Section Cancer Therapy)

Infectious Agents and Oesophageal Cancer (2nd Edition)

edited by

Shan Rajendra

and Mohammed Rabiei

submission deadline 31 May 2026 | Viewed by 45 | Submission Open

Keywords: oesophageal cancer; human papillomavirus; infection; Barrett’ s oesophagus; cancer; oesophageal adenocarcinoma; oesophageal squamous cell carcinoma

(This special issue belongs to the Section Infectious Agents and Cancer)

Advances in Neoadjuvant Chemotherapy and Radiotherapy for Breast Cancer: Surgical Impact and Clinical Outcomes

edited by Amparo García-Tejedor

submission deadline 31 May 2026 | Viewed by 44 | Submission Open

Keywords: neoadjuvant chemotherapy; radiotherapy; breast cancer; surgical outcomes; tumor downstaging; personalized therapy; breast-conserving surgery; mastectomy; clinical outcomes

(This special issue belongs to the Section Cancer Therapy)

Multimodality Management of Sarcomas (2nd Edition)

edited by

Eelco de Bree

submission deadline 31 May 2026 | Viewed by 42 | Submission Open

Keywords: sarcomas; multimodal; pathology; radiology; surgery; chemotherapy; radiotherapy

(This special issue belongs to the Section Cancer Therapy)

Reducing the Risk of Hepatitis B-Associated Chronic Liver Disease and Hepatocellular Carcinoma

edited by

Mark A. Feitelson

submission deadline 31 May 2026 | Viewed by 37 | Submission Open

Keywords: HBsAg loss; prolonged nucleoside therapy; autoimmune diseases; gut dysbiosis; hepatitis delta coinfection; HIV coinfection; functional cure; immunomodulation; HBV integration; immune-mediated CLD; combination therapies

(This special issue belongs to the Section Clinical Research of Cancer)

Targeted Therapy in Gastrointestinal Cancer (2nd Edition)

edited by

Wei Kang

and

Ka Fai To

submission deadline 31 May 2026 | Viewed by 36 | Submission Open

Keywords: gastrointestinal cancer; tumor microenvironment; gut microbiome; molecular mechanism; cancer treatment; prognostic and predictive biomarker; therapeutic target; cancer prognosis; targeted therapy; targeted drug development

(This special issue belongs to the Section Cancer Therapy)

Current Status and Prospects of Multimodal Treatment for Upper Gastrointestinal Cancer

edited by Koichi Okamoto

submission deadline 31 May 2026 | Viewed by 32 | Submission Open

Keywords: upper gastrointestinal cancer; esophageal cancer; gastric cancer; esophagogastric junction cancer; chemotherapy; oncology; endoscopic resection; minimally invasive surgery; robotic surgery

(This special issue belongs to the Section Cancer Therapy)

Head and Neck Cancer: MRI and PET/CT Diagnosis and Surgical Treatment

edited by

Lavinia Manuela Lenghel

submission deadline 31 May 2026 | Viewed by 28 | Submission Open

Keywords: head and neck cancer; MRI; PET/CT; diagnostic imaging; surgical treatment; tumor staging; image-guided surgery; multidisciplinary approach; oncologic outcomes

(This special issue belongs to the Section Cancer Therapy)

Nano-Targeting of Cancer

edited by Thomas Ming Swi Chang OC MD CM PhD DSc FRCPC FRSC FCAHS

submission deadline 31 May 2026 | Viewed by 25 | Submission Open

Keywords: drug delivery; artificial intelligence; targeted delivery; nanorobotics; prodrug activation; intracellular action; liposome; PEGylation; nanoparticles; nanocapsules; nanoartificial cells

(This special issue belongs to the Section Cancer Therapy)

Image-Guided Radiotherapy in Head and Neck Cancer

edited by Petar Suton

submission deadline 31 May 2026 | Viewed by 18 | Submission Open

Keywords: image-guided radiotherapy (IGRT); head and neck cancer; radiation therapy; cone-beam CT (CBCT); adaptive radiotherapy

(This special issue belongs to the Section Cancer Therapy)

Radiotherapy for the Management of Brain Metastases

edited by Alla Gabriella Wernicke

submission deadline 31 May 2026 | Viewed by 16 | Submission Open

Keywords: brain metastases; molecular profiles; imaging advancements; systemic treatment options; radiotherapeutic techniques; primary irradiation; re-irradiation; cutting-edge clinical research

(This special issue belongs to the Section Cancer Metastasis)

Single-Cell and Spatial Data Analytics in Cancers

edited by

Yu Shyr

and Qi Liu

submission deadline 31 May 2026 | Viewed by 1 | Submission Open

Keywords: single-cell and spatial omics; tumor heterogeneity; tumor progression; tumor microenvironment; cancer immunotherapy

(This special issue belongs to the Section Cancer Informatics and Big Data)

The Role of Medical Imaging in Gynecological Cancer

edited by Emma R. Allanson and Ming Yin Lin

submission deadline 1 Jun 2026 | 6 articles | Viewed by 11086 | Submission Open

Keywords: cervical cancer; endometrial cancer; ovarian cancer; staging; ultrasound; MRI; PET-CT; radiotherapy; image-guided brachytherapy

(This special issue belongs to the Section Methods and Technologies Development)

Drug Repurposing and Reformulation for Cancer Treatment: 2nd Edition

edited by

Arati Sharma

Dhimant Desai

and

Abhijit Date

submission deadline 1 Jun 2026 | 1 articles | Viewed by 6331 | Submission Open

Keywords: drug repurposing; cancer; drug resistance; metastasis; drug delivery; liposomes; nanoparticles; bioavailability; drug targeting; reformulation

(This special issue belongs to the Section Cancer Drug Development)

New Developments in Breast Cancer Surgery, Risk, and Related Quality of Life

edited by Vesna Bjelic-Radisic,