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Biomedicines publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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SARS-CoV-2 Infection: Focus on Pathophysiological Characteristics, Complications and Effects of Vaccinations

edited by

Barbara Brogna

Marina Piscopo

and

Carlo Brogna

submission deadline 31 Dec 2025 | 7 articles | Viewed by 31008 | Submission Open

Keywords: SARS-CoV-2 complications; SARS-CoV2 prognostic and predictive biomarkers; long COVID-19 and autoimmune disease; COVID-19 and microbiome; artificial intelligence

(This special issue belongs to the Section Microbiology in Human Health and Disease)

Advances in Neurological Diseases: Pathogenesis, Diagnosis and Therapeutic Strategies

edited by

Foteini Christidi

and

Dimitrios Tsiptsios

submission deadline 31 Dec 2025 | 8 articles | Viewed by 24872 | Submission Open

Keywords: neurological diseases; neurodegenerative diseases; stroke; multiple sclerosis; epilepsy; neuromuscular disorders; demyelinating diseases; traumatic brain injury; clinical neurophysiology; neuroimaging; genetics; neuropsychological tests; molecular and cellular mechanisms; biomarkers; diagnosis and therapeutics; prognosis; neurorehabilitation

(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)

Cardiovascular Diseases: From Pathophysiology to Novel Therapeutic Approaches

edited by

Serafino Fazio

and Valentina Mercurio

submission deadline 31 Dec 2025 | 10 articles | Viewed by 17936 | Submission Open

Keywords: cardiovascular diseases; heart failure; cardiac arrhythmias; metabolic syndrome; stroke; pulmonary hypertension; peripheral artery disease (PAD); acute coronary syndrome; myocarditis; pericarditis; valvulopathies

(This special issue belongs to the Section Molecular and Translational Medicine)

Advanced Research on Heart Failure and Heart Transplantation

edited by

Nandan Kumar Mondal

submission deadline 31 Dec 2025 | 12 articles | Viewed by 16197 | Submission Open

Keywords: heart failure; heart transplantation; DBD (donation after brain death); DCD (donation after cardiac death); cardiac arrest; ischemic time and reperfusion injury; myocardial damage; preservation techniques; post-transplant outcomes

(This special issue belongs to the Section Molecular and Translational Medicine)

Challenges in the Diagnosis and Treatment of Parkinson’s Disease

edited by Iro Boura and Cleanthe Spanaki

submission deadline 31 Dec 2025 | 6 articles | Viewed by 13736 | Submission Open

Keywords: Parkinson’ s disease; diagnosis; treatment; pathophysiology; biomarkers; prodromal; advanced therapies; subtypes; imaging; genetic

(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)

Advanced Research in Neuroprotection

edited by Evangelia Kesidou, Iliana Michailidou and

Christos Bakirtzis

submission deadline 31 Dec 2025 | 6 articles | Viewed by 13015 | Submission Open

Keywords: neuroprotection; neurodegeneration; neuroinflammation; axonal loss; neuropharmacology; traumatic brain injury; blood– brain barrier

(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)

Mechanisms, Implications, and Therapeutic Targets in Infectious Diseases

edited by Mihai Lazăr and

Oana Săndulescu

submission deadline 31 Dec 2025 | 6 articles | Viewed by 12934 | Submission Open

Keywords: infectious diseases; virus; antibiotics; pathophysiology; molecular mechanism; therapeutic management

(This special issue belongs to the Section Immunology and Immunotherapy)

Tumor Immune Microenvironment and Novel Strategies for Cancer Immunotherapy

edited by Sidra Islam

submission deadline 31 Dec 2025 | 6 articles | Viewed by 12500 | Submission Open

Keywords: tumor microenvironment cancer immunotherapy; immune markers; tumor infilterating immune cells; tumors

(This special issue belongs to the Section Immunology and Immunotherapy)

Cellular Senescence in Age-Related Diseases: Pathophysiology and Therapeutic Approaches

edited by

David J. Rademacher

submission deadline 31 Dec 2025 | 3 articles | Viewed by 10627 | Submission Open

Keywords: cellular senescence; senescence-associated secretory phenotype; aging; senolytics; senomorphics; senoreverters; therapeutics

(This special issue belongs to the Section Cell Biology and Pathology)

Novel Biomarker and Treatments for Diabetic Neuropathy

edited by Arun V. Krishnan and Tushar Issar

submission deadline 31 Dec 2025 | 4 articles | Viewed by 10535 | Submission Open

Keywords: diabetic peripheral neuropathy; type 1 diabetes; type 2 diabetes; glucagon-like peptide-1 receptor agonists; metabolic syndrome; in vivo corneal confocal microscopy; nerve ultrasonography; obesity; exercise

(This special issue belongs to the Section Endocrinology and Metabolism Research)

Role of Factors in Embryo Implantation and Placental Development

edited by

Micol Massimiani

and Valentina Lacconi

submission deadline 31 Dec 2025 | 4 articles | Viewed by 10427 | Submission Open

Keywords: placental development; implantation; embryo development; pregnancy disorders; endometrium; implantation failure; recurrent pregnancy loss; decidualization

(This special issue belongs to the Section Molecular and Translational Medicine)

Traumatic CNS Injury: From Bench to Bedside (2nd Edition)

edited by

Andres M. Rubiano

submission deadline 31 Dec 2025 | 3 articles | Viewed by 10092 | Submission Open

Keywords: neurotrauma; traumatic brain injury; translational science; bench to bedside; neuroprotection

(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)

Periodontal Disease: From Pathophysiology to Novel Therapeutic Approaches

edited by

Lu Li

submission deadline 31 Dec 2025 | 4 articles | Viewed by 9345 | Submission Open

Keywords: periodontal disease; oral microbiome; dysbiosis; artificial intelligence (AI); personalized therapeutic interventions

(This special issue belongs to the Section Molecular and Translational Medicine)

Advances in Hepatology

edited by Yuanwen Chen

submission deadline 31 Dec 2025 | 8 articles | Viewed by 9163 | Submission Open

Keywords: metabolic dysfunction-associated steatotic liver disease (MASLD); metabolic dysfunction-associated steatohepatitis (MASH); alcohol-associated liver disease (ALD); alcohol-associated hepatitis; viral hepatitis; liver cancer; autoimmune liver diseases; liver fibrosis; gut microbiota; neuroimmune; inflammatory mechanisms; oxidative stress; reversibly oxidized human non-mercaptalbumin-1; irreversibly oxidized human non-mercaptalbumin-2 (HNA2)

(This special issue belongs to the Section Molecular and Translational Medicine)

Biological Therapies for Asthma: Targeting Type 1 and Type 2 Inflammation

edited by Mohammad Irshad Reza and Nilesh Sudhakar Ambhore

submission deadline 31 Dec 2025 | 2 articles | Viewed by 8585 | Submission Open

Keywords: asthma endotypes; type 1 inflammation; type 2 inflammation; biological therapies for asthma; non-type 2 asthma; cytokine pathways in asthma; precision medicine in asthma; inflammatory biomarkers in asthma; Th1/Th2 immune responses

(This special issue belongs to the Section Molecular and Translational Medicine)

The Promise and Challenge of Induced Pluripotent Stem Cells (iPSCs): 2nd Edition

edited by

Xiufang Guo

submission deadline 31 Dec 2025 | 2 articles | Viewed by 6088 | Submission Open

Keywords: iPSC; cell differentiation; disease model; disease-in-a-dish; body-on-a-chip; CRISPR/Cas9; gene edition; stem cell therapy; cell transplantation; translational

(This special issue belongs to the Section Molecular and Translational Medicine)

Molecular Research in Breast Cancer

edited by

Anna De Blasio

and

Daniela Carlisi

submission deadline 31 Dec 2025 | 3 articles | Viewed by 6003 | Submission Open

Keywords: breast cancer; apoptosis; signaling pathways; drug resistance; metastasis; cancer stem cells; microRNA; biomarkers; drug target; tumor metabolism; tumor immunity

(This special issue belongs to the Section Molecular and Translational Medicine)

Epigenetic Regulation in Cancer Progression

edited by

Yonghwan Shin

submission deadline 31 Dec 2025 | 3 articles | Viewed by 5902 | Submission Open

Keywords: cancer progression; epigenetic regulation; gene expression; dysregulation; therapeutic targets

(This special issue belongs to the Section Molecular Genetics and Genetic Diseases)

New Insights in Hematologic Malignancies: From Pathophysiologic Mechanisms to Therapeutic Strategies

edited by

Yun Chen

submission deadline 31 Dec 2025 | 4 articles | Viewed by 5360 | Submission Open

Keywords: leukemia; hematological malignancies; tumor microenvironment; disease models; precision medicine; immunotherapy; targeted therapy; drug resistance; biomarkers; translational research

(This special issue belongs to the Section Cancer Biology and Oncology)

Neurotransmitters in Health and Diseases

edited by

Zsolt Bagosi

and Krisztina Csabafi

submission deadline 31 Dec 2025 | 3 articles | Viewed by 4924 | Submission Open

Keywords: neurotransmitters; GABA; dopamine; glutamate; acetylcholine; neurohormones; neuromodulators

(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)

New Insights in Respiratory Diseases

edited by

Diego Bagnasco

submission deadline 31 Dec 2025 | 5 articles | Viewed by 4651 | Submission Open

Keywords: asthma; COPD; bronchiectasis; genetic; therapeutics

(This special issue belongs to the Section Molecular and Translational Medicine)

Nano-Based Drug Delivery and Drug Discovery

edited by

Xiangli Shao

submission deadline 31 Dec 2025 | 3 articles | Viewed by 4586 | Submission Open

Keywords: nanotechnology; drug discovery; drug delivery; nanocarriers; nanomaterials; drug targeting; drug release; drug therapeutic

(This special issue belongs to the Section Nanomedicine and Nanobiology)

Advanced Research on Psychiatric Disorders

edited by Wen Zhang

submission deadline 31 Dec 2025 | 1 articles | Viewed by 4519 | Submission Open

Keywords: psychiatric disorders; artificial intelligence; predictive modeling; personalized treatment strategies; animal experiments; risk factors; multimodal approaches

(This special issue belongs to the Section Molecular and Translational Medicine)

State-of-the-Art Molecular and Translational Medicine in USA

edited by

Maaike van Gerwen

and

Stephanie J. Tuminello

submission deadline 31 Dec 2025 | 3 articles | Viewed by 3882 | Submission Open

Keywords: diagnostics; therapeutics; prevention; cellular biology; disease mechanisms; precision medicine; biomarker discovery; immunotherapies; bioinformatics

(This special issue belongs to the Section Molecular and Translational Medicine)

Antioxidant Materials with Additional Biological Properties

edited by

Nurettin Sahiner

submission deadline 31 Dec 2025 | 2 articles | Viewed by 3789 | Submission Open

Keywords: natural antioxidants; flavonoids; and polyphenols; biocompatible and blood compatible; hydrogel; microgels; nanogel; and particles; polymeric particles; carbon quantum dots; and g-C3N4; stimuli-responsive materials; drug delivery systems; controlled release; and targeted delivery/therapies; antibacterial; antifungal; antiviral; anticancer; and biocidal; ROS-scavenging activity; proteins; enzyme; peptides; and amino acids; activate-able materials and photodynamic therapy

(This special issue belongs to the Section Biomedical Engineering and Materials)

From Molecules to Minds: Translational Breakthroughs in Preclinical Psychiatry

edited by

Masaru Tanaka

Simone Battaglia

and

Sandra Barbalho

submission deadline 31 Dec 2025 | 1 articles | Viewed by 3434 | Submission Open

Keywords: depression; anxiety; bipolar disorder; post-traumatic stress disorder; mental disorders; epigenomics; psychiatric disorders/genetics; circadian rhythm; sex characteristics; mitochondrial dysfunction; neurotoxins; intergenerational transmission; cannabinoid receptor modulators; adolescent neuroplasticity; synaptic pruning; psychoimmunology; preclinical studies; translational medical research; neuroplasticity; neuromodulation; phytochemicals; plant extracts; transcranial magnetic stimulation

(This special issue belongs to the Section Molecular and Translational Medicine)

Advances in Reproductive Medicine and Health

edited by Athanasios Zikopoulos, Sofoklis Stavros and

Anastasios Potiris

submission deadline 31 Dec 2025 | 2 articles | Viewed by 3403 | Submission Open

Keywords: reproductive medicine; assisted reproductive technology; fertility preservation; IVF; early pregnancy; miscarriages; proteomics; metabolomics; transcriptomics; infertility; bioethics; cryopreservation; personalized medicine

(This special issue belongs to the Section Molecular and Translational Medicine)

Oxidative Stress in Health and Disease

edited by Federica Mannino

submission deadline 31 Dec 2025 | 1 articles | Viewed by 3319 | Submission Open

Keywords: oxidative stress; inflammation; human diseases; apoptosis; peroxidation; DNA damage; mitochondria

(This special issue belongs to the Section Cell Biology and Pathology)

Advances in Age-Related Diseases: Molecular Mechanisms, Treatments, and Clinical Implications

edited by

Stefano Cacciatore

and

Emanuele Marzetti

submission deadline 31 Dec 2025 | 2 articles | Viewed by 2905 | Submission Open

Keywords: aging; age-related diseases; cellular senescence; mitochondrial dysfunction; inflammation and oxidative stress; biomarkers; precision medicine; pharmacological interventions; healthy aging; translational geriatric research

(This special issue belongs to the Section Molecular and Translational Medicine)

Liver Disease: Etiology, Pathology, and Treatment

edited by Ivana Mikolašević

submission deadline 31 Dec 2025 | 2 articles | Viewed by 2596 | Submission Open

Keywords: chronic liver disease; metabolic-associated fatty liver disease; liver fibrosis; liver injury; etiology; pathology; molecular and cellular mechanisms; biomarkers and therapeutic targets; immunotherapy; prevention and treatment

(This special issue belongs to the Section Cell Biology and Pathology)

Zebrafish Models for Development and Disease—5th Edition

edited by

James A. Marrs

submission deadline 31 Dec 2025 | 1 articles | Viewed by 2563 | Submission Open

Keywords: disease model; drug screening model; teratogen screening; toxicological screening; neuroscience; behavior; developmental biology

(This special issue belongs to the Section Molecular and Translational Medicine)

Navigating the Complex Landscape of Non-Communicable Respiratory Diseases: Emerging Challenges and Opportunities

edited by

Katya Rigatto

submission deadline 31 Dec 2025 | 3 articles | Viewed by 2379 | Submission Open

Keywords: non-communicable respiratory diseases; asthma; idiopathic pulmonary fibrosis; chronic obstructive pulmonary disease

(This special issue belongs to the Section Molecular and Translational Medicine)

Glomerular Disease and Cystic Kidney Disease: From Pathogenesis to Novel Therapeutic Approaches—2nd Edition

edited by Vassilis Filiopoulos and

Chrysanthi Skalioti

submission deadline 31 Dec 2025 | 1 articles | Viewed by 2338 | Submission Open

Keywords: glomerular disease; glomerulonephritis; glomerulopathy; podocytopathies; ciliopathies; cystic kidney disease; polycystic kidney disease; tolvaptan; vasopressin

(This special issue belongs to the Section Molecular and Translational Medicine)

The Role of Telomere and Telomerase in Human Disease—2nd Edition

edited by

Orit Uziel

submission deadline 31 Dec 2025 | 2 articles | Viewed by 2091 | Submission Open

Keywords: telomere; telomerase; cancer; aging

(This special issue belongs to the Section Molecular and Translational Medicine)

Pathophysiology of Fatty Acid Metabolism

edited by

Nikolina Kolobarić

and

Ines Drenjančević

submission deadline 31 Dec 2025 | 2 articles | Viewed by 2056 | Submission Open

Keywords: fatty acids; signalling molecules; gene expression; metabolic disorders

(This special issue belongs to the Section Endocrinology and Metabolism Research)

Animal Models for the Study of Cardiovascular Physiology—Second Edition

edited by Sandra Lia Amaral

submission deadline 31 Dec 2025 | 2 articles | Viewed by 2005 | Submission Open

Keywords: hypertension; stroke; myocardium infarction; arterial stiffness; supravalvular aortic stenosis; cardiac remodeling; capillary angiogenesis; exercise training; vascular diseases; non-pharmacological treatment

(This special issue belongs to the Section Cell Biology and Pathology)

Breast Cancer Research: Charting Future Directions

edited by

Mohamad Adam Bujang

submission deadline 31 Dec 2025 | 3 articles | Viewed by 1940 | Submission Open

Keywords: personalized medicine; biomarkers for early detection; immunotherapy; patient-reported outcomes

(This special issue belongs to the Section Cancer Biology and Oncology)

Recent Therapeutic Advances in Parkinson’s Disease

edited by

Chieh-Sen Chuang

submission deadline 31 Dec 2025 | 2 articles | Viewed by 1925 | Submission Open

Keywords: Parkinson's disease; disease-modifying therapy; continuous dopaminergic stimulation; non-dopaminergic drugs; deep brain stimulation; drug repurposing; immunotherapies; gene therapies

(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)

Recent Advances in Gastrointestinal Cancers: From Microbiota Modulation to New Therapeutic Approaches—2nd Edition

edited by

Serena Martinelli

submission deadline 31 Dec 2025 | 2 articles | Viewed by 1909 | Submission Open

Keywords: gastrointestinal cancers; microbiota; anticancer therapy; immunotherapy; precision medicine

(This special issue belongs to the Section Cancer Biology and Oncology)

Current Perspectives on Gynecologic Cancers

edited by

Kecheng Huang

submission deadline 31 Dec 2025 | 2 articles | Viewed by 1807 | Submission Open

Keywords: gynecology; genetics; biology; bioinformatics; review; predictive model; artificial intelligence

(This special issue belongs to the Section Cancer Biology and Oncology)

The Gut Microbiome in Early Life and Beyond: Implications for Health and Disease

edited by

Ye Peng

and

Shilan Wang

submission deadline 31 Dec 2025 | 1 articles | Viewed by 1652 | Submission Open

Keywords: gut microbiome; early-life development; DOHaD; microbial dysbiosis; chronic disease; probiotics; prebiotics; microbiome– host interactions; developmental programming; translational research

(This special issue belongs to the Section Microbiology in Human Health and Disease)

HIV Therapy: The Latest Developments in Antiviral Drugs

edited by

Francisco Javier Fanjul Losa

submission deadline 31 Dec 2025 | 1 articles | Viewed by 1599 | Submission Open

Keywords: HIV; antiviral drugs; experimental therapeutics; drug discovery; viral reservoirs; mechanism of action; preclinical models; novel HIV targets; antiretroviral therapy (ART); immunotherapy (experimental aspects)

(This special issue belongs to the Section Drug Discovery, Development and Delivery)

Genetic and Molecular Mechanisms of Cardiometabolic Diseases and Cancers—2nd Edition

edited by Tao Wu and

Dafang Chen

submission deadline 31 Dec 2025 | 1 articles | Viewed by 1523 | Submission Open

Keywords: cardiometabolic disease; oncology; comorbidity; genetic pleiotropy; direct genetic effects; indirect genetic effects; parent-of-origin

(This special issue belongs to the Section Molecular Genetics and Genetic Diseases)

New Challenges in the Study of Liver Diseases: From Molecular Pathogenesis to Therapeutic Approaches—4th Edition

edited by

Marica Meroni

submission deadline 31 Dec 2025 | 2 articles | Viewed by 1267 | Submission Open

Keywords: liver diseases and related pathologies; non-alcoholic fatty liver diseases (NAFLDs); obesity; type 2 diabetes; cardiovascular diseases; gut– liver axis; viral hepatitis; alcoholic liver diseases (ALDs); cholestatic disorders; personalized medicine

(This special issue belongs to the Section Molecular and Translational Medicine)

Current Trends in Regenerative Medicine

edited by

Leonidas Kandilogiannakis

and

Eirini Filidou

submission deadline 31 Dec 2025 | Viewed by 1180 | Submission Open

Keywords: regenerative medicine; stem cells; organoids; tissue engineering; gene therapy; cell therapy; biomaterials; personalized medicine

(This special issue belongs to the Section Gene and Cell Therapy)

MicroRNAs in Precision Medicine: Regulation, Biomarkers and Novel Therapeutics

edited by Shing Cheng Tan

submission deadline 31 Dec 2025 | 1 articles | Viewed by 1136 | Submission Open

Keywords: MicroRNAs; non-coding RNAs; biomarkers; therapeutic targets; cancer; omics technologies; precision medicine; disease pathogenesis

(This special issue belongs to the Section Molecular and Translational Medicine)

Advanced Research on Diabetic Retinopathy

edited by Stamatios Lampsas

submission deadline 31 Dec 2025 | 1 articles | Viewed by 1085 | Submission Open

Keywords: diebetic retinopathy; retinal diseases; novel treatment strategies; progression; pathogenetic mechanisms; non-proliferative diabetic retinopathy; proliferative diabetic retinopathy

(This special issue belongs to the Section Molecular and Translational Medicine)

Advances in Precision Oncology for Thyroid Carcinoma: Integrating Artificial Intelligence, Genomics and Molecular Diagnostics

edited by

Kyoung Sik Park

submission deadline 31 Dec 2025 | 1 articles | Viewed by 1064 | Submission Open

Keywords: thyroid carcinoma; artificial intelligence; genomics; precision oncology; molecular diagnostics

(This special issue belongs to the Section Cancer Biology and Oncology)

Liver Fibrosis: Molecular Mechanisms, Potential Therapeutic Targets and Clinical Biomarkers, 2nd Edition

edited by

Takefumi Kimura

submission deadline 31 Dec 2025 | 1 articles | Viewed by 1050 | Submission Open

Keywords: liver fibrosis treatment; therapeutic target biomarker; hepatitis; NAFLD; NASH; MAFLD; HSC; GPCR; immunity cell death

(This special issue belongs to the Section Molecular and Translational Medicine)

Diagnosis, Pathogenesis and Treatment of CNS Tumors (2nd Edition)

edited by

Dimitrios Kanakis

submission deadline 31 Dec 2025 | 1 articles | Viewed by 965 | Submission Open

Keywords: CNS tumors; diagnosis; pathogenesis; treatment; prognosis; molecular markers

(This special issue belongs to the Section Molecular and Translational Medicine)

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