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Cancers publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Palliative and Supportive Care in Cancers
edited by Ahmed Elsayem
submission deadline 31 Jul 2025 | Viewed by 456 | Submission Open
Keywords: palliative care; symptom distress; oncology; emergency medicine; critical care; goals of care
(This special issue belongs to the Section Cancer Survivorship and Quality of Life)
Novel Diagnosis and Treatment Approaches in Pancreatic Cancer
edited by
submission deadline 31 Jul 2025 | Viewed by 444 | Submission Open
Keywords: pancreatic cancer; pancreatic fibrosis; biomarker; risk factor; genetic testing; artificial intelligence; endoscopic ultrasound; stroma; cancer-associated fibroblasts; familial pancreatic cancer
(This special issue belongs to the Section Cancer Therapy)
Cancer Induced Organ Dysfunctions (Cachexia)
edited by and Sarama Saha
submission deadline 31 Jul 2025 | Viewed by 402 | Submission Open
Keywords: cancer; cachexia; organ dysfunction; cancer-induced cachexia; cancer-induced organ dysfunction; muscle wasting
(This special issue belongs to the Section Molecular Cancer Biology)
Innovation, New Technologies, and Future Prospects in Endometrial Cancer Surgery
edited by
submission deadline 31 Jul 2025 | Viewed by 255 | Submission Open
Keywords: endometrial cancer surgery; robotic surgery; minimally invasive procedures; image-guided surgery; artificial intelligence; surgical innovations; patient outcomes; surgical precision; future prospects; fertility sparing
(This special issue belongs to the Section Clinical Research of Cancer)
Applications of Single-Cell Genomics in Cancer Research
edited by Clelia Peano
submission deadline 31 Jul 2025 | Viewed by 242 | Submission Open
Keywords: single-cell genomics; spatial transcriptomics; spatial multi-omics analysis; gene expression; tumor microenvironment
(This special issue belongs to the Section Methods and Technologies Development)
Glioblastoma Stem Cells: Molecule Pathways and Cancer Therapy
edited by Shilpi Singh
submission deadline 31 Jul 2025 | Viewed by 235 | Submission Open
Keywords: glioblastoma; glioma stem cells; therapeutic resistance; tumor recurrence; tumor microenvironment; cellular and molecular pathways
(This special issue belongs to the Section Molecular Cancer Biology)
Glioma: From Intracellular Oncogenic Pathways to Targeting Therapeutic Strategies
edited by
submission deadline 31 Jul 2025 | Viewed by 201 | Submission Open
Keywords: glioma; targeted therapies; resistance mechanisms; oncogenic pathways; therapeutic resistance; combination therapies; tumor heterogeneity
(This special issue belongs to the Section Cancer Therapy)
Significance of CAR T-Cell Therapy in Aggressive B-Cell Lymphoma Treatment
edited by
submission deadline 31 Jul 2025 | Viewed by 196 | Submission Open
Keywords: CAR-T therapy; non-hodgkin lymphoma; hodgkin lymphoma; CAR-T persistence; immune-related adverse events (irAEs); resistance mechanisms; combination therapy; tumor microenvironment; multiomics data analysis
(This special issue belongs to the Section Cancer Therapy)
Mesothelioma—From Diagnosis to Treatment submission deadline 31 Jul 2025 | Viewed by 183 | Submission Open
Keywords: mesothelioma; thoracic pathology; thoracic oncology; targeted therapy; tumor microenvironment; molecular diagnostics; immunohistochemistry; cancer genomics; epigenetics; novel biomarkers
(This special issue belongs to the Section Molecular Cancer Biology)
Rethinking Cancer Epidemiology, Aging and Machine Learning: 2nd Edition submission deadline 31 Jul 2025 | Viewed by 156 | Submission Open
Keywords: cancer epidemiology; aging; cancer control; artificial intelligence; machine learning; cancer– health equity
(This special issue belongs to the Section Cancer Epidemiology and Prevention)
Extracellular Matrix—Role in the Tumor Microenvironment and Impact on Cancer Therapy
edited by Heena Kumra and Makoto Noda
submission deadline 31 Jul 2025 | Viewed by 150 | Submission Open
Keywords: extracellular matrix; stroma; tumor microenvironment; therapy resistance
(This special issue belongs to the Section Cancer Pathophysiology)
Liver Inflammation and Hepato-Pancreatic Biliary Cancers (HPBCs)
edited by Tsutomu Masaki
submission deadline 31 Jul 2025 | Viewed by 142 | Submission Open
Keywords: liver inflammation; hepato-pancreatic biliary cancers; basic study; clinical study; epidemiological study
(This special issue belongs to the Section Clinical Research of Cancer)
Pituitary Tumors: Molecular Insights, Diagnosis, and Targeted Therapy (2nd Edition) submission deadline 1 Aug 2025 | 7 articles | Viewed by 10677 | Submission Open
Keywords: acromegaly; adrenocorticotropic hormone; Cushing’ s disease; diagnosis; growth hormone; pituitary tumor; proliferation; transcriptional factor; treatment
(This special issue belongs to the Section Cancer Therapy)
Inflammation, Immunity, and Cancer Progression: 2nd Edition submission deadline 1 Aug 2025 | 1 articles | Viewed by 4433 | Submission Open
Keywords: inflammation; cancer immunity; transcriptomics; epigenomics; immunometabolism; pharmacogenomic; bioinformatics data; immunopharmacogenomics
(This special issue belongs to the Section Cancer Immunology and Immunotherapy)
BRCA Associated Cancers: Latest Predictive and Therapeutic Approaches
edited by Melpomeni Kalofonou
submission deadline 1 Aug 2025 | 2 articles | Viewed by 3490 | Submission Open
Keywords: BRCA; ovarian cancer; breast cancer; prostate cancer; pancreatic cancer; genetics; epigenetics
(This special issue belongs to the Section Cancer Therapy)
Radiomics in Cancer
edited by Isabelle M. Germano
submission deadline 1 Aug 2025 | 3 articles | Viewed by 2277 | Submission Open
Keywords: radiomic; medical imaging; personalized treatment; diagnosis; staging; management; targeted treatment; patient outcome; clinical practice; cancer therapies; patient care
(This special issue belongs to the Section Cancer Therapy)
High-Quality Cancer Care in Older Adults submission deadline 1 Aug 2025 | 2 articles | Viewed by 2208 | Submission Open
Keywords: elderly; target therapy; cancer treatment; cancer care
(This special issue belongs to the Section Cancer Survivorship and Quality of Life)
miRNAs in Targeted Cancer Therapy
edited by Mustafa Özen
submission deadline 1 Aug 2025 | Viewed by 150 | Submission Open
Keywords: miRNA; micro-RNA; targeted therapy; cancer treatment; solid tumors; hematological malignancies; non-coding RNAs; epigenetic regulation; cancer therapeutics; gene therapy
(This special issue belongs to the Section Cancer Therapy)
Breast Cancer and Hormone-Related Therapy
edited by
submission deadline 10 Aug 2025 | 12 articles | Viewed by 44340 | Submission Open
Keywords: breast cancer; estrogen receptor; hormone activated transcription factors; hormonal therapy; molecular mechanisms
(This special issue belongs to the Section Cancer Therapy)
Epigenetic Regulation in Cancers
edited by and
submission deadline 10 Aug 2025 | 3 articles | Viewed by 6077 | Submission Open
Keywords: oncogenes; tumor suppressor genes; tumor microenvironment; cancer therapy; DNA and histone methylation; microRNAs; epitranscriptomics; RNA modifications; modifying proteins
(This special issue belongs to the Section Tumor Microenvironment)
Alternative Cell Death Modes in Regulating Cancer Stem Cells and Therapeutic Strategies
edited by Mun-Ock Kim and
submission deadline 10 Aug 2025 | 2 articles | Viewed by 5210 | Submission Open
Keywords: cancer stem cell; alternative cell death mode; tumor microenvironment; immune mechanism; cellular basis of cancer therapy resistance; cellular transformation; small-molecule-based therapeutics
(This special issue belongs to the Section Molecular Cancer Biology)
Cutting-Edge Nanomedicine Advancements in Cancer Disease submission deadline 10 Aug 2025 | Viewed by 209 | Submission Open
Keywords: active targeting; breast cancer; drug delivery; liposomes; lung cancer; metallic nanoparticles; polymeric nanoparticles; theragnostic
(This special issue belongs to the Section Methods and Technologies Development)
Advances in Skin Cancer: Diagnosis, Treatment and Prognosis
edited by Iris Zalaudek and
submission deadline 15 Aug 2025 | 12 articles | Viewed by 18669 | Submission Open
Keywords: skin cancer; melanoma; basal cell carcinoma; cutaneous squamous cell carcinoma; diagnosis; noninvasive imaging; therapy; prognosis; immunotherapy; targeted therapy
(This special issue belongs to the Section Cancer Therapy)
Research on Early-Stage Breast Cancer: Management and Treatment
edited by Ernyu Tan
submission deadline 15 Aug 2025 | 7 articles | Viewed by 15830 | Submission Open
Keywords: early-stage breast cancer; adjuvant treatment; systemic therapy; risk stratification; survival
(This special issue belongs to the Section Cancer Therapy)
Advancements in Lung Cancer Surgical Treatment and Prognosis
edited by Sai Yendamuri and
submission deadline 15 Aug 2025 | 8 articles | Viewed by 15177 | Submission Open
Keywords: lung cancer; surgical techniques; targeted therapies; immunotherapies; accurate staging; biomarker detection; clinical trials; multimodality therapy; artificial intelligence (AI) in thoracic oncology; enhanced recovery after thoracic surgery (ERATS)
(This special issue belongs to the Section Cancer Therapy)
Clinical Surgery for Hepato-Pancreato-Biliary (HPB) Cancer submission deadline 15 Aug 2025 | 7 articles | Viewed by 7829 | Submission Open
Keywords: pancreatic malignancies; HPB malignancies; pancreatic ductal adenocarcinoma; liver cholangiocarcinoma; HPB surgery; liver resection; pancreatic resection
(This special issue belongs to the Section Cancer Therapy)
Impact of Social Determinants on Cancer Care
edited by
submission deadline 15 Aug 2025 | 4 articles | Viewed by 5399 | Submission Open
Keywords: social determinants of health; cancer disparities; socioeconomic status; transportation barriers; stress genomics; health equity; cancer outcomes
(This special issue belongs to the Section Cancer Survivorship and Quality of Life)
Advances in Esophageal Cancer
edited by Sacheen Kumar
submission deadline 15 Aug 2025 | 2 articles | Viewed by 2063 | Submission Open
Keywords: esophageal adenocarcinoma; esophageal squamous cell carcinoma; long-term survival; biomarkers; disease surveillance; treatment response
(This special issue belongs to the Section Cancer Therapy)
Oligometastases Hypothesis to Advancing New Perspectives on Cancer: Oligo-Reurrence submission deadline 15 Aug 2025 | 1 articles | Viewed by 816 | Submission Open
Keywords: oligometastases; oligo-recurrence; sync-oligometastases
(This special issue belongs to the Section Cancer Metastasis)
Robot-Assisted Surgery for Urologic Cancer
edited by Gabriele Sorce, Francesco Pellegrino and Ettore Di Trapani
submission deadline 15 Aug 2025 | 1 articles | Viewed by 723 | Submission Open
Keywords: robot-assisted surgery; urologic oncology; minimally invasive surgery; prostate cancer surgery; kidney cancer surgery; bladder cancer surgery; robotic platforms; robotic surgery training
(This special issue belongs to the Section Cancer Therapy)
Prostate Cancer Epidemiology and Genetics: 2nd Edition
edited by
submission deadline 15 Aug 2025 | 1 articles | Viewed by 669 | Submission Open
Keywords: prostate cancer; epidemiology; clinical genetics; aging; population-level databases
(This special issue belongs to the Section Cancer Epidemiology and Prevention)
Role of Autophagy in Cancer Stem Cells and the Tumor Microenvironment: New Frontiers in Cancer Drug Discovery
edited by Yasser Heakal, and
submission deadline 15 Aug 2025 | Viewed by 462 | Submission Open
Keywords: autophagy; cancer stem cells; tumor microenvironment; therapeutic resistance; metastasis
(This special issue belongs to the Section Tumor Microenvironment)
Breast Conservation and Radiotherapy in the Era of De-Escalation of Breast Cancer Treatments submission deadline 15 Aug 2025 | Viewed by 377 | Submission Open
Keywords: breast cancer; breast conserving treatment; mastectomy; radiotherapy; neoadjuvant treatment; psychology; quality of life; breast imaging
(This special issue belongs to the Section Cancer Therapy)
Palliative Radiotherapy of Cancer submission deadline 15 Aug 2025 | Viewed by 264 | Submission Open
Keywords: palliative radiotherapy; cancer pain management; advanced radiotherapy techniques; multidisciplinary cancer care; stereotactic body radiotherapy (SBRT); quality of life in cancer; cancer symptom management
(This special issue belongs to the Section Cancer Therapy)
Antioxidants in Cancers
edited by Asif Raza
submission deadline 15 Aug 2025 | Viewed by 239 | Submission Open
Keywords: antioxidants in cancer; oxidative stress and cancer; tumor microenvironment; cancer prevention strategies; therapy resistance and antioxidants; reactive oxygen species (ROS); natural antioxidants; synthetic antioxidants; precision oncology; chemoprevention
(This special issue belongs to the Section Cancer Therapy)
Radiotherapy for Sarcoma
edited by Safia K. Ahmed and Miranda Lam
submission deadline 15 Aug 2025 | Viewed by 137 | Submission Open
Keywords: soft tissue sarcoma; bone sarcoma; advanced sarcoma; radiation therapy; particle therapy; multidisciplinary sarcoma care
(This special issue belongs to the Section Cancer Therapy)
Immunotherapy of Glioblastoma
edited by
submission deadline 16 Aug 2025 | Viewed by 235 | Submission Open
Keywords: glioblastoma; immunotherapy; antigen presentation; CNS lymphatic system; adoptive cell therapy; cancer vaccine; checkpoint blockage
(This special issue belongs to the Section Cancer Immunology and Immunotherapy)
Bone and Spine Metastases submission deadline 20 Aug 2025 | 9 articles | Viewed by 16644 | Submission Open
Keywords: bone metastases; spinal metastases; stereotactic body radiotherapy; conventional radiotherapy; spine surgery; spondylectomy; minimally invasive surgery; particle-beam radiotherapy; systemic agents; microenvironment
(This special issue belongs to the Section Cancer Metastasis)
Cell Migration and Invasion in Cancer
edited by
submission deadline 20 Aug 2025 | 3 articles | Viewed by 7102 | Submission Open
Keywords: cell migration; invasion; tumor; metastasis; genes; microRNA
(This special issue belongs to the Section Molecular Cancer Biology)
Radiation Exposure, Inflammation and Cancers
edited by
submission deadline 20 Aug 2025 | 3 articles | Viewed by 4350 | Submission Open
Keywords: radiation; DNA damage response; inflammation; oxidative stress; senescence and cancer
(This special issue belongs to the Section Tumor Microenvironment)
Ultrasonography for Pancreatobiliary Cancer
edited by
submission deadline 20 Aug 2025 | 1 articles | Viewed by 1733 | Submission Open
Keywords: endoscopic ultrasonography; abdominal ultrasonography; early diagnosis project; screening; EUS-FNA; interventional EUS; enhancement EUS; EUS-RFA
(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)
Protein Kinases and Their Impact on Tumor Growth: Mechanisms and Therapeutic Targets submission deadline 20 Aug 2025 | 1 articles | Viewed by 1311 | Submission Open
Keywords: protein kinases; PI3K-Akt signaling; MAPK signaling; kinase inhibitors; drug resistance; crosstalk
(This special issue belongs to the Section Methods and Technologies Development)
Research on New Drugs and Drug Targets in Melanoma submission deadline 20 Aug 2025 | 1 articles | Viewed by 1257 | Submission Open
Keywords: melanoma; new drugs; drug targets; mechanism of action; substances with anti-melanoma potential
(This special issue belongs to the Section Cancer Drug Development)
Exploring Non-Coding RNA Signatures in Cancer: Definitions and Implications for Diagnosis and Therapy
edited by and Udhayakumar Gopal
submission deadline 20 Aug 2025 | 2 articles | Viewed by 1011 | Submission Open
Keywords: non-coding RNA; biomarkers; gene regulation; microRNA; long non-coding RNA; circular RNA; therapeutic targets
(This special issue belongs to the Section Cancer Therapy)
New Insights into Esophageal Cancer Chemotherapy
edited by Kenneth Meredith
submission deadline 20 Aug 2025 | Viewed by 366 | Submission Open
Keywords: esophageal cancer; chemotherapy; treatment
(This special issue belongs to the Section Cancer Therapy)
Novel Insights into Microenvironment of Leukemia submission deadline 20 Aug 2025 | Viewed by 198 | Submission Open
Keywords: stromal microenvironment; genetic and epigenetic alterations; bone marrow; chronic and acute leukemia; hematological malignancies
(This special issue belongs to the Section Tumor Microenvironment)
Clinical Advances and State-of-Art Management in Genitourinary Cancers
edited by and Adnan Fazili
submission deadline 25 Aug 2025 | 1 articles | Viewed by 1796 | Submission Open
Keywords: genitourinary malignancies; tumor– immune microenvironment (TIME); tumor biology; genomic characterization; targeted drug therapy; immunotherapy
(This special issue belongs to the Section Clinical Research of Cancer)
Surgical Treatment of Bone Metastases: 2nd Edition submission deadline 29 Aug 2025 | 2 articles | Viewed by 3550 | Submission Open
Keywords: metastatic bone disease; bone metastasis; pathological fractures; surgical treatment; patients survival; implant survival; functional results; surgical technique
(This special issue belongs to the Section Cancer Therapy)
New Challenges in Allogeneic Hematopoietic Stem Cell Transplantation for Acute Myeloid Leukemia
edited by Federico Mosna and Irene Cavattoni
submission deadline 29 Aug 2025 | 1 articles | Viewed by 1000 | Submission Open
Keywords: acute myeloid leukemia (AML); allogeneic hematopoietic stem cells transplantation (allo-HSCT); immunotherapy; leukemic stem cells; graft versus host disease (GVHD); infections in immunodepressed patients; immune reconstitution; post-transplant management; long-term results; clinical
(This special issue belongs to the Section Cancer Therapy)
CRISPR in Cancer Biology and Therapy: 2nd Edition
edited by
submission deadline 29 Aug 2025 | Viewed by 244 | Submission Open
Keywords: cancer drug resistance; CRISPR screens; CRISPR-related technology; base editing; prime editing; off-target analysis; adeno-associated virus
(This special issue belongs to the Section Methods and Technologies Development)
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