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Cancers publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Survivorship and Life with Colorectal Cancer
edited by Daniel Steffens, Bora Kim, Rachel Campbell and Kate White
submission deadline 31 Dec 2025 | Viewed by 288 | Submission Open
Keywords: colorectal cancer; survivorship care; implementation; clinical interventions; supportive care
(This special issue belongs to the Section Cancer Survivorship and Quality of Life)
Advances in the Pathogenesis of Hematopoietic Neoplasms submission deadline 31 Dec 2025 | Viewed by 275 | Submission Open
Keywords: B cell lymphoma; T cell lymphoma; Hodgkin lymphoma; leukemia; myeloma; pathogenesis; genomics; microenvironment
(This special issue belongs to the Section Cancer Pathophysiology)
Surgical Aspects of Ovarian/Tubal/Peritoneal Cancer Management submission deadline 31 Dec 2025 | Viewed by 261 | Submission Open
Keywords: primary cytoreduction; interval cytoreduction; neoadjuvant chemotherapy
(This special issue belongs to the Section Cancer Therapy)
Views and Perspectives of Robot-Assisted Liver Surgery (2nd Edition)
edited by , Ibrahim Dagher and
submission deadline 31 Dec 2025 | Viewed by 257 | Submission Open
Keywords: robotic; liver surgery; liver resection; hepatectomy; minimally invasive; artificial intelligence
(This special issue belongs to the Section Cancer Therapy)
Research Challenges in Adolescent and Young Adult Cancer
edited by Lorna A. Fern and Jeremy Lewin
submission deadline 31 Dec 2025 | Viewed by 237 | Submission Open
Keywords: adolescents and young adults; research enrollment and retention; clinical trials; access; barriers
(This special issue belongs to the Section Pediatric Oncology)
Breast Cancer Research and Treatment
edited by
submission deadline 31 Dec 2025 | Viewed by 231 | Submission Open
Keywords: breast cancer; tumor microenvironment; immune microenvironment; intratumoral heterogeneity; immunotherapy
(This special issue belongs to the Section Tumor Microenvironment)
Emerging Concepts in Mesothelioma
edited by Georgios T. Stathopoulos and Tonia Adamides
submission deadline 31 Dec 2025 | Viewed by 215 | Submission Open
Keywords: mesothelioma; asbestos; pleura; tumor suppressor; cell lines; patient-derived xenograft; surgery; chemotherapy; folate antagonist; immunotherapy
(This special issue belongs to the Section Clinical Research of Cancer)
Nanomedicine’s Role in Oncology submission deadline 31 Dec 2025 | Viewed by 201 | Submission Open
Keywords: nanomedicine; oncology; interventional oncology; nanotechnology development; cancer diagnosis; cancer treatment; cancer imaging
(This special issue belongs to the Section Methods and Technologies Development)
Sarcoma Management in Orthopaedic Oncology
edited by and Jendrik Hardes
submission deadline 31 Dec 2025 | 1 articles | Viewed by 187 | Submission Open
Keywords: orthopaedic surgical oncology; sarcoma; orthopaedic surgery; bone and soft tissue sarcoma; diagnose; neoadjuvant therapy; targeted therapy; immunotherapy
(This special issue belongs to the Section Methods and Technologies Development)
Oral Cancer: Prevention and Early Detection (2nd Edition) submission deadline 31 Dec 2025 | Viewed by 185 | Submission Open
Keywords: oral cancer; oral squamous cell carcinoma; alcohol and tobacco; human papillomavirus (HPV); biomarkers; biopsy and liquid biopsy; oral potentially malignant disorders (OPMDs); oral pathology and oral medicine; oral and maxillofacial surgery; radiotherapy and chemotherapy
(This special issue belongs to the Section Cancer Epidemiology and Prevention)
Natural Compounds in Cancers: 2nd Edition submission deadline 31 Dec 2025 | 1 articles | Viewed by 183 | Submission Open
Keywords: nutrition; bioactive molecules; inflammation; natural extracts; nutraceuticals; immunotherapy; chemotherapy
(This special issue belongs to the Section Molecular Cancer Biology)
Image-Guided Adaptive Radiation Therapy (IGART): Advancing Precision Oncology
edited by An Liu, Bin Cai and Murat Surucu
submission deadline 31 Dec 2025 | Viewed by 174 | Submission Open
Keywords: advanced imaging techniques; adaptive radiotherapy; computational models
(This special issue belongs to the Section Methods and Technologies Development)
Feature Papers in the Section “Cancer Therapy” in 2025
edited by , Qiang Wang and
submission deadline 31 Dec 2025 | Viewed by 169 | Submission Open
Keywords: chemotherapy; immunotherapy for cancer; oncology; systemic treatment and targeted therapy.
(This special issue belongs to the Section Cancer Therapy)
Artificial Intelligence (AI), Robotics, and Cancer Surgery
edited by Zaid M. Abdelsattar
submission deadline 31 Dec 2025 | Viewed by 144 | Submission Open
Keywords: cancer surgery; artificial intelligence; robotics surgery; surgical outcome; decision-making
(This special issue belongs to the Section Methods and Technologies Development)
Optimizing Surgical Procedures and Enhancing Outcomes in the Management of Gastrointestinal Cancer
edited by Tim Strate and
submission deadline 31 Dec 2025 | Viewed by 136 | Submission Open
Keywords: gastrointestinal malignancies; surgical oncology; postoperative outcome; quality of life; anastomotic leakage; anastomotic technique; HIPEC; PIPAC
(This special issue belongs to the Section Cancer Therapy)
The Role of Anatomical Resections in Secondary Lung Cancer: Indications, Techniques, and Outcomes submission deadline 31 Dec 2025 | Viewed by 134 | Submission Open
Keywords: anatomical resections; segmentectomy; lobectomy; secondary lung cancer; pulmonary metastases; thoracic surgery; minimally invasive surgery; surgical outcomes; lung neoplasms; personalized treatment
(This special issue belongs to the Section Clinical Research of Cancer)
At the Interface of Genetics, Epigenetics, and Metabolism in Cancer: 2nd Edition
edited by and
submission deadline 31 Dec 2025 | Viewed by 131 | Submission Open
Keywords: cancer metabolism; epigenetic reprogramming; histone modification; DNA methylation; chromatin structure; intermediary metabolites; microenvironment; mTOR complexes; glioblastoma
(This special issue belongs to the Section Cancer Pathophysiology)
Oxidative Stress-Mediated Regulation of Specific Signaling Pathways in Skin Cancers submission deadline 31 Dec 2025 | Viewed by 130 | Submission Open
Keywords: reactive oxygen species; reactive nitrogen species; oxidative stress; epigenetic regulation; UV-exposure; skin pigmentation; skin cancer; melanoma
(This special issue belongs to the Section Cancer Epidemiology and Prevention)
Multidisciplinary Treatment with Surgery and Chemotherapy of Liver Metastases from Colorectal Cancer
edited by and Pietro Majno
submission deadline 31 Dec 2025 | Viewed by 130 | Submission Open
Keywords: colorectal liver metastases; liver surgery; oncology; multidisciplinary approach; prognosis; recurrence; precision medicine; genetics; tumor biology; liver transplantation; perioperative therapy and conversion therapy
(This special issue belongs to the Section Cancer Therapy)
Cancers in Chronic HIV Infection
edited by Diego Ripamonti
submission deadline 31 Dec 2025 | Viewed by 124 | Submission Open
Keywords: cancer; HIV; AIDS; cancer screening; hematologic malignancy; Kaposi sarcoma; HPV; anal cancer; lymphoma
(This special issue belongs to the Section Infectious Agents and Cancer)
Next-Generation Cancer Therapies
edited by , Ioannis Lamprou and Erasmia Xanthopoulou
submission deadline 31 Dec 2025 | Viewed by 123 | Submission Open
Keywords: cancer; current therapies; cancer cells metabolism; autophagy; immunotherapy; targeted treatments; oncolytic viruses; vaccines
(This special issue belongs to the Section Cancer Therapy)
Head and Neck Cancer Surgery and Rehabilitation: A Bridge Between Medicine and Dentistry for Reconstruction with Regeneration
edited by and Samuel Ebele Udeabor
submission deadline 31 Dec 2025 | Viewed by 122 | Submission Open
Keywords: oral squamous cell carcinoma; oral cancer; head and neck cancer; odontogenic tumors; OSCC management; tumor recurrence; tumor metastasis; adjuvant therapy; biomaterials for maxillofacial reconstruction; tissue regeneration; cancer rehabilitation
(This special issue belongs to the Section Cancer Therapy)
Neoadjuvant Chemotherapy in Pancreatic Cancer submission deadline 31 Dec 2025 | Viewed by 115 | Submission Open
Keywords: neoadjuvant chemotherapy; pancreatic cancer; treatment decision
(This special issue belongs to the Section Cancer Therapy)
Advances in Breast Cancer Imaging: From Detection to Personalized Diagnosis submission deadline 31 Dec 2025 | Viewed by 114 | Submission Open
Keywords: breast cancer imaging; artificial intelligence; radiomics; deep learning; personalized diagnosis; multimodal imaging; predictive modeling; early detection; treatment response; clinical applications
(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)
New Insights into Pheochromocytoma and Paraganglioma
edited by
submission deadline 31 Dec 2025 | Viewed by 114 | Submission Open
Keywords: pheochromocytoma; paraganglioma; diagnosis; genetics; imaging; long-term follow-up; standards
(This special issue belongs to the Section Clinical Research of Cancer)
New Insights in Parotid Tumors
edited by Chiara Gaudino and Stefan Rohde
submission deadline 31 Dec 2025 | Viewed by 111 | Submission Open
Keywords: advanced imaging in parotid tumors; artificial intelligence tools; parotid gland surgery; facial nerve preservation and reconstruction; chemotherapy in parotid gland malignant tumors; radiotherapy and proton therapy in malignant parotid gland tumors
(This special issue belongs to the Section Cancer Therapy)
Feature Papers in Section “Methods and Technologies Development” in 2025 submission deadline 31 Dec 2025 | Viewed by 109 | Submission Open
Keywords: innovative diagnostic technology; artificial intelligence; cancer diagnosis; personalized treatment; diagnostic and therapeutic strategies
(This special issue belongs to the Section Methods and Technologies Development)
Clinical and Biological Studies of Pediatric Adrenocortical Tumors, Pheochromocytomas and Paragangliomas submission deadline 31 Dec 2025 | Viewed by 104 | Submission Open
Keywords: adrenal gland; pheochromocytoma; paraganglioma; adrenocortical adenoma; adrenocortical carcinoma; pediatric; adrenal tumor
(This special issue belongs to the Section Pediatric Oncology)
Advanced Research in Surgical Treatment for Spinal Tumors
edited by Alessandro Gasbarrini, Stefano Bandiera and
submission deadline 31 Dec 2025 | Viewed by 103 | Submission Open
Keywords: spine oncology; primary tumors; metastatic tumors; spondylectomy; en bloc resection; minimally invasive surgery; anterior reconstruction; biomaterials; radiosurgery; electrochemotherapy
(This special issue belongs to the Section Cancer Therapy)
Advances in Genitourinary Cancer: Biomarkers, Immunotherapy and Novel Therapeutics
edited by Lingbin Meng
submission deadline 31 Dec 2025 | Viewed by 100 | Submission Open
Keywords: genitourinary cancer; biomarkers; immunotherapy; targeted therapy; chemotherapy; drug resistance; tumor microenvironment; liquid biopsy; ctDNA; precision oncology
(This special issue belongs to the Section Cancer Therapy)
Contemporary Trends and Advances in Minimally Invasive and Endoscopic Management of Genitourinary Malignancies submission deadline 31 Dec 2025 | Viewed by 99 | Submission Open
Keywords: robotic surgery; laparoscopic surgery; endourology; urologic oncology; prostate cancer; urothelial cancer; kidney cancer; testicular cancer; single-port surgery; image-guided surgery; surgical outcomes; oncologic outcomes; advanced surgical techniques; precision medicine
(This special issue belongs to the Section Cancer Therapy)
Innovations in Microsurgical Techniques for Breast Cancer Reconstruction
edited by and Robert J. Allen
submission deadline 31 Dec 2025 | Viewed by 99 | Submission Open
Keywords: breast reconstruction; autologous breast reconstruction; DIEP flap; robotic DIEP flap; sensibility; alternative flaps; post-mastectomy pain; PAP flap; LAP flap; GAP flap; LTP flap; perforator flap; latissimus flap; fat grafting; nerve repair
(This special issue belongs to the Section Methods and Technologies Development)
Hippo Signaling in Cancer (2nd Edition)
edited by and
submission deadline 31 Dec 2025 | Viewed by 88 | Submission Open
Keywords: Hippo signaling; Salvador– Warts– Hippo (SWH) pathway; YAP/TAZ; cancer development; progression; metastasis; therapeutic resistance
(This special issue belongs to the Section Tumor Microenvironment)
The Extracellular Matrix and Tissue Engineering: Roles in the Tumor Microenvironment and Implications for Cancer Treatment submission deadline 31 Dec 2025 | Viewed by 82 | Submission Open
Keywords: extracellular matrix remodeling; stiffness; cancer progression; tumor metastasis; tissue engineering; 3D models; anti-cancer therapies
(This special issue belongs to the Section Cancer Therapy)
Faulty Ribosome Biogenesis and Cancer: Mechanisms and Therapeutic Perspectives submission deadline 31 Dec 2025 | Viewed by 81 | Submission Open
Keywords: ribosome biogenesis; ribosomal proteins; nucleolar stress; genomic instability; oncoribosome; ribosomapathies; ribosome-targeting drugs; cancer biomarkers; animal models
(This special issue belongs to the Section Cancer Biomarkers)
New Insights into Microbial-Based Cancer Therapy
edited by Amitabha Ray
submission deadline 31 Dec 2025 | Viewed by 75 | Submission Open
Keywords: microbial therapy; cancer immunotherapy; bioengineering; immune modulation; tumor microenvironment
(This special issue belongs to the Section Cancer Therapy)
Advances in the Molecular Biology of Sarcoma and Drug Development
edited by Francis Hornicek and
submission deadline 31 Dec 2025 | Viewed by 64 | Submission Open
Keywords: sarcoma; sarcoma models; kinases; drug development; multidrug resistance; targeted therapy; immunotherapy
(This special issue belongs to the Section Molecular Cancer Biology)
Molecular and Genetic Biomarkers in Oral Squamous Cell Carcinoma
edited by
submission deadline 31 Dec 2025 | Viewed by 63 | Submission Open
Keywords: oral cancer; oropharyngeal cancer; biomarkers; liquid biopsy; genetic determinants
(This special issue belongs to the Section Cancer Biomarkers)
Advances in Minimally Invasive Surgery for Colorectal Cancer
edited by Jonathan S. Abelson and Christine A. Schad
submission deadline 31 Dec 2025 | Viewed by 61 | Submission Open
Keywords: colorectal cancer; minimally invasive surgery; endoscopic surgery; endoluminal surgery; laparoscopic surgery; ro-botic surgery; single incision laparoscopic surgery; postoperative outcomes; survival
(This special issue belongs to the Section Cancer Therapy)
Chromatin-Remodeling Factors in Cancer Cells
edited by
submission deadline 31 Dec 2025 | Viewed by 56 | Submission Open
Keywords: chromatin remodeling; transcription factors; epigenetic therapy; cancer epigenomics; SWI/SNF complex; CRISPR functional screens; single-cell epigenomics; gene regulation in cancer; therapy resistance; targeted cancer therapies
(This special issue belongs to the Section Cancer Pathophysiology)
ALK in Cancer: Lessons from the Future (2nd Edition) submission deadline 31 Dec 2025 | Viewed by 49 | Submission Open
Keywords: ALK inhibitors; ALK fusion variants; TP53 mutations; immunotherapy; liquid biopsies; disease monitoring; therapeutic sequencing
(This special issue belongs to the Section Cancer Pathophysiology)
Modern Neurosurgical Management of Gliomas submission deadline 31 Dec 2025 | Viewed by 47 | Submission Open
Keywords: precision medicine; personalized oncological surgery; intraoperative imaging; fluorescence-guided surgery; intraoperative histopathology; liquid biopsy; minimally invasive oncological surgery; radiosurgery
(This special issue belongs to the Section Cancer Therapy)
Advanced Ovarian Cancer (2nd Edition)
edited by
submission deadline 31 Dec 2025 | Viewed by 46 | Submission Open
Keywords: advanced ovarian cancer; medical treatment; surgical treatment; hyperthermic intraperitoneal chemotherapy; intraperitoneal chemotherapy
(This special issue belongs to the Section Cancer Therapy)
Oncogenetics of Colorectal Cancer (2nd Edition)
edited by and Marc Bissonnette
submission deadline 31 Dec 2025 | Viewed by 41 | Submission Open
Keywords: colorectal carcinoma; somatic mutation; microsatellite instability; methylation; copy number change; tumor-infiltrating leukocyte; immune checkpoint inhibitor; drug resistance; cell-free DNA
(This special issue belongs to the Section Cancer Pathophysiology)
Leukemia Cell Signaling Pathways: Recent Advances, Future Perspectives, and Potential Clinical Applications submission deadline 31 Dec 2025 | Viewed by 39 | Submission Open
Keywords: leukemia; cell signaling; bone marrow microenvironment; leukemic transformation; drug resistance; therapeutic discovery; cell signaling inhibitors; precision medicine
(This special issue belongs to the Section Tumor Microenvironment)
Feature Paper in Section ‘Cancer Epidemiology and Prevention’ in 2025
edited by Roger Anderson and
submission deadline 31 Dec 2025 | Viewed by 37 | Submission Open
Keywords: cancer prevention; cancer epidemiology; health policy; public health; global health; health education; health promotion
(This special issue belongs to the Section Cancer Epidemiology and Prevention)
Pituitary Tumors: Clinical and Surgical Challenges
edited by and
submission deadline 31 Dec 2025 | Viewed by 29 | Submission Open
Keywords: pituitary; neuroendocrine tumors; transsphenoidal endoscopic surgery; MRI imaging; quality of life
(This special issue belongs to the Section Clinical Research of Cancer)
Patients’ Perspective in Gynecological Cancer
edited by
submission deadline 31 Dec 2025 | Viewed by 22 | Submission Open
Keywords: patient perspective; expectations; PROMs; quality of life; best supportive care
(This special issue belongs to the Section Cancer Survivorship and Quality of Life)
Tumor Microenvironment of Gynecological Tumors submission deadline 10 Jan 2026 | Viewed by 84 | Submission Open
Keywords: tumor microenvironment; gynecological cancers; immunomodulation; cancer-associated fibroblasts; angiogenesis; cancer-like stem cells; extracellular matrix; immune evasion; cell signaling; therapeutics
(This special issue belongs to the Section Tumor Microenvironment)
The Role of Flow Cytometry in Hematologic Malignancies
edited by and Lucy Fu
submission deadline 12 Jan 2026 | Viewed by 34 | Submission Open
Keywords: flow cytometry; hematology; oncology; malignancy; lymphoma; leukemia; pathology; innovation; methodology; diagnosis
(This special issue belongs to the Section Methods and Technologies Development)
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