Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
6.8
3.9
Journals
Biomedicines
Special Issues
Emerging Trends in Liver Diseases and Cirrhosis Research
share announcement

Emerging Trends in Liver Diseases and Cirrhosis Research

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Molecular and Translational Medicine".

Deadline for manuscript submissions: 31 March 2026 | Viewed by 542

Special Issue Editor

Dr. Hariklia Kranidioti

E-Mail
Guest Editor
2nd Academic Department of Internal Medicine, General Hospital of Athens “Hippokratio”, Medical School of National and Kapodistrian University of Athens, Athens, Greece
Interests: viral hepatitis; liver diseases and immunology; cirrhosis
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

I am pleased to invite you to contribute to this Special Issue, entitled “Emerging Trends in Liver Diseases and Cirrhosis Research”. Liver diseases remain a growing global health challenge, with cirrhosis being one of the leading causes of morbidity and mortality worldwide. The clinical landscape is rapidly changing, driven by the rising prevalence of metabolic-associated steatotic liver disease (MASLD), autoimmune conditions like primary biliary cholangitis (PBC), and persistent viral hepatitis. At the same time, advances in diagnostic tools, molecular understanding, and therapeutic strategies are providing new hope for earlier intervention and better outcomes. This Special Issue provides an opportunity to highlight recent advancements and emerging frontiers in hepatology research.

We aim to gather cutting-edge research and comprehensive reviews focusing on new developments in the diagnosis, pathophysiology, and management of cirrhosis. Special attention will be given to innovations in the diagnosis and treatment of MASLD, PBC, and other chronic liver conditions. The collection aligns with the journal's commitment to publishing high-quality research that advances clinical and scientific understanding of complex disease processes.

We look forward to receiving your contributions.

Dr. Hariklia Kranidioti
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomedicines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • pathogenesis of liver fibrosis and cirrhosis
  • MASLD
  • hepatitis B, C and D
  • primary biliary cholangitis (PBC): immunopathology and treatment advances
  • alcohol-associated liver disease
  • liver regeneration and stem-cell-based therapies
  • biomarkers for early diagnosis and prognosis
  • emerging antifibrotic treatments
  • liver complications and systemic comorbidities
  • personalized medicine in liver disease

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.

Further information on MDPI's Special Issue policies can be found here.

Published Papers (1 paper)

Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Other

29 pages, 4504 KB  
Systematic Review
When the Liver Echoes to the Heart: Assessing Subclinical Cardiac Dysfunction in NAFLD Using Speckle Tracking Echocardiography—A Systematic Review and Meta-Analysis
by Micha Gruber, Malaz Almasri, Rania Abdulredha, Iulia Tecar, Daniel-Corneliu Leucuta, Stefan-Lucian Popa, Dan L. Dumitrascu and Abdulrahman Ismaiel
Biomedicines 2025, 13(12), 2908; https://doi.org/10.3390/biomedicines13122908 - 27 Nov 2025
Viewed by 351
Abstract
Introduction: Worldwide, non-alcoholic fatty liver disease (NAFLD) is the most prevalent chronic liver disorder, strongly associated with increased cardiovascular morbidity and mortality. Although patients have a preserved left ventricular ejection fraction (LVEF), individuals having NAFLD may demonstrate subclinical cardiac dysfunction. Speckle tracking echocardiography [...] Read more.
Introduction: Worldwide, non-alcoholic fatty liver disease (NAFLD) is the most prevalent chronic liver disorder, strongly associated with increased cardiovascular morbidity and mortality. Although patients have a preserved left ventricular ejection fraction (LVEF), individuals having NAFLD may demonstrate subclinical cardiac dysfunction. Speckle tracking echocardiography (STE) enables a more sensitive evaluation, identifying even subtle alterations of myocardial strain, compared to conventional LVEF measurements. This systematic review and meta-analysis sought to examine the relationship between NAFLD and subclinical left ventricular systolic impairment, utilizing STE-derived strain parameters. Methods: A comprehensive search of the literature was undertaken using PubMed, EMBASE, and Scopus. Observational studies evaluating patients with NAFLD through STE-derived myocardial strain parameters were included. Study quality was appraised using the Newcastle-Ottawa Scale. The primary outcomes were the mean differences (MD) in global longitudinal strain (GLS), global circumferential strain (GCS), global radial strain (GRS), global area strain (GAS), and related strain rate indices between NAFLD spectrum patients and controls. Results: A total of sixteen studies, comprising 8359 participants, were included in the analysis. Compared to controls, patients with NAFLD demonstrated significant reductions in GLS (MD: −2.043; 95% CI: −2.868, −1.218), GAS (MD: −3.706; 95% CI: −4.999, −2.413), and GCS (MD: −1.415; 95% CI: −2.893, 0.064). These reductions were more substantial among individuals with moderate to severe NAFLD and those with concomitant type 2 diabetes mellitus (GLS MD: −4.385; 95% CI: −5.400, −3.369 in diabetic NAFLD vs. diabetic controls). Subgroup analysis further revealed a progressive deterioration in strain parameters from simple steatosis to more severe NAFLD. Notably, LVEF remained preserved in all groups, highlighting the subclinical nature of this dysfunction. Conclusions: This meta-analysis verifies the presence of subclinical left ventricular systolic dysfunction in individuals with NAFLD, which is identifiable by STE despite preserved LVEF. Myocardial strain metrics, particularly GLS, serve as sensitive early markers of myocardial impairment. Routine application of STE in the clinical assessment of NAFLD may support earlier cardiovascular risk detection and timely intervention. Full article
(This article belongs to the Special Issue Emerging Trends in Liver Diseases and Cirrhosis Research)
►▼ Show Figures

Figure 1

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-1
Back to TopTop