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Cancers publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Recent Advances in Radiological Imaging for Head and Neck Squamous Cell Carcinoma

edited by Mintu Nath and

Fergus McKiddie

submission deadline 15 Apr 2026 | Viewed by 276 | Submission Open

Keywords: head and neck squamous cell carcinoma; computed tomography (CT); positron emission tomography (PET); PET-CT; radiological imaging; image processing; image segmentation; diagnosis; treatment modalities; prediction and prognostic models; mathematical and statistical models; machine learning and deep learning techniques

(This special issue belongs to the Section Methods and Technologies Development)

Advanced Insights into the Etiology of Lymphoma

edited by Susan L. Slager and James R. Cerhan

submission deadline 15 Apr 2026 | Viewed by 226 | Submission Open

Keywords: lymphoma etiology; genetic predisposition; clonal hematopoiesis; precursor conditions; risk stratification; viral oncogenesis; non-Hodgkin lymphoma; Hodgkin lymphoma

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

Advances in Cellular Heterogeneity and Plasticity in the Tumor Microenvironment

edited by

Loredana Albonici

and

Manuel Scimeca

submission deadline 15 Apr 2026 | Viewed by 146 | Submission Open

Keywords: tumor microenvironment (TME); tumor microenvironmental heterogeneity and drug resistance; cancer cell plasticity and immune evasion; epithelial– mesenchymal transition (EMT); tumor immune context

(This special issue belongs to the Section Tumor Microenvironment)

State-of-the-Art Surgical Treatment for Lung Cancers

edited by

Andrea Axtell

and

Malcolm DeCamp

submission deadline 15 Apr 2026 | Viewed by 114 | Submission Open

Keywords: lung cancer; lung cancer surgery; sublobar resection; segmentectomy; minimally invasive surgery; robotic surgery; tumor localization; mediastinal staging

(This special issue belongs to the Section Cancer Therapy)

Brain Tumors—Related Cognitive Impairment

edited by

Djaina Satoer

and

Anne Marie Buunk

submission deadline 15 Apr 2026 | Viewed by 107 | Submission Open

Keywords: aphasia; cognition; brain tumor; surgery; adjuvant treatment; rehabilitation

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

Advances in Radiation Therapy for Brain Metastases

edited by Luis A. Pérez-Romasanta

submission deadline 15 Apr 2026 | Viewed by 93 | Submission Open

Keywords: brain metastasis; metastatic brain tumor; imaging; radiotherapy; stereotactic radiosurgery; radiomics; machine learning; magnetic resonance imaging; positron emission tomography

(This special issue belongs to the Section Cancer Therapy)

Clinical and Molecular Biomarkers in Breast Cancer Management

edited by Zahi I. Mitri

submission deadline 15 Apr 2026 | Viewed by 52 | Submission Open

Keywords: prognostic biomarkers; predictive biomarkers; molecular assays; therapeutics; special situations in breast cancer

(This special issue belongs to the Section Cancer Biomarkers)

Prostate Cancer: Molecular Imaging and Magnetic Resonance Imaging (MRI)

edited by Marco Paciotti and Davide Maffei

submission deadline 17 Apr 2026 | 5 articles | Viewed by 7071 | Submission Open

Keywords: prostate cancer; prostate imaging; diagnosis; clinical staging; magnetic resonance imaging (MRI); fusion biopsy; molecular imaging; positron emission tomography (PET); PSMA PET/CT; PSMA-based therapy

(This special issue belongs to the Section Methods and Technologies Development)

Unique Perspectives in Cancer Signaling (2nd Edition)

edited by

Peiwen Fei

submission deadline 18 Apr 2026 | 1 articles | Viewed by 617 | Submission Open

Keywords: oncogenesis; cancer signaling; technology; translational; clinical; epidemiology

(This special issue belongs to the Section Cancer Therapy)

Advancements in Child, Adolescent, and Young Adult Cancer Survivorship

edited by

Juan A. Ortega-García

submission deadline 20 Apr 2026 | 5 articles | Viewed by 9102 | Submission Open

Keywords: late effects; chronic diseases; prevention; rehabilitation; remediation; psychosocial factors; quality of life; lifestyles; surveillance; survivors; educational strategies

(This special issue belongs to the Section Pediatric Oncology)

Immunotherapy and Transplantation in the Era of Transplant Oncology (2nd Edition)

edited by

Maen Abdelrahim

submission deadline 20 Apr 2026 | Viewed by 81 | Submission Open

Keywords: transplant oncology; liver transplantation; solid organ transplantation; hepatocellular carcinoma; immunotherapy; immune-checkpoint inhibitors; CTLA-4 inhibitors; PD-1 inhibitors; allograft rejection

(This special issue belongs to the Section Transplant Oncology)

Thyroid Cancer Recurrence: Integrating Surgical, Clinical, and Translational Research

edited by

Nikola Slijepčević

and Ioannis Koutelidakis

submission deadline 20 Apr 2026 | Viewed by 53 | Submission Open

Keywords: thyroid cancer; recurrence; surgery; clinical management; aggressive subtypes; rare subtypes; biomarkers; imaging; translational research; targeted therapy

(This special issue belongs to the Section Clinical Research of Cancer)

Research on Current Progress in Penile Cancer

edited by Juan J. Chipollini and Ahmet Murat Aydin

submission deadline 25 Apr 2026 | 4 articles | Viewed by 11842 | Submission Open

(This special issue belongs to the Section Cancer Therapy)

Hepatocellular Carcinoma: Current Treatment Strategies for Advanced Disease and Recurrence: 2nd Edition

edited by

Takefumi Kimura

submission deadline 25 Apr 2026 | 2 articles | Viewed by 3689 | Submission Open

Keywords: hepatocellular carcinoma; surgery; anticancer drugs; radiation therapy; recurrence

(This special issue belongs to the Section Cancer Therapy)

Clinical Applications of Integrative Analysis of Validated Somatic and Germline Genomic Results in Oncology

edited by

Arezou A. Ghazani

submission deadline 25 Apr 2026 | 1 articles | Viewed by 3540 | Submission Open

Keywords: tumor and constitutional genome integration; clinical application of somatic and germline findings; precision oncology

(This special issue belongs to the Section Molecular Cancer Biology)

PD-1/PD-L1 Immune Checkpoint Therapy: From Predictive Biomarkers to Noninvasive Imaging 2nd Edition

edited by

Patrizia Ferroni

Fiorella Guadagni

and

Mario Roselli

submission deadline 25 Apr 2026 | Viewed by 382 | Submission Open

Keywords: PD-1; PD-L1; anti-cancer immune response; immune checkpoint; immunotherapy; biomarker; immuno-PET radiotracers; drug combinations

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

Clinical Benefit of Hybrid PET/MRI Molecular Imaging in Oncology

edited by Ana María García-Vicente and

Edel Noriega-Álvarez

submission deadline 25 Apr 2026 | Viewed by 67 | Submission Open

Keywords: PET/MRI; hybrid imaging; gynecological cancer; prostate cancer; glioma; brain metastases; brain meningioma; sarcoma; liver cancer; hepato-biliary cancer; pancreatic cancer; rectal cancer; breast cancer

(This special issue belongs to the Section Clinical Research of Cancer)

Surgical Treatment of Hepato-Pancreato-Biliary Cancers

edited by Mariano C. Giglio

submission deadline 27 Apr 2026 | 1 articles | Viewed by 1195 | Submission Open

Keywords: pancreatic cancer; hepatocellular carcinoma; colorectal liver metastases; liver surgery; pancreatic surgery; hepato-biliary cancers

(This special issue belongs to the Section Cancer Therapy)

Head and Neck Cancer: Advanced PET/CT and MRI Imaging with a Focus on Current and Emerging Molecular Theranostics

edited by Bennett Chin, Jorge Oldan and Steven P. Rowe

submission deadline 28 Apr 2026 | 6 articles | Viewed by 13868 | Submission Open

Keywords: head and neck cancer; thyroid cancer; PET/SPECT/CT molecular imaging; radionuclide therapy; nuclear medicine

(This special issue belongs to the Section Cancer Therapy)

Immune Biomarkers in Solid Tumors: From Peripheral Blood Parameters to Tissue-Based Indicators for Prognosis and Therapy Response

edited by

Ioannis P. Trontzas

and

Konstantinos Syrigos

submission deadline 28 Apr 2026 | 2 articles | Viewed by 1848 | Submission Open

Keywords: immune biomarkers; solid tumors; peripheral blood immune parameters; circulating immune cells; cytokines; tissue-based biomarkers; immune checkpoint molecules; prognostic biomarkers; predictive biomarkers; tumor microenvironment; immunotherapy response; translational oncology

(This special issue belongs to the Section Cancer Biomarkers)

Advancements in Molecular Research of Prostate Cancer

edited by

Anait S. Levenson

submission deadline 30 Apr 2026 | 6 articles | Viewed by 12102 | Submission Open

Keywords: prostate cancer; molecular targets; tumor heterogeneity; targeted interception and therapies; noninvasive biomarkers; precision oncology

(This special issue belongs to the Section Molecular Cancer Biology)

Quality of Life and Management of Pediatric Cancer

edited by

Luca Giacomelli

and

Momcilo Jankovic

submission deadline 30 Apr 2026 | 5 articles | Viewed by 9889 | Submission Open

Keywords: pediatric palliative care; oncology; quality of life; early management

(This special issue belongs to the Section Pediatric Oncology)

Immune Microenvironment and Immunotherapy in Malignant Brain Tumors

edited by Masaki Terabe and

Mark R. Gilbert

submission deadline 30 Apr 2026 | 5 articles | Viewed by 9374 | Submission Open

Keywords: glioma; brain metastasis; primary brain cancer; tumor immunity; neuroimmunology; immune microenvi-ronment; T cells; myeloid cells; cancer neuroscience

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

The Future of Machine Learning in Predicting the Treatment Responses of Cancers

edited by Alfredo Vellido,

Ana Candiota

and

Margarida Julia-Sape

submission deadline 30 Apr 2026 | 4 articles | Viewed by 8464 | Submission Open

Keywords: cancer treatment response; medical decision support systems; cancer outcome prediction; personalized medicine; pre-clinical models; artificial intelligence; machine learning; deep learning; progression-free survival; disease-free survival; event-free survival; overall survival; adverse event; quality of life; surrogate endpoint

(This special issue belongs to the Section Methods and Technologies Development)

Human Microbiome, Diet and Cancerogenesis

edited by Ewa Brzeziańska-Lasota

submission deadline 30 Apr 2026 | 3 articles | Viewed by 8343 | Submission Open

Keywords: microbiota; dysbiosis; oncobiome; cell disruptors; cell signaling; epigenetics; diet; dietary intervention; microbiota disorders; cancerogenesis

(This special issue belongs to the Section Tumor Microenvironment)

Targeted Therapy in Head and Neck Cancer

edited by

Pietro De Luca

, Angelo Camaioni and Luca de Campora

submission deadline 30 Apr 2026 | 4 articles | Viewed by 5723 | Submission Open

Keywords: salivary glands; thyroid; laryngeal cancer; molecular oncology; reconstruction; microsurgery; oral cancer; HPV; oropharyngeal cancer

(This special issue belongs to the Section Cancer Therapy)

Surgical Oncology for Hepato-Pancreato-Biliary Cancer

edited by Zaed Z. R. Hamady

submission deadline 30 Apr 2026 | 5 articles | Viewed by 5363 | Submission Open

Keywords: pancreatic cancer; liver cancer; liver metastases; surgical oncology; multidisciplinary approach

(This special issue belongs to the Section Clinical Research of Cancer)

Neuroblastoma: Molecular Insights and Clinical Implications

edited by Mary Beth Madonna

submission deadline 30 Apr 2026 | 1 articles | Viewed by 5285 | Submission Open

Keywords: neuroblastoma; molecular mechanisms; targeted therapies; immunotherapies; small molecule therapies

(This special issue belongs to the Section Molecular Cancer Biology)

Combination Therapy in Lymphoma

edited by

Afua Adjeiwaa Mensah

and Alberto Arribas

submission deadline 30 Apr 2026 | 2 articles | Viewed by 5012 | Submission Open

Keywords: combination therapy; non-Hodgkin lymphoma; Hodgkin lymphoma; targeted agents; antibody drug conjugates; bispecific agents; cellular therapies; immune checkpoint inhibitors and epigenetic agents

(This special issue belongs to the Section Cancer Therapy)

Radiomics in Cancer Imaging: Theory and Applications in Solid Tumours

edited by

Francesco Bianconi

and

Barbara Palumbo

submission deadline 30 Apr 2026 | 3 articles | Viewed by 4820 | Submission Open

Keywords: radiomics for the diagnosis; prognostication and treatment planning of solid tumours; methods; translational research and clinical applications; conventional and deep learning radiomics; interpretability of radiomics features and prediction models; image processing (including acquisition; segmentation and feature extraction); imaging methods (including CT; MRI; PET; SPECT and US)

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

Epidemiology of Cancer and Risk Factors: Pushing Boundaries in Public Health Research and Policy

edited by

The Phuong Nguyen

submission deadline 30 Apr 2026 | 4 articles | Viewed by 4808 | Submission Open

Keywords: cancer epidemiology; risk factors; public health policy; cancer prevention; early detection; genetic determinants; environmental exposures; behavioral health; interdisciplinary approaches; innovative methodologies

(This special issue belongs to the Section Cancer Epidemiology and Prevention)

Mesothelioma Epidemiology, Pathogenesis, Emerging Treatments and Pre-Clinical Models

edited by

Francesca Pentimalli

submission deadline 30 Apr 2026 | 2 articles | Viewed by 3240 | Submission Open

Keywords: mesothelioma; epidemiology; pathogenesis; emerging treatments; risk factors; biomarkers; surgical techniques; targeted therapies; immunotherapies; pre-clinical models

(This special issue belongs to the Section Cancer Epidemiology and Prevention)

Integrating Bioinformatics, AI, Imaging, and Clinical Informatics in Cancer Research

edited by Jason Li

submission deadline 30 Apr 2026 | 1 articles | Viewed by 2879 | Submission Open

Keywords: bioinformatics; multiomics; genomics; transcriptomics artificial intelligence; deep learning; clinical informatics; medical imaging; functional genomics; multi-discipline

(This special issue belongs to the Section Cancer Informatics and Big Data)

G Protein-Coupled Receptors in Cancer Progression

edited by

Songhai Chen

submission deadline 30 Apr 2026 | 1 articles | Viewed by 2238 | Submission Open

Keywords: GPCRs; heterotrimeric G proteins; signal transduction; mutations; cancer development

(This special issue belongs to the Section Tumor Microenvironment)

Health Disparities and Outcomes in Cancer Survivors

edited by

Claire Jungyoun Han

submission deadline 30 Apr 2026 | 2 articles | Viewed by 2079 | Submission Open

Keywords: cancer survivorship; quality of life; social behavioral determinants of health (SBDH); health disparities; symptom management

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

Acute Myeloid Leukemia: Updates on Diagnosis, Treatment and Management

edited by

Francesco Lanza

and

Giovanni Marconi

submission deadline 30 Apr 2026 | 2 articles | Viewed by 2066 | Submission Open

Keywords: acute myeloid leukemia; treatment; targeted therapy; molecular profiling; resistance

(This special issue belongs to the Section Methods and Technologies Development)

Real-World Evidence and Emerging Therapeutic Strategies in Refractory Metastatic Colorectal Cancer

edited by

Carlo Signorelli

submission deadline 30 Apr 2026 | 2 articles | Viewed by 1788 | Submission Open

Keywords: real-world evidence; refractory metastatic colorectal cancer; treatment resistance; third-line and beyond therapies; targeted therapies; immunotherapy; patient outcomes; clinical practice; biomarkers; precision oncology

(This special issue belongs to the Section Cancer Metastasis)

Immune Checkpoint Therapy in Liver Cancer: Current Evidence, Underlying Biology, and What's Next

edited by

Luca Marzi

and

Rodolfo Sacco

submission deadline 30 Apr 2026 | 1 articles | Viewed by 1684 | Submission Open

Keywords: hepatocellular carcinoma; immunotherapy; immuno-oncology; immune checkpoint inhibitors; clinical trial; immunological microenvironments

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

Advances in Molecular and Genetic Biomarkers in Head and Neck Squamous Cell Carcinoma

edited by

Joanna Katarzyna Strzelczyk

and Michal Masternak

submission deadline 30 Apr 2026 | 1 articles | Viewed by 1672 | Submission Open

Keywords: head and neck squamous cell carcinoma (HNSCC); molecular biomarkers; genetic biomarkers; multi-omics approaches; HNSCC carcinogenesis; prognostic biomarkers; translational medicine; molecular pathology

(This special issue belongs to the Section Molecular Cancer Biology)

Molecular PET Imaging in Cancer Metabolic Studies

edited by

Aditi Mulgaonkar

and

Sashi Debnath

submission deadline 30 Apr 2026 | 1 articles | Viewed by 1563 | Submission Open

Keywords: PET imaging; PET/CT; PET/MRI; cancer metabolism; tumor microenvironment; cancer antigens; radiotracers

(This special issue belongs to the Section Methods and Technologies Development)

Stem Cell Origin of Cancers: Biological and Clinical Implications of a Unified Theory of Cancer (2nd Edition)

edited by Shi-Ming Tu, Louis L. Pisters and

John F. Ward

submission deadline 30 Apr 2026 | 2 articles | Viewed by 1561 | Submission Open

Keywords: cancer stem cells; cancer-initiating cell; progenitor cell; epithelial; Mesenchymal transition; pluripotency; plasticity; heterogeneity; embryogenesis; stem-like; stemness

(This special issue belongs to the Section Cancer Pathophysiology)

Prostate Cancer Epidemiology and Genetics: 2nd Edition

edited by

Steven Narod

submission deadline 30 Apr 2026 | 2 articles | Viewed by 1478 | Submission Open

Keywords: prostate cancer; epidemiology; clinical genetics; aging; population-level databases

(This special issue belongs to the Section Cancer Epidemiology and Prevention)

Interrogating Molecular Regulators and Chemical Agents in Brain Tumor Progression

edited by Shilpi Singh

submission deadline 30 Apr 2026 | 1 articles | Viewed by 1460 | Submission Open

Keywords: brain tumor progression; molecular mechanisms; small molecule inhibitors; natural compounds; synthetic drugs; biomarkers; oncogenic pathways; metabolic reprogramming

(This special issue belongs to the Section Tumor Microenvironment)

Exosomes in Cancer Metastasis (2nd Edition)

edited by

Theresa L. Whiteside

submission deadline 30 Apr 2026 | 1 articles | Viewed by 1221 | Submission Open

Keywords: exosomes; biomarkers; cancer metastasis

(This special issue belongs to the Section Cancer Metastasis)

Biomarkers for Therapy Response in Gastrointestinal Malignancies: Predicting Outcomes and Personalizing Care

edited by

Devalingam Mahalingam

submission deadline 30 Apr 2026 | 2 articles | Viewed by 1209 | Submission Open

Keywords: immunotherapy; biomarkers; resistance mechanisms; predictive markers; clinical trials; translational research

(This special issue belongs to the Section Cancer Biomarkers)

Chemo-Radio-Immunotherapy for Colorectal Cancer

edited by Shoichi Hazama

submission deadline 30 Apr 2026 | 1 articles | Viewed by 1162 | Submission Open

Keywords: colorectal cancer; immunotherapy; chemotherapy; radiotherapy; combination therapy; neoadjuvant therapy; biomarkers for treatment response; anal cancer; squamous cell carcinoma; minimally invasive surgery; conversion surgery

(This special issue belongs to the Section Cancer Therapy)

From Molecular Insights to Cancer Treatments: Progress in Translational Science

edited by

Sanjay V. Malhotra

, Dhanir Tailor and

Annah Rolig

submission deadline 30 Apr 2026 | 1 articles | Viewed by 1070 | Submission Open

Keywords: cancer biology; therapeutics; molecular targets; translational research

(This special issue belongs to the Section Cancer Therapy)

Prostate Cancer: Contemporary Standards and Challenges

edited by

Filip Ionescu

and

Jingsong Zhang

submission deadline 30 Apr 2026 | 1 articles | Viewed by 1039 | Submission Open

Keywords: prostate cancer; molecular pathogenesis; precision oncology; biomarkers; treatment de-escalation

(This special issue belongs to the Section Cancer Therapy)

Glioma: From Intracellular Oncogenic Pathways to Targeting Therapeutic Strategies

edited by

Shilpi Singh

submission deadline 30 Apr 2026 | 1 articles | Viewed by 945 | Submission Open

Keywords: glioma; targeted therapies; resistance mechanisms; oncogenic pathways; therapeutic resistance; combination therapies; tumor heterogeneity

(This special issue belongs to the Section Cancer Therapy)

Myeloma: Pathogenesis and Targeted Therapies

edited by Fenghuang (Frank) Zhan, Gang An and Cody Ashby

submission deadline 30 Apr 2026 | 1 articles | Viewed by 893 | Submission Open

Keywords: multiple myeloma; drug resistance; car-t cell therapy; immunotherapy targets; biomarkers; genetic alterations; molecular pathogenesis

(This special issue belongs to the Section Tumor Microenvironment)

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