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The Role of E3, E4 Ubiquitin Ligase (UBE4B) in Human Pathologies

1
Molecular Carcinogenesis Group, Department of Histology and Embryology, School of Medicine, National Kapodistrian University of Athens, 75 Mikras Asias Str., Goudi, GR-11527 Athens, Greece
2
Department of Pharmacy, National Kapodistrian University of Athens, Panepistimiopolis Zografou, GR-15771 Athens, Greece
3
General Maternal Hospital of Athens “Elena Venizelou”, GR-11521 Athens, Greece
4
First Department of Surgery, Laikon Teaching Hospital, School of Medicine, National Kapodistrian University of Athens, 75 Mikras Asias Str., Goudi, GR-11527 Athens, Greece
5
The David and Inez Myers Laboratory for Cancer Research, Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine, George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv 69978, Israel
6
Oncology Unit, Department of Clinical Therapeutics, Medical School, National and Kapodistrian University of Athens, Alexandra Hospital, GR-11528 Athens, Greece
7
Biomedical Research Foundation of the Academy of Athens, GR-11527 Athens, Greece
8
Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester M20 4GJ, UK
*
Authors to whom correspondence should be addressed.
These authors contribute equally to this work.
Cancers 2020, 12(1), 62; https://doi.org/10.3390/cancers12010062
Received: 8 October 2019 / Revised: 21 November 2019 / Accepted: 23 November 2019 / Published: 24 December 2019
The genome is exposed daily to many deleterious factors. Ubiquitination is a mechanism that regulates several crucial cellular functions, allowing cells to react upon various stimuli in order to preserve their homeostasis. Ubiquitin ligases act as specific regulators and actively participate among others in the DNA damage response (DDR) network. UBE4B is a newly identified member of E3 ubiquitin ligases that appears to be overexpressed in several human neoplasms. The aim of this review is to provide insights into the role of UBE4B ubiquitin ligase in DDR and its association with p53 expression, shedding light particularly on the molecular mechanisms of carcinogenesis. View Full-Text
Keywords: UBE4B; ubiquitin ligases; DNA damage response; cancer disease; p53 UBE4B; ubiquitin ligases; DNA damage response; cancer disease; p53
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Antoniou, N.; Lagopati, N.; Balourdas, D.I.; Nikolaou, M.; Papalampros, A.; Vasileiou, P.V.S.; Myrianthopoulos, V.; Kotsinas, A.; Shiloh, Y.; Liontos, M.; Gorgoulis, V.G. The Role of E3, E4 Ubiquitin Ligase (UBE4B) in Human Pathologies. Cancers 2020, 12, 62.

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