Renin-Angiotensin System in Cardiovascular Biology, 2nd Edition
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Molecular and Translational Medicine".
Deadline for manuscript submissions: 31 October 2025 | Viewed by 1021
Special Issue Editors
Interests: renin-angiotensin system (RAS); vascular; vascular remodeling; hypertension; atherosclerosis; endocannabinoid system
Special Issues, Collections and Topics in MDPI journals
Interests: cardiovascular physiology; angiotensin II; renin-angiotensin system (RAS); vascular; hypertension; coronary vessels; cerebral vessels
Special Issues, Collections and Topics in MDPI journals
Interests: cardiovascular physiology & pharmacology; renin-angiotensin system (RAS); local blood flow control; hypersensititvity reaction (HSR); nanomedicines; complement; CARPA
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Based on our successful Special Issue on the same topic entitled "Renin-Angiotensin System in Cardiovascular Biology" (Biomedicines | Special Issue : Renin-Angiotensin System in Cardiovascular Biology (mdpi.com)), we have launched a 2nd edition of the Special Issue.
The aim of this Special Issue is to present the latest updates on the role of the renin-angiotensin system (RAS) in cardiovascular biology, from cellular mechanisms to organ functions and novel therapeutic mechanisms. The RAS has an important role in the regulation of blood pressure and salt water homeostasis. Angiotensin II (AngII) is the main regulator, which operates by stimulating AT1 receptors, a member of the G protein-coupled receptor family, and activating mainly calcium signaling mechanisms inducing, e.g., smooth muscle contraction, vasoconstriction and blood pressure elevation. Long-term overactivation of the RAS may result in inflammatory mechanisms, vascular hypertrophy and remodeling, water retention, hypertension and atherosclerosis. Therapies based on angiotensin-converting enzyme (ACE) inhibitors (ACEIs) and blockers of AT1 angiotensin receptors have been effectively used in the therapy of hypertension for decades. Other RAS pathways have more recently become the focus of research, including ACE2 and AT2 receptor signaling, as well as the conversion of AngII to Ang 1–7, which may provide links between the deleterious and beneficial actions of RAS. Alternative activation of these pathways may also propose novel additional molecular mechanisms and beneficial therapeutic potential in cardiovascular pathology.
This Special Issue therefore invites original research papers and review articles providing the latest insights into the complexity of the cell signaling and biological mechanisms of the RAS components to propose novel mechanisms in cardiovascular physiology and pathophysiology. By targeting this system, works may provide novel therapeutic potential in cardiovascular and related diseases such as hypertension, heart failure, atherosclerosis and diabetes mellitus.
Dr. Mária Szekeres
Dr. György L. Nádasy
Dr. László Dézsi
Guest Editors
Manuscript Submission Information
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Keywords
- renin–angiotensin system (RAS)
- signaling mechanisms of angiotensin receptors
- GPCR
- AT1R
- AT2R
- ACE
- ACE2
- ACEI
- angiotensin II
- signal transduction
- cardiovascular system
- hypertension
- atherosclerosis
- heart failure
- cardiovascular remodeling
- osmoregulation
- inflammation
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Related Special Issue
- Renin-Angiotensin System in Cardiovascular Biology in Biomedicines (11 articles)
