New Insights in Radiotherapy: Bridging Radiobiology and Oncology
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Cancer Biology and Oncology".
Deadline for manuscript submissions: 30 November 2025 | Viewed by 48
Special Issue Editors
Interests: radiobiology; biomedical imaging; radiation safety; cancer treatment; medical physics; synaptic response; radiosensitization
2. Department of Radiation Oncology, Show Chwan Memorial Hospital, Changhua, Taiwan
3. Research Assistant Center, Show Chwan Memorial Hospital, Changhua, Taiwan
Interests: radiobiology; cancer biology; immunotherapy; radiotherapy
Special Issue Information
Dear Colleagues,
Radiotherapy has long been used to treat or alleviate various types of cancer. Technological advancements have improved radiotherapeutic capacities and enhanced its safety. Nevertheless, the therapeutic outcomes are heavily influenced by associated radiation physics parameters and the induced radiobiological effects. This Special Issue aims to highlight recent advances in the evaluation of physical and biological factors that lead to radiation-induced radiobiological effects, including the immunological effects of radiotherapy, the normal tissue-sparing effect enhanced by FLASH radiotherapy, the bystander effect via synaptic transmission, and radiation-induced lethality on different types of cancers at the organismic, tissue, and cellular levels. Topics of interest include the association of radiation beam quality with the abscopal effect through the activation of the systemic immune response and immunogenic cell death, tissue-specific responses to different irradiation regimens, parameters in mediating radiation effects to non-irradiated neurons, and the modulatory effect of LET on the radiation-induced lethality of different types of cancers. We invite contributions that provide insights into novel biological pathways, biophysical mechanisms, radioprotection and radiosensitization strategies, and regulatory considerations to ensure the appropriateness and safety of medical radiation applications.
Dr. Yuan-Hao Lee
Dr. I-Tsang Chiang
Guest Editors
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Keywords
- tissue-sparing effect
- bystander effect
- factors that affect radiation-induced lethality
- radiation-induced abscopal effect
- mechanisms that enhance tissue radiosensitivity
- synergistic effect from radiotherapy and immunotherapy
- regulatory perspectives on medical radiation safety
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