Inflammatory Mechanisms, Biomarkers and Treatment in Oral Diseases
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Molecular and Translational Medicine".
Deadline for manuscript submissions: 31 March 2026 | Viewed by 1
Special Issue Editor
Interests: periodontal diseases; inflammatory pathways; biomarkers; diabetes mellitus; molecular biology; genetics
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Inflammation is the cornerstone of the oral cavity's defense against microbial invasion, trauma, and other threats. This complex biological response, orchestrated by immune cells, a myriad of signalling molecules (cytokines, chemokines), vascular components, and antioxidants, is essential for maintaining tissue homeostasis and initiating healing. However, when dysregulated, unresolved, or excessive, inflammation becomes the primary driver of the most prevalent oral diseases globally. Chronic inflammatory conditions such as gingivitis, periodontitis, pulpitis, mucositis, peri-implantitis, oral lichen planus, and oral potentially malignant disorders (OPMDs) represent significant burdens on individual health and quality of life. Critically, oral inflammation is not confined to the mouth. It acts as a portal linking oral health to systemic conditions such as cardiovascular disease, diabetes mellitus, rheumatoid arthritis, and adverse pregnancy outcomes through disseminating inflammatory mediators and pathogens. Understanding the intricate molecular and cellular mechanisms governing the initiation, progression, and resolution of inflammation within the unique oral microenvironment is paramount for developing targeted, effective, and personalized preventive and therapeutic strategies.
This Special Issue will compile a comprehensive collection of high-quality original articles that delve into the latest advancements in elucidating the fundamental inflammatory pathways involved in the pathogenesis of oral diseases and explore novel therapeutic approaches targeting these pathways. We will foster a deeper understanding of the interplay between oral microbiota, host genetic profile and immune responses (innate and adaptive), tissue destruction, and attempts at resolution/regeneration in various oral inflammatory states.
We look forward to receiving your contributions, which will illuminate the complexities of oral inflammation and pave the way for the improved prevention, diagnosis, and treatment of oral diseases.
Dr. Raquel M. Scarel-Caminaga
Guest Editor
Manuscript Submission Information
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Keywords
- periodontal diseases
- peri-implantitis
- oral lichen planus
- oral microbial dysbiosis
- inflammatory pathways
- biomarkers
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