Advances in Bone Metabolism, Bone Homeostasis and Osteogenesis

Dear Colleagues,

Healthy bone is maintained by continuous bone remodeling, a dynamic process of bone matrix deposition and resorption during development and homeostasis. This process is tightly regulated by the coordinated action of multiple bone cells, including mesenchymal stem and progenitors, osteoblasts, osteoclasts, and osteocytes. While these cells are responsible for repairing microdamage and replacing aged bone, their functions are affected by circulating factors such as cytokines, hormones, inflammatory factors, and exosomes. Conversely, research over the past several years has demonstrated that bone also acts as an important endocrine organ by secreting peptides or steroid hormones to affect other organs and ultimately regulate whole body energy metabolism.

Understanding the mechanisms by which bone-derived factors affect systemic metabolic functions, and how circulating endocrine factors affect bone homeostasis and osteogenesis, will provide valuable insight for developing novel therapeutic strategies to treat metabolic bone diseases.

This Special Issue will provide an overview of recent advances in bone metabolism, bone homeostasis, and osteogenesis. In particular, it will highlight the impact of metabolic factors on bone remodeling, cellular crosstalk in bone homeostasis, and novel therapeutic targets for bone disorders.

Dr. Youngjae Jeong
Dr. Laura Ortinau
Guest Editors

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