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Cancers publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Clinical and Research Progress in the Resection of Gastro-Esophageal Cancer
edited by Biniam Kidane
submission deadline 15 Jan 2026 | 5 articles | Viewed by 9339 | Submission Open
(This special issue belongs to the Section Clinical Research of Cancer)
New Insights into Cancer Immunotherapy: From Immune Cell to Clinical Practice
edited by Xiaotong Song
submission deadline 15 Jan 2026 | 5 articles | Viewed by 8647 | Submission Open
Keywords: T cell therapy; cancer immunotherapy; CAR T cells; immune checkpoint modulation; tumor microenvironment
(This special issue belongs to the Section Cancer Immunology and Immunotherapy)
Cell Biology of Cancer Invasion: 2nd Edition
edited by
submission deadline 15 Jan 2026 | 2 articles | Viewed by 3257 | Submission Open
Keywords: invasion; metastasis; intravasation; extravasation; invadopodia; tumor microenvironment; epithelial– mesenchymal transition; cell migration; cytoskeleton; cell adhesion; extracellular matrix; matrix metalloprotease; cancer-associated fibroblast; tumor-associated macrophage
(This special issue belongs to the Section Cancer Metastasis)
Circulating Tumour DNA and Liquid Biopsy in Oncology
edited by and Kevin Spring
submission deadline 15 Jan 2026 | 3 articles | Viewed by 2832 | Submission Open
Keywords: cell-free DNA; circulating tumour DNA; liquid biopsy; mutation status; tumour mutational burden; methylation detection; fragmentomics; minimal residual disease; early detection
(This special issue belongs to the Section Cancer Biomarkers)
The Survival of Colon and Rectal Cancer (2nd Edition)
edited by
submission deadline 15 Jan 2026 | 1 articles | Viewed by 1316 | Submission Open
Keywords: colorectal cancer; colorectal cancer surgery; multidisciplinary treatment; survival; prognostic factors; distant metastasis; locoregional recurrences; standardisation; individualisation
(This special issue belongs to the Section Cancer Survivorship and Quality of Life)
Updates on Urothelial Carcinoma
edited by and Yasmin Abu-Ghanem
submission deadline 15 Jan 2026 | Viewed by 276 | Submission Open
Keywords: urothelial carcinoma; systemic therapy; molecular biomarkers; personalized medicine
(This special issue belongs to the Section Cancer Therapy)
Pediatric Cancer Research from Basic Biology to Experimental Therapy
edited by
submission deadline 16 Jan 2026 | 4 articles | Viewed by 12873 | Submission Open
Keywords: pediatric tumors; solid cancers; leukemias; cancer predisposition syndromes; genetics; omics; immunotherapy; therapy resistance
(This special issue belongs to the Section Pediatric Oncology)
Survivorship Following Childhood, Adolescent and Young Adult Cancer
edited by Magdalena Balcerek and Judith Gebauer
submission deadline 20 Jan 2026 | 1 articles | Viewed by 2680 | Submission Open
Keywords: cancer survivorship; late effects; long-term follow-up care; supportive care; health prevention and promotion
(This special issue belongs to the Section Pediatric Oncology)
The Prospect of Nanobiotechnology in Cancers
edited by
submission deadline 20 Jan 2026 | Viewed by 187 | Submission Open
Keywords: nanobiotechnology; cancer therapy; targeted drug delivery; tumor microenvironment
(This special issue belongs to the Section Methods and Technologies Development)
Recent Trends in the Development of Theranostics and Multifunctional Tracers in Oncology
edited by
submission deadline 20 Jan 2026 | Viewed by 184 | Submission Open
Keywords: multifunctional radiopharmaceuticls; PET/CT; multimodal imaging; cancer treatment  
(This special issue belongs to the Section Methods and Technologies Development)
Recent Updates on Imaging and Staging of Gynecologic Cancers
edited by and Alexander B. Olawaiye
submission deadline 21 Jan 2026 | 2 articles | Viewed by 2768 | Submission Open
Keywords: imaging; surgical staging; molecular prognostic features; mortality; prognosis
(This special issue belongs to the Section Methods and Technologies Development)
Roles of the Tumor Microenvironment on Liquid Biopsy (2nd Edition)
edited by
submission deadline 22 Jan 2026 | 1 articles | Viewed by 689 | Submission Open
Keywords: liquid biopsy; CTCs; CTC characterization and CTC clustering; ctDNA and ctDNA profiling; exosomes/extracellular vesicles and biology; tumor microenvironment; bone marrow cellular/molecular heterogeneity; CTCs/blood/BM cells crosstalk; analytical validity; clinical validity; and clinical utility of liquid biopsy; liquid biopsy interplaying dormancy and metastasis
(This special issue belongs to the Section Tumor Microenvironment)
Advancements in Salivary Gland Tumors Management: From Diagnostic Imaging to Treatment Strategies
edited by Wioletta Pietruszewska, Małgorzata Wierzbicka and
submission deadline 22 Jan 2026 | Viewed by 257 | Submission Open
Keywords: salivary gland tumors; MRI; CT; and PET; minimally invasive approaches
(This special issue belongs to the Section Cancer Therapy)
Innovative Immunotherapies: CAR-T Cell Therapy for Cancers: 2nd Edition
edited by
submission deadline 23 Jan 2026 | 3 articles | Viewed by 8971 | Submission Open
Keywords: CAR-T; NK-CAR; immunotherapy; cancer; resistance mechanisms
(This special issue belongs to the Section Cancer Immunology and Immunotherapy)
Targeting Hallmarks of Cancer submission deadline 25 Jan 2026 | Viewed by 744 | Submission Open
Keywords: epigenetic regulators; organotypic culture models; anticancer drugs; hallmarks of cancer
(This special issue belongs to the Section Cancer Biomarkers)
Towards a Personalized Medicine for the Diagnosis and Management of Gynecological Cancers
edited by and Gabriele Centini
submission deadline 30 Jan 2026 | 3 articles | Viewed by 21864 | Submission Open
(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)
The Advance of Pencil Beam Scanning Proton Beam Therapy in Cancers
edited by , Richard A. Amos and Heng Li
submission deadline 30 Jan 2026 | 7 articles | Viewed by 16485 | Submission Open
Keywords: proton therapy; pencil beam scanning; robustness; adaptive radiotherapy; imaging guidance; radiobiological model; FLASH radiotherapy; spatially fractionated radiotherapy (SFRT); proton arc
(This special issue belongs to the Section Cancer Therapy)
Cancer Disparities: Biological, Social, and Environmental Determinants submission deadline 30 Jan 2026 | 3 articles | Viewed by 7107 | Submission Open
Keywords: cancer epidemiology; cancer etiology; environmental factors; screening and diagnostics; SDGs
(This special issue belongs to the Section Cancer Epidemiology and Prevention)
Advances in the Treatment of Upper Gastrointestinal Cancer
edited by Sang-ho Jeong and
submission deadline 30 Jan 2026 | 2 articles | Viewed by 5527 | Submission Open
Keywords: upper gastrointestinal cancer; surgery therapy; chemotherapy therapy; radiation therapy
(This special issue belongs to the Section Cancer Therapy)
Metastasis in Tumor Immunity: Current Perspectives
edited by , Sebastian Torke and
submission deadline 30 Jan 2026 | Viewed by 213 | Submission Open
Keywords: immune escape; immune evasion; immune microenvironment; intervention strategies; senescence on metastasis; anti-tumor immunity; cellular interactions; molecular interactions; immune suppression; immune checkpoints
(This special issue belongs to the Section Cancer Metastasis)
Protein Structure and Cancer—2nd Edition submission deadline 30 Jan 2026 | Viewed by 210 | Submission Open
Keywords: protein structure dynamics; structural cancer biology; protein pathways in cancer; structure– function alterations; in silico protein structure prediction; protein interactions; cancer mutations and protein structure alterations
(This special issue belongs to the Section Molecular Cancer Biology)
Advances in Drug Delivery for Cancer Therapy submission deadline 31 Jan 2026 | 9 articles | Viewed by 43179 | Submission Open
Keywords: cancer; oncology; therapeutic target; drug resistance; immunotherapy; chemotherapy; small molecule inhibitors; drug delivery; nanoparticle
(This special issue belongs to the Section Cancer Drug Development)
How COVID-19 Affects Cancer Patients
edited by
submission deadline 31 Jan 2026 | 15 articles | Viewed by 36527 | Submission Open
Keywords: COVID-19; pandemic; cancer; impact; incidence; mortality; lethality; disparities; gender
(This special issue belongs to the Section Cancer Epidemiology and Prevention)
Surgical Advances in Cancer Treatments: Exploring Innovative Approaches and Emerging Perspectives submission deadline 31 Jan 2026 | 17 articles | Viewed by 34396 | Submission Open
Keywords: surgical oncology; surgical innovation; image-guided surgery; robotic-assisted surgery; multidisciplinary oncology; surgical outcomes research; precision surgery; healthcare economics; surgical training and simulation
(This special issue belongs to the Section Cancer Therapy)
Genetics and Epigenetics of Gynecological Cancer
edited by
submission deadline 31 Jan 2026 | 10 articles | Viewed by 31660 | Submission Open
Keywords: gynecologic cancers; epigenetics; genetics; immunogenetics; predisposing mutations; biomarkers; targeted therapies; chemoresistance
(This special issue belongs to the Section Cancer Pathophysiology)
CAR T Cells in Lymphoma and Multiple Myeloma submission deadline 31 Jan 2026 | 7 articles | Viewed by 27257 | Submission Open
Keywords: multiple myeloma; lymphoma; CAR T therapy; bi-specific antibodies; cellular therapy
(This special issue belongs to the Section Cancer Immunology and Immunotherapy)
Screening, Early Detection and Prevention of Hepato-Pancreato-Biliary (HPB) Cancers
edited by Zaed Z.R. Hamady
submission deadline 31 Jan 2026 | 7 articles | Viewed by 25343 | Submission Open
Keywords: hepatobiliary cancer; pancreatic cancer; early detection; diagnosis; screening; prevention
(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)
Thyroid Cancer: Diagnosis, Prognosis and Treatment (2nd Edition) submission deadline 31 Jan 2026 | 9 articles | Viewed by 18933 | Submission Open
Keywords: thyroid cancer; ultrasound; molecular imaging; fine-needle aspiration cytology; thyroidectomy; radioactive iodine; radioiodine-refractory thyroid cancer; tyrosine kinase inhibitors
(This special issue belongs to the Section Cancer Therapy)
Emerging Research on Primary Brain Tumors
edited by Jacob S Young and Mitchel S. Berger
submission deadline 31 Jan 2026 | 6 articles | Viewed by 18416 | Submission Open
Keywords: molecular biomarkers; drug delivery; immunotherapy; personalized medicine; targeted therapies; glioma
(This special issue belongs to the Section Cancer Therapy)
Empowering Cancer Survivors: A Comprehensive Approach to Supportive Care Through Pharmacological and Non-Pharmacological Approaches Including Exercise, Physical Activity and Nutrition
edited by Kellie Toohey
submission deadline 31 Jan 2026 | 11 articles | Viewed by 16136 | Submission Open
Keywords: cancer; physical activity; exercise; supportive care; holistic care; rehabilitation
(This special issue belongs to the Section Cancer Survivorship and Quality of Life)
Pathology and Treatment of Triple-Negative Breast Cancer
edited by
submission deadline 31 Jan 2026 | 4 articles | Viewed by 12621 | Submission Open
(This special issue belongs to the Section Cancer Pathophysiology)
Implementation of Physical Activity Promotion in Cancer Care
edited by Sarah Hardcastle
submission deadline 31 Jan 2026 | 4 articles | Viewed by 10865 | Submission Open
Keywords: physical activity; cancer survivors; behaviour change; interventions; cancer care; implementation; health
(This special issue belongs to the Section Cancer Survivorship and Quality of Life)
The Tumor Microenvironment: Interplay Between Immune Cells
edited by Jared Rowe and Kristen E. Pauken
submission deadline 31 Jan 2026 | 5 articles | Viewed by 10831 | Submission Open
Keywords: tumor immune microenvironment; metabolic microenvironment; immune cells
(This special issue belongs to the Section Tumor Microenvironment)
Recent Advances and Challenges in Breast Cancer Surgery: 2nd Edition submission deadline 31 Jan 2026 | 6 articles | Viewed by 9408 | Submission Open
Keywords: breast cancer surgery; axillary management; sentinel node oncoplastic surgery; reconstructive surgery; surgical technology; cancer risk reduction surgery; radio-guided surgery
(This special issue belongs to the Section Cancer Therapy)
Gynecological Cancer: Prevention, Diagnosis, Prognosis and Treatment
edited by Joanna P. Kacperczyk-Bartnik, Tibor Andrea Zwimpfer and
submission deadline 31 Jan 2026 | 7 articles | Viewed by 8567 | Submission Open
Keywords: gynecological cancer; ovarian cancer; cervical cancer; endometrial cancer; early diagnosis; cancer prevention; prognosis; molecular mechanisms; personalized medicine; novel therapies
(This special issue belongs to the Section Clinical Research of Cancer)
Recent Advances in Oncology Imaging: 2nd Edition
edited by and
submission deadline 31 Jan 2026 | 4 articles | Viewed by 8176 | Submission Open
Keywords: medical imaging; cancer; oncology; molecular imaging; theragnostics
(This special issue belongs to the Section Methods and Technologies Development)
Biomarkers and Targeted Therapy in Malignant Pleural Mesothelioma
edited by
submission deadline 31 Jan 2026 | 4 articles | Viewed by 7482 | Submission Open
Keywords: malignant mesothelioma; target therapy; biomarkers
(This special issue belongs to the Section Cancer Biomarkers)
Exploring Skin Cancer: Insights into New Diagnostic, Prognostic, and Therapeutic Strategies
edited by
submission deadline 31 Jan 2026 | 5 articles | Viewed by 6389 | Submission Open
Keywords: melanoma; non-melanoma skin cancer; NMSC; Merkel cell carcinoma; tumor microenvironment; prognosis; treatment
Cancer Screening and Primary Care
edited by Marievelisse Soto-Salgado
submission deadline 31 Jan 2026 | 5 articles | Viewed by 6300 | Submission Open
Keywords: screening amenable cancers; screening; primary care; disparities in cancer care; cancer outcomes
(This special issue belongs to the Section Cancer Epidemiology and Prevention)
Advances in the Use of PET/CT and MRI in Prostate Cancer
edited by Carmelo Caldarella
submission deadline 31 Jan 2026 | 3 articles | Viewed by 5559 | Submission Open
Keywords: PET/CT; MRI; prostate cancer; radiomic; receptor-targeted radiopharmaceuticals
(This special issue belongs to the Section Methods and Technologies Development)
The Role of Apoptosis and Autophagy in Cancer
edited by
submission deadline 31 Jan 2026 | 3 articles | Viewed by 5268 | Submission Open
Keywords: apoptosis; cell death; tumor
(This special issue belongs to the Section Molecular Cancer Biology)
Oral Cancer: The Latest Advances in Clinical and Basic Research (Second Edition)
edited by and Fumihiko Uchida
submission deadline 31 Jan 2026 | 4 articles | Viewed by 5016 | Submission Open
Keywords: oral cancer; clinical research; basic research; surgery; radiotherapy; chemotherapy; molecular biology; immune checkpoint inhibitor
(This special issue belongs to the Section Clinical Research of Cancer)
Clinical Studies and Outcomes in Urologic Cancer
edited by Nikolaos Pyrgidis
submission deadline 31 Jan 2026 | 4 articles | Viewed by 4686 | Submission Open
Keywords: urologic cancer; clinical outcomes; prostate cancer; urothelial cancer; kidney cancer; survival analysis; treatment response; quality of life; novel therapies; oncology
(This special issue belongs to the Section Clinical Research of Cancer)
Prediction of Melanoma
edited by
submission deadline 31 Jan 2026 | 3 articles | Viewed by 4236 | Submission Open
Keywords: melanoma; melanoma genetics; biomarkers; predictive tools; risk prediction; risk factors; artificial intelligence
(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)
Post-Neoadjuvant Strategies in Breast Cancer (2nd Edition)
edited by , Tanja Fehm and
submission deadline 31 Jan 2026 | 1 articles | Viewed by 3494 | Submission Open
Keywords: chemotherapy; prospective trials; clinical investigation; breast tumor; local recurrence; overall survival
(This special issue belongs to the Section Cancer Therapy)
Minimally Invasive Approaches in Urological Oncology: Current Trends and Innovations submission deadline 31 Jan 2026 | 3 articles | Viewed by 3197 | Submission Open
Keywords: minimally invasive; robotic; laparoscopic; uro-oncology; prostate cancer; bladder cancer; kidney cancer; testicular cancers; quality of life; penile cancer
(This special issue belongs to the Section Clinical Research of Cancer)
Recent Advances in Nanomedicine-Based Cancer Immunotherapy
edited by Navin Kumar Verma, and
submission deadline 31 Jan 2026 | 1 articles | Viewed by 2938 | Submission Open
Keywords: cancer nano-therapy; nano-enabled therapeutic; immune checkpoint inhibitors; tumor immunosuppression; adoptive cell therapy; CAR T-cell therapy; tumor-infiltrating lymphocyte therapy; monoclonal antibody therapy for cancer; cancer vaccines; immune system modulators
(This special issue belongs to the Section Cancer Immunology and Immunotherapy)
Computational Research in Cancer Neuroscience
edited by Shaolei Teng
submission deadline 31 Jan 2026 | 1 articles | Viewed by 2876 | Submission Open
Keywords: machine learning; large language models; protein structure modeling; omics data analysis; neural– cancer communication; tumor microenvironments; personalized medicine; targeted therapies; cancer neuroscience
(This special issue belongs to the Section Methods and Technologies Development)
Novel Perspectives in Hepato-Biliary and Pancreatic Cancer
edited by Tudor Mocan and Emil-Ioan Moiș
submission deadline 31 Jan 2026 | 2 articles | Viewed by 2597 | Submission Open
Keywords: HCC; cholangiocarcinoma; surgery; biliary drainage; pancreatic cancer; combination therapies
(This special issue belongs to the Section Cancer Therapy)
Advances and Future Developments in Liver Transplantation for Cancers: 2nd Edition
edited by
submission deadline 31 Jan 2026 | 2 articles | Viewed by 2534 | Submission Open
Keywords: machine perfusion; marginal graft; split liver; immunotherapy; auxiliary liver transplantation; digital twin; modeling; organoid
(This special issue belongs to the Section Transplant Oncology)
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