Advances in Atherosclerosis: From Pathogenesis to Diagnostics and Targeted Therapies

Dear Colleagues,

We invite original research articles, reviews, and perspectives that advance the understanding of the genetic and molecular pathogenesis of atherosclerosis and contribute to the development of improved diagnostic approaches, including those integrating information on molecular pathogenesis with diagnostic imaging modalities, as well as innovative therapeutic strategies. Submissions addressing monogenic disorders that confer atherosclerotic risk are encouraged, as are studies employing large-scale or imaging-based genome-wide association analyses to identify common variants and further delineate the polygenic architecture of the disease. Investigations involving the development, validation, and clinical implementation of polygenic risk scores are likewise of interest. Research utilizing functional genomics, fine-mapping, single-cell or spatial transcriptomics, or proteogenomic methodologies to elucidate the molecular consequences of noncoding risk loci and their linkage to specific cell types or regulatory pathways is particularly welcome.

Studies focused on genetic and molecular biomarkers, including miRNAs, lncRNAs, epigenetic modifications, and proteomic signatures associated with plaque burden, vulnerability, or clinical outcomes, also fall within the scope of this Special Issue. In addition, we seek contributions on therapeutic strategies informed by genetic discoveries, encompassing lipid-lowering gene therapies, RNA-based interventions, and genome-editing approaches targeting key atherogenic pathways.

Prof. Dr. Daniel Petroviĉ
Dr. Ana Peterlin
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomedicines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.