Advances in Bone Metabolism, Bone Homeostasis and Osteogenesis
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Cell Biology and Pathology".
Deadline for manuscript submissions: 31 March 2026 | Viewed by 14
Special Issue Editors
Interests: skeletal stem and progenitors; molecular and cellular mechanism in musculoskeletal disease; stem cell niche; muscle–bone crosstalk; bone aging
Special Issue Information
Dear Colleagues,
Healthy bone is maintained by continuous bone remodeling, a dynamic process of bone matrix deposition and resorption during development and homeostasis. This process is tightly regulated by the coordinated action of multiple bone cells, including mesenchymal stem and progenitors, osteoblasts, osteoclasts, and osteocytes. While these cells are responsible for repairing microdamage and replacing aged bone, their functions are affected by circulating factors such as cytokines, hormones, inflammatory factors, and exosomes. Conversely, research over the past several years has demonstrated that bone also acts as an important endocrine organ by secreting peptides or steroid hormones to affect other organs and ultimately regulate whole body energy metabolism.
Understanding the mechanisms by which bone-derived factors affect systemic metabolic functions, and how circulating endocrine factors affect bone homeostasis and osteogenesis, will provide valuable insight for developing novel therapeutic strategies to treat metabolic bone diseases.
This Special Issue will provide an overview of recent advances in bone metabolism, bone homeostasis, and osteogenesis. In particular, it will highlight the impact of metabolic factors on bone remodeling, cellular crosstalk in bone homeostasis, and novel therapeutic targets for bone disorders.
Dr. Youngjae Jeong
Dr. Laura Ortinau
Guest Editors
Manuscript Submission Information
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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- bone homeostasis and maintenance
- bone remodeling
- osteoblast–osteoclast interaction
- endocrine signaling by bone
- bone metabolic disease
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