Incorporating DNA Damage Response (DDR) Mechanisms in Cancer Systems

Dear Colleagues,

The chronic exposure of cells and organisms to exogenous (environmental) or endogenous stress can lead to the deterioration of the defense and homeostatic mechanisms, like antioxidants, DNA damage response (DDR), and immune response, which are strongly associated. This phenomenon is always fueled by the increasing and persistent genomic instability, which is considered to be one of the major detrimental effects of the different types of stresses originating from ionizing and non-ionizing radiations, replication problems, and others. From simple cellular systems to complex biological systems like tissues or organs, it is important to know how each system responds to DNA damage, especially of a complex type, and what are the final short- and long-terms effects?

Authors are invited to submit manuscripts dealing with the mechanisms or phenomena that can lead to any type of DDR induction in any biological system, or even method papers for the proper measurement of DDR and its biological outcome. We live in the era of omics and big data, therefore, teams working in this field by means of bioinformatics, systems biology, and machine learning, as well as any type of omics, are highly welcome.

In this Topical Collection, we are reaching out for teams or groups working in many interdisciplinary fields towards a better understanding of the complexity of cancer evolution, especially the role of malfunctioning DDR and its repair. We also expect contributions from groups working on the clinical aspects of DDR and its role in the regulation of homeostasis in the organism.

Prof. Dr. Alexandros Georgakilas
Collection Editor

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