Fibromyalgia and Neuroinflammation: Unraveling Pathophysiological Links and Therapeutic Targets
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Neurobiology and Clinical Neuroscience".
Deadline for manuscript submissions: 31 March 2026 | Viewed by 18
Special Issue Editor
Interests: fibromyalgia; neuroinflammation; central sensitization; glial activation; cytokines; pain modulation; chronic pain; neuroimmune interaction
Special Issue Information
Dear Colleagues,
Fibromyalgia is a complex, chronic pain syndrome characterized by widespread musculoskeletal pain, fatigue, cognitive disturbances, and mood disorders. Despite its high prevalence, the pathophysiological underpinnings of fibromyalgia remain incompletely understood. Increasing evidence suggests that neuroinflammation—a process involving the activation of glial cells and the release of pro-inflammatory cytokines within the central nervous system—may play a pivotal role in the sensitization of pain pathways and the development of fibromyalgia symptoms.
This Special Issue aims to explore the emerging connection between fibromyalgia and neuroinflammatory processes. We invite original research articles, comprehensive reviews, and translational studies that investigate the role of neuroinflammation in the pathogenesis, diagnosis, and treatment of fibromyalgia. Topics of interest include, but are not limited to, the following:
- Microglial and astrocyte activation in fibromyalgia;
- Cytokine and chemokine profiles in patients with fibromyalgia;
- Neuroimmune mechanisms underlying central sensitization;
- Neuroimaging markers of inflammation in fibromyalgia;
- The gut–brain axis and systemic inflammation in fibromyalgia;
- Role of oxidative stress and mitochondrial dysfunction;
- Preclinical models of fibromyalgia with a focus on neuroinflammatory markers;
- Novel anti-inflammatory therapies targeting neuroimmune pathways;
- Biomarkers for diagnosis and disease progression;
- Interplay between neuroinflammation and psychiatric comorbidities.
This Special Issue seeks to foster interdisciplinary collaboration and facilitate the development of novel therapeutic strategies aimed at mitigating neuroinflammatory processes in fibromyalgia. Contributions from neuroscientists, immunologists, rheumatologists, pain specialists, and psychiatrists are highly encouraged.
Dr. Mario García-Domínguez
Guest Editor
Manuscript Submission Information
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Keywords
- fibromyalgia
- neuroinflammation
- central sensitization
- glial activation
- cytokines
- pain modulation
- chronic pain
- neuroimmune interaction
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