Special Issue "Radiation-Induced Carcinogenesis"
A special issue of Cancers (ISSN 2072-6694).
Deadline for manuscript submissions: closed (15 September 2017)
Prof. Dr. Alexandros G. Georgakilas
DNA Damage Laboratory, Physics Department, School of Applied Mathematical and Physical Sciences, National Technical University of Athens, Zografou Campus, 15780 Athens, Greece
Website | E-Mail
Fax: +30 210 772 3025
Interests: radiation biology; cancer biology; DNA damage and repair; oxidative stress; carcinogenesis
Prof. Dr. Lembit Shiver
EBG MedAustron GmbH: Head of Applied Medical Physics Research, Prof. of Medical Rad. Physics with Specialization in Ion Therapy, Head of Radiation Physics, TU Wien-Atominstitut, Stadionallee 2, 1020 Wien, Österreich, Austria
Website | E-Mail
Interests: radiation therapy; ion therapy; proton therapy; transport simulations; Monte Carlo; DNA damage
Ionizing radiation and related effects in the cell, such as protein, lipid, and DNA damage, are considered as the initial events leading to radiation detrimental effects. Unrepaired or misrepaired damage can lead to mutagenesis, inactivation of DNA damage response pathways, epigenetic changes, and, further, more importantly, genomic instability and malignant transformation. Radiation-induced carcinogenesis is a multi-component function of high-interest to physicists, biologists, and clinicians dealing with radiation-induced secondary cancers. All these fields including the field of non-targeted effects have gained through the years an increased attention. It is of great necessity to clarify and underline the significance and ‘real’ relevance of the initial types of DNA, lipid and/or protein damage in the initiation of carcinogenesis especially at low doses. We would like to invite manuscripts that aim to elucidate the role(s) of radiation-related DNA damage of all forms in primary and secondary carcinogenesis and for various types of cancers like breast, brain, leukemia, lung, prostate, etc. We are particularly interested in manuscripts deciphering the physical and biological mechanisms and pathways that complex DNA damage can lead to mutation and inactivation of DNA repair and apoptotic genes, as well as epigenetic changes and new detection tools. We are also welcome manuscripts focusing on the synergistic effects between inflammation, radiation stress and tumorigenesis in humans and to potential natural anti-inflammatory products that reduce radiation-related cancer risk. New insights gained by the use of omics like genomics, lipidomics, proteomics, as well as theoretical Monte Carlo simulations and modelling, are also welcomed. By devoting a Special Issue to radiation-related carcinogenesis, we hope to join forces and enhance the knowledge in the specific field and above all promote the new era of therapeutic discoveries (like protons) targeting and minimizing radiation-induced adverse effects through the mitigation of harmful radiation effects, especially at the systems biology level.
Assoc. Prof. Dr. Alexandros G. Georgakilas
Prof. Dr. Lembit Shiver
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- Radiation effects
- DNA damage and repair
- inflammation and immune response
- Monte Carlo simulations and Modelling
- Non-targeted and abscopal effects
- genomic instability
- Omics, radiogenomics