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Cancers publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Long-Read Sequencing in Cancer (2nd Edition)
edited by and Patrick Driguez
submission deadline 30 Jun 2026 | Viewed by 102 | Submission Open
Keywords: long-read sequencing; cancer genetics; genomics; transcriptomics; methylomics; cancer research
(This special issue belongs to the Section Molecular Cancer Biology)
Molecular Mechanisms of Cancer Progression and Metastasis
edited by
submission deadline 30 Jun 2026 | Viewed by 94 | Submission Open
Keywords: metastasis; molecular mechanisms; tumor microenvironment (TME); epithelial-to-mesenchymal transition (EMT); cancer stem cell; therapeutic strategies; immune evasion
(This special issue belongs to the Section Cancer Metastasis)
Tumor Heterogeneity in Breast Cancer—the “Omics” Revolution submission deadline 30 Jun 2026 | Viewed by 93 | Submission Open
Keywords: breast cancer; tumor heterogeneity; tumor microenvironment; transcriptional regulation; single-cell RNA-seq; spatial transcriptomics; genomics; epigenomics; proteomics; metabolomics
(This special issue belongs to the Section Molecular Cancer Biology)
CDK4/6 Inhibitors in Cancer: Efficacy, Resistance, and Combination Approaches
edited by
submission deadline 30 Jun 2026 | Viewed by 93 | Submission Open
Keywords: CDK4/6 inhibitors; palbociclib; abemaciclib; ribociclib; cancer; senescence; combinatorial therapy; prognosis; molecular mechanisms
(This special issue belongs to the Section Cancer Therapy)
Ras-Directed Therapies: A Revolution
edited by
submission deadline 30 Jun 2026 | Viewed by 83 | Submission Open
Keywords: Ras-driven cancers; Ras inhibitors; Ras degraders; Ras signaling; mechanisms of resistance; combination therapies
(This special issue belongs to the Section Cancer Therapy)
Radiation Therapy for Metastatic Cancer
edited by Johnny Kao
submission deadline 30 Jun 2026 | Viewed by 80 | Submission Open
Keywords: metastasis; radiation therapy; tumor agnostic; oligometastases; survivorship; combined modality therapy
(This special issue belongs to the Section Cancer Therapy)
Progress in Targeted Nanotherapeutic Delivery Systems for Cancer Precision Medicine
edited by and Dhananjay Suresh
submission deadline 30 Jun 2026 | Viewed by 78 | Submission Open
Keywords: cancer therapy; drug delivery; tumor targeting; nanotechnology; precision medicine; immunotherapy; new approach methodologies (NAMs)
(This special issue belongs to the Section Methods and Technologies Development)
Magnetic Resonance in Cancer Research (2nd Edition)
edited by Qiuhong He and Marie-France Vidaver
submission deadline 30 Jun 2026 | Viewed by 75 | Submission Open
Keywords: magnetic resonance; cancer; MRI; MRS; MRSI; NMR; DWI; MR; molecular imaging
(This special issue belongs to the Section Methods and Technologies Development)
Emerging Opportunities in Radiation Oncology: AI, Radiomics, and Particle Therapy Breakthroughs submission deadline 30 Jun 2026 | Viewed by 70 | Submission Open
Keywords: radiotherapy; artificial intelligence; radiomics; machine learning; adaptive planning; proton therapy; hadron therapy; precision oncology; particle radiotherapy; clinical outcomes
Symptom Burden in Cancer: Assessment and Management: 2nd Edition
edited by Sam M. Salek, and Tatyana Ionova
submission deadline 30 Jun 2026 | Viewed by 69 | Submission Open
Keywords: symptom burden; patient-reported outcomes; symptom assessment; symptom management; cancer survivorship; quality of life
(This special issue belongs to the Section Cancer Survivorship and Quality of Life)
Immunotherapy for Acute Lymphoblastic Leukemia: Novel Strategies and Clinical Perspectives
edited by Paola Minetto and
submission deadline 30 Jun 2026 | Viewed by 69 | Submission Open
Keywords: immunotherapy; CAR T-cell therapy; bispecific antibodies; antibody– drug conjugates; treatment resistance; clinical perspectives; clinical trial in ALL
(This special issue belongs to the Section Cancer Immunology and Immunotherapy)
Fertility and Pregnancy in Cancer
edited by
submission deadline 30 Jun 2026 | Viewed by 57 | Submission Open
Keywords: cancer; gonadotoxic treatment; pregnancy; offspring; long term survivorship; fertility preservation
(This special issue belongs to the Section Cancer Epidemiology and Prevention)
Living with Cancer as a Chronic Disease: Quality of Life and Supportive Care
edited by
submission deadline 30 Jun 2026 | Viewed by 45 | Submission Open
Keywords: long-term symptom management; palliative care; awareness; coping strategies; survivorship; caregiver; multidisciplinary care coordination
(This special issue belongs to the Section Cancer Survivorship and Quality of Life)
Molecular Insights into Drug Resistance in Cancer: 2nd Edition
edited by Yuqi Yang
submission deadline 30 Jun 2026 | Viewed by 35 | Submission Open
Keywords: drug resistance; cancer treatment; molecular mechanism; chemotherapeutic therapy; small molecules; biologics/large molecules; leukemia; solid tumor
Breast Cancer Evolution—Insights from Single-Cell Genomics
edited by
submission deadline 30 Jun 2026 | Viewed by 29 | Submission Open
Keywords: single-cell genomics; tumor evolution; intratumoral heterogeneity; lineage plasticity; therapy resistance; spatial transcriptomics; tumor microenvironment; clonal dynamics; multi-omics profiling
(This special issue belongs to the Section Molecular Cancer Biology)
Diagnostic and Pathological Markers in Human Cancer
edited by , and Qian Zhao
submission deadline 30 Jun 2026 | Viewed by 28 | Submission Open
Keywords: cancer; biomarker; early diagnosis; pathological markers; prognostic model
(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)
Autophagy and Apoptosis in Cancer Progression
edited by Antonio Ieni
submission deadline 30 Jun 2026 | Viewed by 28 | Submission Open
Keywords: autophagy; apoptosis; cancer progression; cell death pathways; therapeutic resistance
(This special issue belongs to the Section Molecular Cancer Biology)
Advances in Treatment of Bladder Cancer submission deadline 30 Jun 2026 | Viewed by 26 | Submission Open
Keywords: bladder cancer; diagnostic biomarkers; genomics; therapeutic approaches
(This special issue belongs to the Section Cancer Therapy)
New Implication in the Platelet–Cancer Interplay
edited by Lenard M. Lichtenberger
submission deadline 30 Jun 2026 | Viewed by 24 | Submission Open
Keywords: platelet; COX-1; aspirin; phosphatidylcholine; colorectal cancer; thrombocytosis
Advances and Challenges in Head and Neck Cancer
edited by , Leonor Abreu Ribeiro and Claúdia Vieira
submission deadline 30 Jun 2026 | Viewed by 23 | Submission Open
Keywords: head and neck cancer; biomarkers; immunotherapy; radiosensitizers; multiple tumors
Cellular Immunotherapy for Leukemias—Advances, Limitations, and the Path Forward
edited by Lohith Gowda and Stuart E. Seropian
submission deadline 30 Jun 2026 | Viewed by 21 | Submission Open
Keywords: cellular therapy; cellular immunotherapy; leukemias
(This special issue belongs to the Section Cancer Immunology and Immunotherapy)
Actual Aspects of Prostate Cancer Treatment—an Interdisciplinary Approach (Third Edition)
edited by
submission deadline 30 Jun 2026 | Viewed by 15 | Submission Open
Keywords: prostate cancer; surgery; radiotherapy; hypofractionation; interdisciplinarity; nuclear medicine; PSMA
(This special issue belongs to the Section Cancer Therapy)
Tumor Microenvironment (TME): Cellular and Molecular Interactions
edited by
submission deadline 30 Jun 2026 | Viewed by 15 | Submission Open
Keywords: cancer stem cells; hypoxia; connexins; tumor microenvironment; extracellular ATP; immune cells; extracellular acidification; extracellular matrix; extracellular vesicles
(This special issue belongs to the Section Tumor Microenvironment)
Advances in Dermoscopy for Melanoma and Non-Melanoma Skin Cancer
edited by , Warren Chan, Jade Conway and
submission deadline 30 Jun 2026 | Viewed by 14 | Submission Open
Keywords: dermoscopy; skin cancer; diagnosis; artificial intelligence; multimodal imaging; teledermoscopy
(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)
Novel Insights into Mechanisms of Cancer-Associated Thrombosis: 2nd Edition
edited by Tom A J Mckinnon
submission deadline 30 Jun 2026 | Viewed by 14 | Submission Open
Keywords: cancer; thrombosis; venous; arterial
(This special issue belongs to the Section Molecular Cancer Biology)
Digital Pathology and AI for Tumor Microenvironment Mapping
edited by Mohammadreza Azimi
submission deadline 30 Jun 2026 | Viewed by 12 | Submission Open
Keywords: tumor microenvironment; digital pathology; artificial intelligence; spatial analysis; computational histopathology; deep learning; cancer prognostics; machine learning; image-based biomarkers; federated learning
Tumor Immune Microenvironment: Molecular Mechanism and Signaling Pathway
edited by Hua Tian
submission deadline 30 Jun 2026 | Viewed by 10 | Submission Open
Keywords: tumor immune microenvironment; signaling pathways; immunotherapy; crosstalk
Calcium-Linked Messaging in Cancer
edited by
submission deadline 30 Jun 2026 | Viewed by 5 | Submission Open
Keywords: interorganellar Ca2+ communication; membrane contact sites; tumor progression; intracellular Ca2+ flux; cation channels; calcium dysregulation; cell fate; targeted therapy
(This special issue belongs to the Section Tumor Microenvironment)
Psychosocial Health and Quality of Life Across the Cancer Care Continuum
edited by and Serene Si Ning Goh
submission deadline 30 Jun 2026 | Viewed by 4 | Submission Open
Keywords: cancer survivorship; psychological outcomes; quality of life; health-related quality of life; patient-reported outcomes; fear of recurrence; cancer-related fatigue; mental health; body image; supportive care
(This special issue belongs to the Section Cancer Survivorship and Quality of Life)
Clinical Studies in Gastrointestinal Malignancies: 2nd Edition submission deadline 30 Jun 2026 | Viewed by 3 | Submission Open
Keywords: gastrointestinal cancers; clinical studies; multimodal treatment; study design; outcomes
(This special issue belongs to the Section Clinical Research of Cancer)
Reappearance of Dawn: CAR-T Restricts Glioblastoma
edited by
submission deadline 30 Jun 2026 | Viewed by 2 | Submission Open
Keywords: CAR-T cell therapy; glioblastoma (GBM); immunotherapy; antigen escape; blood– brain barrier; immunosuppressive tumor microenvironment; clinical efficacy; toxicity; combination therapy; future strategies
(This special issue belongs to the Section Cancer Immunology and Immunotherapy)
The Use of Artificial Intelligence in Predicting Response to Cancer Therapy submission deadline 30 Jun 2026 | Submission Open
Keywords: artificial intelligence; response prediction; precision oncology; machine learning; multimodal data integration; immunotherapy biomarkers; treatment resistance; clinical decision support; real-world data; explainable AI
Cancer-Associated Thrombosis, Arterial and Venous Thromboembolism
edited by
submission deadline 30 Jun 2026 | Submission Open
Keywords: cancer; deep vein thrombosis; pulmonary embolism; venous thromboembolism; anticoagulants; cardio-oncology; artificial intelligence; machine learning
(This special issue belongs to the Section Cancer Pathophysiology)
Advances in Therapeutic Strategies for Prostate Cancer
edited by Angelo Naselli and
submission deadline 1 Jul 2026 | 5 articles | Viewed by 22505 | Submission Open
Keywords: immunotherapy; radiation therapy; hormone therapy; targeted therapies
(This special issue belongs to the Section Cancer Therapy)
Pediatric Brain Tumors: Symptoms, Diagnosis and Treatments
edited by Christian Ott and Julius Höhne
submission deadline 1 Jul 2026 | 3 articles | Viewed by 8309 | Submission Open
Keywords: MRI/CT scans; radiation therapy; chemotherapy; combined therapy
(This special issue belongs to the Section Cancer Therapy)
The Role of Radiotherapy, Immunotherapy and New Surgical Techniques in the Treatment of Lung Neoplasms
edited by
submission deadline 1 Jul 2026 | 3 articles | Viewed by 7580 | Submission Open
Keywords: radiotherapy; immunotherapy; new surgical techniques; lung cancer
(This special issue belongs to the Section Cancer Therapy)
The Mediastinum—Pandora’s Box
edited by
submission deadline 1 Jul 2026 | Viewed by 557 | Submission Open
Keywords: mediastinum; thymus; imaging; surgery; thymoma; germ cell tumors
Clinical Trials for Diffuse Large B-Cell Lymphomas (DLBCL)
edited by
submission deadline 1 Jul 2026 | Viewed by 333 | Submission Open
Keywords: DLBCL; immunotherapy; drug combinations; elderly patients; ctDNA; biomarkers; radiotherapy; clinical trial management; artificial intelligence
(This special issue belongs to the Section Clinical Research of Cancer)
Advancing CAR-T Cell Therapy: The Next Evolution in Breast Cancer Treatment submission deadline 1 Jul 2026 | Viewed by 194 | Submission Open
Keywords: CAR-T cell therapy; breast cancer; triple-negative breast cancer (TNBC); HER2-positive breast cancer; tumor microenvironment; immunotherapy
(This special issue belongs to the Section Cancer Immunology and Immunotherapy)
The Role of Opioid Therapy for Cancers
edited by Brian Le and
submission deadline 1 Jul 2026 | Viewed by 53 | Submission Open
Keywords: opioids; palliative care; chronic cancer pain
(This special issue belongs to the Section Cancer Therapy)
Metals in Cancer: From Molecular Mechanisms to Innovative Therapeutics submission deadline 5 Jul 2026 | Viewed by 81 | Submission Open
Keywords: essential and toxic metals; metal-induced carcinogenesis; metal homeostasis; metallotherapeutics; oxidative stress; tumor microenvironment; immune modulation; metabolic reprogramming; therapy resistance; drug delivery systems
(This special issue belongs to the Section Molecular Cancer Biology)
Microfluidic Technology in Cancer
edited by and
submission deadline 5 Jul 2026 | Viewed by 69 | Submission Open
Keywords: cancer cells separation; cancer cells isolation; cancer cells treatment; lab-on-a-chip technology; bio microfluidics; biomedical microdevices; biosensors; and detection in microfluidics
(This special issue belongs to the Section Methods and Technologies Development)
Perioperative Management and Cancer Outcomes (2nd Edition)
edited by
submission deadline 9 Jul 2026 | Viewed by 138 | Submission Open
Keywords: perioperative management; cancer treatment outcomes; onco-anesthesiology; preoperative risk assessment; enhanced recovery after surgery (ERAS); pain management; personalized medicine
(This special issue belongs to the Section Cancer Therapy)
Upper Tract Urothelial Carcinoma: Current Knowledge and Perspectives
edited by Katie S. Murray and Saum Ghodoussipour
submission deadline 10 Jul 2026 | 3 articles | Viewed by 8020 | Submission Open
Keywords: upper tract urothelial carcinoma; upper tract disease; urothelial cell carcinoma
(This special issue belongs to the Section Cancer Therapy)
Neuroendocrine Neoplasms: Pathogenesis, Diagnostics, and Therapy
edited by
submission deadline 10 Jul 2026 | 1 articles | Viewed by 6579 | Submission Open
Keywords: neuroendocrine neoplasms; pathogenesis; diagnostics; therapy
(This special issue belongs to the Section Cancer Therapy)
Clinicopathological Study of Gynecologic Cancer (2nd Edition)
edited by
submission deadline 10 Jul 2026 | 1 articles | Viewed by 1232 | Submission Open
Keywords: gynecological oncology; gynecological cancer; female cancer; uterine cancer; ovarian cancer; endometrial cancer; cancerogenesis; cancer biology; cell transformation; cancer pathology; cancer biology
(This special issue belongs to the Section Clinical Research of Cancer)
Preoperative Optimisation in Patients Undergoing Cancer Surgery: 2nd Edition
edited by and
submission deadline 10 Jul 2026 | Viewed by 84 | Submission Open
Keywords: prehabilitation; medical optimization; exercise; nutrition; psychological interventions; surgery; cancer; surgical outcome; preoperative; clinical trials
(This special issue belongs to the Section Cancer Survivorship and Quality of Life)
Beyond Cancer: Enhancing Quality of Life for Cancer Survivors (Second Edition)
edited by , Maryam Lustberg and Muna Al-Khaifi
submission deadline 10 Jul 2026 | Viewed by 84 | Submission Open
Keywords: psychosocial oncology; cancer survivorship; long-term effects of cancer; psychoeducational interventions; nnovative care models; continuing education; knowledge translation
(This special issue belongs to the Section Cancer Survivorship and Quality of Life)
Lung Cancer: Diagnosis and Targeted Therapy
edited by Myung-Ju Ahn and
submission deadline 10 Jul 2026 | Viewed by 5 | Submission Open
Keywords: lung cancer; modern diagnostics; screening; imaging; pathologic and molecular profiling; biomarkers; targeted therapies; next-generation TKIs; antibody– drug conjugates (ADCs); drug resistance
Molecular Biology, Diagnosis and Management of Endometrial Cancer
edited by , and Thomas Vrekoussis
submission deadline 12 Jul 2026 | 4 articles | Viewed by 9388 | Submission Open
Keywords: endometrial cancer; molecular biology; lymph node dissection; sentinel lymph node mapping; sentinel lymph node dissection; surgery; systemic therapy; radiotherapy; fertility preservation; molecular targeted therapies
(This special issue belongs to the Section Molecular Cancer Biology)
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