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Ionizing Radiation and Complex DNA Damage: Quantifying the Radiobiological Damage Using Monte Carlo Simulations

1
3dmi Research Group, Department of Medical Physics, School of Medicine, University of Patras, 26504 Rion, Greece
2
Bioemission Technology Solutions (BIOEMTECH), 11472 Athens, Greece
3
Department of Medical Physics, School of Medicine, University of Ioannina, 45500 Ioannina, Greece
4
DNA Damage Laboratory, Department of Physics, School of Applied Mathematical and Physical Sciences, National Technical University of Athens (NTUA), 15780 Athens, Greece
5
Radiation Institute for Science & Engineering, Prairie View A&M University, Prairie View, TX 77446, USA
*
Author to whom correspondence should be addressed.
Cancers 2020, 12(4), 799; https://doi.org/10.3390/cancers12040799
Received: 10 February 2020 / Revised: 23 March 2020 / Accepted: 25 March 2020 / Published: 26 March 2020
Ionizing radiation is a common tool in medical procedures. Monte Carlo (MC) techniques are widely used when dosimetry is the matter of investigation. The scientific community has invested, over the last 20 years, a lot of effort into improving the knowledge of radiation biology. The present article aims to summarize the understanding of the field of DNA damage response (DDR) to ionizing radiation by providing an overview on MC simulation studies that try to explain several aspects of radiation biology. The need for accurate techniques for the quantification of DNA damage is crucial, as it becomes a clinical need to evaluate the outcome of various applications including both low- and high-energy radiation medical procedures. Understanding DNA repair processes would improve radiation therapy procedures. Monte Carlo simulations are a promising tool in radiobiology studies, as there are clear prospects for more advanced tools that could be used in multidisciplinary studies, in the fields of physics, medicine, biology and chemistry. Still, lot of effort is needed to evolve MC simulation tools and apply them in multiscale studies starting from small DNA segments and reaching a population of cells. View Full-Text
Keywords: radiobiology; nanoscale simulations; Monte Carlo method; ionizing radiation; complex DNA damage; biological response radiobiology; nanoscale simulations; Monte Carlo method; ionizing radiation; complex DNA damage; biological response
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Chatzipapas, K.P.; Papadimitroulas, P.; Emfietzoglou, D.; Kalospyros, S.A.; Hada, M.; Georgakilas, A.G.; Kagadis, G.C. Ionizing Radiation and Complex DNA Damage: Quantifying the Radiobiological Damage Using Monte Carlo Simulations. Cancers 2020, 12, 799.

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