Advances in the Pathogenesis and Treatment of Acute Myeloid Leukemia—2nd Edition
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Cancer Biology and Oncology".
Deadline for manuscript submissions: 30 November 2025 | Viewed by 8
Special Issue Editor
Interests: acute myeloid leukemia; hematopoietic stem cell transplantation; target therapies; bone marrow microenvironment
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Acute myeloid leukemia (AML) is an extremely heterogeneous disease and remains difficult to treat. A better understanding of the AML biological landscape is allowing the development of new target therapies and biological strategies that are opening up new possibilities, even in unfavorable populations such as relapse/refractory or older patients. This new therapeutic armamentarium includes Bcl-2 inhibitors, FLT3 inhibitors, IDH1-2 inhibitors, and many other small synthetic molecules. The recognition of specific gene mutations, as well as the identification of peculiar signature pathways, such as Homeobox gene A and B overexpression, can help in the identification of shared therapeutic targets, as is currently the case for Menin inhibitors. Interactions between AML blasts and the microenvironment and the remaining immune compartment are still poorly understood and could partially explain the largely heterogeneous course of the disease, even in the era of new target therapies. The rational use of these compounds in clinical practice cannot, therefore, disregard a better understanding of resistance and immune-escape mechanisms.
This Special Issue will be dedicated to recent progress in understanding the pathogenetic AML landscape and possible therapeutic strategies. We invite authors to submit original research and review articles. Suitable topics include, but are not limited to, the following:
- Potential targeted therapies and combination strategies in acute myeloid leukemia;
- The pathogenesis of acute myeloid leukemia;
- The bone marrow microenvironment in acute myeloid leukemia;
- Precision medicine in acute myeloid leukemia;
- Mechanisms of resistance.
Dr. Alessandra Sperotto
Guest Editor
Manuscript Submission Information
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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- acute myeloid leukemia
- target therapies
- molecular pathogenesis
- biological therapy
- precision medicine
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