Tumor Immune Microenvironment: Molecular Mechanism and Signaling Pathway

Dear Colleagues,

The tumor immune microenvironment (TIME) governs critical processes in cancer progression, metastasis, immune evasion, and therapeutic response. Recent advances have uncovered intricate molecular crosstalk between tumor cells, immune infiltrates (e.g., T cells, macrophages, MDSCs), stromal components, and soluble mediators—orchestrated through key signaling pathways such as JAK/STAT, NF-κB, PI3K/AKT, WNT/β-catenin, and cGAS-STING. Elucidating these mechanisms is essential for decoding immune activation versus suppression and for designing next-generation immunotherapies. This Special Issue invites submissions that explore novel molecular mechanisms and signaling pathways for TIME. We welcome original research articles, reviews, and mini-reviews.

In this Special Issue, original research articles and reviews are welcome. Research areas may include (but are not limited to) the following:

1. Immune cell subpopulations and their functional regulatory mechanisms;
2. Metabolic crosstalk between tumor and immune cells;
3. The role of key signaling pathways in TIME;
4. Resistance mechanisms to immunotherapy: signaling perspectives;
5. Transcriptional and epigenetic control of immune cell fate in tumors;
6. Overcoming immunotherapy resistance through TME modulation.

We sincerely invite researchers in related fields to contribute and collaborate in advancing this cutting-edge area.

Dr. Hua Tian
Guest Editor

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