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Biomedicines
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Advances in Cardiac Remodeling
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Advances in Cardiac Remodeling

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Molecular and Translational Medicine".

Deadline for manuscript submissions: 30 November 2026 | Viewed by 1588

Special Issue Editors

Dr. Silvio Assis de Oliveira-Junior

E-Mail Website
Guest Editor
School of Physical Therapy, Federal University of Mato Grosso do Sul—UFMS, Campo Grande 79070-900, MS, Brazil
Interests: heart; exercise training; performance; hypertrophy
Dr. André Soares Leopoldo

E-Mail Website
Guest Editor
Postgraduate Program in Nutrition and Health and Physiological Science, Health Sciences Center, Federal University of Espírito Santo, Vitória 29075-910, ES, Brazil
Interests: exercise physiology and chronic noncommunicable diseases; physiology, biochemistry, and exercise in experimental models; biochemical and physiological adaptations in nutritional intervention models; obesity, diabetes and cardiac adaptations

Special Issue Information

Dear Colleagues,

Cardiac remodeling involves an adaptive heart process to maintain myocardial performance in response to different stimuli, not only clinical circumstances but also environmental, dietary, and effort demands. In this context, remodeling is characterized by time-dependent evolution and consists of several adaptive changes, clinically represented by modifications of cardiac form, size, and performance.

In this context, the current Special Issue intends to publish articles reporting on recent advances in cardiac remodeling as a process secondary to nutritional and/or metabolic conditions such as dietary interventions, obesity, and diabetes. From this perspective, papers based on experimental models, clinical trials, or applied studies focused on the assessment and prevention of and interventions for different conditions are very welcome to be submitted to this Special Issue. Likewise, original research papers, reviews focused on phenotypical adaptive alterations, and innovations in terms of molecular mechanisms and clinical relevance configuring potential issues are also welcome to be submitted. With this Special Issue, we aim to demonstrate how these new advances have responded to demands pertaining to human health in terms of evidence-based practice within different levels of care. Therefore, we hope that this Special Issue will provide an academic and scientific background for graduate students, researchers, and diverse health professions worldwide.

Dr. Silvio Assis de Oliveira-Junior
Dr. André Soares Leopoldo
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomedicines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • cardiac remodeling
  • cardiomyocyte contractile
  • obesity
  • diabetes
  • diets
  • training
  • rats
  • humans

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Published Papers (2 papers)

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Research

19 pages, 1874 KB  
Article
Circadian Activity Disruption in Cardiac Remodeling Patients Underlies Autonomic Dysfunction in Heart Failure
by Natalia Buitrago-Ricaurte, Andre J. Riveros, Rafael González Niño, Liliana Otero, Juan David Meléndez and Alain Riveros-Rivera
Biomedicines 2026, 14(5), 1054; https://doi.org/10.3390/biomedicines14051054 - 6 May 2026
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Abstract
Background: Heart failure (HF) is a complex clinical syndrome that presents significant challenges in diagnosis and treatment. Exploring innovative pathways to better understand the physiopathological mechanisms has led to the concept of cardiac remodeling (CR), which helps elucidate the diversity in clinical manifestations [...] Read more.
Background: Heart failure (HF) is a complex clinical syndrome that presents significant challenges in diagnosis and treatment. Exploring innovative pathways to better understand the physiopathological mechanisms has led to the concept of cardiac remodeling (CR), which helps elucidate the diversity in clinical manifestations and treatment responses. However, the extent to which CR influences autonomic cardiac dynamics across the circadian cycle remains unclear. Methods: Recordings of 24 h ECG recordings from 86 Control subjects and 86 patients meeting the criteria for cardiac remodeling were analyzed. Heart rate variability (HRV) parameters were estimated using 5 min Blackman–Harris windows per hour. Autonomic influences on cardiac electrical activity were assessed using time-domain, frequency-domain, and nonlinear methods. Circadian parameters (MESOR, amplitude, and acrophase) were derived via Cosinor modeling, and group differences were evaluated while controlling for age, sex, and medication effects. Results: Patients with CR exhibited reduced oscillatory activity in HRV measures compared with Control. MESOR and amplitude were significantly lower in CR patients, who also displayed an advanced-phase phenotype across multiple HRV domains over 24 h. Additionally, CR patients showed decreased complexity and entropy in nonlinear dynamics. Conclusions: Altered circadian rhythmicity of cardiac electrical activity is evidenced in cardiac remodeling by changes in circadian HRV parameters and nonlinear dynamics. Full article
(This article belongs to the Special Issue Advances in Cardiac Remodeling)
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22 pages, 15619 KB  
Article
Transcriptional Heterogeneity of Cardiac Remodeling Between Type 1 and Type 2 Diabetes
by Feng Liang, Shaohua Li, Guo Zhou, Huanhuan Huo, Yijie Huang, Haiping Chen, Zhaohua Cai, Yi Li and Ben He
Biomedicines 2026, 14(4), 746; https://doi.org/10.3390/biomedicines14040746 - 25 Mar 2026
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Abstract
Background: Cardiovascular complications stemming from diabetes pose a grave threat to patients’ survival. Both type 1 diabetes (T1D) and type 2 diabetes (T2D) significantly increase the risk of heart failure, yet no reports have clarified whether there are differences in the pathway alterations [...] Read more.
Background: Cardiovascular complications stemming from diabetes pose a grave threat to patients’ survival. Both type 1 diabetes (T1D) and type 2 diabetes (T2D) significantly increase the risk of heart failure, yet no reports have clarified whether there are differences in the pathway alterations involved in these two conditions. Investigating the heterogeneity of the cardiac remodeling between these two types of diabetes is conducive to reducing the incidence of cardiovascular events in diabetic patients in clinical practice. Methods: T1D and T2D models were established in adult mice, and the hearts were collected for RNA sequencing. Differential expression analysis (DEA) was performed. Integrating functional enrichment analyses, we probed into gene and pathway heterogeneity. Subsequently, we compared single-cell RNA sequencing (scRNA-seq) data of hearts from T1D and T2D mice, focusing on three cell populations (endothelial cells, macrophages, and fibroblasts) to identify gene and pathway differences. Finally, we evaluated shared genes and common signaling pathway changes across these three cell populations in both diabetes types. Results: We have successfully established T1D and T2D models in mice. Compared with shared genes, the two types of diabetes had more consistent pathway changes. Further scRNA-seq analysis identified endothelial cells, macrophages, and fibroblasts as significantly associated with the diabetic phenotype. In shared pathway, endothelial cells were significantly enriched in pathways related to endothelial proliferation and angiogenesis; macrophages were enriched in immune response pathways; and fibroblasts were enriched in pathways involving fibrosis, cell proliferation, and apoptosis. In endothelial cells, inflammatory response and fatty acid metabolism pathways were predominantly enriched in T1D, while energy metabolism pathways were dominant in T2D. In macrophages, antiviral immune pathways were specifically enriched in T1D, whereas macrophages in T2D were additionally implicated in the regulation of cardiomyocyte function. In fibroblasts, immune-related pathways were characteristically enriched in T1D, while cell respiration and energy supply pathways were prominent in T2D. Common functional enrichment pathways across the three cell types in both diabetes types mainly involved innate immune responses and cardiac morphogenesis, with the proportion of shared pathways being significantly higher than that of shared genes. Conclusions: This study, by combining RNA sequencing and scRNA-seq, revealed that cardiac pathologies induced by T1D and T2D exhibit a higher degree of consistent pathway changes compared to shared gene changes. Interventions targeting these common pathways may hold greater value in preventing and treating diabetic cardiomyopathy. Full article
(This article belongs to the Special Issue Advances in Cardiac Remodeling)
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