New Insights in Hematologic Malignancies: From Pathophysiologic Mechanisms to Therapeutic Strategies
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Cancer Biology and Oncology".
Deadline for manuscript submissions: 31 December 2025 | Viewed by 28
Special Issue Editor
Interests: hematopoietic malignancies; protein phosphorylation; small molecule targeted drugs; rare blood disorders
Special Issue Information
Dear Colleagues,
This Special Issue will focus on the pathogenesis, diagnosis, prognosis, and treatment of hematologic malignancies, including but not limited to leukemia, lymphoma, and myeloma. Hematologic malignancies are a diverse group of disorders arising from the abnormal proliferation and differentiation of hematopoietic cells, often driven by complex genetic, epigenetic, and microenvironmental factors. While targeted therapies and immunotherapies have improved outcomes for some patients, resistance and relapse continue to pose major challenges, emphasizing the urgency of uncovering fundamental disease mechanisms and identifying new therapeutic targets.
This Special Issue will also consider studies on emerging disease models, including organoids, 3D cultures, and patient-derived xenografts, which can help recreate the tumor microenvironment and support precision medicine. Contributions addressing novel diagnostic biomarkers, resistance mechanisms, immune evasion, treatment-related complications, and translational strategies are highly encouraged. Research exploring the interactions between malignant cells and the bone marrow or lymphoid niche, as well as the impact of systemic inflammation, immune dysregulation, and disease-associated comorbidities, will also be included.
Overall, this Special Issue aims to bring together recent insights into the biological and clinical management of hematologic malignancies, fostering interdisciplinary collaboration and facilitating translational advancements toward optimized precision medicine.
Dr. Yun Chen
Guest Editor
Manuscript Submission Information
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Keywords
- leukemia
- hematological malignancies
- tumor microenvironment
- disease models
- precision medicine
- immunotherapy
- targeted therapy
- drug resistance
- biomarkers
- translational research
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