Medical Imaging in Brain Tumor: Charting the Future

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Neurobiology and Clinical Neuroscience".

Deadline for manuscript submissions: 31 March 2026 | Viewed by 1210

Special Issue Editors


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Guest Editor
1. Medical Research Institute, Pusan National University, Yangsan 50612, Republic of Korea
2. Department of Biomedical Engineering, School of Medicine, Pusan National University, Yangsan 50612, Republic of Korea
Interests: medical image analysis; pattern recognition; digital pathology; oncology; digital image processing; computer vision; segmentation; classification; deep learning; machine learning; smart healthcare

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Guest Editor
Section of Neurosurgery, Department of Surgery, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, Canada
Interests: artificial intelligence; machine learning; deep learning; computer vision; image and video processing; anomaly detection; super-resolution; reconstruction; large language models; medical image analysis

Special Issue Information

Dear Colleagues,

This Special Issue, entitled “Medical Imaging in Brain Tumor: Charting the Future”, welcomes publications of cutting-edge research in advanced imaging technologies in the diagnosis, treatment planning, and monitoring of brain tumors. After rapid advancements in imaging modalities such as MRI, CT, PET and emerging techniques like AI-driven image analysis, this issue highlights innovative research and breakthroughs that are reshaping the field.

We invite submissions that focus on improving tumor detection, classification, and segmentation, as well as enhancing the understanding of tumor biology through imaging biomarkers. This issue will address the integration of imaging data with radiomics, radiogenomics, and personalized medicine, offering new avenues for precision oncology. By bringing together multidisciplinary perspectives, this Special Issue seeks to provide a comprehensive overview of current advancements and future directions in brain tumor imaging, ultimately contributing to improved patient outcomes and clinical decision-making.

These technologies are not only enhancing the accuracy of tumor detection and characterization, but are also enabling the identification of imaging biomarkers that provide insights into tumor biology, genetics, and microenvironment.

This Special Issue will feature a balanced mix of review and research articles:

  • Review articles will provide an in-depth analysis of the latest innovations in medical imaging in tumor detection, classification, and monitoring, as well as the integration of imaging biomarkers into clinical practice.
  • Research articles will present innovative imaging techniques for diagnosis and monitoring that push the boundaries of brain tumor imaging.

Dr. Subrata Bhattacharjee
Dr. Mansoor Hayat
Guest Editors

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomedicines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • brain tumor diagnosis
  • artificial intelligence (AI) in medical imaging
  • imaging biomarkers for brain tumor
  • detection, segmentation and classification
  • radiomics and radiogenomics
  • precision oncology
  • deep learning and machine learning
  • neuro oncology
  • digital pathology
  • treatment response monitoring

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Published Papers (1 paper)

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Review

16 pages, 254 KB  
Review
Advanced Neuroimaging and Emerging Systemic Therapies in Glioblastoma: Current Evidence and Future Directions
by Ilona Bar-Letkiewicz, Anna Pieczyńska, Małgorzata Dudzic, Michał Szkudlarek, Krystyna Adamska and Katarzyna Hojan
Biomedicines 2025, 13(11), 2597; https://doi.org/10.3390/biomedicines13112597 - 23 Oct 2025
Viewed by 492
Abstract
Despite technological progress, glioblastoma (GBM) continues to confer dismal prognoses. Modern neuroimaging methods are assuming an ever greater role in diagnosing and monitoring brain tumors. This review shows current neuroimaging approaches and systemic therapeutic strategies for glioblastoma, with a focus on emerging and [...] Read more.
Despite technological progress, glioblastoma (GBM) continues to confer dismal prognoses. Modern neuroimaging methods are assuming an ever greater role in diagnosing and monitoring brain tumors. This review shows current neuroimaging approaches and systemic therapeutic strategies for glioblastoma, with a focus on emerging and innovative treatments. Advances in multiparametric magnetic resonance imaging—MRI (diffusion, perfusion, and spectroscopy) and novel positron emission tomography (PET) tracers, complemented by radiomics and artificial intelligence (AI), now refine tumor delineation, differentiate progression from treatment effects, and may help predict treatment responses. Maximal safe resection followed by chemoradiotherapy with temozolomide remains the standard, with the greatest benefit seen in O6-methylguanine DNA methyltransferase (MGMT) promoter-methylated tumors. Bevacizumab and other targeted modalities offer mainly progression-free, not overall survival, gains. Immune checkpoint inhibitors (e.g., nivolumab) have not improved survival in unselected GBM, while early multi-antigen CAR-T (chimeric antigen receptor T-cell) strategies show preliminary bioactivity without established durability. While actionable alterations (NTRK fusions and BRAF V600E) justify selective targeted therapy trials, their definitive benefit in classical GBM is unproven. Future priorities include harmonized imaging molecular integration, AI-driven prognostic modeling, novel PET tracers, and strategies to breach or transiently open the blood–brain barrier to enhance drug delivery. Convergence of these domains may convert diagnostic precision into improved patient outcomes. Full article
(This article belongs to the Special Issue Medical Imaging in Brain Tumor: Charting the Future)
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