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Biomedicines publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Heart Failure: New Diagnostic and Therapeutic Approaches, 2nd Edition

edited by

Anand Prakash Singh

submission deadline 30 Apr 2026 | 1 articles | Viewed by 429 | Submission Open

Keywords: heart failure; clinical treatment; basic cardiac research; future perspective; heart failure therapy; cardiotoxicity

(This special issue belongs to the Section Molecular and Translational Medicine)

Post Tuberculosis Lung Disease from Lung Damage to the Loss of Lung Function

edited by

Oana Cristina Arghir

and Ariadna Petronela Fildan

submission deadline 30 Apr 2026 | Viewed by 352 | Submission Open

Keywords: post-tuberculosis lung disease (PTLD); post-TB conditions; TB sequelae; obstructive post-TB disease; post-TB syndromes

(This special issue belongs to the Section Molecular and Translational Medicine)

Mechanisms and Novel Therapeutic Approaches for Neurodegenerative Diseases (3rd Edition)

edited by

Fernando Cardona

submission deadline 30 Apr 2026 | 1 articles | Viewed by 263 | Submission Open

Keywords: neurodegenerative diseases; cellular mechanisms; molecular mechanisms; mutations; neurodegeneration models; protein misfolding; protein aggregation; neuronal death; molecular therapy; cellular therapy; therapeutics; medical chemistry; drug screening

(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)

Bone Diseases: Pathophysiology and Molecular Biology

edited by

Tommaso Greco

Carlo Perisano

and Nicola De Gasperis

submission deadline 30 Apr 2026 | Viewed by 251 | Submission Open

Keywords: bone diseases; osteoporosis; osteoarthritis; Paget’ s disease; bone tumors

(This special issue belongs to the Section Molecular and Translational Medicine)

Oxidative Stress, Inflammation and Endothelial Dysfunction in COVID-19 Era and Long COVID-19 Complications

edited by

Ekaterina Georgieva

submission deadline 30 Apr 2026 | Viewed by 217 | Submission Open

Keywords: oxidative stress; redox-disbalance; COVID-19; post-COVID-19; cytokines; mitochondrial dysfunction; endothelial damages; ROS and RNS; thrombosis; antioxidant therapy; oxidative shock

(This special issue belongs to the Section Molecular and Translational Medicine)

Molecular and Cellular Mechanisms of Cardiovascular Diseases: 2nd Edition

edited by

Antonella Galeone

submission deadline 30 Apr 2026 | Viewed by 214 | Submission Open

Keywords: hypertension; diabetes; coronary heart disease; valvular heart disease; infective endocarditis; aortic dissection; aortic aneurysm; heart failure; cardiomyopathy

(This special issue belongs to the Section Molecular and Translational Medicine)

Selective Glucocorticoid Receptor Agonists and Modulators (SEGRAMs)

edited by

Dimitra Mitsiou

submission deadline 30 Apr 2026 | Viewed by 209 | Submission Open

Keywords: glucocorticoid receptor; glucocorticoids; transactivation; transrepression; selective glucocorticoid receptor agonists; selective glucocorticoid receptor modulators; inflammation; anti-inflammatory action; side effects; therapeutic potential

(This special issue belongs to the Section Endocrinology and Metabolism Research)

Bone Metabolism in Health and Disease

edited by

Kun Chen

submission deadline 30 Apr 2026 | Viewed by 196 | Submission Open

Keywords: bone remodeling; skeletal stem cells; osteocyte; osteoblasts; osteoclasts; osteoporosis; osteoarthritis; bone regeneration; bone aging; bone therapeutics

(This special issue belongs to the Section Molecular and Translational Medicine)

Nanoparticle-Labeled Exosomes as Theranostic Agents

edited by Karrer M. Alghazali

submission deadline 30 Apr 2026 | Viewed by 194 | Submission Open

Keywords: exosomes; nanotheranostic agent; nanoparticles; exosome labeling; photothermal therapy; drug delivery vehicle; imaging probe

(This special issue belongs to the Section Cell Biology and Pathology)

Intracellular Optogenetics Tools to Probe Biological Signaling Pathways

edited by

Qunxiang Ong

submission deadline 30 Apr 2026 | Viewed by 178 | Submission Open

Keywords: optogenetics; signaling transduction; neuroscience; immunology; cancer signaling; synthetic biology; spatiotemporal resolution

(This special issue belongs to the Section Molecular and Translational Medicine)

Emerging Trends in Kidney Disease (2nd Edition)

edited by Andrea Angioi

submission deadline 30 Apr 2026 | Viewed by 148 | Submission Open

Keywords: kidney disease; glomerular diseases; vasculitis; dialysis; hypertension; pediatric nephrology; transplantation; precision medicine; therapeutic advancements

(This special issue belongs to the Section Molecular and Translational Medicine)

Mechanisms and Novel Therapeutic Approaches for Gliomas: 2nd Edition

edited by Maria V. Chatziathanasiadou

submission deadline 30 Apr 2026 | Viewed by 129 | Submission Open

Keywords: glioma; molecular mechanisms; tumour immunity; tumour metabolism; tumour microenvironment; metabolic therapies; immunotherapies; combination treatment

(This special issue belongs to the Section Cancer Biology and Oncology)

Advances in Natural and Synthetic Anticancer Agents: Mechanistic Insights and Translational Pathways

edited by

Gul-E-Saba Chaudhry

submission deadline 30 Apr 2026 | Viewed by 125 | Submission Open

Keywords: cancer; drug discovery; synthetic anti-cancer; natural bioactive compounds; nano targeted targeted drug delivery; cancer biomarkers; mechanism of cell death; novel anti-cancer compounds

(This special issue belongs to the Section Cancer Biology and Oncology)

New Advances in Oral Pathology and Medicine

edited by

Christian Bacci

submission deadline 30 Apr 2026 | Viewed by 109 | Submission Open

Keywords: molecular diagnostics; imaging technologies; artificial intelligence; targeted therapies; regenerative medicine

(This special issue belongs to the Section Molecular and Translational Medicine)

Advances in Ocular Surface Disease

edited by

Kofi Asiedu

submission deadline 30 Apr 2026 | Viewed by 105 | Submission Open

Keywords: dry eye disease; corneal neuroimmune interactions; meibomian gland dysfunction; microbial keratitis; ocular allergy; corneal degeneration

(This special issue belongs to the Section Molecular and Translational Medicine)

Modern Applications of Advanced Imaging to Neurological Disease

edited by Manisha Koneru and

Hamza Adel Salim

submission deadline 30 Apr 2026 | Viewed by 91 | Submission Open

Keywords: neuroimaging; cerebrovascular disease; neuro-oncology; compted tomography; magnetic resonance imaging; patient outcomes; neurosciences; neuroradiology

(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)

Correlative Light and Electron Microscopy (CLEM) in Biomedicine: Advances and Applications

edited by

Hideya Kawasaki

submission deadline 30 Apr 2026 | Viewed by 91 | Submission Open

Keywords: CLEM; correlative microscopy; biomedicine; pathology; virology; oncology; immunolabeling; cryo-microscopy; ultrastructure; image analysis

(This special issue belongs to the Section Cell Biology and Pathology)

State-of-the-Art Drug Discovery and Development in Poland (3rd Edition)

edited by

Aleksandra Romaniuk-Drapała

submission deadline 30 Apr 2026 | Viewed by 87 | Submission Open

Keywords: in silico drug target profiling; drug delivery systems; drug– drug interaction; target-based screening; phenotypic screening; pharmaceutical modeling; computational chemistry; targeted therapy; biomarkers; bioimaging

(This special issue belongs to the Section Drug Discovery, Development and Delivery)

Cancer Genetics: Bench-to-Bedside Advances

edited by

Hengrui Liu

submission deadline 30 Apr 2026 | Viewed by 85 | Submission Open

Keywords: cancer genetics; somatic mutations; biomarkers; cfDNA/ctDNA; epigenetics; tumor microenvironment; multi-omics; precision medicine

(This special issue belongs to the Section Molecular Genetics and Genetic Diseases)

Animal Models in Pulmonary Research: Shaping the Future of Translational Respiratory Medicine

edited by

Badrul Hisham Yahaya

submission deadline 30 Apr 2026 | Viewed by 84 | Submission Open

Keywords: pulmonary disease; lung regeneration and repair; animal models; genetically modified models; lung injury induction; translational research

(This special issue belongs to the Section Molecular and Translational Medicine)

Advancements in Understanding and Treating Oral Pathologies: From Dry Mouth to Oral Cancer—2nd Edition

edited by Eleni Georgakopoulou and George Laskaris

submission deadline 30 Apr 2026 | Viewed by 80 | Submission Open

Keywords: oral pathologies; oral diseases; pathogenesis; therapeutic interventions; interdisciplinary nature of oral healthcare; xerostomia; dysgeusia; oral cancer; precancerous lesions; oral inflammatory conditions

(This special issue belongs to the Section Cell Biology and Pathology)

Genome Engineering Technologies for Diseases

edited by Kosuke Ishikawa

submission deadline 30 Apr 2026 | Viewed by 77 | Submission Open

Keywords: genome engineering; gene editing; gene delivery; transposable elements; insertinal mutagenesis; functional genomics; in silico analysis; cell-based assays; disease modeling; cell therapy

(This special issue belongs to the Section Molecular Genetics and Genetic Diseases)

Recent Advances in Cancer Metastasis Models

edited by

Lin Zhang

submission deadline 30 Apr 2026 | Viewed by 77 | Submission Open

Keywords: cancer metastasis; tumor microenvironment; metastasis models; 3D cell culture; organoids; artificial intelligence in oncology; machine learning; bioinformatics; in vivo imaging; multi-omics integration

(This special issue belongs to the Section Cancer Biology and Oncology)

Advances in Research on Spermatozoa and Male Infertility: From Molecular Mechanism to Therapeutic Perspectives

edited by

Francesca Paola Luongo

and

Alice Luddi

submission deadline 30 Apr 2026 | Viewed by 77 | Submission Open

Keywords: spermatozoa biology; molecular mechanisms of spermatogenesis; oxidative stress and sperm function; therapeutic strategies for addressing male infertility

(This special issue belongs to the Section Molecular and Translational Medicine)

Decoding Aging with AI and Computational Modeling

edited by Bingrui Li, Xuanye Cao and Wen Jiang

submission deadline 30 Apr 2026 | Viewed by 77 | Submission Open

Keywords: aging; computational modeling; AI; healthspan and lifespan prediction; systems biology

(This special issue belongs to the Section Cell Biology and Pathology)

Integrative Roles of Natural Products in Cancer Treatment and Chronic Inflammatory Disease

edited by

Seungho Baek

submission deadline 30 Apr 2026 | Viewed by 75 | Submission Open

Keywords: natural products; cancer; chronic inflammatory diseases; therapy; oxidative stress

(This special issue belongs to the Section Molecular and Translational Medicine)

Alzheimer's Disease: Pathogenesis, Diagnostics and Novel Treatment Options

edited by

Rui Zhong

and Ling Li

submission deadline 30 Apr 2026 | Viewed by 73 | Submission Open

Keywords: amyloid and tau pathology; neuroinflammation and oxidative stress; neuromodulation; fluid biomarkers; imaging and other diagnostic approaches; small-molecule therapeutics; novel therapeutics and emerging therapies; disease-modifying therapies; experimental and clinical pharmacology

(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)

Extracellular Vesicles: A New Frontier in Liquid Biopsy

edited by Chen Zhao and You-Ren Ji

submission deadline 30 Apr 2026 | Viewed by 73 | Submission Open

Keywords: extracellular vesicles (EVs); liquid biopsy; circulating biomarkers; exosome; nanomedicine; translational oncology; precision medicine

(This special issue belongs to the Section Cell Biology and Pathology)

Roles of Extracellular Vesicles in Health and Diseases

edited by David R. Brigstock and Xinlei Li

submission deadline 30 Apr 2026 | Viewed by 70 | Submission Open

Keywords: extracellular vesicle; exosome; pathogenesis; therapy; cancer; neurodegenerative diseases; pulmonary diseases; cardiovascular diseases; inflammatory diseases; infectious diseases; kidney diseases; gastrointestinal diseases; aging; diabetes; autoimmune disorders

(This special issue belongs to the Section Molecular and Translational Medicine)

New Insights into the Tumor Microenvironment: Mechanisms and Therapeutic Strategies

edited by

Denggang Fu

submission deadline 30 Apr 2026 | Viewed by 69 | Submission Open

Keywords: tumor microenvironment (TME); immune evasion; tumor– immune interaction; stromal remodeling; cancer immunotherapy; metabolic reprogramming; epigenetic regulation; multi-omics and spatial analysis; anticancer drug development

(This special issue belongs to the Section Immunology and Immunotherapy)

Recent Advances in Research on Neuroendocrine Neoplasms and Endocrine Sequelae After Oncological Disease

edited by Hermann L. Müller

submission deadline 30 Apr 2026 | Viewed by 64 | Submission Open

Keywords: neuroendocrine tumors; endocrinology; hormones; cancer; sequelae; late effects; neurogenic tumors

(This special issue belongs to the Section Cancer Biology and Oncology)

Nanocarriers in Mucosal Drug Delivery

edited by

Hatem Hassan

submission deadline 30 Apr 2026 | Viewed by 64 | Submission Open

Keywords: nanocarriers; mucosal drug delivery; mucoadhesion; mucus penetration; controlled release; bioavailability enhancement; targeted delivery; stimuli-responsive systems

(This special issue belongs to the Section Drug Discovery, Development and Delivery)

Biomaterials and Nanotechnology for Advanced Wound Dressings

edited by Javad Esmaeili

submission deadline 30 Apr 2026 | Viewed by 64 | Submission Open

Keywords: wound dressings; wound healing; biomaterials and nanotechnology; regenerative medicine; targeted delivery

(This special issue belongs to the Section Nanomedicine and Nanobiology)

Nanoparticles in Biomedical Engineering: From Drug Delivery to Tissue Engineering

edited by Jia Nong

submission deadline 30 Apr 2026 | Viewed by 62 | Submission Open

Keywords: nanoparticle; nanomedicine; nanoconjugates; drug delivery; biomaterials; wound healing; angiogenesis; antimicrobial agents; regenerative medicine; theranostics

(This special issue belongs to the Section Nanomedicine and Nanobiology)

Digestive Disorders: Translation and Bridging the Gap Between Research, Diagnosis, and Treatment (2nd Edition)

edited by Goran Poropat and Goran Hauser

submission deadline 30 Apr 2026 | Viewed by 61 | Submission Open

Keywords: acute pancreatitis; clinical nutrition; metabolic disorders; NAFLD; obesity; DGBA; gut microbiota

(This special issue belongs to the Section Molecular and Translational Medicine)

Cardiometabolic Diseases: Molecular Biomarkers and Treatment Strategies

edited by

Jelena Radovanović

and

Sonja Zafirovic

submission deadline 30 Apr 2026 | Viewed by 58 | Submission Open

Keywords: cardiometabolic disease; obesity; diabetes mellitus; insulin resistance; lipid status; biomarkers; hypertension; metabolic dysregulation; personalized therapy; omics technologies

(This special issue belongs to the Section Endocrinology and Metabolism Research)

Diabetic Nephropathy and Diabetic Atherosclerosis (2nd Edition)

edited by

Satyesh K. Sinha

submission deadline 30 Apr 2026 | Viewed by 56 | Submission Open

Keywords: diabetic nephropathy; diabetic atherosclerosis; diabetes; inflammation; oxidative stress; renal and vascular cell dysfunction; basic science; clinical practice; patient outcomes

(This special issue belongs to the Section Molecular and Translational Medicine)

Personalized Diagnosis and Therapy in Endocrinology and Gynecology

edited by

Sarah Allegra

submission deadline 30 Apr 2026 | Viewed by 56 | Submission Open

Keywords: personalized medicine; endocrine disorders; gynecological diseases; reproductive endocrinology; pharmacogenomics; hormonal therapy; polycystic ovary syndrome (PCOS); precision medicine; biomarkers; women’ s health

(This special issue belongs to the Section Molecular and Translational Medicine)

Autophagy-Mediated Signalling in Cancer Metastasis and Progression

edited by

Ahmed M. Elshazly

and

David A. Gewirtz

submission deadline 30 Apr 2026 | Viewed by 55 | Submission Open

Keywords: autophagy; cancer; resistance; metastasis; tumor microenvironment; immune evasion

(This special issue belongs to the Section Cancer Biology and Oncology)

Artificial Intelligence in Cancer Imaging: Advancing Precision Oncology

edited by Farhan Akram

submission deadline 30 Apr 2026 | Viewed by 55 | Submission Open

Keywords: artificial intelligence; cancer imaging; digital pathology; machine learning; deep learning; radiomics; tumor characterization; precision oncology; biomarker discovery; clinical translation

(This special issue belongs to the Section Cancer Biology and Oncology)

Gynecological Cancers: Progress and Challenges

edited by

Yi-Fen Chiang

submission deadline 30 Apr 2026 | Viewed by 55 | Submission Open

Keywords: gynecological cancer; therapeutic targets; precision medicine; immunotherapy; drug resistance; biomarkers; molecular mechanisms; natural compound; translational research; adjuvant therapy

(This special issue belongs to the Section Cancer Biology and Oncology)

Epilepsy: From Mechanisms to Therapeutic Approaches (2nd Edition)

edited by

Prosper N'Gouemo

submission deadline 30 Apr 2026 | Viewed by 54 | Submission Open

Keywords: genetic epilepsy; acquired epilepsy; neonatal seizures; epileptogenesis; pharmacoresistant epilepsy; ion channels; calcium signaling

(This special issue belongs to the Section Molecular and Translational Medicine)

Novel Directions for Effective Treatments of Malignant Brain Tumors, Particularly Glioblastoma, Indicated by In Vivo Observations

edited by

Jacek M. Kwiecien

submission deadline 30 Apr 2026 | Viewed by 52 | Submission Open

Keywords: glioblastoma; glioblastoma cell invasion; inhibition of glioblastoma cell migration; glioblastoma cell proliferation; killing of glioblastoma cells; white matter inflammation post-neurosurgery; white matter inflammation post-irradiation; cerebral vasogenic edema; treatment of neuroinflammation and vasogenic edema; imaging of glioblastoma

(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)

Expanding Opioid Receptor Pharmacology: From Pain Control to Novel Therapeutic Applications in Neurobiology, Immunology, and Psychiatry

edited by

Luca Gentilucci

submission deadline 30 Apr 2026 | Viewed by 52 | Submission Open

Keywords: opioid; pain; mood; stress; addiction; neuropeptides

(This special issue belongs to the Section Drug Discovery, Development and Delivery)

Muscular Dystrophy: From Mechanisms to Therapeutic Approaches

edited by

Gisela Gaina

and Marco A.F. Fernandes

submission deadline 30 Apr 2026 | Viewed by 51 | Submission Open

Keywords: muscular dystrophy; genetic diseases; muscle regeneration; therapeutic approaches; molecular diagnosis; in vitro and in vivo models

(This special issue belongs to the Section Molecular Genetics and Genetic Diseases)

Rheumatic Diseases: From Pathophysiology to Current and Emerging Therapeutic Approaches

edited by Harriet Morf

submission deadline 30 Apr 2026 | Viewed by 51 | Submission Open

Keywords: rheumatic diseases; molecular mechanisms; treatment; artificial intelligence; cytokine; anti-rheumatic drugs

(This special issue belongs to the Section Immunology and Immunotherapy)

Role of Oxidative Stress, Antioxidants, and Gut Microbiota in Obesity and Metabolic Disorders

edited by Lunawati Bennett

submission deadline 30 Apr 2026 | Viewed by 50 | Submission Open

Keywords: obesity; metabolic diseases; antioxidants; gut microbiota; inflammation; reactive oxygen species; cardiovascular diseases

(This special issue belongs to the Section Endocrinology and Metabolism Research)

Immunological Barriers and Novel Therapeutic Strategies in Pediatric Brain Tumor Immunotherapy

edited by Dalia Haydar

submission deadline 30 Apr 2026 | Viewed by 48 | Submission Open

Keywords: pediatric brain tumors; diffuse intrinsic pontine glioma (DIPG); medulloblastoma; chimeric antigen receptor (CAR) T cells; blood– brain barrier (BBB); tumor microenvironment (TME); immune resistance; adoptive cell therapy; biomarkers; combination immunotherapy

(This special issue belongs to the Section Cancer Biology and Oncology)

Biomarker, Phenotyping and Therapeutics for Asthma

edited by

Ran Wang

submission deadline 30 Apr 2026 | Viewed by 48 | Submission Open

Keywords: allergy; biomarkers; pathogenesis; exhaled breath; multi-omics; lung physiology; phenotyping; endotypes; therapeutic targets

(This special issue belongs to the Section Molecular and Translational Medicine)

Targeting Mast Cells in Human Disease: Bridging Pathology and Therapy

edited by Marianna Criscuolo

submission deadline 30 Apr 2026 | Viewed by 47 | Submission Open

Keywords: mast cell; mast cell activation syndrome; anaphylaxis; mastocytosis; anti-mediator therapy

(This special issue belongs to the Section Immunology and Immunotherapy)

Displaying special issue 551-600 on page 12 of 15.

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