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Biomedicines
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Current Perspectives on Human Papillomavirus (HPV)—Second Edition
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Current Perspectives on Human Papillomavirus (HPV)—Second Edition

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Microbiology in Human Health and Disease".

Deadline for manuscript submissions: 31 March 2026 | Viewed by 340

Special Issue Editors

Dr. Vanja Kaliterna

E-Mail Website
Guest Editor
Teaching Institute of Public Health of Split-Dalmatia County, Split, Croatia
Interests: human papillomavirus (HPV)
Special Issues, Collections and Topics in MDPI journals
Dr. Tomislav Meštrović

E-Mail Website
Guest Editor
University Centre Varaždin, University North, Varaždin, Croatia
Interests: microbiome; microbiota; gut microbiome; vaginal microbiome
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

A highly prevalent human papillomavirus (HPV) infection can be responsible for a myriad of health issues, thus unveiling the need for a comprehensive overview of the latest research developments and insights into various aspects of this viral agent. This Special Issue aims to cover the most important aspects of human papillomavirus (HPV) infections, including fundamental research, diagnostics, new treatment options, and new vaccine strategies. The scope of this Special Issue includes research on the biology and molecular mechanisms of HPV, as well as studies on the clinical aspects of HPV-related diseases.

In terms of diagnostics and treatment, the Special Issue will focus on the latest advancements in diagnostic methods, particularly concerning molecular tests and their use in disease-screening strategies, but also novel treatment approaches such as immunotherapy and targeted treatments. Additionally, the Special Issue will provide insights into HPV-related diseases, including the associated complications and malignancies. Likewise, prevention strategies represent an important focus of this Special Issue, including vaccination and screening as two crucial strategies for prevention and early detection, respectively.

We invite experts from the scientific fields of microbiology, virology, pathology, infectious diseases, dermatology, oncology, gynecology, and urology to share their latest research results, experiences, and innovations in the field of HPV research and prevention.

Dr. Vanja Kaliterna
Dr. Tomislav Meštrović
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomedicines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • human papillomavirus (HPV)
  • molecular mechanisms
  • diagnosis
  • treatment
  • prevention
  • vaccination
  • screening
  • immunotherapy
  • cancer

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Published Papers (1 paper)

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Research

18 pages, 1984 KB  
Article
PGRMC1 Promotes the Development of Cervical Intraepithelial Neoplasia in HPV-Positive Patients
by Wen Lai, Shuyu Liu, Tianming Wang, Min Gong, Qiaoling Liu, Ling Ling and Jianquan Chen
Biomedicines 2025, 13(10), 2454; https://doi.org/10.3390/biomedicines13102454 - 9 Oct 2025
Viewed by 252
Abstract
Background/Objectives: Persistent human papillomavirus (HPV) infection is the leading cause of cervical intraepithelial neoplasia (CIN), a known precursor to cervical squamous carcinoma. While progesterone receptor membrane component 1 (PGRMC1) has been implicated in various cancers, its specific role in cervical carcinogenesis has [...] Read more.
Background/Objectives: Persistent human papillomavirus (HPV) infection is the leading cause of cervical intraepithelial neoplasia (CIN), a known precursor to cervical squamous carcinoma. While progesterone receptor membrane component 1 (PGRMC1) has been implicated in various cancers, its specific role in cervical carcinogenesis has remained uncertain. This study aimed to elucidate the function of PGRMC1 in the progression of CIN. Methods: Bioinformatics techniques were employed to assess the expression levels of PGRMC1 in cervical cancer tissues and to investigate its correlation with patient prognosis. To explore the functional role of PGRMC1, we manipulated its expression in the cervical cancer cell line HeLa using siRNA. Subsequently, we evaluated cell migration via the scratch assay, and invasion through the Transwell assay. We employed mass spectrometry to identify proteins interacting with PGRMC1 and confirmed these interactions using co-immunoprecipitation (co-IP). Further co-IP experiments were conducted to pinpoint the specific binding sites of these protein interactions, and immunofluorescence staining was utilized to observe the spatial distribution of interacting proteins within the cells. The phosphorylation status of VIM was further confirmed by WB. At the clinical level, we collected cervical biopsy specimens from HPV-positive patients and verified the expression patterns of PGRMC1 and VIM using immunohistochemical staining in cervical squamous cell carcinoma (CSCC) tissues. Results: We discovered a correlation between progressively increasing PGRMC1 expression and the severity of CIN as well as a poor prognosis. Knockdown of PGRMC1 resulted in the inhibition of migration and invasion capabilities in cervical cancer cells. Furthermore, PGRMC1 was found to physically interact and colocalize with Vimentin (VIM). Notably, PGRMC1 knockdown specifically increased phosphorylation at the Ser-39 residue of VIM. Conclusions: Our findings suggest that PGRMC1 facilitates CIN progression by binding to VIM and suppressing Ser-39 phosphorylation, thereby promoting the migration and invasion of cervical carcinoma cells. This study enhances our understanding of PGRMC1’s role in CIN progression and lays an experimental foundation for targeted therapeutic approaches to cervical squamous carcinoma. Full article
(This article belongs to the Special Issue Current Perspectives on Human Papillomavirus (HPV)—Second Edition)
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