Special Issues

Biomolecules publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Targeted Protein Degradation and Beyond: Integrated Biological, Chemical and Computational Approaches to Proximity-Based Modulation submission deadline 31 Mar 2026 | Viewed by 178 | Submission Open
Keywords: PROTACs; protein degradation; drug discovery; chemical biology; ternary complex; undruggable targets
Structure, Molecular Dynamics, Assembly, and Evolution of Protein Systems with AI-Enhanced Modeling in Pharmacology and Structural Biology submission deadline 31 Mar 2026 | Viewed by 152 | Submission Open
Keywords: machine learning in structural biology; molecular dynamics simulations; protein– ligand interactions; computational pharmacology; structure-based drug design
(This special issue belongs to the Section Molecular Biology)
Zebrafish: A Powerful Model in Neuroscience to Investigate Genes, Brain Mechanisms, and Behavior submission deadline 31 Mar 2026 | Viewed by 152 | Submission Open
Keywords: zebrafish; behavioural neuroscience; neurodevelopment; neurodegeneration
(This special issue belongs to the Section Chemical Biology)
The Role of Heparin in Blood
edited by , and Denisa Cont
submission deadline 31 Mar 2026 | Viewed by 151 | Submission Open
Keywords: heparin; glycocalyx; anti-inflammatory properties; immunothrombosis; sepsis; inflammation; hemocompatibility; extracorporeal therapies; antiviral activity; heparin-induced thrombocytopenia (HIT)
(This special issue belongs to the Section Molecular Medicine)
Post-Translational Modifications in Disease: From Computational Prediction to Functional Mechanisms
edited by
submission deadline 31 Mar 2026 | Viewed by 137 | Submission Open
Keywords: post-translational modifications; PTMs; disease
Exploring the Molecular and Cellular Mechanisms of Pulmonary Arterial Hypertension
edited by and Grégoire Ruffenach
submission deadline 31 Mar 2026 | Viewed by 134 | Submission Open
Keywords: pulmonary arterial hypertension; PAH predisposing genes; ion channels; transcription factors; RNA-binding protein; omics approaches
(This special issue belongs to the Section Molecular Medicine)
SAM Domains in Health and Diseases: Structural and Functional Insights submission deadline 31 Mar 2026 | Viewed by 130 | Submission Open
Keywords: SAM domains; oligomer- and polymer-forming SAM; mid-loop/end-helix architecture of binding; SAM physiological and pathological signaling pathways; SAM domains as drug targets
(This special issue belongs to the Section Molecular Biophysics: Structure, Dynamics, and Function)
Fibronectin, Integrins and Related Molecules in Health and Diseases
edited by
submission deadline 31 Mar 2026 | Viewed by 114 | Submission Open
Keywords: integrin; fibronectin; cytokines
(This special issue belongs to the Section Chemical Biology)
From Molecular Mechanisms to Therapies: Advances in Retinal Disease Research submission deadline 31 Mar 2026 | Viewed by 104 | Submission Open
Keywords: retinal diseases; retinal pathologies; preclinical studies
(This special issue belongs to the Section Molecular Biology)
Citrin Deficiency: Molecular Pathogenesis and Novel Targets for Therapy
edited by
submission deadline 31 Mar 2026 | Viewed by 103 | Submission Open
Keywords: citrin deficiency; pathogenesis; therapeutic procedures
(This special issue belongs to the Section Molecular Medicine)
Molecular and Cellular Mechanisms of Therapy Resistance in Acute Myeloid Leukemia
edited by
submission deadline 31 Mar 2026 | Viewed by 100 | Submission Open
Keywords: acute myeloid leukemia; molecular mechanism; cellular mechanism; therapy resistance; microenvironment
(This special issue belongs to the Section Cellular Biochemistry)
Synthetic Biology's Potential to Address Undruggable Targets and Difficult-to-Treat Diseases
edited by
submission deadline 31 Mar 2026 | Viewed by 93 | Submission Open
Keywords: synthetic biology; protein engineering; drug development; biologics; undruggable targets
(This special issue belongs to the Section Molecular Medicine)
Mitochondrial Calcium Signaling in Cardiac Health and Disease
edited by Enrique Balderas
submission deadline 2 Apr 2026 | Viewed by 100 | Submission Open
Keywords: mitochondrial Ca2+; OXPHOS; H+ gradient; ATP-synthesis; NAD(H) balance; Ca2+-overload; mitochondrial permeability; apoptosis; mtDNA; ROS production-clearance
(This special issue belongs to the Section Cellular Biochemistry)
The Urokinase System in Cancer: From Stress Responses to Therapeutic Targeting submission deadline 3 Apr 2026 | 1 articles | Viewed by 1668 | Submission Open
Keywords: urokinase plasminogen activator; PAI1; urokinase plasminogen activator receptor; transcription; regulation; cancer; migration; invasion; stress
DNA Damage and Repair in Cancer Treatment submission deadline 15 Apr 2026 | 1 articles | Viewed by 6785 | Submission Open
Keywords: ionizing radiation; DNA damage; DNA repair; genomic instability; patient radioprotection; tumour radiosensitization; radiation-induced carcinogenesis
(This special issue belongs to the Section Molecular Biology)
Extracellular Vesicles as Biomarkers of Diseases: 2nd Edition submission deadline 15 Apr 2026 | Viewed by 41 | Submission Open
Keywords: extracellular vesicles; metabolic syndrome; cancer; cardiovascular diseases; neurodegenerative diseases; biomarkers
(This special issue belongs to the Section Molecular Biomarkers)
Molecular Aspects of Diseases Origin and Development
edited by
submission deadline 20 Apr 2026 | 7 articles | Viewed by 27775 | Submission Open
(This special issue belongs to the Section Molecular Medicine)
Novel Approaches to Harness Neuropathic Pain: Modulation of Glial Cells as a Therapeutic Strategy submission deadline 20 Apr 2026 | Viewed by 135 | Submission Open
Keywords: neuropathic pain; neuroinflammation; descending pain modulation; glial cells; pharmacological therapies; non-pharmacological therapies; microglia; astrocytes  
Recent Advances in the Role of Translation Machinery and Translational Control in the Cardiovascular System, 2nd Edition
edited by Peng Yao and
submission deadline 20 Apr 2026 | Viewed by 95 | Submission Open
Keywords: translational control; translation machinery; RNA-binding protein; non-coding RNA
(This special issue belongs to the Section Molecular Genetics)
Synthetic Chemistry in Drug Discovery: Novel Compounds for Antimicrobial and Antioxidant Applications submission deadline 25 Apr 2026 | 3 articles | Viewed by 3622 | Submission Open
Keywords: synthetic chemistry; drug discovery; essential oils; antimicrobial activity; antiproliferative agents; antioxidant properties; bioactive molecules; structure– activity relationship; natural product derivatives; medicinal chemistry; chemical synthesis; pharmacological evaluation
(This special issue belongs to the Section Chemical Biology)
Mitochondria and Central Nervous System Disorders: 3rd Edition submission deadline 30 Apr 2026 | 6 articles | Viewed by 15527 | Submission Open
Keywords: mitochondria; metabolism; neurodegeneration; neuroinflammation; ageing; central nervous system
(This special issue belongs to the Section Molecular Biology)
Advances in Melanoma Targeted Therapy
edited by
submission deadline 30 Apr 2026 | 3 articles | Viewed by 10507 | Submission Open
Keywords: melanoma; drug discovery; new targets; target discovery
(This special issue belongs to the Section Molecular Medicine)
Cellular Signaling in Cancer
edited by , Shabana Bano and Kasturi Nayak
submission deadline 30 Apr 2026 | 4 articles | Viewed by 9055 | Submission Open
Keywords: signaling pathways; cancer; anti-cancer
(This special issue belongs to the Section Cellular Biochemistry)
Nanoparticles for Cancer Therapy: Challenges and Opportunities submission deadline 30 Apr 2026 | 2 articles | Viewed by 7531 | Submission Open
Keywords: nanoparticles; cancer; nanotheranostics; drug delivery; gene delivery
(This special issue belongs to the Section Bio-Engineered Materials)
Bioactive Compounds as Modifiers of Mitochondrial Function
edited by Mihail "Mike" Mitov
submission deadline 30 Apr 2026 | 2 articles | Viewed by 7350 | Submission Open
Keywords: natural bioactive compounds; synthesized bioactive compounds; mitochondrial function; electron transport chain (ETC); ATP production rate; oxygen consumption rate (OCR); extracellular acidification rate (ECAR)
(This special issue belongs to the Section Natural and Bio-derived Molecules)
Biomarkers in Neurodegenerative Diseases: Shaping the Future of Diagnosis and Treatment submission deadline 30 Apr 2026 | 5 articles | Viewed by 6885 | Submission Open
Keywords: molecular diagnostics; lipidomics; genomics; proteomics; transcriptomics
(This special issue belongs to the Section Molecular Biomarkers)
Genetics and Epigenetics of Breast Cancer submission deadline 30 Apr 2026 | 2 articles | Viewed by 6403 | Submission Open
Keywords: breast cancer; genetic landscape; epigenetics; diagnostic/prognostic/predictive biomarkers
(This special issue belongs to the Section Molecular Genetics)
Probiotics and Their Metabolites, 2nd Edition submission deadline 30 Apr 2026 | 3 articles | Viewed by 5637 | Submission Open
Keywords: probiotics; metabolites; functionality; biochemical aspects; biophysical aspects; physicochemical approach; molecular mechanism; interaction; synergy; adhesion; colonization; stability; prebiotics; postbiotics; synbiotics; viability; formulation; rational design; human health; animal health; plant health
(This special issue belongs to the Section Natural and Bio-derived Molecules)
Neuroinflammation in Ocular Diseases: Emerging Insights into Mechanisms, Biomarkers, and Therapeutic Targets
edited by
submission deadline 30 Apr 2026 | 3 articles | Viewed by 5593 | Submission Open
Keywords: neuroinflammation; vision; retina; optic nerve; neurodegeneration; inflammation; biomarker; therapeutic strategies; pharmacological treatments
(This special issue belongs to the Section Molecular Biomarkers)
Molecular Mechanisms and Therapeutic Targets in Leukaemia
edited by and
submission deadline 30 Apr 2026 | 3 articles | Viewed by 5356 | Submission Open
Keywords: leukaemia; blood; genetics; genomics; chromosome
(This special issue belongs to the Section Molecular Medicine)
Roles of Alpha-1 Antitrypsin in Human Health and Disease Models
edited by
submission deadline 30 Apr 2026 | 3 articles | Viewed by 4849 | Submission Open
Keywords: alpha-1 antitrypsin; serine proteinase inhibitor (SERPIN); autoimmunity; inflammation; aging; cancer
(This special issue belongs to the Section Molecular Medicine)
Genomics in Biodiversity Conservation (Vertebrates and Invertebrates) submission deadline 30 Apr 2026 | 2 articles | Viewed by 3941 | Submission Open
Keywords: genomics; mitochondrial genome; genetic diversity; phylogenetic analyses; conservation genetics; gene arrangements; evolution
(This special issue belongs to the Section Molecular Genetics)
Recent Advances in Bioactive Compounds from Microalgae submission deadline 30 Apr 2026 | 4 articles | Viewed by 3700 | Submission Open
Keywords: microalgae; bioactive compounds; biomolecules; innovations
(This special issue belongs to the Section Natural and Bio-derived Molecules)
Molecular Mechanisms and Pathophysiology of Gliomas
edited by Fengchao Lang
submission deadline 30 Apr 2026 | 1 articles | Viewed by 3580 | Submission Open
Keywords: gliomas; cell cycle; epigenetic modifications; metabolic reprogramming; tumor microenvironment; targeted therapies
(This special issue belongs to the Section Molecular Biology)
Advances in Antimicrobial Peptides (AMPs)
edited by
submission deadline 30 Apr 2026 | 1 articles | Viewed by 3197 | Submission Open
Keywords: antimicrobial peptides (AMPs); host defense peptides (HDPs); peptidomimetics; antimicrobial resistance (AMR); membrane interaction; cryptides; immunomodulation; peptide design and synthesis; biofilm inhibition; drug delivery systems
Molecular Mechanisms and Genetics of Human Disease
edited by and Ata Abbas
submission deadline 30 Apr 2026 | 1 articles | Viewed by 2833 | Submission Open
Keywords: genomic rearrangement; genetic diseases; molecular mechanism; recombination; gene duplication
(This special issue belongs to the Section Molecular Genetics)
Molecular Mechanisms and Signaling Pathways in Autoimmune Diseases
edited by
submission deadline 30 Apr 2026 | 2 articles | Viewed by 2545 | Submission Open
Keywords: autoimmune diseases; molecular mechanisms; signaling pathways; therapeutic targets; biomarkers
(This special issue belongs to the Section Molecular Biology)
New Insights into Hormonal Control of Plant Growth and Development
edited by
submission deadline 30 Apr 2026 | 2 articles | Viewed by 2442 | Submission Open
Keywords: plant hormones; auxins; cytokinin; gibberellins; ethylene; abscisic acid; jasmonic acid; salicylic acid; peptide hormones; growth and development
(This special issue belongs to the Section Molecular Biology)
Recent Advances in Anti-Tumor Metal Complexes and Drug Delivery Systems: 2nd Edition
edited by Jasmina Dimitrić Marković, and
submission deadline 30 Apr 2026 | 1 articles | Viewed by 2237 | Submission Open
Keywords: transition metal complexes; synthesis; structural characterization; biological activity; in silico methods; drug delivery
Food, Microbe, Viral and Parasite-Derived Antibodies in Autoimmune and Chronic Diseases submission deadline 30 Apr 2026 | 1 articles | Viewed by 2231 | Submission Open
Keywords: food antigens; antigens; auto-antigens; antibodies; auto-antibodies; auto-immune diseases; chronic diseases; microbes; bacteria; fungi; virus; parasites; cross-reaction; infection; chronic diseases
(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)
Homocysteine and H2S in Health and Disease, 2nd Edition submission deadline 30 Apr 2026 | 1 articles | Viewed by 1840 | Submission Open
Keywords: homocysteine (Hcy); hydrogen sulfide (H2S); oxidative stress; inflammation
(This special issue belongs to the Section Chemical Biology)
Multiple Myeloma: From Pathophysiology to Novel Therapeutic Approaches
edited by
submission deadline 30 Apr 2026 | 2 articles | Viewed by 1741 | Submission Open
Keywords: multiple myeloma; tumor immunology; MGUS; sMM
Metallic Nanoparticles: Biosynthesis and Therapeutic Potential submission deadline 30 Apr 2026 | 1 articles | Viewed by 1716 | Submission Open
Keywords: silver nanoparticle; antibacterial agent; green synthesis; therapeutics
(This special issue belongs to the Section Biological Factors)
Metal-Based Complexes in Medicine: From Therapeutics to Diagnostics and Theranostics submission deadline 30 Apr 2026 | 2 articles | Viewed by 1575 | Submission Open
Keywords: anticancer metal complexes; antitumor metallodrugs; antimicrobial agents; antiviral metallodrugs; medicinal inorganic chemistry; bioinorganic chemistry; computational design; molecular dynamics; docking; spectroscopic methods; NMR; mechanistic studies; rational drug development; synthesis; biological evaluation; drug delivery; experimental; in vitro; in vivo; theranostics; medicinal imaging
The Role and Metabolism of Metals in Cancer submission deadline 30 Apr 2026 | 1 articles | Viewed by 1115 | Submission Open
Keywords: metals; cancer; cancer metabolism
(This special issue belongs to the Section Chemical Biology)
Gas Chromatography–Mass Spectrometry as a Versatile Tool for Plant Metabolomics submission deadline 30 Apr 2026 | 1 articles | Viewed by 1084 | Submission Open
Keywords: GC-MS; plant metabolomics; biologically active metabolites; metabolomics-assisted breeding; stress response; multi-omics integration
(This special issue belongs to the Section Molecular Biology)
Biomolecular Sciences and Precision Medicine in Vascular Disease
edited by
submission deadline 30 Apr 2026 | 1 articles | Viewed by 907 | Submission Open
Keywords: precision medicine; vascular disease; vascular surgery
(This special issue belongs to the Section Molecular Medicine)
Lipids and Lipoproteins in Human Health and Disease
edited by
submission deadline 30 Apr 2026 | 1 articles | Viewed by 855 | Submission Open
Keywords: lipid; lipoprotein; lipophilic molecules
(This special issue belongs to the Section Biological Factors)
Phytochemicals: Bioactivity in Disease Prevention, Anti-Inflammation, and Animal/Human Health submission deadline 30 Apr 2026 | Viewed by 819 | Submission Open
Keywords: phytochemicals; anti-inflammatory; metabolic health; oxidative stress; gut microbiome; nutrigenomics; animal health; human health; systems biology; AI/ML
(This special issue belongs to the Section Molecular Medicine)
Advances in S-Triazine-Based Therapeutics: From Antimicrobials to Neurodegenerative Disease Modulators
edited by
submission deadline 30 Apr 2026 | 1 articles | Viewed by 667 | Submission Open
Keywords: 1; 3; 5-triazine; s-triazine; biological activity; drug discovery; antibacterial agent; antifungal agent; anticancer activity; antiviral agents; antimalarial activity; anti-Alzheimer’ s activity; anti-Alzheimer’ s agents; cholinesterase inhibitors; BACE1 inhibitors; anti-neurodegenerative effects; anti-inflammatory activity; molecular mechanisms of s-triazine activity
(This special issue belongs to the Section Chemical Biology)
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