Special Issues

Biomedicines publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Central Role of Mitochondrial Oxidative Stress in the Pathophysiology of Disorders (2nd Edition)
edited by and André Quincozes-Santos
submission deadline 31 Mar 2026 | 1 articles | Viewed by 1465 | Submission Open
Keywords: mitochondrial dysfunction; reactive oxygen species; bioenergetics; mitochondrial quality control; pathologies; protective agents
(This special issue belongs to the Section Molecular and Translational Medicine)
Skin Fibrosis and Cutaneous Wound Healing—2nd Edition submission deadline 31 Mar 2026 | 1 articles | Viewed by 1456 | Submission Open
Keywords: fibroblasts; inflammation; fibrosis; cutaneous wound healing
(This special issue belongs to the Section Molecular and Translational Medicine)
New Trends in Regional Anesthesia and Pain Management
edited by
submission deadline 31 Mar 2026 | 2 articles | Viewed by 1417 | Submission Open
Keywords: regional anesthesia; ultrasound-guided/stimulator-guided nerve blocks; novel techniques for motor-sparing neural intervention; continuous catheter infusions; opioid-sparing techniques; perioperative pain management; novel local anesthetics; cadaveric dissection exploring the anatomical knowledge of motor-sparing techniques; modalities (techniques; technologies; or drug regimen) to prolong the effect of local anesthetics; ERAS-related studies; AI applications in regional anesthesia and pain management; innovations and protocols/curriculum regarding regional anesthesia and pain management in the battlefield; studies comparing new technologies/simulation (such as EpiFaith; SPRint PNS system; or CompuFlo) with traditional methods in improving regional anesthesia and pain management; regenerative medicine; nutritional pain medicine; application of bone marrow aspirate concentration or other stem cell components in pain medicine; multidisciplinary/comprehensive care program; transarterial embolization for pain management; joint denervation for pain management
(This special issue belongs to the Section Molecular and Translational Medicine)
Medical Imaging in Brain Tumor: Charting the Future submission deadline 31 Mar 2026 | 1 articles | Viewed by 1360 | Submission Open
Keywords: brain tumor diagnosis; artificial intelligence (AI) in medical imaging; imaging biomarkers for brain tumor; detection; segmentation and classification; radiomics and radiogenomics; precision oncology; deep learning and machine learning; neuro oncology; digital pathology; treatment response monitoring
(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)
Stem Cell Therapy: Traps and Tricks
edited by and Željka Večerić-Haler
submission deadline 31 Mar 2026 | 1 articles | Viewed by 1350 | Submission Open
Keywords: mesenchymal stem cells; MSC therapy; preclinical research; regenerative medicine
(This special issue belongs to the Section Biomedical Engineering and Materials)
Recent Advances in Molecular Neuroimaging
edited by
submission deadline 31 Mar 2026 | 1 articles | Viewed by 936 | Submission Open
Keywords: molecular neuroimaging; imaging techniques; clinical applications; imaging probes; personalized medicine; diagnostic imaging; therapeutic monitoring; clinical decision support
(This special issue belongs to the Section Molecular and Translational Medicine)
Recent Advances in Endocrine Disease and Atherosclerosis submission deadline 31 Mar 2026 | 1 articles | Viewed by 885 | Submission Open
Keywords: diabetes; dyslipidemia; obesity; insulin resistance; subclinical atherosclerosis; atherosclerosis; cardiovascular disease
(This special issue belongs to the Section Endocrinology and Metabolism Research)
Noncoding RNAs (ncRNAs): The Role in Gene Regulation and Human Diseases
edited by and
submission deadline 31 Mar 2026 | Viewed by 878 | Submission Open
Keywords: ncRNAs; genomic editing; epigenetics; stem cell biology and regenerative medicine
(This special issue belongs to the Section Molecular Genetics and Genetic Diseases)
Innovations and Perspectives in Kidney Transplantation
edited by Vassilis Filiopoulos
submission deadline 31 Mar 2026 | 1 articles | Viewed by 840 | Submission Open
Keywords: bioartificial kidney; immunology; immunosuppression; kidney transplantation; tolerance; graft rejection; graft survival; xenotransplantation; kidney regeneration
(This special issue belongs to the Section Immunology and Immunotherapy)
Genetic Insights and Pharmacogenomic Approaches in Cancer Treatment submission deadline 31 Mar 2026 | 1 articles | Viewed by 646 | Submission Open
Keywords: pharmacogenetics; genetic basis; cancer treatments
(This special issue belongs to the Section Cancer Biology and Oncology)
Drug Discovery, Development and Delivery: Current Status and Future Perspectives submission deadline 31 Mar 2026 | 1 articles | Viewed by 646 | Submission Open
Keywords: drug discovery; rational drug design; computer-aided drug design (CADD); drug repurposing; artificial intelligence (AI) and machine learning (ML); cancer therapeutics; infectious diseases; natural products
(This special issue belongs to the Section Drug Discovery, Development and Delivery)
Feature Reviews in Target Identification and Drug Discovery
edited by
submission deadline 31 Mar 2026 | Viewed by 591 | Submission Open
Keywords: drug discovery; biological target; bioactive compounds; pharmacology
(This special issue belongs to the Section Drug Discovery, Development and Delivery)
Advances in Skin Diseases
edited by Nazia M. Saiyed and
submission deadline 31 Mar 2026 | 1 articles | Viewed by 471 | Submission Open
Keywords: skin diseases; dermatology; diagnostic innovations; targeted therapies; molecular mechanisms; immunodermatology; translational research; inflammatory skin disorders; clinical dermatology; precision medicine
(This special issue belongs to the Section Molecular and Translational Medicine)
Current Perspectives on Human Papillomavirus (HPV)—Second Edition submission deadline 31 Mar 2026 | 1 articles | Viewed by 457 | Submission Open
Keywords: human papillomavirus (HPV); molecular mechanisms; diagnosis; treatment; prevention; vaccination; screening; immunotherapy; cancer
(This special issue belongs to the Section Microbiology in Human Health and Disease)
Advanced Research in Antiviral Innate Immunity
edited by Junji Zhu
submission deadline 31 Mar 2026 | Viewed by 400 | Submission Open
Keywords: antiviral immunity; innate immune signaling; toll-like receptors (TLRs); RIG-I-like receptors (RLRs); cGAS-STING pathway; type I interferon; viral infection; post-translational modification (PTM); phase separation; host– pathogen interactions; therapeutic strategies
(This special issue belongs to the Section Microbiology in Human Health and Disease)
Roles of Extracellular Vesicles in Cancer Immunotherapy
edited by Shujing Liu and Zhiyuan Qin
submission deadline 31 Mar 2026 | Viewed by 328 | Submission Open
Keywords: extracellular vesicles; microvesicles; exosomes; cancer biology; cancer immunity; cancer immunotherapy; biomarkers; cancer vaccines; antigen presentation; drug delivery
(This special issue belongs to the Section Cancer Biology and Oncology)
Neural Plasticity: Mechanisms and Therapeutic Implications
edited by Linlin Sun
submission deadline 31 Mar 2026 | Viewed by 288 | Submission Open
Keywords: neural plasticity; synaptic plasticity; neurogenesis; neural regeneration; brain injury; non-invasive brain stimulation techniques
(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)
Mycobacterial Infections: Insights into Pathogenesis, Diagnosis, and Treatment
edited by
submission deadline 31 Mar 2026 | Viewed by 270 | Submission Open
Keywords: mycobacterium; pathogenesis; host– pathogen interactions; virulence factors; antimicrobial resistance; diagnosis; therapeutics; host-directed therapy; vaccine development; drug resistance
(This special issue belongs to the Section Microbiology in Human Health and Disease)
Obesity and Obesity-Related Pathology
edited by
submission deadline 31 Mar 2026 | Viewed by 256 | Submission Open
Keywords: obesity; obesity-related cardiovascular diseases; obesity-related chronic kidney diseases; diabetes mellitus; depression; obesity-related cancer; adipose tissue; adipocytes; cancer-associated adipocytes; obesity therapies
(This special issue belongs to the Section Endocrinology and Metabolism Research)
Tumor Immune Microenvironment, Metabolic Remodeling and Mechanism of Cancer Metastasis
edited by and
submission deadline 31 Mar 2026 | Viewed by 243 | Submission Open
Keywords: tumor immune microenvironment; metabolic remodeling; cancer metastasis; immune– metabolic crosstalk; novel therapeutic targets for metastasis
(This special issue belongs to the Section Cancer Biology and Oncology)
Head and Neck Cancer: From Mechanisms to Therapeutic Approaches—Advances and Challenges submission deadline 31 Mar 2026 | Viewed by 239 | Submission Open
Keywords: head and neck cancers; target therapy; biomarkers; molecular targets; translational research; pathogenesis; prognosis; diagnostic tool
(This special issue belongs to the Section Cancer Biology and Oncology)
Molecular Psychiatry and Antipsychotics
edited by
submission deadline 31 Mar 2026 | Viewed by 232 | Submission Open
Keywords: psychiatric diseases; schizophrenia; antipsychotics; molecular psychiatry; molecular pathways; neurotransmitter systems; positive; negative and cognitive symptoms
(This special issue belongs to the Section Molecular and Translational Medicine)
Epigenetics in the Perioperative Setting
edited by Rump Katharina
submission deadline 31 Mar 2026 | Viewed by 228 | Submission Open
Keywords: epigenetics; perioperative setting; surgical stress; anesthesia; gene expression; cognitive impairment; postoperative delirium; postoperative cognitive dysfunction (POCD); neuroinflammation; therapeutic approaches
(This special issue belongs to the Section Immunology and Immunotherapy)
Advances in Oral Squamous Cell Carcinoma Research
edited by Sangang Wu
submission deadline 31 Mar 2026 | Viewed by 223 | Submission Open
Keywords: oral squamous cell carcinoma; diagnostic biomarkers; therapeutic strategies; tumor microenvironment; radiotherapy; single-cell sequencing; artificial intelligence in oncology; personalized medicine; molecular mechanism; recurrence and metastasis
(This special issue belongs to the Section Cancer Biology and Oncology)
Lymphomas: From Mechanisms to Therapeutic Approaches
edited by Delfa Radić-Krišto and
submission deadline 31 Mar 2026 | Viewed by 217 | Submission Open
Keywords: aggressive lymphomas; cellular therapy; cellular immunotherapy; translational medicine; lymphomagenesis; indolent lymphomas; phase I/II clinical trials; targeted therapy; biomarkers; in vitro and in vivo models of lymphomas
(This special issue belongs to the Section Cancer Biology and Oncology)
Advances in Head and Neck Cancer: Mechanisms, Diagnosis, and Therapeutic Progress
edited by and Hideto Saijo
submission deadline 31 Mar 2026 | Viewed by 213 | Submission Open
Keywords: head and neck cancer; oral cancer; laryngeal cancer; nasopharyngeal cancer; thyroid cancer; diagnostic and treatment strategies
(This special issue belongs to the Section Cancer Biology and Oncology)
New Advances in the Pathology, Diagnosis and Treatment of Thyroid Tumors submission deadline 31 Mar 2026 | Viewed by 207 | Submission Open
Keywords: goitre; thyroid cancer; screening; bias; paraneoplastic syndrome  ; immunosurveillance  ; thyroiditis  ; thyroidectomy  ; immunotherapy
(This special issue belongs to the Section Endocrinology and Metabolism Research)
Epigenetics and Immune Perspectives in Cancer: Overcoming Therapy Resistance
edited by
submission deadline 31 Mar 2026 | Viewed by 189 | Submission Open
Keywords: epigenetics; immunotherapy; therapy resistance; tumor microenvironment; DNA methylation; histone modifications; dietary intervention; non-coding RNAs; immune evasion; combination therapy
(This special issue belongs to the Section Cancer Biology and Oncology)
Matrix Biology Insights: Unraveling the Role of Proteinases, Fibroblasts, and Extracellular Matrix Metalloproteinase Inducer in the Tumor Microenvironment
edited by
submission deadline 31 Mar 2026 | Viewed by 173 | Submission Open
Keywords: tumor microenvironment; proteinases; fibroblasts; EMMPRIN; matrix biology; extracellular matrix (ECM); matrix metalloproteinases (MMPs)
(This special issue belongs to the Section Cancer Biology and Oncology)
Type 2 Diabetes: Current Progress and Future Challenges
edited by
submission deadline 31 Mar 2026 | Viewed by 171 | Submission Open
Keywords: type 2 diabetes; cardiovascular risk; novel antidiabetics; clinical guidelines therapeutic inertia; obesity; insulin resistance; metabolic syndrome; diabetology; family medicine
(This special issue belongs to the Section Endocrinology and Metabolism Research)
Recent Advances in Endothelial Dysfunction
edited by
submission deadline 31 Mar 2026 | Viewed by 171 | Submission Open
Keywords: endothelial dysfunction; atherosclerosis; nitric oxide (NO); hyperlipidemia; hypertension; hyperglycemia; vasodilation; perivascular adipose tissue (PVAT); insulin resistance
(This special issue belongs to the Section Endocrinology and Metabolism Research)
Stem Cell Biology and Tissue Engineering for Cardiology
edited by Otilia Țica
submission deadline 31 Mar 2026 | Viewed by 152 | Submission Open
Keywords: cardiac regeneration; stem cell therapy; cardiac tissue engineering; mesenchymal stem cells (MSCs); induced pluripotent stem cells (iPSCs); cardiomyocyte differentiation; myocardial repair; 3D bioprinting; biomaterials in cardiology; cardiac scaffolds; heart organoids; translational regenerative medicine; cell-based therapy; cardiovascular bioengineering; immunomodulation in cardiac repair
(This special issue belongs to the Section Molecular and Translational Medicine)
Zebrafish Models: From Basic Research to Translational Medicine
edited by and Vishal Arora
submission deadline 31 Mar 2026 | Viewed by 148 | Submission Open
Keywords: zebrafish; animal models; in vivo whole model organism imaging; epigenetics; physiological and functional discoveries; genetic engineered transgenic cellular and mutant phenotype; developmental biology; drug discovery; high-throughput drug screening; pharmacogenomics; translational research; toxicology; genomics; cardiology; cardio-oncology; cardiovascular diseases; cardio-oncology; cancer models; melanoma; tumor microenvironment; dermatology; ophthalmology; neuroscience; aging; neurodegenerative disease; diabetes; kidney disease; hematology
(This special issue belongs to the Section Molecular and Translational Medicine)
Applications of Biomedical Engineering and Biomaterials in Human Diseases
edited by Rui Sang
submission deadline 31 Mar 2026 | Viewed by 148 | Submission Open
Keywords: biosensors and diagnostics; biomedical engineering; nanotechnology in medicine; artificial intelligence in healthcare; precision medicine; drug delivery systems; regenerative medicine; 3D bioprinting; CRISPR-based technologies
(This special issue belongs to the Section Biomedical Engineering and Materials)
Inflammatory Mechanisms, Biomarkers and Treatment in Oral Diseases submission deadline 31 Mar 2026 | Viewed by 143 | Submission Open
Keywords: periodontal diseases; peri-implantitis; oral lichen planus; oral microbial dysbiosis; inflammatory pathways; biomarkers
(This special issue belongs to the Section Molecular and Translational Medicine)
Imaging and Modeling Alzheimer's Disease: The Quest for Mechanistic Understanding, Early Diagnosis, and Novel Treatments
edited by Guoshi Li
submission deadline 31 Mar 2026 | Viewed by 140 | Submission Open
Keywords: biomarker identification; connectome analysis; computational neuroimaging; biophysical modeling; network models; machine learning; brain stimulation; neurodegeneration
(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)
Fibromyalgia and Neuroinflammation: Unraveling Pathophysiological Links and Therapeutic Targets
edited by Mario García-Domínguez
submission deadline 31 Mar 2026 | Viewed by 139 | Submission Open
Keywords: fibromyalgia; neuroinflammation; central sensitization; glial activation; cytokines; pain modulation; chronic pain; neuroimmune interaction
(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)
Sepsis and Systemic Inflammation: Mechanisms and Therapeutic Innovations
edited by
submission deadline 31 Mar 2026 | Viewed by 138 | Submission Open
Keywords: sepsis; systemic inflammation; microcirculation; intravital imaging; immune dysregulation; septic shock; therapeutic innovations
(This special issue belongs to the Section Immunology and Immunotherapy)
Advancements in the Treatment of Colorectal Cancer submission deadline 31 Mar 2026 | Viewed by 136 | Submission Open
Keywords: genomic profiling; advanced nutritional support; AI; MDT; adjuvant therapy
(This special issue belongs to the Section Cancer Biology and Oncology)
New Approaches to Spinal Cord-Related Diseases
edited by Corentin Dauleac
submission deadline 31 Mar 2026 | Viewed by 129 | Submission Open
Keywords: spinal cord; spinal cord injury; stem cell; neuromodulation; rehabilitation; plasticity; spasticity; pain; neuroimaging
(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)
Emerging Trends in Liver Diseases and Cirrhosis Research submission deadline 31 Mar 2026 | Viewed by 128 | Submission Open
Keywords: pathogenesis of liver fibrosis and cirrhosis; MASLD; hepatitis B; C and D; primary biliary cholangitis (PBC): immunopathology and treatment advances; alcohol-associated liver disease; liver regeneration and stem-cell-based therapies; biomarkers for early diagnosis and prognosis; emerging antifibrotic treatments; liver complications and systemic comorbidities; personalized medicine in liver disease
(This special issue belongs to the Section Molecular and Translational Medicine)
Oxidative Stress, Mitochondrial Dysfunction, and Aβ Pathology: Converging Pathways in Aging and Neurodegeneration
edited by , Laxmi Rathor and
submission deadline 31 Mar 2026 | Viewed by 128 | Submission Open
Keywords: oxidative stress; aging; amyloid beta; tau phosphorylation; neurodegeneration; regulated cell death; mitochondrial biogenesis; Drosophila; C. elegans
(This special issue belongs to the Section Cell Biology and Pathology)
Advances in Cardiac Remodeling
edited by Silvio Assis de Oliveira-Junior and André Soares Leopoldo
submission deadline 31 Mar 2026 | Viewed by 125 | Submission Open
Keywords: cardiac remodeling; cardiomyocyte contractile; obesity; diabetes; diets; training; rats; humans
(This special issue belongs to the Section Molecular and Translational Medicine)
Decoding Neurodegeneration: Insights From Multi-Omics and Neuroimaging Integration
edited by
submission deadline 31 Mar 2026 | Viewed by 124 | Submission Open
Keywords: neurodegenerative; neuroimaging; executive functions; electrophysiology; brain connectivity; multi omics data; bio-molecular data; biomarkers; systems biology; single-cell omics; translational neuroscience
(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)
Glioblastoma: Novel Multitargeted Approaches
edited by
submission deadline 31 Mar 2026 | Viewed by 119 | Submission Open
Keywords: glioblastoma; multitargeted therapy; tumor heterogeneity; immunotherapy; targeted agents; nanomedicine; RNA therapeutics; combination therapy; translational oncology
Advances in Bone Metabolism, Bone Homeostasis and Osteogenesis
edited by and Laura Ortinau
submission deadline 31 Mar 2026 | Viewed by 106 | Submission Open
Keywords: bone homeostasis and maintenance; bone remodeling; osteoblast– osteoclast interaction; endocrine signaling by bone; bone metabolic disease
(This special issue belongs to the Section Cell Biology and Pathology)
Natural and Synthetic Molecules with Anticancer Activity: Pharmacological Basis and Mechanistic Insight—2nd Edition submission deadline 31 Mar 2026 | Viewed by 102 | Submission Open
Keywords: anticancer; molecular pharmacology; mechanistic mode of action; signal transduction; in vitro; preclinical; natural products; synthesis
(This special issue belongs to the Section Drug Discovery, Development and Delivery)
Innovations in Radiation Oncology
edited by
submission deadline 31 Mar 2026 | Viewed by 100 | Submission Open
Keywords: adaptive radiotherapy; cancer biomarkers; genomics; artificial intelligence; radiation oncology; machine learning; precision oncology; radiogenomics; ctDNA
(This special issue belongs to the Section Cancer Biology and Oncology)
Drug Delivery and Nanocarrier
edited by
submission deadline 31 Mar 2026 | Viewed by 97 | Submission Open
Keywords: nanocarriers; targeted drug delivery; controlled release; theranostics; biocompatibility; functionalized nanoparticles; nanomedicine; translational nanotechnology
(This special issue belongs to the Section Nanomedicine and Nanobiology)
Emerging Trends and Applications in Nanomedicine and Targeted Therapies submission deadline 31 Mar 2026 | Viewed by 94 | Submission Open
Keywords: nanomedicine; drug delivery systems; targeted therapy; biomaterials; cancer therapy; smart nanocarriers; biodegradable nanoparticles; photothermal therapy; nano-diagnostics; translational nanotechnology
(This special issue belongs to the Section Nanomedicine and Nanobiology)
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