Special Issues

Cancers publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Rare Gynecological Cancers submission deadline 10 Jun 2025 | 15 articles | Viewed by 43710 | Submission Open
Keywords: rare gynecological cancers; trophoblastic disease; uterine sarcomas; small-cell carcinoma of the genital tract; vaginal cancers; vulvar cancers
(This special issue belongs to the Section Molecular Cancer Biology)
Screening, Diagnosis and Staging of Lung Cancer submission deadline 10 Jun 2025 | 7 articles | Viewed by 12587 | Submission Open
Keywords: screening lung cancer; diagnosis lung cancer; staging lung cancer; clinical trial; high-risk populations; lung-cancer related mortality; oncological management
(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)
Recent Advances in Management of Renal Cell Carcinoma
edited by , and Prantik Das
submission deadline 10 Jun 2025 | 2 articles | Viewed by 3146 | Submission Open
Keywords: renal cell carcinoma; different types of therapies; molecular and cellular targets; genetic basis; epigenetic mechanism; drug resistance; imaging modalities; new drugs; real world studies
(This special issue belongs to the Section Cancer Therapy)
Advances in the Multidisciplinary Management of Hepatocellular Carcinoma submission deadline 12 Jun 2025 | 4 articles | Viewed by 4599 | Submission Open
Keywords: hepatocellular carcinoma; liver function; prognosis; systemic treatment; local treatment; resection; trans-plantation
(This special issue belongs to the Section Cancer Therapy)
Role of Cancer Biomarkers for Diagnosis, Prognosis and Targeted Therapy in Gastrointestinal Cancers
edited by
submission deadline 13 Jun 2025 | 3 articles | Viewed by 1658 | Submission Open
Keywords: liquid biopsy; esophageal cancer; gastric cancer; colorectal cancer; pancreatic cancer; hepatocellular cancer; appendiceal cancer; cancer biomarker; DNA sequencing; transcriptomics; proteomics; immunohistochemistry
(This special issue belongs to the Section Cancer Biomarkers)
Neoadjuvant Therapy of Breast Cancer
edited by and Takaaki Fujii
submission deadline 15 Jun 2025 | 8 articles | Viewed by 15356 | Submission Open
Keywords: neoadjuvant systemic therapy; chemotherapy; endocrine therapy; molecular targeted therapy; molecular subtypes; response-guided therapy; clinical trials
(This special issue belongs to the Section Cancer Therapy)
Bone and Soft Tissue Tumors: Molecular Mechanisms, Clinical Practice, and Emerging Therapeutics
edited by Toshihiro Akisue, and Toru Akiyama
submission deadline 15 Jun 2025 | 4 articles | Viewed by 8548 | Submission Open
Keywords: bone and soft tissue sarcoma; imaging modality; surgical treatment; systemic treatment; molecular-targeted treatment; biomarkers; prognostic parameters
(This special issue belongs to the Section Clinical Research of Cancer)
Histopathology of Urological Cancers
edited by Vikas Mehta, Antoun Toubaji and Vijayalakshmi Ananthanarayanan
submission deadline 15 Jun 2025 | 3 articles | Viewed by 5316 | Submission Open
Keywords: renal cell carcinoma; prostate; testis Ggrm cell tumors; urothelial carcinoma; artificial intelligence; ductal adenocarcinoma of prostate; neuroendocrine differentiation of prostate carcinoma; next-generation sequencing
(This special issue belongs to the Section Cancer Pathophysiology)
Drug Repurposing and Reformulation for Cancer Treatment: 2nd Edition submission deadline 15 Jun 2025 | 1 articles | Viewed by 4919 | Submission Open
Keywords: drug repurposing; cancer; drug resistance; metastasis; drug delivery; liposomes; nanoparticles; bioavailability; drug targeting; reformulation
(This special issue belongs to the Section Cancer Drug Development)
Mathematical Oncology: Using Mathematics to Enable Cancer Discoveries submission deadline 15 Jun 2025 | 1 articles | Viewed by 3397 | Submission Open
Keywords: mathematical oncology; computational biology; mathematical modeling; computational oncology; data-driven modeling; physical oncology
(This special issue belongs to the Section Methods and Technologies Development)
Advances in B-cell Lymphoma: From Diagnostics to Cure
edited by and Megan E. Melody
submission deadline 15 Jun 2025 | 2 articles | Viewed by 2463 | Submission Open
Keywords: B-cell lymphoma; treatment; molecular profiling; immunotherapies; cellular therapies
(This special issue belongs to the Section Cancer Therapy)
Adjuvant Therapy and Neoadjuvant Therapy for Melanoma
edited by Michele Del Vecchio
submission deadline 15 Jun 2025 | 2 articles | Viewed by 2062 | Submission Open
Keywords: adjuvant therapy; neoadjuvant therapy; melanoma; skin cancer; treatment; survival
(This special issue belongs to the Section Cancer Therapy)
Application of Large-Scale Genome Data in Identifying Clinically Actionable Targets in Cancer
edited by
submission deadline 15 Jun 2025 | 1 articles | Viewed by 1468 | Submission Open
Keywords: genome; cancers; oncology
(This special issue belongs to the Section Molecular Cancer Biology)
Bridging Gaps: Emerging Trends and Challenges in Cancer Research Across Africa
edited by and Luiz Zerbini
submission deadline 15 Jun 2025 | Viewed by 599 | Submission Open
Keywords: Africa; omics; translational medicine; genetic diversity
(This special issue belongs to the Section Cancer Informatics and Big Data)
The Parallel Universe of RNA beyond the Codifying Genome: ncRNAs, RNA Editing, RBP, and Epitranscriptome in Cancer submission deadline 15 Jun 2025 | Viewed by 588 | Submission Open
Keywords: RNA editing; ncRNA; RNA binding proteins (RBPs); epitranscriptome; RNA methylation
(This special issue belongs to the Section Methods and Technologies Development)
Targeting the Tumor Microenvironment in Blood Cancer submission deadline 15 Jun 2025 | Viewed by 434 | Submission Open
Keywords: hematological cancers; tumor microenvironment; multiple myeloma; leukemia; lymphoma; myelodysplastic syndromes; therapeutic targets; drug repurposing; precision medicine
(This special issue belongs to the Section Cancer Immunology and Immunotherapy)
Multicellular 3D Models of Cancer submission deadline 15 Jun 2025 | Viewed by 281 | Submission Open
Keywords: 3D in vitro cancer models; multicellular cancer models; cancer microenvironment; tumour– stroma interactions
(This special issue belongs to the Section Methods and Technologies Development)
Signaling Pathways Influencing Cancer Cell Proliferation and Dormancy States
edited by Larisa Litovchick
submission deadline 15 Jun 2025 | Viewed by 240 | Submission Open
Keywords: signaling pathway; cell proliferation; cell dormancy; drug resistance
(This special issue belongs to the Section Molecular Cancer Biology)
Immunotherapy and Transplantation in the Era of Transplant Oncology submission deadline 20 Jun 2025 | 10 articles | Viewed by 31701 | Submission Open
Keywords: transplant oncology; liver transplantation; solid organ transplantation; hepatocellular carcinoma; immunotherapy; immune-checkpoint inhibitors; CTLA-4 inhibitors; PD-1 inhibitors; allograft rejection
(This special issue belongs to the Section Transplant Oncology)
Novel Developments on Skin Cancer Diagnostics and Treatment submission deadline 20 Jun 2025 | 6 articles | Viewed by 14591 | Submission Open
Keywords: melanoma; cutaneous squamous cell carcinoma; uveal melanoma; basal cell carcinoma; Merkel cell carcinoma; liquid biopsy; molecular diagnostics; immune checkpoint inhibition; immune cell subsets; treatment resistance
(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)
Preoperative Optimisation in Patients Undergoing Cancer Surgery
edited by and
submission deadline 20 Jun 2025 | 8 articles | Viewed by 13409 | Submission Open
Keywords: prehabilitation; medical optimisation; exercise; nutrition; psychological interventions; surgery; cancer; surgical outcome; preoperative; clinical trials
(This special issue belongs to the Section Cancer Survivorship and Quality of Life)
Novel Approaches and Advances in Interventional Oncology
edited by and
submission deadline 20 Jun 2025 | 8 articles | Viewed by 8913 | Submission Open
Keywords: interventional oncological treatments; combination treatments; hypo- and hyper-thermal ablation; transarterial chemoembolization; transarterial chemoperfusion; transarterial embolization; selective internal radiotherapy; immunotherapy
(This special issue belongs to the Section Methods and Technologies Development)
The Advance of Pencil Beam Scanning Proton Beam Therapy in Cancers
edited by , Richard A. Amos and Heng Li
submission deadline 20 Jun 2025 | 4 articles | Viewed by 8241 | Submission Open
Keywords: proton therapy; pencil beam scanning; robustness; adaptive radiotherapy; imaging guidance; radiobiological model; FLASH radiotherapy; spatially fractionated radiotherapy (SFRT); proton arc
(This special issue belongs to the Section Cancer Therapy)
Perioperative Care and Pain Management in Cancer Patients: From Basic Science to Clinical Practice
edited by and
submission deadline 20 Jun 2025 | 2 articles | Viewed by 7773 | Submission Open
Keywords: cancer anesthesia; palliative care; chronic cancer pain; oncologic surgery; mini-invasive techniques; nanomedicine; cancer biomarkers; chronic interventional pain; opioids; regional anesthesia; opioid-free anesthesia
(This special issue belongs to the Section Cancer Survivorship and Quality of Life)
Application of Artificial Intelligence in Radiation Oncology
edited by Xiaofeng Yang, Lei Qiu and Tonghe Wang
submission deadline 20 Jun 2025 | 1 articles | Viewed by 1668 | Submission Open
Keywords: artificial intelligence; radiation oncology; medical physics; cancer biology; medical imaging; segmentation; treatment planning; adaptive radiation therapy; predictive modeling; patient safety; clinical workflows; personalized treatment; biomarkers
(This special issue belongs to the Section Methods and Technologies Development)
Alterations in Ribosome Structure, Integrity and Function in Cancer and in Response to Cancer Treatments
edited by Amadeo Mark Parissenti and Kenneth Pritzker
submission deadline 20 Jun 2025 | Viewed by 539 | Submission Open
Keywords: ribosome; protein translation; ribosome evolution; ribosome modification; oncoribosome; ribosomal anti-cancer targets; stress; ribosome turnover; ribosomal RNA (rRNA); rRNA degradation pathways; tumour cell death; clinical trials; chemotherapy; predictive and prognostic biomarkers; personalized medicine
(This special issue belongs to the Section Molecular Cancer Biology)
Pulmonary Nodule and Lung Cancer: Diagnosis and Clinical Treatment
edited by
submission deadline 20 Jun 2025 | Viewed by 267 | Submission Open
Keywords: pulmonary nodules; localized lung cancer; advanced imaging techniques; minimally invasive surgery; systemic therapies
(This special issue belongs to the Section Cancer Therapy)
Primary and Recurrent Gynecological Cancer: Epidemiology, Management and New Therapies
edited by Nithya Ratnavelu and Ioannis Biliatis
submission deadline 20 Jun 2025 | Viewed by 257 | Submission Open
Keywords: ovarian cancer; endometrial cancer; cervical cancer; vulva cancer; vaginal cancer; gynecological cancer
(This special issue belongs to the Section Cancer Epidemiology and Prevention)
Advances in Molecular and Genetic Biomarkers in Head and Neck Squamous Cell Carcinoma
edited by and Michal Masternak
submission deadline 24 Jun 2025 | Viewed by 419 | Submission Open
Keywords: head and neck squamous cell carcinoma (HNSCC); molecular biomarkers; genetic biomarkers; multi-omics approaches; HNSCC carcinogenesis; prognostic biomarkers; translational medicine; molecular pathology
(This special issue belongs to the Section Molecular Cancer Biology)
Looking for New Biochemical Mechanisms in Cancer: The New Dawn in the Omics Sciences
edited by , Marco Bocchetti and
submission deadline 26 Jun 2025 | 1 articles | Viewed by 1985 | Submission Open
Keywords: multi-omics; machine learning; sequencing; signal transduction; molecular mechanisms; circulating biomarker; cancer
(This special issue belongs to the Section Molecular Cancer Biology)
Pre-Clinical Studies of Personalized Medicine for Cancer Research
edited by
submission deadline 30 Jun 2025 | 12 articles | Viewed by 54211 | Submission Open
Keywords: patient-derived models; genomic profiling; drug screening; biomarker validation; combination therapies; mechanistic studies; tumor heterogeneity; data analysis and interpretation
(This special issue belongs to the Section Cancer Biomarkers)
Views and Perspectives of Cutaneous Squamous Cell Carcinoma submission deadline 30 Jun 2025 | 13 articles | Viewed by 31221 | Submission Open
Keywords: actinic keratosis; Morbus Bowen; UV exposure; immunosuppression; advanced cSCC; metastatic cSCC; cancer progression; cancer biomarker; immunotherapy; cancer prevention
(This special issue belongs to the Section Cancer Biomarkers)
Novel Biomarkers in Non-Small Cell Lung Cancer (NSCLC)
edited by
submission deadline 30 Jun 2025 | 10 articles | Viewed by 28209 | Submission Open
Keywords: NSCLC; biomarkers; next-generation sequencing (NGS); liquid biopsy; immunotherapy; targeted therapies
(This special issue belongs to the Section Cancer Biomarkers)
Radiation Therapy in Lymphoma
edited by Hans Theodor Eich and
submission deadline 30 Jun 2025 | 9 articles | Viewed by 21773 | Submission Open
Keywords: radiation therapy; lymphoma; radiotherapy; radiation doses; non-Hodgkin lymphoma; Hodgkin lymphoma; radiation treatment; immunotherapeutic; chemotherapeutic
(This special issue belongs to the Section Cancer Therapy)
Cancer Smart Nanomedicine (2nd Edition) submission deadline 30 Jun 2025 | 4 articles | Viewed by 17669 | Submission Open
Keywords: drug delivery; cancer nanomedicine; nanoparticles; targeted therapy
(This special issue belongs to the Section Cancer Pathophysiology)
“Cancer Metastasis” in 2023–2024
edited by
submission deadline 30 Jun 2025 | 7 articles | Viewed by 17442 | Submission Open
Keywords: immunotherapy; tumor suppression; cancer metastasis
(This special issue belongs to the Section Cancer Metastasis)
The Warburg Effect in Cancers
edited by and
submission deadline 30 Jun 2025 | 6 articles | Viewed by 17285 | Submission Open
Keywords: aerobic glycolysis; redox balance; tumor microenvironment; tumor initiation; tumor metastasis; cancer diagnosis; patient prognosis  
(This special issue belongs to the Section Tumor Microenvironment)
Advances in the Prevention and Treatment of Liver Cancer
edited by Ewa Janczewska
submission deadline 30 Jun 2025 | 8 articles | Viewed by 14607 | Submission Open
Keywords: new screening techniques; enhanced imaging; biomarker tests; radiofrequency ablation; transarterial chemoembolization
(This special issue belongs to the Section Cancer Therapy)
Recent Advances in Hepatobiliary Cancers: From Diagnosis to Treatment (2nd Edition)
edited by
submission deadline 30 Jun 2025 | 7 articles | Viewed by 13454 | Submission Open
Keywords: hepatobiliary cancers; hepatocellular carcinoma; cholangiocarcinoma; gallbladder cancer; immunotherapy; targeted therapy; precision medicine
(This special issue belongs to the Section Cancer Therapy)
Aging and Cancers
edited by and Saloni Sinha
submission deadline 30 Jun 2025 | 5 articles | Viewed by 13222 | Submission Open
Keywords: aging; cancer development; cell competition; tissue maintenance and decline; cell senescence; immune surveillance; clonal evolution; tissue pattern
(This special issue belongs to the Section Tumor Microenvironment)
Socio-Demographic Factors and Cancer Research
edited by and Amanda N. Goldin
submission deadline 30 Jun 2025 | 9 articles | Viewed by 12874 | Submission Open
Keywords: socioeconomic disparity; cancer delivery; cancer survival; metastatic cancer; culture-specific cancer outcomes; AI; machine learning
(This special issue belongs to the Section Cancer Survivorship and Quality of Life)
Lung Cancer—Molecular Insights and Targeted Therapies (Volume II) submission deadline 30 Jun 2025 | 6 articles | Viewed by 12688 | Submission Open
Keywords: lung cancer; non-small-cell lung cancer; small-cell lung cancer; biomarkers; oncogene-drive tumors; molecular mechanisms; targeted therapies; immunotherapy; precision medicine; preclinical models
(This special issue belongs to the Section Molecular Cancer Biology)
New Challenges for Gastric Cancer—Gut Microbiota, Post-eradication and Chemotherapy
edited by Kazunari Murakami and
submission deadline 30 Jun 2025 | 6 articles | Viewed by 11612 | Submission Open
Keywords: gastric cancer; microbiota; Helicobacter pylori; after Helicobacter pylori eradication therapy; chemotherapy; immune checkpoint inhibitor
(This special issue belongs to the Section Cancer Therapy)
Immune Checkpoint Inhibitors, Targeted Therapies and Adjuvant Treatment of Lung Cancer
edited by Ilaria Attili
submission deadline 30 Jun 2025 | 3 articles | Viewed by 10812 | Submission Open
Keywords: lung cancer; immunotherapy; immune checkpoint inhibitors; targeted therapy; tyrosine kinase inhibitors (TKI); resectable; next-generation sequencing; molecular oncology; adjuvant treatment
(This special issue belongs to the Section Cancer Therapy)
CAR T Therapy of Solid Cancers: Problems and Progress
edited by John F. Marshall and Lauren Cutmore
submission deadline 30 Jun 2025 | 4 articles | Viewed by 10770 | Submission Open
Keywords: CAR T therapy; tumor microenvironment; solid tumor; treatment; immuno-competent models
(This special issue belongs to the Section Cancer Immunology and Immunotherapy)
Experimental and Clinical Advances in Counteracting Progression of Solid Cancers Volume II submission deadline 30 Jun 2025 | 3 articles | Viewed by 10442 | Submission Open
Keywords: solid cancers; cancer progression; tumor cross-talk; cancer genetics; cancer molecular biology; cancer immunology; cancer immunotherapy
(This special issue belongs to the Section Clinical Research of Cancer)
Blood Stem Cell and Hematological Malignancies
edited by DIrk Loeffler
submission deadline 30 Jun 2025 | 6 articles | Viewed by 9038 | Submission Open
Keywords: hematopoietic stem cells; hematological malignancies; clonal hematopoiesis; clonal evolution; preleukemia and leukemia; self-renewal and differentiation; asymmetric cell division; cell polarity; therapy resistance; transformation
(This special issue belongs to the Section Molecular Cancer Biology)
Current Status of Neuroendocrine Tumors with a Special Focus on Diagnosis and Novel Treatments—2nd Edition
edited by
submission deadline 30 Jun 2025 | 3 articles | Viewed by 8772 | Submission Open
Keywords: neuroendocrine tumors; somatostatin analogues; PRRT; chemotherapy; 68Gallium-DOTATOC; PET; CT; targeted therapies; mTOR; inhibitors; angiogenesis
(This special issue belongs to the Section Cancer Therapy)
Editorial Board Members’ Collection Series: Treatment of Pediatric Solid Tumors
edited by and
submission deadline 30 Jun 2025 | 5 articles | Viewed by 8204 | Submission Open
Keywords: pediatric solid tumor; brain tumors; therapeutic strategies; immunotherapy; targeted therapy
(This special issue belongs to the Section Pediatric Oncology)
Current Status, Challenges and Future of Precision Medicine for Colorectal Cancer
edited by Brian Davidson, Jamie Murphy and
submission deadline 30 Jun 2025 | 4 articles | Viewed by 7752 | Submission Open
Keywords: colorectal cancer  ; precision medicine; personalised medicine; synchronous resection  ; downstaging  ; liver transplant  ; molecular profiling  ; biomarkers  ; radiomics  ; targeted therapy  ; immunotherapy  ; liquid biopsy  ; next-generation sequencing  ; machine learning  ; artificial intelligence
(This special issue belongs to the Section Cancer Therapy)
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