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Cancers publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Onco-Nephrology: From Molecular to Clinical Studies

edited by

Hans Kristian Lorenzo

submission deadline 12 Oct 2025 | Viewed by 416 | Submission Open

Keywords: acute kidney injury in oncology; chronic kidney disease and cancer; paraneoplastic glomerulonephritis; immunotherapy-related nephrotoxicity; tumor lysis syndrome; nephrotoxicity of chemotherapeutic agents; DNA damage; epigenetic modifications; molecular pathways in cancer-associated kidney injury; biomarkers for early detection of kidney injury

(This special issue belongs to the Section Clinical Research of Cancer)

Cancer and Chronic Illness

edited by

Silvia Riondino

and

Vincenzo Formica

submission deadline 15 Oct 2025 | 7 articles | Viewed by 17621 | Submission Open

Keywords: cancer; chronic disease; inflammatory disease; cytokines; immune disease; radiotherapy-induced diseases; immunotherapy-induced disease; gastrointestinal chronic disorders; end-stage renal disease; lung cancer chronic disease

(This special issue belongs to the Section Cancer Pathophysiology)

New Precision Medicine Approaches in Haematological Malignancies: Novel Targets and Advanced Therapies (2nd Edition)

edited by

Ilaria Stefania Pagani

and

Teresa Sadras

submission deadline 15 Oct 2025 | 4 articles | Viewed by 12860 | Submission Open

Keywords: blood cancer; cancer relapse; resistance; targeted therapies; immune therapies; metabolism; cancer mutations

(This special issue belongs to the Section Methods and Technologies Development)

Bridging the Gap: Integrating AI into Clinical Practice for Oncological PET/CT Imaging

edited by Fereshteh Yousefirizi

submission deadline 15 Oct 2025 | 8 articles | Viewed by 12015 | Submission Open

Keywords: physician-in-the-loop; PET/CT; AI; foundation model; generalist model; tumor segmentation; outcome prediction; whole-body PET; cancers

(This special issue belongs to the Section Cancer Therapy)

Imaging in Breast Cancer Diagnosis and Treatment

edited by

Tommaso Susini

and Jacopo Nori Cucchiari

submission deadline 15 Oct 2025 | 6 articles | Viewed by 11651 | Submission Open

Keywords: mammography; breast ultrasound; axillary ultrasound; breast MRI; contrast-enhanced mammography; digital breast thomosynthesis; thermoablation; crioablation

(This special issue belongs to the Section Cancer Therapy)

Treatment of Peripheral T-cell Lymphomas

edited by

Raphael Koch

submission deadline 15 Oct 2025 | 4 articles | Viewed by 9034 | Submission Open

Keywords: T-cell lymphoma; PTCL; molecular targets; targeted therapy; immunotherapy; combination therapy; biomarker

(This special issue belongs to the Section Tumor Microenvironment)

Current Progress in the Clinical Management and Basic Science of Head and Neck Cancer

edited by

Takumi Kumai

submission deadline 15 Oct 2025 | 3 articles | Viewed by 4780 | Submission Open

Keywords: head and neck cancer; immunotherapy; chemoradiotherapy; surgery; molecular biology; oncogenesis; cancer immunology

(This special issue belongs to the Section Clinical Research of Cancer)

De-escalation of Axillary and Breast Cancer Surgery in the Setting of Neo-Adjuvant Chemotherapy

edited by Corrado Tinterri and

Damiano Gentile

submission deadline 15 Oct 2025 | 2 articles | Viewed by 4232 | Submission Open

Keywords: breast neoplasm; breast cancer; surgery; breast cancer surgery; systemic therapy; neo-adjuvant chemotherapy; axilla; axillary surgery; sentinel lymph node biopsy; de-escalation surgery

(This special issue belongs to the Section Cancer Therapy)

Targeting Pathogenic Variants in Hereditary Cancer Diagnosis and Screening

edited by Yanhong Liu

submission deadline 15 Oct 2025 | 3 articles | Viewed by 4113 | Submission Open

Keywords: disease susceptibility; prognosis and outcomes; genetic association; genetic epidemiology; germline variants; pathogenic variants; rare variants; exome sequencing; whole genome sequencing; target sequencing

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

Recent Advance in Colorectal Cancer Liver Metastases

edited by

Peter Metrakos

and Jennifer Kalil

submission deadline 15 Oct 2025 | 2 articles | Viewed by 3522 | Submission Open

Keywords: colorectal cancer liver metastases; histological growth patterns; chemotherapy optimization; liver regeneration; future liver remnant; liquid biopsy; treatment resistance

(This special issue belongs to the Section Cancer Metastasis)

Inflammatory Bowel Disease and Cancers

edited by

Ferdinando D'Amico

submission deadline 15 Oct 2025 | 2 articles | Viewed by 2826 | Submission Open

Keywords: inflammatory bowel disease; ulcerative colitis; Crohn’ s disease; cancer; malignancy

(This special issue belongs to the Section Cancer Therapy)

First-Line Therapy in Thoracic Oncology

edited by Antonio D'Andrilli and

Giulio Maurizi

submission deadline 15 Oct 2025 | 2 articles | Viewed by 2456 | Submission Open

Keywords: thoracic oncology; lung cancer; thymoma; mediastinal tumors

(This special issue belongs to the Section Cancer Therapy)

Endoscopic Management of Pancreatic Neoplasms (2nd Edition)

edited by

Nam Quoc Nguyen

submission deadline 15 Oct 2025 | 1 articles | Viewed by 1736 | Submission Open

Keywords: pancreatic cancer; pancreatic neoplasm; endoscopic retrograde cholangiopancreatography; endoscopic ultrasound; fine needle aspiration/biopsy; local treatment; biliary stent; biliary drainage; contrast enhancement

(This special issue belongs to the Section Methods and Technologies Development)

Treatments of Uveal Melanoma

edited by

Rumana N. Hussain

submission deadline 15 Oct 2025 | 2 articles | Viewed by 1182 | Submission Open

Keywords: uveal melanoma; radiotherapy; radiation retinopathy; liver metastases; prognostication

(This special issue belongs to the Section Cancer Therapy)

Cutaneous Metastases: State-of-the-Art Research and Management

edited by Marios Papadakis and

Dimitra Koumaki

submission deadline 15 Oct 2025 | Viewed by 362 | Submission Open

Keywords: cutaneous metastases; cancer skin metastasis; metastatic skin lesions; diagnosis of cutaneous metastases; oncology; skin oncology; patient outcomes

(This special issue belongs to the Section Cancer Metastasis)

Head and Neck Cancer Recurrence: Diagnosis, Treatment and Prognosis (2nd Edition)

edited by

Oreste Gallo

submission deadline 15 Oct 2025 | Viewed by 302 | Submission Open

Keywords: head and neck cancer; recurrence; squamous cell carcinoma; HPV; larynx; oral cavity; oropharynx

(This special issue belongs to the Section Cancer Therapy)

Radiomics and Molecular Biology in Glioma: A Synergistic Approach

edited by Anna Luisa Di Stefano and Gianluca Grimod

submission deadline 15 Oct 2025 | Viewed by 161 | Submission Open

Keywords: glioma; radiomics; molecular biology; MRI; PET; genomics; proteomics; liquid biopsy; personalized medicine; prognostic biomarkers

(This special issue belongs to the Section Methods and Technologies Development)

Liquid Biopsy in Cancer 2.0

edited by

Fabio Puglisi

Lorenzo Gerratana

and

Linda Cucciniello

submission deadline 20 Oct 2025 | 9 articles | Viewed by 25687 | Submission Open

Keywords: circulating biomarkers; clinical utility; circulating tumor DNA; circulating tumor cells; exosomes; circulating RNA; precision medicine

(This special issue belongs to the Section Cancer Therapy)

What’s behind the Scenes? New Insights in Endometrial Cancer Management and Risk Stratification

edited by

Emanuele Perrone

submission deadline 20 Oct 2025 | 5 articles | Viewed by 16120 | Submission Open

Keywords: endometrial cancer; molecular classification; surgical staging; surgery; target therapy; gynecologic oncology; precision medicine; immunohistochemistry

(This special issue belongs to the Section Cancer Epidemiology and Prevention)

Advanced Research in Oncology in 2025

edited by

Dimitrios Moris

submission deadline 20 Oct 2025 | 6 articles | Viewed by 11760 | Submission Open

Keywords: cancer; tumour; oncology

Clinical Treatment of Osteosarcoma

edited by

Masanori Okamoto

submission deadline 20 Oct 2025 | 5 articles | Viewed by 10232 | Submission Open

(This special issue belongs to the Section Clinical Research of Cancer)

Obesity and Cancers

edited by Edward Sauter and Tanya Agurs-Collins

submission deadline 20 Oct 2025 | 4 articles | Viewed by 8640 | Submission Open

Keywords: obesity; cancer; mitigating factors; weight loss; weight gain; obesity interventions

(This special issue belongs to the Section Cancer Epidemiology and Prevention)

State-of-the-Art Strategies for Non-Coding RNA Function Detection and Regulation in Cancer

edited by

Antonis Giakountis

and

Nikolaos Balatsos

submission deadline 20 Oct 2025 | 4 articles | Viewed by 7847 | Submission Open

Keywords: long non-coding RNAs; miRNAs; regulatory non-coding variants; ribodiagnostics; RNA therapeutics; targeted therapy; cancer

(This special issue belongs to the Section Tumor Microenvironment)

Advances in Salivary Gland Carcinoma: 2nd Edition

edited by

Giulio Cantù

submission deadline 20 Oct 2025 | 2 articles | Viewed by 4661 | Submission Open

Keywords: salivary gland tumors; head and neck cancer; facial nerve preservation; facial nerve reconstruction; facial nerve sacrifice; parotid cancer; parotidectomy; prognostic factors

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

Clinical Applications of Ultrasound in Cancer Imaging and Treatment

edited by Gregory Jan Czarnota

submission deadline 20 Oct 2025 | 3 articles | Viewed by 4209 | Submission Open

Keywords: ultrasound; imaging; CT; MRI; treatment

(This special issue belongs to the Section Methods and Technologies Development)

Potential Biomarkers in Immune Checkpoint Inhibitors

edited by Goulnar Kasymjanova

submission deadline 20 Oct 2025 | Viewed by 187 | Submission Open

Keywords: advanced metastatic cancer; personalized immunotherapy; predictive biomarkers; circulating tumor DNA; resistance mechanisms; tumor microenvironment (TME); adverse events; real-world evidence

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

Cancer Epigenetic Biomarkers: 2nd Edition

edited by

Fabio Coppedè

submission deadline 22 Oct 2025 | 2 articles | Viewed by 2206 | Submission Open

Keywords: cancer; biomarker; epigenetics; DNA methylation; miRNA; diagnostic biomarkers; pharmacoepigenetics; epigenetic drugs

(This special issue belongs to the Section Cancer Biomarkers)

New Developments in Adolescent and Young Adult Oncology

edited by

Olga Husson

and

Winette T.A. van der Graaf

submission deadline 24 Oct 2025 | 1 articles | Viewed by 2692 | Submission Open

Keywords: adolescent and young adult oncology; epidemiology; health-related quality of life; late effects; survivorship; clinical care

(This special issue belongs to the Section Clinical Research of Cancer)

Radiation Therapy for Brain Tumors

edited by

Jim Zhong

submission deadline 25 Oct 2025 | 4 articles | Viewed by 10444 | Submission Open

Keywords: radiosurgery; hypofractionated radiosurgery; spectroscopic MRI; proton radiation; image-guided radiotherapy; radiotherapy for benign tumors; radiotherapy for gliomas; gamma knife

(This special issue belongs to the Section Cancer Therapy)

Research on Surgical Treatment for Ovarian Cancer

edited by Antonios Apostolos K. Tentes and Theo Panoskaltsis

submission deadline 25 Oct 2025 | 6 articles | Viewed by 9551 | Submission Open

Keywords: ovarian cancer; surgical; cancer treatment

(This special issue belongs to the Section Cancer Therapy)

Prevention, Screening and Early Detection of Cancer

edited by

Nadir Arber

and

Shiran Shapira

submission deadline 25 Oct 2025 | 4 articles | Viewed by 6202 | Submission Open

Keywords: cancer prevention; screening; early detection; risk factors; lifestyle modification; biomarkers; genetic testing; lifestyle interventions; cancer risk factors; liquid biopsy; pan-cancer screening tests

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

Study on Acute Myeloid Leukemia

edited by Olga K. Weinberg

submission deadline 25 Oct 2025 | 3 articles | Viewed by 3703 | Submission Open

Keywords: acute myeloid leukemia (AML); cancer treatment; genetic

(This special issue belongs to the Section Cancer Therapy)

The State of the Art in the Diagnosis, Staging, Treatment and Prognosis of Gastrointestinal and Urogenital Malignancies

edited by

Agnieszka Kulczyńska-Przybik

and

Sara Pączek

submission deadline 30 Oct 2025 | 3 articles | Viewed by 7972 | Submission Open

(This special issue belongs to the Section Clinical Research of Cancer)

Radiopharmaceuticals for Cancers

edited by Joseph Lau and Hwan Lee

submission deadline 30 Oct 2025 | 2 articles | Viewed by 6117 | Submission Open

Keywords: radiopharmaceutical; positron emission tomography; single photon emission computed tomography; targeted radionuclide therapy; dosimetry; cancer; in vitro and in vivo characterization

(This special issue belongs to the Section Cancer Drug Development)

Prevention, Early Detection, and Surgical Oncology in Hepatocellular Carcinoma, Pancreatic Cancer, and Gastrointestinal Cancer

edited by

Mingyao Chen

and

Kuang-Chun Hu

submission deadline 30 Oct 2025 | 2 articles | Viewed by 2922 | Submission Open

Keywords: early image detection in cancer; biomarker of cancer; surgical treatment; gastrointestinal cancer

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

G Protein-Coupled Receptors in Cancer Progression

edited by

Songhai Chen

submission deadline 30 Oct 2025 | 1 articles | Viewed by 2189 | Submission Open

Keywords: GPCRs; heterotrimeric G proteins; signal transduction; mutations; cancer development

(This special issue belongs to the Section Tumor Microenvironment)

Cancer Immunotherapy as Part of Precision Clinical Medicine

edited by

Peter Lang

and

Christo Kole

submission deadline 30 Oct 2025 | 1 articles | Viewed by 1101 | Submission Open

Keywords: cancer; immunotherapy; tumor microenvironment; molecular biology and genetics

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

Treg Cell Immunotherapy in Cancer

edited by

Maria Velegraki

submission deadline 30 Oct 2025 | Viewed by 867 | Submission Open

Keywords: treg cells; cancer immunotherapy; immune evasion; antitumor immune responses; targeting therapeutic interventions

(This special issue belongs to the Section Cancer Therapy)

Management of Pancreatic Cancer

edited by

Traian Dumitrascu

submission deadline 31 Oct 2025 | 20 articles | Viewed by 40520 | Submission Open

Keywords: pancreatic cancer; adenocarcinoma; neuroendocrine carcinomas; molecular and pathological aspects; diagnosis; medical treatment; palliative therapy

(This special issue belongs to the Section Cancer Therapy)

Neurofibromatosis

edited by Rianne Oostenbrink,

Ignaci Blanco

and Enrico Opocher

submission deadline 31 Oct 2025 | 9 articles | Viewed by 18535 | Submission Open

Keywords: neurofibromatosis; schwannomatosis; tumor; longitudinal history; treatment; biomarker; outcomes

(This special issue belongs to the Section Cancer Therapy)

Treatment Outcomes in Older Adults with Cancer

edited by

Mackenzi Pergolotti

submission deadline 31 Oct 2025 | 7 articles | Viewed by 12551 | Submission Open

Keywords: older adults with cancer; geriatric oncology; geriatric assessment; supportive care; palliative care; cancer rehabilitation; nutrition; physical activity; functional status; survivorship

(This special issue belongs to the Section Cancer Therapy)

Clinical Research Advances in Endometrial Carcinoma

edited by Salvatore Lopez

submission deadline 31 Oct 2025 | 5 articles | Viewed by 12211 | Submission Open

Keywords: endometrial cancer; uterine serous carcinoma; immunotherapy; MMRd; POLE; endometrioid carcinoma; target therapies; surgery; preclinical research

(This special issue belongs to the Section Clinical Research of Cancer)

Molecular Mechanisms in Head and Neck Cancer

edited by Désirée Gül, Jan Hagemann and

Roland Hans Stauber

submission deadline 31 Oct 2025 | 6 articles | Viewed by 12050 | Submission Open

Keywords: head and neck cancer; translational research; molecular pathways; cellular signaling; biomarkers; liquid biopsies; transcriptome; proteome; survival

(This special issue belongs to the Section Molecular Cancer Biology)

Novel Prognostic Biomarkers in Human Cancers: From Discovery to Application

edited by

Zakaria Y. Abd Elmageed

submission deadline 31 Oct 2025 | 4 articles | Viewed by 11992 | Submission Open

Keywords: tumor biomarkers; investigational markers; prognosis; biochemical relapse; overall survival; clinical trials; advancement in biomarker discovery; bioinformatics and marker discovery; AI and biomarker discovery

(This special issue belongs to the Section Cancer Biomarkers)

Advances and Challenges in the Diagnosis and Treatment of Urological Malignancies (2nd Edition)

edited by

Bartosz Małkiewicz

Jakub Dobruch

and

Łukasz Nowak

submission deadline 31 Oct 2025 | 7 articles | Viewed by 11471 | Submission Open

Keywords: prostate cancer; bladder cancer; upper urinary tract tumors; kidney cancer; testicular tumors; molecular markers; lymph node metastasis; diagnosis; radical treatment; systemic treatment

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

Molecular Advances in Lung Cancer: From Pathogenesis to Precision Therapy

edited by

Federico Pio Fabrizio

submission deadline 31 Oct 2025 | 3 articles | Viewed by 11179 | Submission Open

Keywords: lung cancer molecular biology; targeted therapy; precision medicine; biomarkers; therapeutic resistance

(This special issue belongs to the Section Cancer Therapy)

Lifestyle Choices and Endocrine Dysfunction on Cancer Onset and Risk

edited by

Ariane Zamoner

Marco G. Alves

and

Ana Paula S. Perez

submission deadline 31 Oct 2025 | 5 articles | Viewed by 10403 | Submission Open

Keywords: occupational exposure; obesity; nutrition; exercise; endocrine disruptors; reproduction; development; hormone

(This special issue belongs to the Section Tumor Microenvironment)

Combination Therapies for Brain Tumors

edited by Jason H. Huang and Ekokobe Fonkem

submission deadline 31 Oct 2025 | 5 articles | Viewed by 9689 | Submission Open

Keywords: novel diagnostics; therapies; glioblastoma; meningioma; astrocytoma

(This special issue belongs to the Section Cancer Therapy)

Advances in Uveal Melanoma

edited by

Takami Sato

and

Mizue Terai

submission deadline 31 Oct 2025 | 6 articles | Viewed by 9376 | Submission Open

Keywords: uveal melanoma; eye cancer; liver metastasis; Gα q/11 mutations; BAP1; SF3B1; PRAME; dormancy; liver-directed treatment; T-cell engager

(This special issue belongs to the Section Molecular Cancer Biology)

Advances in TNBC: New Markers for Innovative Treatments

edited by

Pia Giovannelli

submission deadline 31 Oct 2025 | 3 articles | Viewed by 9065 | Submission Open

Keywords: TNBC treatment; TNBC target; signaling pathways in TNBC; epigenetic modifications in TNBC; immunotherapy; personalized medicine

(This special issue belongs to the Section Cancer Therapy)

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