Feature Reviews in Cardiovascular Diseases, 2nd Edition

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Molecular and Translational Medicine".

Deadline for manuscript submissions: 30 November 2026 | Viewed by 4289

Editors

Department of Translational Medical Sciences, University of Campania “Luigi Vanvitelli”, 80131 Naples, Italy
Interests: genetic dyslipidemias; familial hypercholesterolemia; LDL mutations; lipid metabolism; cardiovascular genetics; PCSK9; cardiomyopathies
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Dear Colleagues,

Despite the progress made in the prevention and treatment of cardiovascular diseases, the number of hospital admissions, healthcare spending, and mortality from cardiovascular causes still rank first in developed and developing countries. However, it must be admitted that cardiovascular diseases are a branch of medicine in which the greatest progress is made every year. Maybe we missed something? One of the topics on which a lot of work has been carried out is heart failure, which is the endpoint of the vast majority of cardiac pathologies. While the situation is sufficiently defined, from a therapeutic point of view, for HF with reduced ejection fraction (HFrEF), this is, unfortunately, not the case for HF with preserved EF (EFpEF), which has been seen to have a prevalence of approximately 50% of forms of HF. Albeit lacking, however, there has been considerable progress both in the knowledge of the pathophysiological mechanisms and in the therapeutic approach of this form of HF. In light of these developments, we have proposed this Special Issue entitled "Feature Reviews in Cardiovascular Diseases, 2nd Edition". It aims to collect the newest and most significant data on cardiovascular research, both in the field of cardiovascular prevention and mechanisms and on therapeutic innovations such as inhibitors of SGLT2 receptors and GLP1 receptor agonists, which have given positive results on adverse cardiovascular outcomes, even regardless of the presence of diabetes.

Dr. Serafino Fazio
Dr. Arturo Cesaro
Guest Editors

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Keywords

  • cardiovascular diseases
  • heart failure
  • cardiac arrhythmias
  • metabolic syndrome
  • stroke
  • pulmonary hypertension
  • peripheral artery disease (PAD)
  • acute coronary syndrome
  • myocarditis
  • pericarditis
  • valvulopathies

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Published Papers (1 paper)

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9 pages, 336 KB  
Perspective
Insulin Resistance/Hyperinsulinemia Should Be Considered in the Prevention and Treatment of Essential Hypertension
by Serafino Fazio and Flora Affuso
Biomedicines 2025, 13(12), 3102; https://doi.org/10.3390/biomedicines13123102 - 16 Dec 2025
Cited by 3 | Viewed by 3173
Abstract
Essential (primary) hypertension is defined as such because it does not have an identifiable cause, which is different from secondary hypertension which generally recognizes renal, endocrine, or blood vessel disorders. It is a recognized important risk factor for cardiovascular diseases and it is [...] Read more.
Essential (primary) hypertension is defined as such because it does not have an identifiable cause, which is different from secondary hypertension which generally recognizes renal, endocrine, or blood vessel disorders. It is a recognized important risk factor for cardiovascular diseases and it is well known that it is largely more prevalent than secondary hypertension, accounting for 90–95% of affected adults. Therefore, in the vast majority of these cases, we do not recognize the real causes of hypertension, but we treat it without addressing the point that we should be treating hypertension by directly counteracting the cause. Essential hypertension (EH) and insulin resistance (IR) are frequently associated in the same patients, and it should be noted that EH has a comparable and rather high prevalence in adults worldwide, i.e., between 30 and 40%. Also, IR with associated hyperinsulinemia (Hyperin) is an important risk factor for cardiovascular diseases. It can cause hypertension through multiple established pathophysiological mechanisms. IR/Hyperin could be an important cause of most of the cases of essential hypertension. The aim of this Perspective article is to analyze whether the time has come to identify IR as a main contributing cause of essential hypertension. This could produce a better cure for hypertension that is also aimed at treating insulin resistance. Full article
(This article belongs to the Special Issue Feature Reviews in Cardiovascular Diseases, 2nd Edition)
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